Die Stiftung von Autorschaft in der neulateinischen Literatur (ca. 1350-ca. 1650)

This monograph throws new light on the question of authorship in the Latin literature of the early modern period. It shows that authorship was not something to be taken for granted in an empathic sense, but was chiefly to be found in the paratextual features of works – the dedication, preface, author’s portrait and so on.; Readership: All interested in the history of literature, questions regarding authorship and readership, paratexts, literary practices and rituals (such as dedications), book history, sociology of literature, history of scholarship and science, and the transmission of knowledge

Translating Early Modern Science (Volume 51)

Translating Early Modern Science explores the roles of translation and the practices of translators in early modern Europe. In a period when multiple European vernaculars challenged the hegemony long held by Latin as the language of learning, translation assumed a heightened significance. This volume illustrates how the act of translating texts and images was an essential component in the circulation and exchange of scientific knowledge. It also makes apparent that translation was hardly ever an end in itself; rather it was also a livelihood, a way of promoting the translator’s own ideas, and a means of establishing the connections that in turn constituted far-reaching scientific networks

Monumenta illustrata. Raumwissen und antiquarische Gelehrsamkeit

Bereits zur Zeit der europäischen Renaissance, lange vor der Ausrufung eines spatial turn in den Kulturwissenschaften, wurde das wechselseitige Verhältnis von Raum und Wissen als Analysekategorie eingeführt. Der Band demonstriert das mit Untersuchungen zu den archäologischen Landeskunden des 15. bis 17. Jahrhundert. In der geographisch-historischen Betrachtung erschlossen sich im 15. Jahrhundert Raumkonzepte, die wiederum auf das eigene Selbstverständnis zurückwirkten. Der vorliegende Band geht in Fallstudien zu landeskundlichen Forschungen der frühen Neuzeit der Geschichte des Raumwissens nach. Dabei kommt Flavio Biondos Italia Illustrata (erschienen 1474) ein besonderes Interesse zu, da das Werk in vielen Bereichen Europas ähnliche Untersuchungen angeregt hat, etwa in Spanien, Skandinavien, der Schweiz und im Rheingebiet

Altered Composition of Liver Proteasome Assemblies Contributes to Enhanced Proteasome Activity in the Exceptionally Long-Lived Naked Mole-Rat

The longest-lived rodent, the naked mole-rat (Bathyergidae; Heterocephalus glaber), maintains robust health for at least 75% of its 32 year lifespan, suggesting that the decline in genomic integrity or protein homeostasis routinely observed during aging, is either attenuated or delayed in this extraordinarily long-lived species. The ubiquitin proteasome system (UPS) plays an integral role in protein homeostasis by degrading oxidatively-damaged and misfolded proteins. In this study, we examined proteasome activity in naked mole-rats and mice in whole liver lysates as well as three subcellular fractions to probe the mechanisms behind the apparently enhanced effectiveness of UPS. We found that when compared with mouse samples, naked mole-rats had significantly higher chymotrypsin-like (ChT-L) activity and a two-fold increase in trypsin-like (T-L) in both whole lysates as well as cytosolic fractions. Native gel electrophoresis of the whole tissue lysates showed that the 20S proteasome was more active in the longer-lived species and that 26S proteasome was both more active and more populous. Western blot analyses revealed that both 19S subunits and immunoproteasome catalytic subunits are present in greater amounts in the naked mole-rat suggesting that the observed higher specific activity may be due to the greater proportion of immunoproteasomes in livers of healthy young adults. It thus appears that proteasomes in this species are primed for the efficient removal of stress-damaged proteins. Further characterization of the naked mole-rat proteasome and its regulation could lead to important insights on how the cells in these animals handle increased stress and protein damage to maintain a longer health in their tissues and ultimately a longer life