3,264 research outputs found
Numerical modelling of the lobes of radio galaxies in cluster environments -- IV. Remnant radio galaxies
© 2019 The Author(s) Published by Oxford University Press on behalf of the Royal Astronomical Society.We examine the remnant phase of radio galaxies using three-dimensional hydrodynamical simulations of relativistic jets propagating through cluster environments. By switching the jets off once the lobes have reached a certain length we can study how the energy distribution between the lobes and shocked intra-cluster medium compares to that of an active source, as well as calculate synchrotron emission properties of the remnant sources. We see that as a result of disturbed cluster gas beginning to settle back into the initial cluster potential, streams of dense gas are pushed along the jet axis behind the remnant lobes, causing them to rise out of the cluster faster than they would due to buoyancy. This leads to increased adiabatic losses and a rapid dimming. The rapid decay of total flux density and surface brightness may explain the small number of remnant sources found in samples with a high flux density limit and may cause analytic models to overestimate the remnant fraction expected in sensitive surveys such as those now being carried out with LOFAR.Peer reviewedFinal Accepted Versio
The Fragmenting Superbubble Associated with the HII Region W4
New observations at high latitudes above the HII region W4 show that the
structure formerly identified as a chimney candidate, an opening to the
Galactic halo, is instead a superbubble in the process of fragmenting and
possibly evolving into a chimney. Data at high Galactic latitudes (b > 5
degrees) above the W3/W4 star forming region at 1420 and 408 MHz Stokes I
(total power) and 1420 MHz Stokes Q and U (linear polarization) reveal an
egg-shaped structure with morphological correlations between our data and the
H-alpha data of Dennison, Topasna, & Simonetti. Polarized intensity images show
depolarization extending from W4 up the walls of the superbubble, providing
strong evidence that the radio continuum is generated by thermal emission
coincident with the H-alpha emission regions. We conclude that the parts of the
HII region hitherto known as W4 and the newly revealed thermal emission are all
ionized by the open cluster OCl 352. Assuming a distance of 2.35 kpc, the ovoid
structure is 164 pc wide and extends 246 pc above the mid-plane of the Galaxy.
The shell's emission decreases in total-intensity and polarized intensity in
various locations, appearing to have a break at its top and another on one
side. Using a geometric analysis of the depolarization in the shell's walls, we
estimate that a magnetic field line-of-sight component of 3 to 5 uG exists in
the shell. We explore the connection between W4 and the Galactic halo,
considering whether sufficient radiation can escape from the fragmenting
superbubble to ionize the kpc-scale H-alpha loop discovered by Reynolds,
Sterling & Haffner.Comment: 42 pages, 14 figures; Accepted for publication in Ap
Hyperfine-interaction- and magnetic-field-induced Bose-Einstein-statistics suppressed two-photon transitions
Two-photon transitions between atomic states of total electronic angular
momentum and are forbidden when the photons are of the same
energy. This selection rule is analogous to the Landau-Yang theorem in particle
physics that forbids decays of vector particle into two photons. It arises
because it is impossible to construct a total angular momentum
quantum-mechanical state of two photons that is permutation symmetric, as
required by Bose-Einstein statistics. In atoms with non-zero nuclear spin, the
selection rule can be violated due to hyperfine interactions. Two distinct
mechanisms responsible for the hyperfine-induced two-photon transitions are
identified, and the hyperfine structure of the induced transitions is
evaluated. The selection rule is also relaxed, even for zero-nuclear-spin
atoms, by application of an external magnetic field. Once again, there are two
similar mechanisms at play: Zeeman splitting of the intermediate-state
sublevels, and off-diagonal mixing of states with different total electronic
angular momentum in the final state. The present theoretical treatment is
relevant to the ongoing experimental search for a possible
Bose-Einstein-statistics violation using two-photon transitions in barium,
where the hyperfine-induced transitions have been recently observed, and the
magnetic-field-induced transitions are being considered both as a possible
systematic effect, and as a way to calibrate the measurement
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Endogenous VEGF isoform expression regulates tumour cell motility
Background: Vascular endothelial growth factor-A (VEGF) is produced by most cancer cells as multiple alternatively spliced isoforms, which display distinct receptor and matrix binding characteristics. In addition to being a major inducer of tumour angiogenesis, VEGF also has complex functions in angiogenesis-independent aspects of tumour growth,but the role of individual VEGF isoforms remains poorly understood. Here we investigated the effects of endogenous VEGF isoform expression on tumour cell migration and invasion.
Method: We used a panel of mouse fibrosarcoma cells we developed (fs188, fs164 and fs120) that express single VEGF isoforms (188, 164 or 120 respectively), under endogenous promoter control. We investigated adhesion to different matrices, 2D migration and invasion through 3D collagen.
Results: Fs188 cells, are typically mesenchymal, form ruffles, display strong integrin-dependent adhesion and express high levels of pERK1/2 and pAKT. In contrast, fs164 and fs120 cells are not typically mesenchymal in morphology; they display weak binding to collagen, lack ruffles and align longitudinally forming long multicellular chains and abundant cell-cell contacts. On 3D collagen, fs188 cells remain mesenchymal while fs164 and fs120 cells adopt a rounded/amoeboid and a mix of rounded/mesenchymal morphologies respectively. Cell morphology and migration are dependent on the cytoskeleton and actinomyosin contractility, to provide traction force in mesenchymal movement, and cortical contraction for rounded amoeboid motility. Consistent with their mesenchymal characteristics, fs188 cells migrated faster in 2D and invaded 3D collagen more efficiently than fs164 or fs120 cells. Contractility inhibitors caused fs164/fs120 cells to switch to a mesenchymal morphology and accelerated their migration but not that of fs188 cells.
Conclusion: VEGF isoforms are emerging as potential biomarkers for anti-VEGF therapies. Our results suggest that individual VEGF isoforms influence the migration and invasion strategies of tumour cells thus adding to the complexity of VEGF signaling within the tumor microenvironment. Acknowledgements This work was funded by Cancer Research UK
Long-Term Potentiation: One Kind or Many?
Do neurobiologists aim to discover natural kinds? I address this question in this chapter via a critical analysis of classification practices operative across the 43-year history of research on long-term potentiation (LTP). I argue that this 43-year history supports the idea that the structure of scientific practice surrounding LTP research has remained an obstacle to the discovery of natural kinds
The HII Region KR 140: Spontaneous Formation of a High Mass Star
We have used a multiwavelength data set from the Canadian Galactic Plane
Survey (CGPS) to study the Galactic HII region KR 140, both on the scale of the
nebula itself and in the context of the star forming activity in the nearby
W3/W4/W5 complex of molecular clouds and HII regions. From both radio and
infrared data we have found a covering factor of about 0.5 for KR 140 and we
interpret the nebula as a bowl-shaped region viewed close to face on.
Extinction measurements place the region on the near side of its parent
molecular cloud. The nebula is kept ionized by one O8.5 V(e) star, VES 735,
which is less than a few million years old. CO data show that VES 735 has
disrupted much of the original molecular cloud for which the estimated mass and
density are about 5000 and 100 cm, respectively. KR 140 is
isolated from the nearest star forming activity, in W3. Our data suggest that
KR 140 is an example of spontaneous (i.e., non-triggered) formation of,
unusually, a high mass star.Comment: 46 pages; includes 15 figures; accepted by the Ap
Advanced power sources for space missions
Approaches to satisfying the power requirements of space-based Strategic Defense Initiative (SDI) missions are studied. The power requirements for non-SDI military space missions and for civil space missions of the National Aeronautics and Space Administration (NASA) are also considered. The more demanding SDI power requirements appear to encompass many, if not all, of the power requirements for those missions. Study results indicate that practical fulfillment of SDI requirements will necessitate substantial advances in the state of the art of power technology. SDI goals include the capability to operate space-based beam weapons, sometimes referred to as directed-energy weapons. Such weapons pose unprecedented power requirements, both during preparation for battle and during battle conditions. The power regimes for these two sets of applications are referred to as alert mode and burst mode, respectively. Alert-mode power requirements are presently stated to range from about 100 kW to a few megawatts for cumulative durations of about a year or more. Burst-mode power requirements are roughly estimated to range from tens to hundreds of megawatts for durations of a few hundred to a few thousand seconds. There are two likely energy sources, chemical and nuclear, for powering SDI directed-energy weapons during the alert and burst modes. The choice between chemical and nuclear space power systems depends in large part on the total duration during which power must be provided. Complete study findings, conclusions, and eight recommendations are reported
Infrastructure to Improve Beef Business Outcomes in the Queensland Gulf
There are significant economic and environmental issues impacting on the short and long term viability of family-run breeding enterprises in the Queensland Gulf. Falling cattle prices and increased business costs threaten the social and financial well-being of many beef producers. Set stocking and overgrazing combine to reduce native 3P (productive, palatable and perennial) grass frequency and herd productivity. The Ryan family on Greenhills Station at George-town in the Queensland Gulf embarked on a 5 year water and fencing infrastructure development program aiming to improve pasture utilisation, land condition and long term carrying capacity
Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells.
Excited-State Photophysics of Hypericin and Its Hexamethoxy Analog: Intramolecular Proton Transfer as a Nonradiative Process in Hypericin
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