Electrochemical investigation of 2-[8-hydroxyquinoline-5-yl)azo]benzo[c]cinnoline on a platinum electrode in dimethysulfoxide

2-[8-hydroxyquinoline-5-yl)azo]benzo[c]cinnoline was synthesized for the first time and shown to possess electrochromic characteristic, i.e. changing color during the forward and back electrolysis at -1.35 V and 0.00 V, respectively, in DMSO medium. Therefore, the electrochemical investigation of this compound appears to be worthwhile. The electrochemical reduction of 2[8-hydroxyquinoline-5-yl)azo]benzo[c]cinnoline was investigated by cyclic voltammetry, controlled potential electrolysis, and chronoamperometry techniques in the presence of 0.10 mol L-1 tetrabutylammonium tetrafluoroborate in dimethyl sulfoxide at platinum electrode. 2-[8-Hydroxyquinoline-5-yl)azo]benzo[c] cinnoline displays three sharp cathodic peaks and three anodic peaks in the cyclic voltammogram. The diffusion coefficients and the number of electrons transferred were calculated by using an ultramicroelectrode and platinum electrode. The number of transferred electrons was found to be one for each peak. The standard heterogeneous rate constant for reduction was calculated by the Klingler Kochi technique. The electrochemical reduction mechanism of 2-[8-hydroxyquinoline-5yl)azo]benzo[c]cinnoline was also investigated by using various electrochemical techniques, such as bulk electrolysis, and spectroscopic methods, like electron spin resonance spectroscopy. Bulk electrolysis results also provided evidence for each peak belonging to reduction of one electron, two of which were confirmed by electron spin resonance spectroscopy. This new chemical is found to be an electrochromic substance.TR Prime Ministry State Planning Organization [98 - K - 120830]; Ankara University Research FundAnkara University [20050705094]We gratefully acknowledge the financial support of TR Prime Ministry State Planning Organization (Project No: 98 - K - 120830) and Ankara University Research Fund (Project No: 20050705094)

Portfolio implementation at Turkish university preparatory schools, and teachers' perceptions of portfolios and problems experienced with portfolio use

Cataloged from PDF version of article.This study seeks to investigate portfolio implementation at Turkish university preparatory schools and the reported aims of portfolio use as targeted by these schools. The study further examines teachers‟ perceptions of portfolio use, specifically, the problems they experience with portfolio use, possible sources of these problems and their suggestions on how portfolio use can be improved. The study was conducted in two phases. In the first phase, data on portfolio use and aims of its use were collected through a questionnaire administered at seven university preparatory schools. In the second phase, data on teachers‟ perceptions were gathered through a second questionnaire administered to 126 teachers at five of the seven preparatory schools. The results reached in the first phase of the study revealed that portfolios are mainly used for the writing component of the preparatory programs. The analyses of the data also revealed that certain key features of portfolios, such as student participation in the selection of portfolio content, self assessment, and student reflection, are not generally included in portfolios at preparatory programs. Regarding the aims of portfolio use targeted by schools, the results indicate that in order to achieve the intended aims, the missing key elements of portfolios should be included. The results reached in the second phase of the study indicate that teachers perceive portfolios as an appropriate tool for assessment purposes. When the results regarding teachers‟ experiences with portfolio use are examined, the outcomes indicate that the problems experienced with portfolio use are in large part felt to be related to students‟ attitudes towards portfolios, which are themselves caused by students‟ study habits and previous educational backgrounds. It was also revealed that problems related to portfolio entries and institutional practices create some challenges in portfolio implementation at schools.Kılıç, EmineM.S

Contribution of heme oxygenase 2 to blood pressure regulation in response to swimming exercise and detraining in spontaneously hypertensive rats

Background: We aimed to determine the effects of exercise followed by detraining on systolic blood pressure (SBP), heme oxygenase 2 (HO-2) expression, and carboxyhemoglobin (COHb) concentration in spontaneously hypertensive rats (SHR) to explain the role of carbon monoxide (CO) in this process. Material/Methods: Animals were randomized into exercised and detrained groups. Corresponding sedentary rats were grouped as Time 1–2. Swimming of 60 min/5 days/week for 10 weeks was applied. Detraining rats discontinued training for an additional 5 weeks. Gene and protein expressions were determined by real-time PCR and immunohistochemistry. Results: Aorta HO-2 histological scores (HSCORE) of hypertensive rats were lower, while SBP was higher. Swimming caused enhancement of HO-2 immunostaining in aorta endothelium and adventitia of SHR. Exercise induced elevation of blood COHb index in SHR. Synchronous BP lowering effect of exercise was observed. HO-2 mRNA expression, HSCORE, and blood COHb index were unaltered during detraining, while SBP was still low in SHR. Conclusions: CO synthesized by HO-2 at least partly plays a role in SBP regulation in the SHR-and BP-lowering effect of exercise. Regular exercise with short-term pauses may be advised to both hypertensives and individuals who are at risk. © Med Sci Monit

Management of autoimmune hemolytic anemia in children and adolescents: A single center experience

Objective: To present and discuss the treatment of autoimmune hemolytic anemia (AIHA). Materials and Methods: The medical records of all patients (n=19) diagnosed in a tertiary hematology center between 1999 and 2010 were retrospectively reviewed.Results: Median age at diagnosis of AIHA was 5 years (range: 4 months-17 years). In all, 13 patients had primary (idiopathic) AIHA, whereas 2 had primary Evans Syndrome (ES), 2 had autoimmune lymphoproliferative syndrome (ALPS)+ES, and 1 had Wiskott-Aldrich syndrome (WAS)+AIHA. Among the 13 primary idiopathic AIHA patients, 9 recovered following a 4-8-week course of prednisolone treatment without relapses, whereas 3 patients required a longer course of prednisolone. One AIHA patient that was very resistant to prednisolone recovered after cyclosporine A was added to the treatment. All patients with primary idiopathic AIHA were in remission for a median of 3 years (range: 4 months-10 years) at the time this manuscript was written. Among the patients with primary ES, 2 had relapses similar to the ALPS patients. Splenectomy was performed in 1 primary ES patient, who at the time this report was written was also in remission. One ALPS patient required the addition of mycophenolate mofetil due to prednisolone resistance. The WAS patient was treatment resistant and died due to septicemia.Conclusions: Primary AIHA in pediatric patients generally has an acute onset and good response to corticosteroids. Primary or secondary ES has a chronic or relapsing course, and treatment may require other immunosuppressive agents in addition to corticosteroids. Complications of splenectomy must not be underestimated in patients with underlying immunodeficiency. AIHA often causes considerable morbidity and mortality in WAS

Future Problems of Uncorrected Refractive Errors in Children

Visual impairment secondary to uncorrected refractive errors in childhood is an important health problem, and can lead social, educational and economical disability in adulthood. In this study, we reviewed the literature to reveal future effects of refractive errors in children on social life. Refractive problems can be easily corrected with spectacles as a cost effective treatment modality. However, recognizing refractive errors in children at family or school level is critical. Screening programs are valuable to prevent refractive error related vision loss in children. Moreover, awareness campaigns and education can help to overcome all barriers against visual rehabilitation. In conclusion, collaboration among teacher, parents, ophthalmologist and child should be well established to prevent visual disability and related socio-economical problems. (C) 2014 The Authors. Published by Elsevier Ltd

In reply Demirtaş et al.,

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Impaired Hemorheology in Exacerbations of COPD

Background. Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation. Cardiovascular-related comorbidities are established to contribute to morbidity and mortality especially during exacerbations. The aim of the current study was to determine alterations in hemorheology (erythrocyte aggregation, deformability) in newly diagnosed COPD patients and their response to medical treatment and to compare with values of COPD patients with exacerbations. Materials and Methods. The study comprised 13 COPD patients, 12 controls, and 16 COPD patients with exacerbations. The severity of COPD was determined according to Global Initiative for Chronic Obstructive Lung Disease guidelines. Red blood cell (RBC) deformability and aggregation were measured by an ektacytometer. Results. RBC deformability of COPD patients with exacerbations was decreased compared to the other groups. Erythrocyte aggregation and plasma fibrinogen of COPD patients determined during exacerbations were higher than control. Conclusion. Decreased RBC deformability and increased aggregation associated with exacerbations of COPD may serve as unfavorable mechanisms to worsen oxygenation and thus clinical symptoms of the patient. Treatment modalities that modify rheological parameters might be beneficial. © 2017 Erhan Ugurlu et al

Siblings with Ethylmalonic Encephalopathy: Case Report

Deficiency of mitochondrial sulfur dioxygenase (ETHE1) causes a rare inborn error of metabolism, ethylmalonic encephalopathy, which is characterized by early-onset encephalopathy, chronic hemorrhagic diarrhea, recurrent petechiae, orthostatic acrocyanosis, defective cytochrome C oxidase because of hydrogen sulfide accumulation and death in the first years of life. Biochemical hallmarks of the disease are high level of lactate, C4-C5-acylcarnitines in blood and markedly elevated urinary excretion of methylsuccinic and ethylmalonic acids. We report on two siblings who were admitted to a pediatric metabolic unit with acrocyanosis, chronic diarrhea and psychomotor retardation later diagnosed as ethylmalonic encephalopathy. Molecular analyses revealed a homozygous for p.R163Q (c.488 G>A) mutation in ETHE1 gene