1,488 research outputs found

    PCV18 ECONOMIC EVALUATION OF ORAL THERAPIES FOR PULMONARY ARTERIAL HYPERTENSION

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    Locations of small earthquakes near the trifurcation of the San Jacinto fault southeast of Anza, California

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    About 100 small earthquakes (M ≈ 1/2 to 2) which occurred near the trifurcation of the San Jacinto fault southeast of Anza, California, have been accurately located using five- and six-station arrays with dimensions of about 10 km. The pattern of epicenters is complex and extends several km outside of the area outlined by the traces of faulting. Patterns of seismicity observed on opposite sides of the San Jacinto fault are significantly different. On the southwest side, a concentration of foci lies at a depth of about 4-7 km along the projected extension of the Coyote Creek fault a few km northwest of the last surface evidence of faulting. On the northeast side, earthquakes are concentrated at depths between 10 and 15 km. A group of the latter events recorded about 1 week after the magnitude 4.7 earthquake of May 21, 1967 forms a linear pattern parallel to the San Jacinto fault with depths from 3 to 15 km. This pattern may represent the zone of energy release or slip for that earthquake and possibly the plane of the San Jacinto fault at depth, although the epicenters are located about 2 to 3 km to the northeast of the trace of the San Jacinto fault. Most of the earthquakes located in this study are not aftershocks in the usual sense, i.e., easily correlated with a preceding large earthquake. They represent a complex pattern of seismicity which has continued at least for the last 3 years on the micro-earthquake level and for the last 30 years on the macroseismic level

    Theology, News and Notes - Vol. 36, No. 02

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    Theology News & Notes was a theological journal published by Fuller Theological Seminary from 1954 through 2014.https://digitalcommons.fuller.edu/tnn/1103/thumbnail.jp

    Conical emission, pulse splitting and X-wave parametric amplification in nonlinear dynamics of ultrashort light pulses

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    The precise observation of the angle-frequency spectrum of light filaments in water reveals a scenario incompatible with current models of conical emission (CE). Its description in terms of linear X-wave modes leads us to understand filamentation dynamics requiring a phase- and group-matched, Kerr-driven four-wave-mixing process that involves two highly localized pumps and two X-waves. CE and temporal splitting arise naturally as two manifestations of this process

    Expatriate career support: predicting expatriate turnover and performance

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    This study aimed at explaining why multinational companies have difficulty retaining their repatriates as well as how multinational companies can improve in- and expatriate performance. In the study 100 in- and expatriates of a multinational company operating in the food and personal care industry reported the career support they experienced, their perceived career prospects within and outside the home organization, their intentions to leave, and their performance. As predicted, it was found that perceived career support negatively related to intentions to leave. Additionally, it was found that perceived career support positively related to perceived career prospects within the home organization and expatriate performance. Interestingly, no relationship was found between perceived career prospects outside the home organization and intentions to leave. Implications and directions for future research and HR practices in multinational companies are discussed

    Topical Flunixin Meglumine Effects on Pain Associated Biomarkers after Dehorning

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    Twenty-four calves were dehorned and treated with either topical flunixin meglumine formulated for systemic absorption or a placebo. Biomarkers associated with pain were evaluated for up to 72 hour after the dehorning procedure. Plasma cortisol concentrations, 90 minutes post-dehorning, and mechanical nociception threshold at the control site were the only tested biomarkers where a significant difference was demonstrated. No other differences of biomarkers between the two dehorned groups were observed for any time points. Although this product is easy to dose and dispense, its effects on pain biomarkers appears to be negligible

    Electron Transfer Control in Soluble Methane Monooxygenase

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    The hydroxylation or epoxidation of hydrocarbons by bacterial multicomponent monooxygenases (BMMs) requires the interplay of three or four protein components. How component protein interactions control catalysis, however, is not well understood. In particular, the binding sites of the reductase components on the surface of their cognate hydroxylases and the role(s) that the regulatory proteins play during intermolecular electron transfer leading to the hydroxylase reduction have been enigmatic. Here we determine the reductase binding site on the hydroxylase of a BMM enzyme, soluble methane monooxygenase (sMMO) from Methylococcus capsulatus (Bath). We present evidence that the ferredoxin domain of the reductase binds to the canyon region of the hydroxylase, previously determined to be the regulatory protein binding site as well. The latter thus inhibits reductase binding to the hydroxylase and, consequently, intermolecular electron transfer from the reductase to the hydroxylase diiron active site. The binding competition between the regulatory protein and the reductase may serve as a control mechanism for regulating electron transfer, and other BMM enzymes are likely to adopt the same mechanism.National Institutes of Health (U.S.) (Grant GM032134)Waters Corporatio

    Give me a break! Unavoidable fatigue effects in cognitive pupillometry

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    Issue Online: 08 June 2023Pupillometry has a rich history in the study of perception and cognition. One perennial challenge is that the magnitude of the task-evoked pupil response diminishes over the course of an experiment, a phenomenon we refer to as a fatigue effect. Reducing fatigue effects may improve sensitivity to task effects and reduce the likelihood of confounds due to systematic physiological changes over time. In this paper, we investigated the degree to which fatigue effects could be ameliorated by experimenter intervention. In Experiment 1, we assigned participants to one of three groups—no breaks, kinetic breaks (playing with toys, but no social interaction), or chatting with a research assistant—and compared the pupil response across conditions. In Experiment 2, we additionally tested the effect of researcher observation. Only breaks including social interaction significantly reduced the fatigue of the pupil response across trials. However, in all conditions we found robust evidence for fatigue effects: that is, regardless of protocol, the task-evoked pupil response was substantially diminished (at least 60%) over the duration of the experiment. We account for the variance of fatigue effects in our pupillometry data using multiple common statistical modeling approaches (e.g., linear mixed-effects models of peak, mean, and baseline pupil diameters, as well as growth curve models of time-course data). We conclude that pupil attenuation is a predictable phenomenon that should be accommodated in our experimental designs and statistical models.Agencia Estatal de Investigación, Grant/Award Number: CEX2020-001010- S; Eusko Jaurlaritza; National Institutes of Health, Grant/ Award Number: R01 DC014281 and R01 DC019507; National Science Foundation, Grant/Award Number: DGE-174503
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