Development of Materials Resistant to Metal Dusting Degradation-Vol 1

This is Volume 1 of a two-volume report. It provides general information on industrial participation and commercialization. Volume 2 contains details of technical work and results

Preliminary Results from a Study Investigating the Transition from Capstone Design to Industry

This study investigates engineering students’ transitions from academic to professional environments by examining the role capstone design courses play in preparing graduates for the workplace. To better understand how capstone design experiences contribute to graduates’ professional preparation, we are collecting data from participants from four different institutions with project-based capstone courses as they begin post-graduation positions in a variety of engineering workplaces. Through quantitative and qualitative methods, our study is designed to collect insights from participants in their first 12 months on the job. Currently we are collecting and analyzing data from the first of two planned cohorts of participants. Preliminary results for the participants in the first cohort point towards interesting trends regarding participants’ frequency of activities and perception of their preparedness. Professional skills such as team meetings were listed most frequently as activities engaged in by participants, and while there were particular areas such as budgeting where participants felt less prepared, overall their perception of preparedness indicates that capstone design courses and the larger engineering curriculum they are housed within are preparing students for professional careers

New Engineers’ First Three Months: A Study of the Transition from Capstone Design Courses to Workplaces

In preparing engineering students for the workplace, capstone classes provide unique opportunities for students to develop their professional identities and learn critical skills such as engineering design, teamwork, and self-directed learning (Lutz & Paretti). While existing research explores what and how students learn within these courses, we know much less about how capstone courses affect students’ transitions into the workplace. To address this gap, we are following 62 new graduates from four institutions during the participants’ first 12 weeks of work. Participants were drawn from three mechanical engineering programs and one engineering science program. Women were intentionally oversampled in the study, with 29 participants (47%) identifying as female. Weekly surveys were used to collect quantitative data on what types of workplace activities participants engaged in (e.g., team meetings, project budgeting, CAD modeling, engineering calculations) and qualitative data on what challenges they experience in their early work experience. In this paper, we present a descriptive analysis of the data to identify patterns across participants. Preliminary analysis of the quantitative data suggests that the most common activities for our participants were team meetings and project planning (mentioned by \u3e70% of participants) compared to formal presentations and project budgeting (mentioned by The results are intended to inform both capstone faculty and industry to identify areas of strength and improvement. Our recommendations target current practices in capstone education including course design and structure as well as industry onboarding practices

Macrophage-mediated delivery of light activated nitric oxide prodrugs with spatial, temporal and concentration control† †Electronic supplementary information (ESI) available: Includes detailed experimental details plus 10 additional figures. See DOI: 10.1039/c8sc00015h

Nitric oxide (NO) holds great promise as a treatment for cancer hypoxia, if its concentration and localization can be precisely controlled. Here, we report a “Trojan Horse” strategy to provide the necessary spatial, temporal, and dosage control of such drug-delivery therapies at targeted tissues. Described is a unique package consisting of (1) a manganese–nitrosyl complex, which is a photoactivated NO-releasing moiety (photoNORM), plus Nd3+-doped upconverting nanoparticles (Nd-UCNPs) incorporated into (2) biodegradable polymer microparticles that are taken up by (3) bone-marrow derived murine macrophages. Both the photoNORM [Mn(NO)dpaqNO2]BPh4(dpaqNO2 = 2-[N,N-bis(pyridin-2-yl-methyl)]-amino-N′-5-nitro-quinolin-8-yl-acetamido) and the Nd-UCNPs are activated by tissue-penetrating near-infrared (NIR) light at ∼800 nm. Thus, simultaneous therapeutic NO delivery and photoluminescence (PL) imaging can be achieved with a NIR diode laser source. The loaded microparticles are non-toxic to their macrophage hosts in the absence of light. The microparticle-carrying macrophages deeply penetrate into NIH-3T3/4T1 tumor spheroid models, and when the infiltrated spheroids are irradiated with NIR light, NO is released in quantifiable amounts while emission from the Nd-UCNPs provides images of microparticle location. Furthermore, varying the intensity of the NIR excitation allows photochemical control over NO release. Low doses reduce levels of hypoxia inducible factor 1 alpha (HIF-1α) in the tumor cells, while high doses are cytotoxic. The use of macrophages to carry microparticles with a NIR photo-activated theranostic payload into a tumor overcomes challenges often faced with therapeutic administration of NO and offers the potential of multiple treatment strategies with a single system

Part I. Substituted Dihydropyridines as Models for Coenzymes Cationic nad-nadh. Part II. Synthesis of Sulfated Derivatives of Ascorbic Acid

There are two parts to this thesis. In Part I, several compounds containing two 1,4-dihydronicotin-amide moieties (e.g. bis-o-xylylene-3-carbamoyl-1,4-di-hydronicotinamide) have been synthesized. In addition, a number of compounds containing only one 1,4-dihydronicotin-amide moiety were sysnthesized. In Part 2, a method is described for the sulfation of methyl B-glucoside, ascorbic acid and 5,6-isopropylidene-1-ascorbic acid