Bodies, sexualities and women leaders in popular culture: from spectacle to metapicture

Purpose – This paper focuses on visual representation of women leaders and how women leaders’ bodies and sexualities are rendered visible in particular ways. Design/methodology/approach – The arguments are based on a reading of the Danish television drama series, Borgen. The authors interpret the meaning of this text and consider what audiences might gain from watching it. Findings – The analysis of Borgen highlights the role of popular culture in resisting patriarchal values and enabling women to reclaim leadership. Originality/value – The metaphor of the spectacle enables explanation of the representation of women leaders in popular culture as passive, fetishised objects of the masculine gaze. These pervasive representational practices place considerable pressure on women leaders to manage their bodies and sexualities in particular ways. However, popular culture also provides alternative representations of women leaders as embodied and agentic. The notion of the metapicture offers a means of destabilising confining notions of female leadership within popular culture and opening up alternative

Meeting the challenge of diabetes in ageing and diverse populations: a review of the literature from the UK

The impact of type 2 diabetes on ageing societies is great and populations across the globe are becoming more diverse. Complications of diabetes unequally affect particular groups in the UK older people, and people with a South Asian background are two population groups with increased risk whose numbers will grow in the future. We explored the evidence about diabetes care for older people with South Asian ethnicity to understand the contexts and mechanisms behind interventions to reduce inequalities. We used a realist approach to review the literature, mapped the main areas where relevant evidence exists, and explored the concepts and mechanisms which underpinned interventions. From this we constructed a theoretical framework for a programme of research and put forward suggestions for what our analysis might mean to providers, researchers, and policy makers. Broad themes of cultural competency; comorbidities and stratification; and access emerged as mid-level mechanisms which have individualised, culturally intelligent, and ethical care at their heart and through which inequalities can be addressed. These provide a theoretical framework for future research to advance knowledge about concordance; culturally meaningful measures of depression and cognitive impairment; and care planning in different contexts which support effective diabetes care for aging and diverse populations

Sleepless latency of human cytomegalovirus.

As with all human herpesviruses, human cytomegalovirus (HCMV) persists for the lifetime of the host by establishing a latent infection, which is broken by periodic reactivation events. One site of HCMV latency is in the progenitor cells of the myeloid lineage such as CD34+ cells and their CD14+ derivatives. The development of experimental techniques to isolate and culture these primary cells in vitro is enabling detailed analysis of the events that occur during virus latency and reactivation. Ex vivo differentiation of latently infected primary myeloid cells to dendritic cells and macrophages results in the reactivation of latent virus and provides model systems in which to analyse the viral and cellular functions involved in latent carriage and reactivation. Such analyses have shown that, in contrast to primary lytic infection or reactivation which is characterised by a regulated cascade of expression of all viral genes, latent infection is associated with a much more restricted viral transcription programme with expression of only a small number of viral genes. Additionally, concomitant changes in the expression of cellular miRNAs and cellular proteins occur, and this includes changes in the expression of a number of secreted cellular proteins and intracellular anti-apoptotic proteins, which all have profound effects on the latently infected cells. In this review, we concentrate on the effects of one of the latency-associated viral proteins, LAcmvIL-10, and describe how it causes a decrease in the cellular miRNA, hsa-miR-92a, and a concomitant upregulation of the GATA2 myeloid transcription factor, which, in turn, drives the expression of cellular IL-10. Taken together, we argue that HCMV latency, rather than a period of viral quiescence, is associated with the virally driven manipulation of host cell functions, perhaps every bit as complex as lytic infection. A full understanding of these changes in cellular and viral gene expression during latent infection could have far-reaching implications for therapeutic intervention.We thank the MRC for funding, Grant Number G0701279. This research was supported by the Cambridge NIHR BRC cell phenotyping hub.This is the final published version. It first appeared at http://link.springer.com/article/10.1007%2Fs00430-015-0401-6

Understanding HCMV Latency Using Unbiased Proteomic Analyses

Human cytomegalovirus (HCMV) establishes either a latent (non-productive) or lytic (productive) infection depending upon cell type, cytokine milieu and the differentiation status of the infected cell. Undifferentiated cells, such as precursor cells of the myeloid lineage, support a latent infection whereas terminally differentiated cells, such as monocytes or dendritic cells are an environment conducive to reactivation and support a lytic infection. The mechanisms which regulate HCMV in either a latent or lytic infection have been the focus of intense investigation with a view to developing novel treatments for HCMV-associated disease which can have a heavy clinical burden after reactivation or primary infection in, especially, the immune compromised. To this end, a number of studies have been carried out in an unbiased manner to address global changes occurring within the latently infected cell to address the molecular changes associated with HCMV latency. In this review, we will concentrate on the proteomic analyses which have been carried out in undifferentiated myeloid cells which either stably express specific viral latency associated genes in isolation or on cells which have been latently infected with virus

Latent infection of myeloid progenitors by human cytomegalovirus protects cells from FAS-mediated apoptosis through the cellular IL-10/PEA-15 pathway.

Latent infection of primary CD34(+) progenitor cells by human cytomegalovirus (HCMV) results in their increased survival in the face of pro-apoptotic signals. For instance, we have shown previously that primary myeloid cells are refractory to FAS-mediated killing and that cellular IL-10 (cIL-10) is an important survival factor for this effect. However, how cIL-10 mediates this protection is unclear. Here, we have shown that cIL-10 signalling leading to upregulation of the cellular factor PEA-15 mediates latency-associated protection of CD34(+) progenitor cells from the extrinsic death pathway.We gratefully acknowledge funding from the UK Medical Research Council (J.H.S. G:0701279) which supports the current research in our laboratory and also the support of NIHR UK Biomedical Research Centre (J.H.S.). We thank Linda Teague, Roy Whiston and Stuart McGregor Dallas for technical support and Stuart McGregor Dallas for providing validation data for figure 1.This is the final version. It first appeared at http://jgv.sgmjournals.org/content/journal/jgv/10.1099/vir.0.000180

Depletion of cellular pre-replication complex factors results in increased human cytomegalovirus DNA replication.

Although HCMV encodes many genes required for the replication of its DNA genome, no HCMV-encoded orthologue of the origin binding protein, which has been identified in other herpesviruses, has been identified. This has led to speculation that HCMV may use other viral proteins or possibly cellular factors for the initiation of DNA synthesis. It is also unclear whether cellular replication factors are required for efficient replication of viral DNA during or after viral replication origin recognition. Consequently, we have asked whether cellular pre-replication (pre-RC) factors that are either initially associated with cellular origin of replication (e.g. ORC2), those which recruit other replication factors (e.g. Cdt1 or Cdc6) or those which are subsequently recruited (e.g. MCMs) play any role in the HCMV DNA replication. We show that whilst RNAi-mediated knock-down of these factors in the cell affects cellular DNA replication, as predicted, it results in concomitant increases in viral DNA replication. These data show that cellular factors which initiate cellular DNA synthesis are not required for the initiation of replication of viral DNA and suggest that inhibition of cellular DNA synthesis, in itself, fosters conditions which are conducive to viral DNA replication

Participatory Needlework as Tangible and Intangible Heritage

Since the start of the twenty-first century, there has been a resurgence of interest in participatory textile processes (Shercliff and Holroyd 2020). Needlework groups are emerging as knots in a supranational art movement. A ‘textiles turn’ has occurred that raises new questions about alternative art histories, notably those of fibre art practitioners outside a Eurowestern context, such as Cecilia Vicuña, the Tejedoras de Mampuján, Memorarte and Nengi Omuku. This session explores needlework as a practice, a methodology or an object of study. Crucially, we seek to expand existing scholarship tracing different threads that run through the transversal and heterogeneous networks of textile artists and sewing groups emerging across the globe. We disregard structural biases in the art world, dissolving the dichotomy between individual artists and grass-roots embroiderers or patchwork quilters. We called for papers on participatory and artistic needlework practices that consider the economic, historical, political, and creative contexts for sewing groups, or the haptic and visual quality of quilts, embroideries, appliqués and other kinds of textile- based practices. For example: How does the materiality of fabric lend itself to activism and memorialisation? What role do embroidery, appliqué and quilting play in voicing responses to health and humanitarian crises, conflicts, and human rights abuses around the world? How does the therapeutic element of needlework practices sit within the art world? What is the relationship between the labour of needlework and identity? In what ways can participatory needlework projects be considered as tangible and intangible heritage

Return to work after stroke: recording, measuring, and describing occupational therapy intervention

Introduction: Existing research on vocational rehabilitation following stroke has been criticised for not describing intervention in sufficient detail for replication or clinical implementation. The purpose of this study was to test the feasibility of recording and measuring the content of an early stroke-specific vocational rehabilitation intervention delivered to participants in a feasibility randomized controlled trial, using a proforma previously developed for a study of vocational rehabilitation following traumatic brain injury. Method: The proforma was adapted for use in stroke with input from an expert panel and was used to record intervention content, in 10-minute units, following each intervention session. Findings: Twenty-five people, working or in education at the time of stroke, participated in the study. Two thirds of the therapists' time was spent in face-to-face contact (43%) and liaison with the patient and others (20%). Intervention mainly focused on work preparation (21%) and the return to work process (24%). The remaining time was consumed by administration (19%) and travel (18%). Conclusion: The proforma was quick and easy to use and captured the main focus of intervention. This study suggests that it can be used to record stroke-specific vocational rehabilitation intervention content and has potential for wider use in research and clinical practice

Isolating lithologic versus tectonic signals of river profiles to test orogenic models for the Eastern and Southeastern Carpathians

Fluvial morphology is affected by a wide range of forcing factors, which can be external, such as faulting and changes in climate, or internal, such as variations in rock hardness or degree of fracturing. It is a challenge to separate internal and external forcing factors when they are co-located or occur coevally. Failure to account for both factors leads to potential misinterpretations. For example, steepening of channel network due to lithologic contrasts could be misinterpreted to be a function of increased tectonic displacements. These misinterpretations are enhanced over large areas, where landscape properties needed to calculate channel steepness (e.g., channel concavity) can vary significantly in space. In this study, we investigate relative channel steepness over the Eastern Carpathians, where it has been proposed that active rock uplift in the Southeastern Carpathians (SEC) gives way N- and NW-wards to ca. 8 Myrs of post-orogenic quiescence. We develop a technique to quantify relative channel steepness, the relative steepness index, based on a wide range of concavities, and show that the main signal shows an increase in relative steepness index from east to west across the range. Rock hardness measurements and geological studies suggest this difference is driven by lithology. When we isolate channel steepness by lithology to test for ongoing rock uplift along the range, we find steeper channels in the south of the study area compared to the same units in the North. This supports interpretations from longer timescale geological data that active rock uplift is fastest in the southern SEC