Integration of Industry 4.0 technologies into Lean Six Sigma DMAIC: a systematic review

This review examines which Industry 4.0 (I4.0) technologies are suitable for improving Lean Six Sigma (LSS) tasks and the benefits of integrating these technologies into improvement projects. Also, it explores existing integration frameworks and discusses their relevance. A quantitative analysis of 692 papers and an in-depth analysis of 41 papers revealed that “Analyse” is by far the best-supported DMAICs phase through techniques such as Data Mining, Machine Learning, Big Data Analytics, Internet of Things, and Process Mining. This paper also proposes a DMAIC 4.0 framework based on multiple technologies. The mapping of I4.0 related techniques to DMAIC phases and tools is a novelty compared to previous studies regarding the diversity of digital technologies applied. LSS practitioners facing the challenges of increasing complexity and data volumes can benefit from understanding how I4.0 technology can support their DMAIC projects and which of the suggested approaches they can adopt for their context

The integration of Industry 4.0 and Lean Management: A systematic review and constituting elements perspective

This paper explores the prevalent themes for integrating Industry 4.0 and Lean Management to provide a red thread concerning ‘what’ and ‘how’ to execute their integration. Furthermore, gaps in current literature are identified, and an agenda for future research is developed. The research is based on a systematic literature review of 111 papers that were published in academic journals between 2015 and 2021. In contrast to previous reviews, we focus on constituting elements of Lean Management and Industry 4.0 to offer a perspective closely related to practical implementations. The findings suggest Total Productive Maintenance as one exemplary constituting element representing the ‘what’ level and Change Management as a discipline with answers concerning the ‘how’ level. The paper offers a holistic view for practitioners facing the need for an integrated implementation of Industry 4.0 and Lean Management. Prevalent themes can be included in organisational transformation efforts to increase success rates in change projects. Deriving gaps in the current literature and developing an agenda for future research focused on operational concepts offers possibilities for further research with high practical relevance

A Systematic Review of the Integration of Industry 4.0 with Quality-related Operational Excellence Methodologies

This study examines the common themes for integrating Industry 4.0 with quality-related Operational Excellence methodologies to provide a comprehensive overview of ‘what’ and ‘how’ to combine them in an initial integration process. In addition, the gaps in the present literature are aggregated, and a research plan for the future is proposed. The study is based on a systematic review of 37 papers published in academic journals between 2015 and 2021. Unlike previous reviews, this study concentrates on the ‘what’ and ‘how’ level of Total Quality Management, Lean Six Sigma, and Business Process Management as quality-related Operational Excellence methodologies integrated with Industry 4.0 to provide a practical perspective when executing their integration and implementation. Findings indicate a strong technical and data-driven integration focus across the three themes. Furthermore, modes of action as moderators of success were derived as initial variables to be included in quality-driven Industry 4.0 transitions. Identifying gaps in the present literature and defining a research agenda centred on operational principles opens up opportunities for future study with significant practical value

Integrating Lean Management with Industry 4.0: An Explorative Dynamic Capabilities Theory Perspective

This study examines the modes of action for integrating Lean Management with Industry 4.0 through the lens of the Dynamic Capabilities theory. In addition, the gaps in the present knowledge base are aggregated, and a research plan for the future is proposed. The study is based on a Thematic Analysis of 16 in-depth interviews with industry experts engaged in large German manufacturing firms. Unlike previous analyses, this study concentrates on the ‘how’ level to inform practical executions and support firms in their journeys of integrating these two transformational paradigms of Operations Management. The findings indicate a strong methodological and capability-driven focus across the views of industrial experts. Furthermore, modes of action as moderators of success were derived from proposing a processual model to be evaluated through quantitative research. Identifying gaps in the present knowledge base and defining a research agenda centred on operational principles opens up opportunities for future research with significant practical value

Synthesis and in vitro characterization of the genotoxic, mutagenic and cell-transforming potential of nitrosylated heme

Data from epidemiological studies suggest that consumption of red and processed meat is a factor contributing to colorectal carcinogenesis. Red meat contains high amounts of heme, which in turn can be converted to its nitrosylated form, NO-heme, when adding nitrite-containing curing salt to meat. NO-heme might contribute to colorectal cancer formation by causing gene mutations and could thereby be responsible for the association of (processed) red meat consumption with intestinal cancer. Up to now, neither in vitro nor in vivo studies characterizing the mutagenic and cell transforming potential of NO-heme have been published due to the fact that the pure compound is not readily available. Therefore, in the present study, an already existing synthesis protocol was modified to yield, for the first time, purified NO-heme. Thereafter, newly synthesized NO-heme was chemically characterized and used in various in vitro approaches at dietary concentrations to determine whether it can lead to DNA damage and malignant cell transformation. While NO-heme led to a significant dose-dependent increase in the number of DNA strand breaks in the comet assay and was mutagenic in the HPRT assay, this compound tested negative in the Ames test and failed to induce malignant cell transformation in the BALB/c 3T3 cell transformation assay. Interestingly, the non-nitrosylated heme control showed similar effects, but was additionally able to induce malignant transformation in BALB/c 3T3 murine fibroblasts. Taken together, these results suggest that it is the heme molecule rather than the NO moiety which is involved in driving red meat-associated carcinogenesis. © 2020, The Author(s)

Deep Mapping of Small Solar System Bodies with Galactic Cosmic Ray Secondary Particle Showers

Galactic cosmic rays rain steadily from all directions onto asteroids and comets. The interaction of these high-energy ions produces a cascade of secondary particles, including muons, which can penetrate the solid interiors of small solar system bodies. Muons, which are produced in abundance in Earth's atmosphere, have been used to image large structures on Earth, including the Great Pyramids and the interior of volcanoes. In this study, we demonstrate that the transmitted flux of muons is sensitive to the interior density structure of asteroids and comets, less than a few hundred meters in diameter. Muonography has the potential to fill a critical gap in our knowledge of the deep interiors of small bodies, providing information needed for planetary defense, in situ resource utilization, and planetary science. We use Monte Carlo codes (MCNPX and FLUKA), which accurately model galactic cosmic ray showers, to explore systematic variations in the production of muons in solid surfaces. Results of these calculations confirm the scaling of muon production in Earth's atmosphere to solid regolith materials, as predicted by a simple, semi-empirical model. Muons are primarily produced in the top meter of the regoliths of asteroids and comets. Their rate of production is over three orders of magnitude lower than in Earth's atmosphere and depends strongly on regolith density. In practice, the use of muonography to characterize the interiors of small solar system bodies must overcome their low rate of production and their dependence on regolith density, which can vary over the surface of asteroids and comets. We show that interior contrast can be resolved using a muon telescope (hodoscope) with about 1 sq m aperture with integration times ranging from hours to weeks. Design concepts for a practical hodoscope that could be deployed in situ or on an orbiting spacecraft, are described. Regolith density within the top meter of an asteroid can be determined from radar observations. A concept for a pilot mission that combines remote radar measurements with in situ muonography of a near-Earth asteroid is presented. Perceived challenges and next steps for the development of the concept are described

The application of FLUKA to dosimetry and radiation therapy

The FLUKA Monte Carlo code has been evolving over the last several decades and is now widely used for radiation shielding calculations. In order to facilitate the use of FLUKA in dosimetry and therapy applications, supporting software has been developed to allow the direct conversion of the output files from standard CT-scans directly into a voxel geometry for transport within FLUKA. Since the CT-scan information essentially contains only the electron density information over the scanned volume, one needs the specific compositions for each voxel individually. We present here the results of a simple algorithm to assign tissues in the human body to one of four categories: soft-tissue, hard-bone, trabecular-bone and porous-lung. In addition, we explore the problem of the pathlength distributions in porous media such as trabecular bone. A mechanism will be implemented within FLUKA to allow for variable multipal fixed density materials to accommodate the pathlength distributions discovere

Observation of a 4ΣHe Bound State in the H4e(K−,π−) reaction at 600MeV/c

We have observed a clear peak below the Σ+-production threshold in the 4He(K−,π−) reaction at 600MeV/c and θKπ=4∘. This is confirmation of the existence of the bound state of 4ΣHe, which was reported in the 4He(stoppedK−,π−) reaction. As in the case of stopped kaons, no such peak was found in the 4He(K−,π+) spectrum. Quantitatively reliable parameters for this level have been established. The binding energy and the width of the bound state are 4.4±0.3(stat)±1(syst) MeV and 7.0±0.7(stat)+1.2−0.0(syst) MeV, respectively