The Role of Family Functioning in the Association Between Childhood Sexual Victimization and Substance Use in Non-treatment Populations: Results from a Native Canadian Community and Comparisons with the General Population

Using path analytic techniques, this study examines the relationship between childhood sexual victimization and alcohol consumption in adult life, focusing in particular on the role of family functioning and the surrounding social support network of family and friends. Two non-treatment populations are compared, one, an Ontario Native community, and the other, the general Ontario population. The models are estimated separately for males and females. While the results for the two samples differ significantly in certain respects (including by sex), the importance of family functioning as an intervening factor is apparent for both Natives and non-Natives. The results of the path analyses for the two samples suggest that, among the Native group, sexual abuse is significantly and positively related to alcohol consumption through the family dysfunction measure for both males and females and through non-family support for females alone. In the general population sample, conversely, none of the three social support measures tested link sexual abuse to alcohol consumption. Instead, quality of parental relationships appears relatively more important among males in particular in predicting level of family dysfunction and supportive relations with family. These findings provide limited support for the hypothesized mediating influence of the informal support network in the relationship of childhood sexual victimization to substance abuse outcomes; they also point to notable differences for males and females in the dynamics of family life and substance use. The comparability of the Native and non-Native populations with respect to prevalence estimates and implications of the findings for policy are discussed

Determinants of the Risk and Timing of Alcohol and Illicit Drug Use Onset Among Natives and Non-natives: Similarities and Differences

Objective: Employing probability samples from the Ontario Health Survey Supplement (Ontario Ministry of Health, 1990/91) and a community of Native Ontario reserve residents (Embree, 1993), this study compared and contrasted Natives\u27 and Non-natives\u27 determinants of drug and alcohol use onset. Method: Proportional Hazards techniques identified factors associated with the risk and timing of onset of substance use (alcohol and illicit drugs) for both cultural groups, and special attention was paid to the role of family background characteristics as precursors to early alcohol and drug-use onset. Results: The multivariate results reveal that, for both Natives and Non-natives alike, and considering both drinking and drug use onset together, age cohort predominates as a risk factor, with youngest groups at greatest risk, and especially in the case of drug use other than alcohol. Males also exhibit consistently higher risks of both alcohol and other substance use, and this is true to a greater extent for Non-natives. For the model of drug use timing, age of alcohol use onset is the second best predictor for Natives, although its effect is still apparent, albeit weaker, in the case of Non-natives. The results concerning age at first regular drinking lend further support to previous findings that alcohol use is a powerful predisposing factor to the use of illicit substances. However, the evident cultural disparity in the predictive power of this measure also suggests that Natives may lag behind the general population with respect to recently observed shifts in the pattern of substance use progression (i.e., away from alcohol use as a necessary precondition to illicit use of other drugs). As for family characteristics, a number of factors emerge as determinants of risk but appear to depend, at least in part, on the cultural group and the substance under consideration: namely, parental substance abuse, paternal history of depression, quality of parental relations, parental occupational background, and sexual abuse during childhood. Conclusions: Overall, the findings point to the salience of family background in affecting early onset drinking and drug use, behaviors well-recognized to have potentially adverse mental and physical health consequences, as well as negative social outcomes

A community effort in SARS-CoV-2 drug discovery.

peer reviewedThe COVID-19 pandemic continues to pose a substantial threat to human lives and is likely to do so for years to come. Despite the availability of vaccines, searching for efficient small-molecule drugs that are widely available, including in low- and middle-income countries, is an ongoing challenge. In this work, we report the results of an open science community effort, the "Billion molecules against Covid-19 challenge", to identify small-molecule inhibitors against SARS-CoV-2 or relevant human receptors. Participating teams used a wide variety of computational methods to screen a minimum of 1 billion virtual molecules against 6 protein targets. Overall, 31 teams participated, and they suggested a total of 639,024 molecules, which were subsequently ranked to find 'consensus compounds'. The organizing team coordinated with various contract research organizations (CROs) and collaborating institutions to synthesize and test 878 compounds for biological activity against proteases (Nsp5, Nsp3, TMPRSS2), nucleocapsid N, RdRP (only the Nsp12 domain), and (alpha) spike protein S. Overall, 27 compounds with weak inhibition/binding were experimentally identified by binding-, cleavage-, and/or viral suppression assays and are presented here. Open science approaches such as the one presented here contribute to the knowledge base of future drug discovery efforts in finding better SARS-CoV-2 treatments.R-AGR-3826 - COVID19-14715687-CovScreen (01/06/2020 - 31/01/2021) - GLAAB Enric

A community effort to discover small molecule SARS-CoV-2 inhibitors

The COVID-19 pandemic continues to pose a substantial threat to human lives and is likely to do so for years to come. Despite the availability of vaccines, searching for efficient small-molecule drugs that are widely available, including in low- and middle-income countries, is an ongoing challenge. In this work, we report the results of a community effort, the “Billion molecules against Covid-19 challenge”, to identify small-molecule inhibitors against SARS-CoV-2 or relevant human receptors. Participating teams used a wide variety of computational methods to screen a minimum of 1 billion virtual molecules against 6 protein targets. Overall, 31 teams participated, and they suggested a total of 639,024 potentially active molecules, which were subsequently ranked to find ‘consensus compounds’. The organizing team coordinated with various contract research organizations (CROs) and collaborating institutions to synthesize and test 878 compounds for activity against proteases (Nsp5, Nsp3, TMPRSS2), nucleocapsid N, RdRP (Nsp12 domain), and (alpha) spike protein S. Overall, 27 potential inhibitors were experimentally confirmed by binding-, cleavage-, and/or viral suppression assays and are presented here. All results are freely available and can be taken further downstream without IP restrictions. Overall, we show the effectiveness of computational techniques, community efforts, and communication across research fields (i.e., protein expression and crystallography, in silico modeling, synthesis and biological assays) to accelerate the early phases of drug discovery