Babylonian encounters in the Upper Diyala River Valley:Contextualizing the results of regional survey and the 2016–2017 excavations at Khani Masi

Kassite Babylonia counts among the great powers of the Late Bronze Age Near East. Its kings exchanged diplomatic letters with the pharaohs of Egypt and held their own against their Assyrian and Elamite neighbors. Babylonia's internal workings, however, remain understood in their outlines only, as do its elite's expansionary ambitions, the degrees to which they may have been realized, and the nature of ensuing imperial encounters. This is especially the case for the region to the northeast, where the Mesopotamian lowlands meet the Zagros piedmonts in the Diyala River valley and where a series of corridors of movement intersect to form a strategic highland-lowland borderland. In this paper, we present critical new results of regional survey in the Upper Diyala plains of northeast Iraq and excavations at the Late Bronze Age site of Khani Masi. Not only do our data and analyses expand considerably the known extent of Babylonia's cultural sphere, but also the monumental character of Khani Masi and its wider settlement context prompt a fundamental rethinking of the nature and chronology of Babylonian presence in this transitional landscape. As such, this paper contributes an important new case study to the field of archaeological empire and borderland studies

Skeletal muscle stem cells express anti-apoptotic ErbB receptors during activation from quiescence

To be effective for tissue repair, satellite cells (the stem cells of adult muscle) must survive the initial activation from quiescence. Using an in vitro model of satellite cell activation, we show that erbB1, erbB2 and erbB3, members of the EGF receptor tyrosine kinase family, appear on satellite cells within 6 h of activation. We show that signalling via erbB2 provides an anti-apoptotic survival mechanism for satellite cells during the first 24 h, as they progress to a proliferative state. Inhibition of erbB2 signalling with AG825 reduced satellite cell numbers, concomitant with elevated caspase-8 activation and TUNEL labelling of apoptotic satellite cells. In serum-free conditions, satellite cell apoptosis could be largely prevented by a mixture of erbB1, erbB3 and erbB4 ligand growth factors, but not by neuregulin alone (erbB3/erbB4 ligand). Furthermore, using inhibitors specific to discrete intracellular signalling pathways, we identify MEK as a pro-apoptotic mediator, and the erbB-regulated factor STAT3 as an anti-apoptotic mediator during satellite cell activation. These results implicate erbB2 signalling in the preservation of a full compliment of satellite cells as they activate in the context of a damaged muscle

Identification of genes involved in the quiescence and early activation of skeletal muscle satellite cells

EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Place, Encounter, and the Making of Communities: The Lower Sirwan/Upper Diyala River Valley from Prehistory to the Iron Age

This book sketches the first archaeological history of the lower Sirwan/upper Diyala river valley of north-east Iraq and adjacent landscapes over a period of c. 12,000 years, from the earliest signs of human presence until the mid-first millennium BCE, based on data gathered between 2013 and 2023 by the Sirwan Regional Project (SRP). The central research objective of the SRP is to move beyond traditional historical topoi and their predominantly external and state-centric perspectives that have dominated narratives of the region thus far. Instead, we develop an in-depth, archaeological understanding of the nature of the region’s past communities, their cultural and economic practices, the modes of socio-political organisation they developed, adopted, and rejected, and their long-term developments. In order to reconstruct past Sirwan lifeways, the book interweaves regional-scale datasets with the results of ongoing and completed excavations at the Late Chalcolithic site of Shakhi Kora and the Late Bronze to Early Iron Age site of Kani Masi, as well as the results of a wide range of archaeological, Assyriological, art historical, and archaeometric analyses