Improvement of Pork Quality at Different Values of Pig Productivity

This article examines how to increase pork meat productivity and quality indicators through the use of crossbreeding. The aim is to increase the meat productivity of animals; reduce losses during production and processing; and improve the criteria for assessing the quality of meat and the organization of its rational use. The purpose of our research is to study the productive quality of the steppe type of pigs, used in the Rostov region in breeding and crossing systems, and the complex of biological and internal indicators in connection with the defects in the quality of pork. Four groups with 16 animals in each were formed: the first group – with the intensive cultivation technology, included pigs of the DM-1 breed, the second – SM-1, the third – the SM-1 × DM-1 crossbreed, the fourth – the DM-1 × SM-1 crossbreed. Analysis of the raw meat showed that the pork had a good ability to emulsify and gel, and had a high nutritional value. The toxicity index in the muscle and fat tissue samples corresponded to the first permissible toxicity group. The study shows the advantages of crossbred individuals over purebred ones, which can be explained by the consequences of heterosis. According to the research results, the use of pig breeding in the industrial production of pork can be recommended in order to improve feedstock and meat productivity, biological and interior indicators, as well as the quality of raw meat. Keywords: pork, crossbreeding, meat productivity, meat quality, steppe type of pigs, interior indicators, fattening qualities, biological and nutritional value of por

ПРИМЕНЕНИЕ QR-КОДОВ ДЛЯ ОРГАНИЗАЦИИ КОНТРОЛЬНО-ПРОПУСКНОГО ПУНКТА

Today, most companies have an automated pass system in which an employee presents a card that records the time of his entry and exit. But often in companies using this method of work, there are no devices that produce these cards and therefore they must be ordered from other organizations, which requires additional costs. This can be a reason to postpone the hiring of an employee, which can be critical in some situations. Today, the task of automating a checkpoint is one of the most important tasks, so it is necessary to keep track of the time employees arrive at work, unload the queue, and ensure the safety of the enterprise.Purpose – development of automated software components for staff time tracking.Method or methodology of work: the article considers a project for recording staff time and personnel accounting using the C#, Xamarin, SQL programming environment.Results: an application for computers and mobile devices was developed that registers users to register a passage and generates access codes unique for each user, which are immediately converted into QR codes and comparing them with the codes submitted to the reader.Scope of the results: the results obtained are advisable to apply to enterprises to organize a checkpoint in order to track the time of workers. Сегодня большинство компаний имеют автоматизированную систему пропусков, в которой работник подносит карточку, по которой регистрируется время его входа и выхода. Но зачастую в компаниях, использующих такой метод работы, отсутствуют устройства, изготавливающие данные карты и поэтому их необходимо заказывать у других организаций, что требует дополнительных затрат. Это может стать поводом отложить прием сотрудника на работу, что может быть критично в некоторых ситуациях. На сегодняшний день задача автоматизации контрольно-пропускного пункта является одной из самых важных задач, так необходимо вести учет времени прихода сотрудников на работу, разгрузить очередь, обеспечить безопасность работы предприятия.Цель – разработка компонентов автоматизированного программного обеспечения по учёту рабочего времени персонала.Метод или методология проведения работы: в статье рассмотрен проект по учёту рабочего времени персонала и учёта кадров с использованием среды программирования С#, Xamarin, SQL.Результаты: разработано приложение для компьютеров и мобильных устройств, регистрирующая пользователей для регистрации прохода, и генерирующая уникальные для каждого пользователя коды доступа, которые тут же конвертируются в QR-коды и сравнивающие их с кодами, поданными на считыватель.Область применения результатов: полученные результаты целесообразно применять предприятиям для организации контрольно-пропускного пункта с целью учета времени рабочих

BEN domain protein Elba2 can functionally substitute for linker histone H1 in Drosophila in vivo

Metazoan linker histones are essential for development and play crucial roles in organization of chromatin, modification of epigenetic states and regulation of genetic activity. Vertebrates express multiple linker histone H1 isoforms, which may function redundantly. In contrast, H1 isoforms are not present in Dipterans, including D. melanogaster, except for an embryo-specific, distantly related dBigH1. Here we show that Drosophila BEN domain protein Elba2, which is expressed in early embryos and was hypothesized to have insulator-specific functions, can compensate for the loss of H1 in vivo. Although the Elba2 gene is not essential, its mutation causes a disruption of normal internucleosomal spacing of chromatin and reduced nuclear compaction in syncytial embryos. Elba2 protein is distributed ubiquitously in polytene chromosomes and strongly colocalizes with H1. In H1-depleted animals, ectopic expression of Elba2 rescues the increased lethality and ameliorates abnormalities of chromosome architecture and heterochromatin functions. We also demonstrate that ectopic expression of BigH1 similarly complements the deficiency of H1 protein. Thus, in organisms that do not express redundant H1 isoforms, the structural and biological functions performed by canonical linker histones in later development, may be shared in early embryos by weakly homologous proteins, such as BigH1, or even unrelated, non-homologous proteins, such as Elba2

Drosophila SUMM4 complex couples insulator function and DNA replication control

Asynchronous replication of chromosome domains during S phase is essential for eukaryotic genome function, but the mechanisms establishing which domains replicate early versus late in different cell types remain incompletely understood. Intercalary heterochromatin domains replicate very late in both diploid chromosomes of dividing cells and in endoreplicating polytene chromosomes where they are also underrelicated. Drosophila SNF2-related factor SUUR imparts locus-specific underreplication of polytene chromosomes. SUUR negatively regulates DNA replication fork progression; however, its mechanism of action remains obscure. Here we developed a novel method termed MS-Enabled Rapid protein Complex Identification (MERCI) to isolate a stable stoichiometric native complex SUMM4 that comprises SUUR and a chromatin boundary protein Mod(Mdg4)-67.2. Mod(Mdg4) stimulates SUUR ATPase activity and is required for a normal spatiotemporal distribution of SUUR in vivo. SUUR and Mod(Mdg4)-67.2 together mediate the activities of gypsy insulator that prevent certain enhancer-promoter interactions and establish euchromatin-heterochromatin barriers in the genome. Furthermore, SuUR or mod(mdg4) mutations reverse underreplication of intercalary heterochromatin. Thus, SUMM4 can impart late replication of intercalary heterochromatin by attenuating the progression of replication forks through euchromatin/heterochromatin boundaries. Our findings implicate a SNF2 family ATP-dependent motor protein SUUR in the insulator function, reveal that DNA replication can be delayed by a chromatin barrier and uncover a critical role for architectural proteins in replication control. They suggest a mechanism for the establishment of late replication that does not depend on an asynchronous firing of late replication origins

Diabetes mellitus type 1 in childhood

Public organization “Russian Association of Endocrinologists”. Clinical guidlines

Measurement of the very rare K+→π+ννˉK^+ \to \pi^+ \nu \bar\nu decay

The decay K+→π+νν¯ , with a very precisely predicted branching ratio of less than 10−10 , is among the best processes to reveal indirect effects of new physics. The NA62 experiment at CERN SPS is designed to study the K+→π+νν¯ decay and to measure its branching ratio using a decay-in-flight technique. NA62 took data in 2016, 2017 and 2018, reaching the sensitivity of the Standard Model for the K+→π+νν¯ decay by the analysis of the 2016 and 2017 data, and providing the most precise measurement of the branching ratio to date by the analysis of the 2018 data. This measurement is also used to set limits on BR(K+→π+X ), where X is a scalar or pseudo-scalar particle. The final result of the BR(K+→π+νν¯ ) measurement and its interpretation in terms of the K+→π+X decay from the analysis of the full 2016-2018 data set is presented, and future plans and prospects are reviewed