The Complexity Landscape of Outcome Determination in Judgment Aggregation

We provide a comprehensive analysis of the computational complexity of the outcome determination problem for the most important aggregation rules proposed in the literature on logic-based judgment aggregation. Judgment aggregation is a powerful and flexible framework for studying problems of collective decision making that has attracted interest in a range of disciplines, including Legal Theory, Philosophy, Economics, Political Science, and Artificial Intelligence. The problem of computing the outcome for a given list of individual judgments to be aggregated into a single collective judgment is the most fundamental algorithmic challenge arising in this context. Our analysis applies to several different variants of the basic framework of judgment aggregation that have been discussed in the literature, as well as to a new framework that encompasses all existing such frameworks in terms of expressive power and representational succinctness.publishedVersio

Secretion of Novel SEL1L Endogenous Variants Is Promoted by ER Stress/UPR via Endosomes and Shed Vesicles in Human Cancer Cells

We describe here two novel endogenous variants of the human endoplasmic reticulum (ER) cargo receptor SEL1LA, designated p38 and p28. Biochemical and RNA interference studies in tumorigenic and non-tumorigenic cells indicate that p38 and p28 are N-terminal, ER-anchorless and more stable relative to the canonical transmembrane SEL1LA. P38 is expressed and constitutively secreted, with increase after ER stress, in the KMS11 myeloma line and in the breast cancer lines MCF7 and SKBr3, but not in the non-tumorigenic breast epithelial MCF10A line. P28 is detected only in the poorly differentiated SKBr3 cell line, where it is secreted after ER stress. Consistently with the presence of p38 and p28 in culture media, morphological studies of SKBr3 and KMS11 cells detect N-terminal SEL1L immunolabeling in secretory/degradative compartments and extracellularly-released membrane vesicles. Our findings suggest that the two new SEL1L variants are engaged in endosomal trafficking and secretion via vesicles, which could contribute to relieve ER stress in tumorigenic cells. P38 and p28 could therefore be relevant as diagnostic markers and/or therapeutic targets in cancer