28 research outputs found
Density Functional Theory Investigation of the Binding of ThioTEPA to Purine Bases:Thermodynamics and Bond Evolution Theory Analysis
Theoretical Assessment of the Second-Order Nonlinear Optical Responses of Lindqvist-Type Organoimido Polyoxometalates
Theoretical Assessment of the Second-Order Nonlinear Optical Responses of Lindqvist-Type Organoimido Polyoxometalates
TesisLa actual investigación es para optar al título de Ingeniero de Sistemas y tuvo por finalidad determinar el nivel De Gestión De Entrega Y Soporte de Las Tecnologías de la Información Y Comunicación en el Instituto de Educación Superior Tecnológico Publico Teodoro Rivera Taipe De La Provincia De Satipo En El Año 2016. Está fundada en la línea de investigación” Nivel de gestión de la adquisición e implementación de las tecnologías de información y comunicación (TIC) en la Municipalidad Distrital de Santa, provincia del Santa, departamento de Ancash en el año 2013” de la Escuela Profesional de Ingeniería de Sistemas de la Universidad Católica Los Ángeles de Chimbote (ULADECH Católica).
Esta investigación es de tipo cuantitativo, descriptivo, no experimental y de corte transversal. Se trabajó con una población de 42 empleados, entre personal administrativo, docente y el área informática. Para el procedimiento de recopilación de datos se aplicó como instrumento un cuestionario por cada una de las variables, utilizando la técnica de la encuesta.
Los resultados demuestran la I.E.S.T.P Teodoro Rivera Taipe de acuerdo a los niveles de Gestión de Entrega Y Soporte se encuentra en un nivel 1 Inicial – Ad/Hoc, por lo tanto, se concluye que de acuerdo a los niveles de madurez se encuentran en la etapa inicial existiendo los procesos por mejorar para lo cual se recomendó administrar correctamente los recursos, sugiriendo documentar y capacitar por áreas y por ultimo proteger y registrar los servicios TI
Enhancement of Antibacterial Activity of Paludifilum halophilum and Identification of N-(1-Carboxy-ethyl)-phthalamic Acid as the Main Bioactive Compound
The aim of this study was to determine the combined effect of fermentation parameters and enhance the production of cellular biomass and antibacterial compounds from Paludifilum halophilum SMBg3 using the response surface methodology (RSM). Eight variables were screened to assess the effects of fermentation parameters on growth and metabolite production by Taguchi experimental design. Among these, the initial pH, temperature, and the percentage of MgSO4·7H2O in the medium were found to be most influential. The Box–Behnken design was applied to derive a statistical model for the optimization of these three fermentation parameters. The optimal parameters were initial pH: 8.3, temperature growth: 44°C, and MgSO4·7H2O: 1.6%, respectively. The maximum yield of biomass and metabolite production were, respectively, 11 mg/mL dry weight and 15.5 mm inhibition zone diameter against Salmonella enterica, which were in agreement with predicted values. The bioactive compounds were separated by the thick-layer chromatography technique and analyzed by GC/MS, NMR (1D and 2D), and Fourier-transform infrared spectroscopy (FT-IR). In addition to several fatty acids, N-(1-carboxy-ethyl)-phthalamic acid was identified as the main antibacterial compound. This element exhibited a potent activity against the ciprofloxacin-resistant Salmonella enterica CIP 8039 and Pseudomonas aeruginosa ATCC 9027 with a minimum inhibitory concentration (MIC) value range of 12.5–25 μg/mL. Results demonstrated that P. halophilum strain SMBg3 is a promising resource for novel antibacterial production due to its high-level yield potential and the capacity for large-scale fermentation
How to differentiate mucinous eccrine carcinoma from cutaneous metastasis of breast carcinoma?
ccrine skin tumors are rare and represent only 0,05% of all cutaneaous neoplasms. They represent a pitfall especially with cutaneous metastases of carcinoma which are more frequent. We report the case of a 60-year-old woman presented with a frontal scalp mass whose histologic and immunohistochemical features concluded initially to a cutaneous metastasis of breast carcinoma. The diagnosis was reviewed because of the absence of a breast lesion. The final diagnosis was primary sweet gland carcinoma. Histologic distinction between cutaneous metastatic breast carcinoma and primary cutaneous adnexal neoplasms can be very challenging or even impossible. This case illustrates this difficulty and puts emphasis on the necessity of keeping in mind the distinctive features between these two entities
Protective effect of kombucha on rats fed a hypercholesterolemic diet is mediated by its antioxidant activity
CONTEXT: Kombucha (KT) is claimed to have various beneficial effects on human health, but there is very little scientific evidence available in the literature. OBJECTIVE: The present study investigates the effects of Camellia sinensis (GT) Linn. (Theaceae) and KT, two natural drinks, on cholesterol and antioxidant status using a hypercholesterolemia rat model. MATERIALS AND METHODS: The present study compared the free-radical scavenging abilities and polyphenol levels of GT and KT. Wistar rats fed cholesterol-rich diets were given KT or GT (5 mL/kg body weight per day, po) for 16 weeks, then fasted overnight and sacrificed. The plasma lipid levels, thiobarbituric acid reactive substances (TBARS) and aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyl transpeptidase (GGT) serum levels, antioxidant activities of superoxide dismutase (SOD) and catalase (CAT), and creatinine and urea rats were examined. RESULTS: KT had a phenolic compound of 955 ± 0.75 mg GAE/g) followed, by GT (788.92 ± 0.02 mg GAE/g). The free radical scavenging activity of KT was higher than GT. Compared with GT, KT induced lowered serum levels of TC, TG, VLDL-C, and LDL-C by 26, 27, 28, and 36%, respectively, and increased the serum level of high-density lipoprotein cholesterol (HDL-C). KT induced a 55% decrease of TBARS level in liver and 44% in kidney, compared with those of rats fed a cholesterol-rich diet alone. Moreover, CAT and SOD activities were reduced by 29 and 33%, respectively, in liver and 31 and 35%, respectively, in kidney, after oral administration of KT, compared with those of HCD-fed rats. CONCLUSION: The findings revealed that KT administration induced attractive curative effects on hypercholesterolemic, particularly in terms of liver-kidney functions in rats. Its effect on humans needs to be studied further.status: publishe
Elimination du colorant anionique des effluents des industries textiles par l'usage des argiles tunisiennes comme adsorbants. Mesures du potential zêta et du potentiel d' ecoulement induit
International audienceIn the present work, we have investigated the adsorption capacities of natural raw clays originated from Tunisia, such as those from Tabarka (a mixture of kaolinite and illite) and from Fouchana (a mixture of smectite, kaolinite, and illite), a standard kaolinite (KGa-2), and a palygorskite (PFl-1) for the removal of a reactive red dye (RR 120) usually found in textile industry effluents. Thus, batch adsorption experiments were performed and were tuned by varying different parameters such as adsorption contact time, aqueous phase pH, ionic strength, and initial dye concentration. In addition, zeta potential measurements allowed the determination of the electrical charge and of the dye behavior at the clay ewater interface. Despite the fact that palygorskite has higher porosity and specific surface values, the amount of dye adsorbed on this clay is low in comparison to that of the other solid samples, regardless of the values of pH and ionic strength of the aqueous phase. On the other hand, a higher amount of adsorbed dye was observed on KGa-2, having the lowest specific surface area value. This sample, in comparison to smectite and fibrous clays, was found to be more efficient in the removal the anionic dye, and thus it can be used as an adsorbent for the treatment of effluents in the textile industry. Motscl es: Colorant anionique Adsorption Argile Potentiel d' ecoulement induit Potentiel zêta Effluents textiles r é s u m é Dans ce travail, nous avons etudi e les capacit es d'adsorption des argiles naturelles brutes originaires de Tunisie, telles que celles de Tabarka (m elange de kaolinite et d'illite), de Fouchana (m elange de smectite, kaolinite et illite), une kaolinite standard (KGa-2) et une palygorskite (PFl-1), pour eliminer un colorant rouge r eactif (RR 120) pr esent dans les effluents de l'industrie textile. Ainsi, des exp eriences d'adsorption en batch ont et e r ealis ees, examinant diff erents param etres tels que le temps de contact adsorbante adsorbat, le pH et la force ionique de la phase aqueuse, la concentration initiale en colorant. Par ailleurs, des mesures du potential zêta et du potentiel d' ecoulement induit des diff erentes dispersions aqueuses en absence et en pr esence du colorant ont permis de d eterminer la charge electrique et le comportement du colorant a l'interface argileeeau. Les r esultats montrent que, malgr e le fait que la palygorskite pr esente une porosit e et une surface sp ecifique elev ees, la quantit e de colorant adsorb ee sur cette argile est faible par rapport a celles des autres argiles, quelles que soient les valeurs de pH et de force ionique de la phase aqueuse. Par ailleurs, la quantit e de colorant adsorb e la plus elev ee a et e observ ee sur la kaolinite (KGa-2), qui s'est av er eeêtre l'adsorbant le plus efficace pour eliminer le colorant anionique et traiter les effluents de l'industrie textile
An intriguing case of a paravertebral extramedullary erythropoiesis presenting as tumor‐mimicking lesion in a patient with eosinophilia with FIP1L1‐PDGFRA rearrangement
Abstract Extramedullary hematopoiesis in the posterior mediastinum is rare. Our case interested a 28‐year‐old man with a history of eosinophilia with FIP1L1‐PDGFRA fusion gene who had a mediastinal mass surgically excised. Pathological examination concluded to an extramedullary erythropoiesis. This case is original by its location and the presence of only the erythroblastic line rearrangement