20 research outputs found
Integrating Learning Outcomes Assessment In Information Systems Curriculum Revisions
This paper examines various dimensions of outcomes assessment and analyzes the assurance of learning process that is mandated by business schools’ accrediting agency, AACSB International. We describe learning outcomes assessment, various types of assessment, and why it is important to align assessment with learning goals and instruction. Information systems model curriculum 2002 and AACSB International share similar goals in terms of outcomes assessment. IS programs should make sure that feedback from the assessment process along with input from internal and external sources, are used to make curricular adjustments.
An Object-oriented Design for an Adaptive System to Augment a Telecommunication and Networking Systems (TNS) Course
An object-oriented system is designed to enhance the instruction in a telecommunication and networking course. The areas covered include rationale for using a hypermedia structure, multi-modal instruction and development strategies, instructional design components, systems architecture, and course content and unit organization
An Empirical Examination of the Relationship Between Information Technology Infastructure, Customer Focus and Business Advantages
During the past two decades, both academic researchers and business managers have attempted to understand the ways through which information technology (IT) can create business advantages. In this paper, we present a model that tests the relationship between IT infrastructure, customer focus, and business advantages. Customer Focus has been categorized into: customer responsiveness and product/service innovation. The data for the study were obtained from 116 executives from a number of business organizations. IT infrastructure is found to have significant effect on customer responsiveness, but does not show any significant relationship with product/service innovation. IT infrastructure, customer responsiveness, and product/service innovation are found to be significantly related business advantages
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Factors and Impacts of Low Utilization of Internet: The Case of Arab Countries
The Arab countries are greatly behind in terms of their levels of Internet usage. The Arab countries are under pressures to adopt and promote digital transformation. Data in Arab countries are hard to get, resulting in paucity of understanding the factors that affect the use of Internet in Arab countries. This paper combines research from academic and major international organizational literature to examine and synthesize the current use of Internet in Arab Countries. The obstacles and the factors that affect the use and growth of Internet are language, government policies, culture, cost and technology. They are discussed with their impacts
Bioactive compounds screening of Rafflesia sp. and Sapria sp. (Family: Rafflesiaceae) as anti-SARS-CoV-2 via tetra inhibitors: An in silico research
Context: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread, causing a global pandemic with diverse symptoms and increased risk of mortality. Various symptoms and comorbidities contribute to a higher likelihood of death in patients. Additionally, existing antiviral drugs have shown incomplete efficacy. Rafflesia sp. and Sapria sp. are parasitic plants with potential medical applications as anti-SARS-CoV-2 agents.
Aims: To evaluate the bioactive compounds derived from Rafflesia sp. and Sapria sp. as dual inhibitors against SARS-CoV-2.
Methods: Ligand samples were obtained from the PubChem database. Target proteins essential for SARS-CoV-2 entry were obtained from the RCSB PDB. The antiviral potential of the bioactive compounds was evaluated using the Pass Online webserver. The bioactivity and inhibitory potential of selected ligands were analyzed using the SwissADME and Molinspiration web servers. In addition, a specific docking method was performed using PyRx software to determine binding activity and molecular interactions.
Results: Computational analysis revealed that leucoanthocyanidin, ellagic acid, and catechin functioned as dual inhibitors, targeting angiotensin-converting enzyme 2 (ACE2), transmembrane protease serine 2 (TMPRSS2), furin, and cathepsin L for antiviral activity. However, valrubicin and diminazene, serving as control drugs for ACE2 and furin, respectively, demonstrated the most effective results through this mechanism. Further studies are required to validate these findings.
Conclusions: The combination of bioactive compounds derived from Rafflesia sp. and Sapria sp. shows potential antiviral activity through a dual inhibitor mechanism involving leucoanthocyanidin, ellagic acid, and catechin, which target SARS-CoV-2 proteins, namely ACE2, TMPRSS2, furin, and cathepsin L
Garcinoxanthones from Garcinia mangostana L. against SARS-CoV-2 infection and cytokine storm pathway inhibition: A viroinformatics study
Context: Mangosteen (Garcinia mangostana L.) is used in traditional medicine as an antibacterial, antioxidant, and anti-inflammatory.
Aims: To determine the molecular mechanism and potential of garciniaxanthone derivate compounds from G. mangostana as SARS-CoV-2 antiviral and prevent cytokine storm through in silico approach.
Methods: Ligand and protein samples were obtained from databases such as PubChem and Protein Databank, then drug-likeness analysis using Lipinski, Ghose, Veber, Egan, and Muege rules on SwissADME server, prediction of antiviral probability through PASSOnline server. Furthermore, molecular docking simulation with PyRx v1.0 software (Scripps Research, USA) with an academic license, identification of interactions and chemical bond positions of ligands on the target by PoseView server, 3D visualization of PyMOLv.2.5.2 software (Schrödinger, Inc., USA) with an academic license, molecular dynamics simulation for molecular stability prediction by CABS-flex v2.0 server, target prediction of antiviral candidate compounds by SwissTargetPrediction server, pathway analysis through STRING v11.5 database, and toxicity by ProTox-II server were used.
Results: Garciniaxanthone C from G. mangostana was found to be a drug-like molecule with low toxicity. This can be a candidate for SARS-Cov-2 antiviral through inhibitor activity on two viral enzymes consisting of Mpro and replicase with a binding affinity value that is more negative than other garciniaxanthone derivates and is stable. Garciniaxanthone C is predicted to bind and inhibit pro-inflammatory proteins that trigger cytokine storms, such as NFKB1 and PTGS2.
Conclusions: Garciniaxanthone derivative compounds from G. mangostana may be candidates for SARS-CoV-2 antiviral and preventing cytokine storm through garciniaxanthone C activity
Profiling Climate Smart Agriculture for Southern Coastal Region of Bangladesh and its Impact on Productivity, Adaptation and Mitigation
Now a days ensuring sustainable food security is a great concern because of devastating effects of climate change on the most
vulnerable country like Bangladesh. Its coastal southern region agriculture and peoples livelihood is mostly affected by recurrent
cyclone, tidal surge, flood, salinity and dearth of appropriate technology options to manage those. Applying climate smart agricultural practices at community level could minimize the climate change related effects. Thus, climate smart agriculture (CSA) practices those are used and developed by local community, innovator, extension workers and agricultural researchers are being collected through
desktop work, survey, field visit, personal communication and focus group discussion. Lastly through expert level workshop 41
CSA practices were selected under 13 major production systems. Through written questionnaire expert evaluated the production
practices and gave climate smartness score for each practice along with their impact on three pillars of CSA viz. productivity,
adaptation and mitigation. The major production systems were selected as per their contribution to food production and livelihoods. Those production systems are T.aman rice, boro rice, aus rice, jute, spices, oilseeds, vegetable, wheat, pulses, maize, fruit, pond and floodplain aquaculture, and livestock. Climate smartness score largely varied (0.60 to 3.93) because of positive, negative and neutral effect on different criteria. However, most of the production practices have positive effect on production, adaptation and carbon sequestration. Some have impact on reducing greenhouse gas (GHG). Therefore, adoption/adaptation of these production practices would be instrumental to mitigate/minimize the detrimental effect of climate change towards achieving food security and to conduct further research and development work