A novel data collection and monitoring system for health status measures in patients undergoing lateral internal sphincterotomy: The Knowledge Program (TKP)

The Knowledge Program (TKP) allows prospective data collection during routine clinical practice. The aim of this study was to evaluate the efficacy and feasibility of TKP for capturing and monitoring health status measures in patients undergoing lateral internal sphincterotomy (LIS). TKP data of patients undergoing LIS from December 2008 to May 2013 were retrieved. Health status measures including the Cleveland Global Quality of Life (CGQL), European Quality of Life Index (EQ-5D), Fecal Incontinence Severity Index (FISI), anorectal pain scores, and satisfaction questions were evaluated in the study. A total of 500 patients underwent LIS within the study period. Overall patient numbers responding to the health status measures in the pre- and postoperative period were as follows: CGQL: 112 preoperatively, 53 postoperatively, EQ-5D: 112 preoperatively, 55 postoperatively, FISI: 102 preoperatively, 30 postoperatively, and anorectal pain score: 107 preoperatively, 45 postoperatively. Among the responders, the number of patients who completed the health status measures both pre- and postoperatively was as follows: EQ-5D: 31, CGQL: 28, anorectal pain: 24, and FISI: 15. A total of 30 patients completed postoperative satisfaction and recommendation questions. Postoperative earliest (p = 0.02) and most recent (p = 0.01) anorectal pain visual analog scores were significantly lower than the preoperative measurements. The earliest postoperative EQ-5D scores were significantly higher than their preoperative values (p = 0.02). The majority of patients who completed the surveys said they were satisfied (70% and 67%) and would recommended (73% and 70%) LIS to others undergoing postoperative earliest and most recent follow up. LIS reduces anorectal pain without worsening quality of life. TKP captures information directly from patients and records it to a database which may reduce the risk of information loss or alteration

Complications of Ileoanal Pouches

Restorative proctocolectomy with ileal pouch-anal anastomosis is the surgical therapy of choice for patients with chronic ulcerative colitis and the majority of patients with familial adenomatous polyposis. It restores gastrointestinal continuity, re-establishes transanal defecation, and avoids a permanent stoma. Although this technically demanding procedure is associated with low mortality rates, it is frequently accompanied by early and late complications. This article will review these complications and discuss the interventions that are needed to provide appropriate treatment

Optimization of temperature and pretreatments for methane yield of hazelnut shells using the response surface methodology

WOS: 000522876500069In this study, NaOH pretreatment, H2SO4 pretreatment, thermal pretreatment and production temperature were optimized to ensure maximum methane yield from hazelnut shells (HS) using the response surface methodology (RSM). A Box-Behnken design was achieved with four different independent variables and one dependent variable (methane yield). A total of 29 tests were performed after pretreatment according to the RSM design and to different production temperatures, suggesting optimum values for NaOH pretreatment, H2SO4 pretreatment, thermal pretreatment and production temperature were 3.5% w/v, 2.56% v/v, 145.66 degrees C and 34.65 degrees C, respectively. Under these conditions, the RSM-predicted methane yield was 215.896 mL/g volatile solid (VS). The high R-2 value (0.9904) showed that the model could be applied effectively in the digestion of HS for the predicted methane yield according to the production temperature and pretreatments. In addition, lignocellulosic solubilisation was tested after pretreatment of the reactors according to the RSM operating conditions, which showed that the highest cellulose, hemicellulose and lignin solubilisation that could be achieved was 38.7% w/w (R-10), 36.9% w/w (R-22) and 50.5% w/w (R-10), respectively. The modified Gompertz model supported the experimental cumulative methane yields (CMYs).Sivas Cumhuriyet University Scientific Research Projects Unit (CUBAP) [M-747]This study was supported by the Sivas Cumhuriyet University Scientific Research Projects Unit (CUBAP) under project M-747. We appreciate their contribution