College Enhancement Strategies and Socioeconomic Inequality

The study provides new information on the relationships between students’ socioeconomic backgrounds, utilization of college enhancement strategies, and subsequent 4-year college enrollment. Enhancement strategies represent student behaviors used to bolster the competitiveness of a college application, such as Advanced Placement exams and a variety of extracurricular activities. By drawing on two national datasets that span the 1990s (NELS) and the 2000s (ELS), the study uncovers how these relationships have changed during a period marked by escalating demand for college and growing class inequality. The findings provide partial evidence of class adaptation (Alon in Am Soc Rev 74:731–755, 2009) based on the combination of increased use of multiple enhancement strategies (“high overall use”) among higher SES students and increased influence of high overall enhancement strategy use in predicting college enrollment, particularly selective college enrollment. Implications are discussed in terms of the higher education system and pervasive social inequality

Students' Precollege Preparation for Participation in a Diverse Democracy

This study focuses on how students' precollege experiences predisposed them to 3 democratic outcomes: (a) ability to see the world from someone else's perspective; (b) beliefs that conflict enhances democracy; and (c) views about the importance of engaging in social action activities. We analyzed data from 3 flagship universities as part of a nationally funded research project and found first-year females are more likely than males to report values and beliefs consistent with democratic outcomes. Participation in race/ethnic discussions, student clubs, and volunteer work, as well as studying with students of different groups and discussing controversial issues are significant predictors in each model. Results also indicate that students might be unprepared to negotiate conflict in a diverse democracy, suggesting that college engagement will play a key role in fostering the development of democratic citizenship. This study also provides new measures of democratic outcomes to assess the impact of diversity and service learning initiatives.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/43626/1/11162_2004_Article_368191.pd

Nicotinamide alone accelerates the conversion of mouse embryonic stem cells into mature neuronal populations.

Vitamin B3 has been shown to play an important role during embryogenesis. Specifically, there is growing evidence that nicotinamide, the biologically active form of vitamin B3, plays a critical role as a morphogen in the differentiation of stem cells to mature cell phenotypes, including those of the central nervous system (CNS). Detailed knowledge of the action of small molecules during neuronal differentiation is not only critical for uncovering mechanisms underlying lineage-specification, but also to establish more effective differentiation protocols to obtain clinically relevant cells for regenerative therapies for neurodegenerative conditions such as Huntington's disease (HD). Thus, this study aimed to investigate the potential of nicotinamide to promote the conversion of stem cells to mature CNS neurons. METHODS: Nicotinamide was applied to differentiating mouse embryonic stem cells (mESC; Sox1GFP knock-in 46C cell line) during their conversion towards a neural fate. Cells were assessed for changes in their proliferation, differentiation and maturation; using immunocytochemistry and morphometric analysis methods. RESULTS: Results presented indicate that 10 mM nicotinamide, when added at the initial stages of differentiation, promoted accelerated progression of ESCs to a neural lineage in adherent monolayer cultures. By 14 days in vitro (DIV), early exposure to nicotinamide was shown to increase the numbers of differentiated βIII-tubulin-positive neurons. Nicotinamide decreased the proportion of pluripotent stem cells, concomitantly increasing numbers of neural progenitors at 4 DIV. These progenitors then underwent rapid conversion to neurons, observed by a reduction in Sox 1 expression and decreased numbers of neural progenitors in the cultures at 14 DIV. Furthermore, GABAergic neurons generated in the presence of nicotinamide showed increased maturity and complexity of neurites at 14 DIV. Therefore, addition of nicotinamide alone caused an accelerated passage of pluripotent cells through lineage specification and further to non-dividing mature neurons. CONCLUSIONS: Our results show that, within an optimal dose range, nicotinamide is able to singly and selectively direct the conversion of embryonic stem cells to mature neurons, and therefore may be a critical factor for normal brain development, thus supporting previous evidence of the fundamental role of vitamins and their metabolites during early CNS development. In addition, nicotinamide may offer a simple effective supplement to enhance the conversion of stem cells to clinically relevant neurons

Highlights lecture EANM 2015: the search for nuclear medicine’s superheroes

The EANM 2015 Annual Congress, held from October 10th to 14th in Hamburg, Germany, was outstanding in many respects. With 5550 participants, this was by far the largest European congress concerning nuclear medicine. More than 1750 scientific presentations were submitted, with more than 250 abstracts from young scientists, indicating that the future success of our discipline is fuelled by a high number of young individuals becoming involved in a multitude of scientific activities. Significant improvements have been made in molecular imaging of cancer, particularly in prostate cancer. PSMA-directed PET/CT appears to become a new gold standard for staging and restaging purposes. Novel tumour specific compounds have shown their potential for target identification also in other solid neoplasms and further our understanding of tumour biology and heterogeneity. In addition, a variety of nuclear imaging techniques guiding surgical interventions have been introduced. A particular focus of the congress was put on targeted, radionuclide based therapies. Novel theranostic concepts addressing also tumour entities with high incidence rates such as prostate cancer, melanoma, and lymphoma, have shown effective anti-tumour activity. Strategies have been presented to improve further already established therapeutic regimens such as somatostatin receptor based radio receptor therapy for treating advanced neuroendocrine tumours. Significant contributions were presented also in the neurosciences track. An increasing number of target structures of high interest in neurology and psychiatry are now available for PET and SPECT imaging, facilitating specific imaging of different subtypes of dementia and movement disorders as well as neuroinflammation. Major contributions in the cardiovascular track focused on further optimization of cardiac perfusion imaging by reducing radiation exposure, reducing scanning time, and improving motion correction. Besides coronary artery disease, many contributions focused on cardiac inflammation, cardiac sarcoidosis, and specific imaging of large vessel vasculitis. The physics and instrumentation track included many highlights such as novel, high resolution scanners. The most noteworthy news and developments of this meeting were summarized in the highlights lecture. Only 55 scientific contributions were mentioned, and hence they represent only a brief summary, which is outlined in this article. For a more detailed view, all presentations can be accessed by the online version of the European Journal of Nuclear Medicine and Molecular Imaging (Volume 42, Supplement 1)

Examining Sex and Ethnoracial Differences in Graduate School Enrollment

The study examines enrollment disparities in graduate education enrollment among students of differing sex and ethnoracial identities. In doing so, we analyze a national sample of students who successfully completed their undergraduate education to understand the individual and institutional factors that influence their likelihood of enrolling in graduate school within the first few years of finishing college. Results from our general model emphasized the importance of educational aspirations, academics, college involvement, and institutional metrics in understanding the propensity to enroll in graduate school. The results across sex and ethnoracial identity reveal the complexity of the graduate enrollment process, and the importance of understanding how individual and institutional factors operate across these demographic classifications

Supplemental File: Socioeconomic Disparities in the Use of College Admission-Enhancing Strategies among High School Seniors from the 1990s to 2000s

This study examines whether strategies commonly used by high school students for enhancing their chances of gaining college admission may contribute to social inequality in postsecondary education. Comparisons are made between nationally representative samples of high school seniors across two decades, from the early 1990s to the early 2000s. The analyses identify the extent to which students’ SES was associated with the use of admission-enhancing strategies, determine the extent to which the relationships changed across a two-decade period, and examine the role of academic achievement in this process. Results confirm that higher SES students are more likely to employ admission-enhancing strategies than lower SES students, but more importantly that this gap widened over time. These findings suggest that admission-enhancing strategies may be partially responsible for maintaining socioeconomic disparities through education

The critical global citizen

Policy imperatives around mobility encourage students to take up international experiences to increase their marketability. These imperatives are framed in narrow ways by neoliberal metanarratives of globalization. As a result, peripheral mobility experiences are often positioned as a key tool in internationalization and developing global citizenship. This individualized notion of the global citizen is counter to the qualities of critical global citizenship such as resilience, empathy, understanding one’s place in the world, and an ethical understanding of inequalities. Higher education institutions have an important role in shaping the social and disciplinary norms that construct these notions and in recognizing the diversity of local and international experiences that can facilitate global perspectives. This chapter puts forward a challenge to institutions to create supportive environments for the facilitation of critical global citizenship