Curcuma Longa L. vegetable oil characterization as cutting fluid base and Curcuma Longa L. essential oil antimicrobial properties analysis for machining application

Mestrado de dupla diplomação com a UTFPR - Universidade Tecnológica Federal do ParanáThe global demand for lubricants is around 40 million tons and about 40% of that production is lost in processes or accidents. This high demand and waste makes it inevitable to consider another possibility of replacing mineral oil-based lubricants with a renewable source. Many techniques are being developed to achieve more sustainable alternatives, so the production of biolubricants from vegetable oils is a promising market due to its biodegradability and large number of sources. This work aims to investigate the vegetable oil of Curcuma Longa L. as a potential lubricant base and the essential oil of Curcuma Longa L. as a potential biocidal additive, both for machining applications. The method proposes to evaluate the physicochemical properties of vegetable oil of Curcuma Longa L. related to the characteristics of the lubricant (viscosity, thermal stability and wettability) and to evaluate the biocidal activity of three commercial essential oils of Curcuma Longa L using minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and disk diffusion. From the results, the vegetable oil Curcuma Longa L. showed high viscosity value, high wettability for 1045 steel and aluminum and good thermal stability, promising characteristics to be used as a lubricant base and only one essential oil showed good biocidal activity against Klebsiella pneumoniae and Staphylococcus aureus, which indicates that different sources can lead to different bactericidal activities. It is concluded that the oils extracted from the Curcuma Longa L. plant have the potential to be used as a biolubricant

Tokyo Guidelines 2018 management bundles for acute cholangitis and cholecystitis

Management bundles that define items or procedures strongly recommended in clinical practice have been used in many guidelines in recent years. Application of these bundles facilitates the adaptation of guidelines and helps improve the prognosis of target diseases. In Tokyo Guidelines 2013 (TG13), we proposed management bundles for acute cholangitis and cholecystitis. Here, in Tokyo Guidelines 2018 (TG18), we redefine the management bundles for acute cholangitis and cholecystitis. Critical parts of the bundles in TG18 include the diagnostic process, severity assessment, transfer of patients if necessary, and therapeutic approach at each time point. Observance of these items and procedures should improve the prognosis of acute cholangitis and cholecystitis. Studies are now needed to evaluate the dissemination of these TG18 bundles and their effectiveness. Free full articles and mobile app of TG18 are available at: . Related clinical questions and references are also include

Tokyo Guidelines 2018: initial management of acute biliary infection and flowchart for acute cholangitis

The initial management of patients with suspected acute biliary infection starts with the measurement of vital signs to assess whether or not the situation is urgent. If the case is judged to be urgent, initial medical treatment should be started immediately including respiratory/circulatory management if required, without waiting for a definitive diagnosis. The patient's medical history is then taken; an abdominal examination is performed; blood tests, urinalysis, and diagnostic imaging are carried out; and a diagnosis is made using the diagnostic criteria for cholangitis/cholecystitis. Once the diagnosis has been confirmed, initial medical treatment should be started immediately, severity should be assessed according to the severity grading criteria for acute cholangitis/cholecystitis, and the patient's general status should be evaluated. For mild acute cholangitis, in most cases initial treatment including antibiotics is sufficient, and most patients do not require biliary drainage. However, biliary drainage should be considered if a patient does not respond to initial treatment. For moderate acute cholangitis, early endoscopic or percutaneous transhepatic biliary drainage is indicated. If the underlying etiology requires treatment, this should be provided after the patient's general condition has improved; endoscopic sphincterotomy and subsequent choledocholithotomy may be performed together with biliary drainage. For severe acute cholangitis, appropriate respiratory/circulatory management is required. Biliary drainage should be performed as soon as possible after the patient's general condition has been improved by initial treatment and respiratory/circulatory management. Free full articles and mobile app of TG18 are available at: http://www.jshbps.jp/modules/en/index.php?content_id=47 . Related clinical questions and references are also include

Tokyo Guidelines 2018 diagnostic criteria and severity grading of acute cholecystitis (with videos)

The Tokyo Guidelines 2013 (TG13) for acute cholangitis and cholecystitis were globally disseminated and various clinical studies about the management of acute cholecystitis were reported by many researchers and clinicians from all over the world. The 1st edition of the Tokyo Guidelines 2007 (TG07) was revised in 2013. According to that revision, the TG13 diagnostic criteria of acute cholecystitis provided better specificity and higher diagnostic accuracy. Thorough our literature search about diagnostic criteria for acute cholecystitis, new and strong evidence that had been released from 2013 to 2017 was not found with serious and important issues about using TG13 diagnostic criteria of acute cholecystitis. On the other hand, the TG13 severity grading for acute cholecystitis has been validated in numerous studies. As a result of these reviews, the TG13 severity grading for acute cholecystitis was significantly associated with parameters including 30-day overall mortality, length of hospital stay, conversion rates to open surgery, and medical costs. In terms of severity assessment, breakthrough and intensive literature for revising severity grading was not reported. Consequently, TG13 diagnostic criteria and severity grading were judged from numerous validation studies as useful indicators in clinical practice and adopted as TG18/TG13 diagnostic criteria and severity grading of acute cholecystitis without any modification. Free full articles and mobile app of TG18 are available at: http://www.jshbps.jp/modules/en/index.php?content_id=47. Related clinical questions and references are also include

Hyperlipidic diets enriched with soy or fish oil: effect on the hypothalamic serotonergic system

BV UNIFESP: Teses e dissertaçõe