Detecting Accurate Emotions in Faces

Anger race bias is the tendency to misidentify expressions of emotion, specifically anger, in Black or racially ambiguous faces that are fearful or neutral (Hutchings & Haddock, 2008). Anger is often associated with aggression (Murphy et al., 2005). Therefore, the inaccurate perception of anger and threat may lead to an inappropriate response and could increase the likelihood that a police officer will shoot at a suspect (Correll et al., 2007). From 2015 to 2020, police officers shot and killed over 100 unarmed Black males (Washington Post, 2020). This study examined if anger race bias could be reduced through emotion identification training. Faces from the Chicago Face Database were used to train participants on the emotions of neutrality, fear, and anger. Participants identified emotions on a series of Black, White, LatinX, and Asian faces on pre-and post-test measures. Two weeks following the post-test, participants were invited to complete a follow-up test to determine their retention of the training. We found that the experimental group accurately identified more facial expressions on average than the control group. These preliminary results demonstrate feasibility in developing emotion recognition trainings to decrease anger race bias with the potential to be helpful in police settings

Functional analysis of the cell cycle control gene cdc18 in Schizosaccharomyces pombe

The Schizosaccharomyces pombe gene cdc18 has a role both in promoting DNA replication and initiating the checkpoint that acts to prevent mitosis until DNA replication has been successfully completed. It therefore plays an essential role in coordinating the cell cycle, thus maintaining genome integrity. I performed a functional analysis of cdc18 in order to understand its role throughout the cell cycle. I used different cdc18p constructs to discover which domains of the protein are required to carry out its functions. I examined this by assaying the ability of cells to re-replicate and block mitosis when the constructs were overexpressed. I discovered that the C-terminus of cdc18p is required for the re-replication phenotype and that this does not require a decrease in the activity of the mitotic kinase. The C-terminus is also required for the checkpoint function of cdc18p. The N-terminus of cdc18p can also block mitosis indirectly by binding to cdc2p. I then examined the Saccharomyces cerevisiae (ScCDC6), Xenopus laevis (XICDC6) and Homo sapiens (HsCDC6) cdcl8 homologues to determine their ability to complement the cdc18-K46 mutant. I also investigated whether they, like cdc18, are able to induce re-replication when overexpressed. None of the homologues was able to complement cdc18-K46, but overexpression of ScCDC6 was able to induce re-replication. Finally, I constructed a strain in which cdc18 was under the control of a repressible promoter. I made several site specific mutants of cdc18-the nucleotide triphosphate (NTP) binding and hydrolysis motif mutants, known as the Walker A (WA) and Walker B (WB) mutants, respectively, the putative nuclear localization signal mutants (NLS1, NLS2 and NLS1+NLS2) and the cdc2p phosphorylation site mutant (P1-6)-and introduced these at a different locus, where they were expressed under control of the cdc18 promoter. I investigated whether the mutants could proliferate in the absence of wildtype cdc18. Only the cdc18 WA and WB mutants failed to proliferate under these conditions. The WA mutant cannot initiate replication but is unable to inhibit mitosis, so undergoes an aberrant mitosis. The WB mutant is able to initiate, but not complete, replication and initiates a checkpoint signal. However, the checkpoint cannot be maintained and cells also enter an aberrant mitosis

Experiences of older people dying in nursing homes : a narrative systematic review of qualitative studies

Objectives To identify and synthesise qualitative research from 2001 investigating older people's (65+ years) experiences of dying in nursing and care homes. Methods and outcomes Eight electronic databases (AMED, ASSIA, CINAHL Plus, Embase, HMIC, Medline, PsychINFO and Scopus) from 2001 to July 2017 were searched. Studies were included if they were qualitative, primary research and described the experiences of dying in nursing or care homes from the perspectives of the older people themselves, their families or staff. Study quality assessment was undertaken to systematically assess methodological quality, but no studies were excluded as a result. Results 1305 articles were identified. Nine met the inclusion criteria. North American studies dominated. Most used a mixture of observations and interviews. All the included studies highlighted the physical discomfort of dying, with many older people experiencing potentially avoidable symptoms if care were to be improved. Negative psychosocial experiences such as loneliness and depression were also often described in addition to limited support with spiritual needs. Conclusions More qualitative research giving a holistic understanding of older people’s experiences of dying in residential care homes is needed. Undertaking research on this topic is challenging and requires great sensitivity, but the dearth of qualitative research from the perspectives of those most closely involved in older people’s deaths hampers service improvement

Statistical models for over-dispersion in the frequency of peaks over threshold data for a flow series.

In a peaks over threshold analysis of a series of river flows, a sufficiently high threshold is used to extract the peaks of independent flood events. This paper reviews existing, and proposes new, statistical models for both the annual counts of such events and the process of event peak times. The most common existing model for the process of event times is a homogeneous Poisson process. This model is motivated by asymptotic theory. However, empirical evidence suggests that it is not the most appropriate model, since it implies that the mean and variance of the annual counts are the same, whereas the counts appear to be overdispersed, i.e., have a larger variance than mean. This paper describes how the homogeneous Poisson process can be extended to incorporate time variation in the rate at which events occur and so help to account for overdispersion in annual counts through the use of regression and mixed models. The implications of these new models on the implied probability distribution of the annual maxima are also discussed. The models are illustrated using a historical flow series from the River Thames at Kingston

A randomised trial of an internet weight control resource: The UK Weight Control Trial [ISRCTN58621669]

BACKGROUND: Obesity treatment is notoriously unsuccessful and one of the barriers to successful weight loss reported by patients is a lack of social support. The Internet offers a novel and fast approach to the delivery of health information, enabling 24-hour access to help and advice. However, much of the health information available on the Internet is unregulated or not written by qualified health professionals to provide unbiased information. The proposed study aims to compare a web-based weight loss package with traditional dietary treatment of obesity in participants. The project aims to deliver high quality information to the patient and to evaluate the effectiveness of this information, both in terms of weight loss outcomes and cost-effectiveness. METHODS: This study is a randomised controlled trial of a weight loss package against usual care provided within General Practice (GP) surgeries in Leeds, UK. Participants will be recruited via posters placed in participating practices. A target recruitment figure of 220 will enable 180 people to be recruited (allowing for 22% dropout). Participants agreeing to take part in the study will be randomly allocated using minimisation to either the intervention group, receiving access to the Internet site, or the usual care group. The primary outcome of the study will be the ability of the package to promote change in BMI over 6 and 12 months compared with traditional treatment. Secondary outcomes will be the ability of the Internet package to promote change in reported lifestyle behaviours. Data will be collected on participant preferences, adherence to treatment, health care use and time off work. Difference in cost between groups in provision of the intervention and the cost of the primary outcome will also be estimated. CONCLUSION: A positive result from this study would enhance the repertoire of treatment approaches available for the management of obesity. A negative result would be used to inform the research agenda and contribute to redefining future strategies for tackling obesity

A multi-centre qualitative study exploring the experiences of UK South Asian and White Diabetic Patients referred for renal care

Background An exploration of renal complications of diabetes from the patient perspective is important for developing quality care through the diabetic renal disease care pathway. Methods Newly referred South Asian and White diabetic renal patients over 16 years were recruited from nephrology outpatient clinics in three UK centres - Luton, West London and Leicester – and their experiences of the diabetes and renal care recorded. A semi-structured qualitative interview was conducted with 48 patients. Interview transcripts were analysed thematically and comparisons made between the White and South Asian groups. Results 23 South Asian patients and 25 White patients were interviewed. Patient experience of diabetes ranged from a few months to 35 years with a mean time since diagnosis of 12.1 years and 17.1 years for the South Asian and White patients respectively. Confusion emerged as a response to referral shared by both groups. This sense of confusion was associated with reported lack of information at the time of referral, but also before referral. Language barriers exacerbated confusion for South Asian patients. Conclusions The diabetic renal patients who have been referred for specialist renal care and found the referral process confusing have poor of awareness of kidney complications of diabetes. Healthcare providers should be more aware of the ongoing information needs of long term diabetics as well as the context of any information exchange including language barriers

Determining the limits and effects of high-rate cycling on lithium iron phosphate cylindrical cells

The impacts on battery cell ageing from high current operation are investigated using commercial cells. This study utilised two tests−(i) to establish the maximum current limits before cell failure and (ii) applying this maximum current until cell failure. Testing was performed to determine how far cycling parameters could progress beyond the manufacturer’s recommendations. Current fluxes were increased up to 100 C cycling conditions without the cell undergoing catastrophic failure. Charge and discharge current capabilities were possible at magnitudes of 1.38 and 4.4 times, respectively, more than that specified by the manufacturer’s claims. The increased current was used for longer term cycling tests to 500 cycles and the resulting capacity loss and resistance increase was dominated by thermal fatigue of the electrodes. This work shows that there is a discrepancy between manufacturer-stated current limits and actual current limits of the cell, before the cell undergoes catastrophic failure. This presumably is based on manufacturer-defined performance and lifetime criteria, as well as prioritised safety factors. For certain applications, e.g., where high performance is needed, this gap may not be suitable; this paper shows how this gap could be narrowed for these applications using the testing described herein

Evaluating the causal impact of individual alcohol licensing decisions on local health and crime using natural experiments with synthetic controls.

BACKGROUND AND AIMS: Given the costs of alcohol to society, it is important to evaluate whether local alcohol licensing decisions can mitigate the effects of alcohol misuse. Robust natural experiment evaluations of the impact of individual licensing decisions could potentially inform and improve local decision-making. We aimed to assess whether alcohol licensing decisions could be evaluated at small spatial scale by using a causal inference framework. DESIGN: Three natural experiments. SETTING AND PARTICIPANTS: Three English local areas of 1000-15 000 people each. INTERVENTION AND COMPARATOR: The case study interventions were (i) the closure of a nightclub following reviews; (ii) closure of a restaurant/nightclub following reviews and (iii) implementation of new local licensing guidance (LLG). Trends in outcomes were compared with synthetic counterfactuals created using Bayesian structural time-series. MEASUREMENTS: Time-series data were obtained on emergency department admissions, ambulance call-outs and alcohol-related crime at the Lower or Middle Super Output geographical aggregation level. FINDINGS: Closure of the nightclub led to temporary 4-month reductions in antisocial behaviour (-18%; 95% credible interval - 37%, -4%), with no change in other outcomes. Closure of the restaurant/nightclub did not lead to measurable changes in outcomes. The new licensing guidance led to small reductions in drunk and disorderly behaviour (nine of a predicted 21 events averted), and the unplanned end of the LLG coincided with an increase in domestic violence of two incidents per month. CONCLUSIONS: The impact of local alcohol policy, even at the level of individual premises, can be evaluated using a causal inference framework. Local government actions such as closure or restriction of alcohol venues and alcohol licensing may have a positive impact on health and crime in the immediate surrounding area