3 research outputs found

    Early neocortical regionalization in the absence of thalamic innervation

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    There is a long-standing controversy regarding the mechanisms that generate the functional subdivisions of the cerebral neocortex. One model proposes that thalamic axonal input specifies these subdivisions; the competing model postulates that patterning mechanisms intrinsic to the dorsal telencephalon generate neocortical regions. Gbx-2mutant mice, whose thalamic differentiation is disrupted, were investigated. Despite the lack of cortical innervation by thalamic axons, neocortical region–specific gene expression (Cadherin-6, EphA-7, Id-2, andRZR-beta) developed normally. This provides evidence that patterning mechanisms intrinsic to the neocortex specify the basic organization of its functional subdivisions.Peer reviewe

    Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study

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