Kinematic 3D Retro-Deformation of Fault Blocks Picked from 3D Seismics

Movement on fault planes causes a large amount of smaller-scale deformation, ductile or brittle, in the area surrounding the fault. Much of this deformation is below the resolution of reflection seismics (i.e. sub-seismic, <10m displacement), but it is important to determine this deformation, since it can make up a large portion of the total bulk strain, for instance in a developing sedimentary basin. Calculation of the amount of sub-seismic strain around a fault by 3-D geometrical kinematic retro-deformation can also be used to predict the orientation and magnitude of these smaller-scale structures. However, firstly a 3-D model of the fault and its faulted horizons must be constructed at a high enough resolution to be able to preserve fault and horizon morphology with a grid spacing of less than 10 m. Secondly, the kinematics of the fault need to be determined, and thirdly a suitable deformation algorithm chosen to fit the deformation style. Then by restoring the faulted horizons to their pre-deformation state (a ‘regional’), the moved horizons can be interrogated as to the strain they underwent. Since strain is commutative, the deformation demonstrated during this retro-deformation is equivalent to that during the natural, forward deformation...conferenc

Мотивация целевых групп при выводе продукта на рынок

Сделан вывод о том, что при разработке системы мотивации необходимо проводить сегментацию клиентов и персонала по группам преобладающих потребностей, как это делается с рынками в маркетинге. А также выделены целевые группы, влияющие на процесс вывода нового продукта на рынок, и особенности их мотивации

The Influence of Acitretin on Brain Lipidomics in Adolescent Mice : Implications for Pediatric and Adolescent Dermatological Therapy

Administration of systemic retinoids such as acitretin has not been approved yet for pediatric patients. An adverse event of retinoid-therapy that occurs with lower prevalence in children than in adults is hyperlipidemia. This might be based on the lack of comorbidities in young patients, but must not be neglected. Especially for the development of the human brain up to young adulthood, dysbalance of lipids might be deleterious. Here, we provide for the first time an in-depth analysis of the influence of subchronic acitretin-administration on lipid composition of brain parenchyma of young wild type mice. For comparison and to evaluate the systemic effect of the treatment, liver lipids were analogously investigated. As expected, triglycerides increased in liver as well as in brain and a non-significant increase in cholesterol was observed. However, specifically brain showed an increase in lyso-phosphatidylcholine and carnitine as well as in sphingomyelin. Group analysis of lipid classes revealed no statistical effects, while single species were tissue-dependently changed: effects in brain were in general more subtly as compared to those in liver regarding the mere number of changed lipid species. Thus, while the overall impact of acitretin seems comparably small regarding brain, the change in individual species and their role in brain development and maturation has to be considered

Shotgun lipidomics of liver and brain tissue of Alzheimer's disease model mice treated with acitretin

Alzheimer’s disease (AD) is a very frequent neurodegenerative disorder characterized by an accumulation of amyloid-β (Aβ). Acitretin, a retinoid-derivative and approved treatment for Psoriasis vulgaris, increases non-amyloidogenic Amyloid-Precursor-Protein-(APP)-processing, prevents Aβ-production and elicits cognitive improvement in AD mouse models. As an unintended side effect, acitretin could result in hyperlipidemia. Here, we analyzed the impact of acitretin on the lipidome in brain and liver tissue in the 5xFAD mouse-model. In line with literature, triglycerides were increased in liver accompanied by increased PCaa, plasmalogens and acyl-carnitines, whereas SM-species were decreased. In brain, these effects were partially enhanced or similar but also inverted. While for SM and plasmalogens similar effects were found, PCaa, TAG and acyl-carnitines showed an inverse effect in both tissues. Our findings emphasize, that potential pharmaceuticals to treat AD should be carefully monitored with respect to lipid-homeostasis because APP-processing itself modulates lipid-metabolism and medication might result in further and unexpected changes. Moreover, deducing effects of brain lipid-homeostasis from results obtained for other tissues should be considered cautiously. With respect to acitretin, the increase in brain plasmalogens might display a further positive probability in AD-treatment, while other results, such as decreased SM, indicate the need of medical surveillance for treated patients

Tocotrienol Affects Oxidative Stress, Cholesterol Homeostasis and the Amyloidogenic Pathway in Neuroblastoma Cells: Consequences for Alzheimer’s Disease

One of the characteristics of Alzheimer´s disease (AD) is an increased amyloid load and an enhanced level of reactive oxidative species (ROS). Vitamin E has known beneficial neuroprotective effects, and previously, some studies suggested that vitamin E is associated with a reduced risk of AD due to its antioxidative properties. However, epidemiological studies and nutritional approaches of vitamin E treatment are controversial. Here, we investigate the effect of α-tocotrienol, which belongs to the group of vitamin E, on AD-relevant processes in neuronal cell lines. In line with the literature, α-tocotrienol reduced the ROS level in SH-SY5Y cells. In the presence of tocotrienols, cholesterol and cholesterol esters, which have been shown to be risk factors in AD, were decreased. Besides the unambiguous positive effects of tocotrienol, amyloid-β (Aβ) levels were increased accompanied by an increase in the activity of enzymes responsible for Aβ production. Proteins and gene expression of the secretases and their components remained unchanged, whereas tocotrienol accelerates enzyme activity in cell-free assays. Besides enhanced Aβ production, tocotrienols inhibited Aβ degradation in neuro 2a (N2a)-cells. Our results might help to understand the controversial findings of vitamin E studies and demonstrate that besides the known positive neuroprotective properties, tocotrienols also have negative characteristics with respect to AD

Vitamin D and Its Analogues Decrease Amyloid-β (Aβ) Formation and Increase Aβ-Degradation

Alzheimer’s disease (AD) is characterized by extracellular plaques in the brain, mainly consisting of amyloid-β (Aβ), as derived from sequential cleavage of the amyloid precursor protein. Epidemiological studies suggest a tight link between hypovitaminosis of the secosteroid vitamin D and AD. Besides decreased vitamin D level in AD patients, an effect of vitamin D on Aβ-homeostasis is discussed. However, the exact underlying mechanisms remain to be elucidated and nothing is known about the potential effect of vitamin D analogues. Here we systematically investigate the effect of vitamin D and therapeutically used analogues (maxacalcitol, calcipotriol, alfacalcidol, paricalcitol, doxercalciferol) on AD-relevant mechanisms. D2 and D3 analogues decreased Aβ-production and increased Aβ-degradation in neuroblastoma cells or vitamin D deficient mouse brains. Effects were mediated by affecting the Aβ-producing enzymes BACE1 and γ-secretase. A reduced secretase activity was accompanied by a decreased BACE1 protein level and nicastrin expression, an essential component of the γ-secretase. Vitamin D and analogues decreased β-secretase activity, not only in mouse brains with mild vitamin D hypovitaminosis, but also in non-deficient mouse brains. Our results further strengthen the link between AD and vitamin D, suggesting that supplementation of vitamin D or vitamin D analogues might have beneficial effects in AD prevention

Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures

Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo

EcoDM Werkstattbericht - Erkenntnisse aus den Interviews

Das Verbundprojekt EcoDM „Ökosystem Datenmanagement: Analysen – Empfehlungen – FAIRification“ untersucht, wie die stetig wachsenden digitalen Datenmengen aus unterschiedlichen Bereichen systematisch und entsprechend der FAIR-Prinzipien (Findable, Accessible, Interoperable, and Reusable) nachhaltig genutzt werden können. Die Projektergebnisse sollen einen Überblick über bestehende Bedarfe und Herausforderungen sowie konkrete Handlungsempfehlungen für ein FAIRes Datenmanagement enthalten. Damit soll ein Beitrag zur Entwicklung von Strategien für einen bereichsübergreifenden Datenaustausch geleistet werden. Die an EcoDM beteiligten Projektpartner sind das Deutsche Archäologische Institut, das am Helmholtz-Zentrum Potsdam – Deutsches GeoForschungsZentrum GFZ angesiedelte Helmholtz Open Science Office und die Fachhochschule Potsdam. Das Poster gibt als Werkstattbericht einen Überblick zu ersten Erkenntnissen aus der Auswertung der Expert*innen-Interviews. In den Bereichen Wissenschaft und Public Sector wurde der Bedarf an Ausbildungsangeboten sowie eine ungenügende Verankerung des Themas Datenmanagement in der Lehre deutlich. Diese Identifizierung als Problemfelder wurde durch Erkenntnisse aus dem Bereich Qualifizierung gestützt. Im Hinblick darauf, dass in den Bereichen Wissenschaft, Public Sector und Wirtschaft ein wachsender Bedarf an Datenmanagement-Expert*innen zu verzeichnen ist, wurde im Bereich Qualifizierung deutlich, dass sich die Bedarfe von Weiterbildungsangeboten und der thematischen Einbindung in Ausbildungs- und Studiengänge bis hin zur gezielten Ausbildung von Data Scientists, Data Stewards und neuen Berufen erstrecken. Die Notwendigkeit für einen Kulturwandel im Umgang mit Daten bzw. für ein stärkeres Bewusstsein für die Relevanz des Themas Datenmanagement war im Public Sector zu erkennen. Im Bereich Wissenschaft hingegen werden als Bedarfe eine Verstetigung des Datenmanagements und die Bereitstellung von Ressourcen geäußert. In den Interviews aus dem Bereich Wirtschaft hingegen wurde deutlich, dass das Teilen von Daten für Firmen mit einem Mehrwert verbunden sein muss. Hier wurde besonders der Bedarf nach rechtlichen Rahmenbedingungen hervorgehoben