120 research outputs found

    Procedure of building the university graduate training practice-oriented model

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    The aim of the article is to develop and prove the procedure of practical oriented graduate training model based on bringing the educational situation to the conditions of professional activity. Methods. The methods involve comparative analysis of documents (professional and Federal State Educational Standard papers); analysis of domestic and foreign literature on the problem of vocational teacher education, professional-pedagogical training modeling. Results. Inadequacy in the requirements for professional teacher competence identified by professional and Federal State Educational Standards has been revealed. Based on the Master’s programme «Methodology and methods of social education» as an example, the method of educational programs development is described on the basis of underlining professional labor actions that meet the requirements of the profession.Scientific novelty. The contradictions of practice-oriented training in the context of the university education are identified; the ways of the contradictions elimination through the use of the university educational environment opportunities were justified. Practical significance. The practical significance lies in the justification of the procedure of professional training cluster model constructing. The description of the sequential steps required for the practice-oriented educational program development is givenЦелью статьи является разработка и обоснование процедуры построения практико-ориентированной модели подготовки выпускника на основе приближения образовательной ситуации к условиям профессиональной деятельности. Методы, использованные в работе: сравнительный анализ документов (профессионального и федерального государственного образовательного стандарта); обобщение содержания отечественных и зарубежных источников по проблеме профессионально-педагогического образования; моделирование профессионально-педагогической подготовки. Результаты. Выявлены несоответствия в требованиях к профессиональным компетенциям педагога, предъявляемые профессиональными и Федеральными государственными образовательными стандартами. На примере магистерской программы «Методология и методика социального воспитания» продемонстрирован способ разработки образовательной программы на основе выделения трудовых действий, соответствующих требованиям профессии. Научная новизна. Обозначены противоречия практико-ориентированной подготовки в университетах и показаны пути их разрешения через использование возможностей образовательной среды высшего учебного заведения. Практическая значимость работы заключается в предложении процедуры построения кластерной модели профессиональной подготовки. Описаны последовательные шаги разработки практико-ориентированной образовательной программыРоссийский научный фон

    Magnetization Dynamics in Proximity-Coupled Superconductor-Ferromagnet-Superconductor Multilayers:II. Thickness Dependence of the Superconducting Torque

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    In this work, we study magnetization dynamics in superconductor-ferromagnet-superconductor thin-film structures. Results of the broad-band ferromagnetic resonance spectroscopy are reported for a large set of samples with varied thickness of both superconducting and ferromagnetic layers in a wide frequency, field, and temperature ranges. Experimentally the one-dimensional anisotropic action of superconducting torque on magnetization dynamics is established; its dependence on thickness of layers is revealed. It is demonstrated that experimental findings support the recently proposed mechanism of the superconducting torque formation via the interplay between the superconducting imaginary conductance and magnetization precession at superconductor-ferromagnet interfaces. Microwave spectroscopy studies in this work are supplemented by investigations of the crystal structure and the microstructure of studied multilayers.</p

    DIAGNOSTIC VALUE OF CERULOPLASMIN IN SYSTEMIC SCLERODERMA

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    Objective of study: refining immune diagnostics of systemic scleroderma through determining ceruloplasmin antibodies, its amount and enzymatic activity, as well as control of effectiveness of therapy with ceruloplasmin-based immobilized magnetocontrollable immunosorbents.Materials and methods. 30 apparently healthy individuals and 68 patients with systemic scleroderma were examined. The study included patients with referral diagnosis of systemic scleroderma who signed an informed consent. The study was performed in accordance with the principles of World Medical Association Declaration of Helsinki rev. 2013 (ACR/EULAR). All participants had their blood tested with the method of immunoenzymatic determination of antibodies to ceruloplasmin upon admission to hospital and prior to discharge.Results. It was established that patients with systemic scleroderma show reduced oxidase activity of ceruloplasmin, increased ceruloplasmin levels, as well as elevated antibodies to ceruloplasmin compared with the control group. A link between the amount of antibodies to the studied enzyme, and the activity, nature, course and stage of the disease was established. It was found that there is a reliable negative correlation between the level of ceruloplasmin antibodies, and the amount of RBCs, the hemoglobin level. For the first time a complex assessment of three parameters was employed, the parameters being the enzymatic activity, ceruloplasmin amount, and antibodies to ceruloplasmin. It was established that autoantibodies to ceruloplasmin are more often found in systemic scleroderma patients who show a high disease activity, subacute course with involvement of the liver, lungs, and with anemia. It was found that antibodies to ceruloplasmin are detected at early stages of systemic scleroderma development and can be used in timely diagnosis of the condition. It was shown that the change of parameters under study over time can serve as a basis on which to evaluate the effectiveness of administered therapy.Conclusion. Decreased enzymatic activity of ceruloplasmin, its elevated amount and increased antibodies to ceruloplasmin can be taken as additional diagnostic tools in evaluation of systemic scleroderma activity. These parameters promote a more accurate assessment of the disease activity and of the nature of the pathologic process; they can serve as an indication of a variety of clinical forms of the disease. Employing these parameters for monitoring of administered therapy in hospital settings permits a more accurate assessment of its effectiveness and making adjustments. Studying ceruloplasmin antibody formation, amount of ceruloplasmin and its biochemical activity extends the existing concept of rheumatic disease pathogeny, outlines a way forward for further research and reflects the involvement of antioxidant system in immune disorders

    Сatalase antibodies in patients with systemic scleroderma as a diagnostic and prognostic marker of the disease

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    The study covered 30 apparently healthy individuals and 38 patients with systemic scleroderma. The patients gave their consent to participate in the study in accordance with the World Medical Association Declaration of Helsinki in the current (2013) version (ACR/EULAR). The donors and patients had their blood tested for catalase antibodies with immunoenzyme assay and using magnetic sorbents upon hospital admission and before discharge. It was found that the patients with systemic scleroderma had a reduced oxidase activity of catalase as well as elevated catalase antibodies, compared with the controls. We revealed a statistically significant regularity that the concentration of catalase immunoglobulins is associated with activity and course of the disease. To assess the activity of systemic scleroderma we performed a complex evaluation of two parameters: enzymatic activity and catalase antibody levels. It was established that catalase autoantibodies are mostly revealed in patients with high-activity scleroderma, subacute and acute course of the disease, and when the lungs, skin, kidneys, joints and nervous system were involved, which was conclusively confirmed by a correlation analysis. It is especially important that catalase antibodies should be revealed at early stage of the disease development; they are of especial diagnostic importance, and their changes over time may form the basis for assessing efficiency of administered therapy. The changes in biochemical activity of catalase, elevated antibody titers provide additional criteria of diagnosis in systemic scleroderma. Monitoring of these parameters in hospital settings helps to evaluate the effectiveness of administered therapy and adjust its correction, which is confirmed by inclusion of such extracorporal techniques as plasma separation into the combined treatment schedules. Studying biochemical activity of catalase and formation of catalase antibodies expands our understanding of scleroderma development and opens new avenues for research

    Materials based on BIFEVOX and bismuth or iron simple oxides nanopowders

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    Received: 22.09.2017; accepted: 17.10.2017; published: 20.10.2017.Compositions of composite materials based on BIFEVOX and nanopowders of bismuth and iron oxides have been obtained. The absence of chemical interaction between the components has been proved, the total electrical conductivity of materials in the average temperature region has been determined. It has been shown that under the selected formation conditions, it has not yet been possible to achieve significant improvement of the functional characteristics of heterogeneous compositions in comparison with individual phases. However positive results on chemical and structural stability give way to further investigations.The work was partially supported by the Scholarship of the President (SP-3376.2016.1) and Russian Foundation for Basic Research (project No 17-53-04098)

    An analysis of methods for assessing information security risks of financial institutions

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    The paper presents an analysis of the existing methods for assessing information security risks, their features, advantages and disadvantages, as well as determines the possibility of using such techniques for assessing information security risks in financial institutions. Criteria for comparing information security risk assessment methods have been formed, the advantages and disadvantages of the methods are described. It is shown that, despite the requirements of regulators for assessing information security risks, most of the regulatory documents deal with operational risks. The evaluation of information security risks of credit and financial institutions does not have sufficient regulation and formalization. The authors substantiate the necessity of developing a method for assessing information security risks for credit and financial organizations, taking into account the features of risk assessment inherent to the mentioned organizations. The paper considers the need to create lists of existing threats to the credit and financial sector and their linking to existing vulnerabilities to optimize the process of assessing information security risks. The development of a methodology for assessing information security risks will increase the degree of compliance of credit and financial institutions with the requirements of international, state and industry standards through an optimal set of protection measures and models for evaluating information security risks

    Synthesis of multi-loop automatic control systems by the nonlinear programming method

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    The article deals with the problem of calculation of the multi-loop control systems optimal tuning parameters by numerical methods and nonlinear programming methods. For this purpose, in the paper the Optimization Toolbox of Matlab is used

    Influence of povidone-yodine on the sensitivity of clinical isolates of <i>Klebsiella pneumoniae</i> to antibiotics

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    Introduction. Cross-resistance of microorganisms to antibiotics against the background of the use of biocides in subinhibitory concentrations is an urgent problem of modern health care. The aim of the work is to study the effect of povidone-iodine on the sensitivity of clinical isolates of Klebsiella pneumoniae to antibiotics. Materials and methods. The work analyzed the effect of povidone-iodine at subinhibitory concentrations on changes in the sensitivity of clinical isolates of K. pneumoniae (n = 9) to antibacterial agents (n = 15). Adaptation of bacteria to povidone-iodine was carried out using periodic cultivation of microorganisms, which was carried out in 96-well culture plates for suspension cultures (non-treated) without stirring. The sensitivity of bacteria to antibiotics was assessed using an automatic analyzer Vitek2Compact (BioMerieux) using AST-204 charts. Results. During the adaptation of clinical isolates of K. pneumoniae to povidone-iodine, an increase in the sensitivity of bacteria to antibiotics was shown. The minimum inhibitory concentrations (MIC) of 11 antibacterial agents in relation to the studied cultures decreased by an average of 2.3523.2 times compared with the control values. Under the experimental conditions, the sensitivity of the studied cultures increased to amoxicillin/clavulanic acid by 2 8 times, piperacillin/tazobactam by 2 32 times, ceftazidime by 4 16 times, ami-kacin 2 16 times, ertapenem 2.08.0 times, meropinem 28 times, cefepim 4 64 times, ciprofloxacin 4 16 times, gentamicin 2 8 times, norfloxacin 28 times, nitrofurantoin 24 times. An increase in the level of sensitivity to antibiotics was found in 50100% of the studied clinical bacterial isolates. A similar effect has not been established for ampicillin, cefotaxime, imipenem, and trimethoprim/sulfamethoxazole. It should be noted that under the conditions of the experiment, intraspecific heterogeneity of clinical isolates of K. pneumoniae was revealed in terms of the level of acquired sensitivity to antibacterial agents. Discussion. Our results are not described in the scientific literature and require further study and explanation
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