Basic physiological systems indicator's informative assessment for children and adolescents obesity diagnosis tasks

The healthcare computerization creates opportunities to the clinical decision support system development. In the course of diagnosis, doctor manipulates a considerable amount of data and makes a decision in the context of uncertainty basing upon the first-hand experience and knowledge. The situation is exacerbated by the fact that the knowledge scope in medicine is incrementally growing, but the decision-making time does not increase. The amount of medical malpractice is growing and it leads to various negative effects, even the mortality rate increase. IT-solution's development for clinical purposes is one of the most promising and efficient ways to prevent these effects. That is why the efforts of many IT specialists are directed to the doctor's heuristics simulating software or expert-based medical decision-making algorithms development. Thus, the objective of this study is to develop techniques and approaches for the body physiological system's informative value assessment index for the obesity degree evaluation based on the diagnostic findings

The current consensus for the diagnostic and treatment of extramammary Paget’s disease

Extramammary Paget's disease is a slow-growing cutaneous intraepithelial adenocarcinoma of the apocrine glands in the anogenital and axillary regions. The disease is extremely rare, affects predominantly postmenopausal women, and has nonspecific clinical caracteristics, so that it can take 210 years from the first clinical signs to diagnosis. The vulva and the perianal region are the most affected zones. Extramammary Pagets disease is clinically manifested as well-defined erythematous plaques with secondary changes, such as scaling, ulceration and even bleeding. Differential diagnosis is made between primary and secondary forms of Extramammary Pagets disease, candidiasis, contact dermatitis, Crohn's disease, eczema, erosive lichen planus, hydradenitis suppurativa, Langerhans cell histiocytosis, sclerosing lichen, psoriasis, squamous cell carcinoma in situ, amelanotic melanoma and mycosis fungoide. Treatment mainly includes the surgical component, as well as the use of photodynamic therapy, cytostatic agents, and, depending on the stage, systemic chemotherapy

Chimeric Antibody 14D5 Protects Mice against the Far-Eastern, Siberian, and European Tick-borne Encephalitis Virus

Tick-borne encephalitis virus (TBEV), belonging to the Flaviviridae family, is the most significant pathogen transmitted by Ixodes ticks and causing one of the most severe human neuroinfections. In Russia, serum immunoglobulin produced from the donor blood is currently used for post-exposure prophylactic and therapy of tick-borne encephalitis virus. However, it is known that preparations obtained from donated blood have certain disadvantages, and therefore development of novel preparations for post exposure prophylaxis and therapy of tick-borne encephalitis is required. To develop an alternative preparation, which does not include donor blood, a chimeric antibody ch14D5 against glycoprotein E of TBEV was constructed.This study was aimed to investigate protective efficacy of the chimeric antibody ch14D5 against the Far-Eastern, Siberian, and European subtypes of TBEV in in vivo experiments.A peripheral mouse model of tick-borne encephalitis was used in this study: the chimeric antibody ch14D5 was administrated intravenously in mice one day after their intraperitoneal infection with TBEV strains Sofjin, Vasilchenko, and Absettarov. Anti-TBEV serum immunoglobulin was used as a control preparation, which was administered in the same way. Protective efficacy of the chimeric antibodies 14D5 was assessed using the log-rank test. In the study, the presence or absence of antibody-dependent enhancement of infection (ADE) was examined when mice, infected with different subtypes of the TBEV, got the antibody ch14d5.Obtained results demonstrated high efficacy of the ch14D5 antibody in post-exposure prophylaxis of the disease in mice infected with any of the used TBEV strains, as well as the absence of ADE.It was shown that protective efficacy of antibody ch14D5 is higher than that of the anti-TBEV serum immunoglobulin, and antibody ch14D5 could be used for development of a therapeutic preparation for post-exposure prophylaxis

Particularities of speech readiness for schooling in pre-school children having general speech underdevelopment: a social and pedagogical aspect

The relevance of the research is due to the necessity of creating the pedagogical conditions for correction and development of speech in children having the general speech underdevelopment. For them, difficulties generating a coherent utterance are characteristic, which prevents a sufficient speech readiness for schooling forming in them as well as successful socialization. With regard to this, the paper is aimed at finding out the particularities of coherent monologic and dialogical speech in senior pre-school children having the general speech underdevelopment. The leading method to studying this problem is experimental studying, which allows viewing the particularities of coherent dialogical and monologic speech in pre-schoolers having the general speech underdevelopment in an integrated way. The paper describes particularities of coherent monologic and dialogical speech in pre-school children having the general underdevelopment depending on the level of formation. The quantitative and qualitative analysis of the data obtained has shown that pre-school children having the general speech underdevelopment have significant difficulty carrying on a dialogue and making up detailed utterances. Examples of various lexical and grammatical, logical and meaning-related mistakes of the children are given. The materials of the paper may be of use for specialists rendering the psychological and pedagogical support for children having speech disorders in the educational process

Basic physiological systems indicator's informative assessment for children and adolescents obesity diagnosis tasks

The healthcare computerization creates opportunities to the clinical decision support system development. In the course of diagnosis, doctor manipulates a considerable amount of data and makes a decision in the context of uncertainty basing upon the first-hand experience and knowledge. The situation is exacerbated by the fact that the knowledge scope in medicine is incrementally growing, but the decision-making time does not increase. The amount of medical malpractice is growing and it leads to various negative effects, even the mortality rate increase. IT-solution's development for clinical purposes is one of the most promising and efficient ways to prevent these effects. That is why the efforts of many IT specialists are directed to the doctor's heuristics simulating software or expert-based medical decision-making algorithms development. Thus, the objective of this study is to develop techniques and approaches for the body physiological system's informative value assessment index for the obesity degree evaluation based on the diagnostic findings

Mapping groundwater-dependent ecosystems using remote sensing measures of vegetation and moisture dynamics

Protection of groundwater-dependent ecosystems (GDEs) is an important criterion in sustainable groundwater management, particularly when human water consumption is in competition with environmental water demands; however, the delineation of GDEs is commonly a challenging task. The Groundwater-dependent Ecosystem Mapping (GEM) method proposed here is based on interpretation of the land surface response to the drying process derived from combined changes in two multispectral indices, the Normalised Difference Vegetation Index and the Normalised Difference Wetness Index, both derived from Landsat imagery. The GEM method predicts three land cover classes used for delineation of potential GDEs: vegetation with permanent access to groundwater; vegetation with diminishing access to groundwater; and water bodies that can persist through a prolonged dry period. The method was applied to a study site in the Ellen Brook region of Western Australia, where a number of GDEs associated with localised groundwater, diffuse discharge zones, and riparian vegetation were known. The estimated accuracy of the method indicated a good agreement between the predicted and known GDEs; Producer's accuracy was calculated as up to 91% for some areas. The method is most applicable for mapping GDEs in regions with a distinct drying period

Physical Vapor Deposition Features of Ultrathin Nanocrystals of Bi2(TexSe1- x)3

Structural and electronic properties of ultrathin nanocrystals of chalcogenide Bi2(TexSe1-x)3were studied. The nanocrystals were formed from the parent compound Bi2Te2Se on as-grown and thermally oxidized Si(100) substrates using Ar-assisted physical vapor deposition, resulting in well-faceted single crystals several quintuple layers thick and a few hundreds nanometers large. The chemical composition and structure of the nanocrystals were analyzed by energy-dispersive X-ray spectroscopy, X-ray photoelectron spectroscopy, electron backscattering, and X-ray diffraction. The electron transport through nanocrystals connected to superconducting Nb electrodes demonstrated Josephson behavior, with the predominance of the topological channels [ Stolyarov et al. Commun. Mater., 2020, 1, 38 ]. The present paper focuses on the effect of the growth conditions on the morphology, structural, and electronic properties of nanocrystals

Ferromagnet/Superconductor Hybrid Magnonic Metamaterials

In this work, a class of metamaterials is proposed on the basis of ferromagnet/superconductor hybridization for applications in magnonics. These metamaterials comprise of a ferromagnetic magnon medium that is coupled inductively to a superconducting periodic microstructure. Spectroscopy of magnetization dynamics in such hybrid evidences formation of areas in the medium with alternating dispersions for spin wave propagation, which is the basic requirement for the development of metamaterials known as magnonic crystals. The spectrum allows for derivation of the impact of the superconducting structure on the dispersion: it takes place due to a diamagnetic response of superconductors on the external and stray magnetic fields. In addition, the spectrum displays a dependence on the superconducting critical state of the structure: the Meissner and the mixed states of a type II superconductor are distinguished. This dependence hints toward nonlinear response of hybrid metamaterials on the magnetic field. Investigation of the spin wave dispersion in hybrid metamaterials shows formation of allowed and forbidden bands for spin wave propagation. The band structures are governed by the geometry of spin wave propagation: in the backward volume geometry the band structure is conventional, while in the surface geometry the band structure is nonreciprocal and is formed by indirect band gaps

Josephson current mediated by ballistic topological states in Bi2Te2.3Se0.7 single nanocrystals

Topological insulators in contact with a superconductor could house unusual physical states such as Majorana fermions. Here, the authors fabricate and report the  electron-transport characteristics of Josephson junctions built using a nanoscale topological insulator, finding evidence for ballistic transport in the surface states of the nanocrystals