Heartbeat detection by Laser Doppler Vibrometry and Machine Learning

none6openAntognoli, Luca; Moccia, Sara; Migliorelli, Lucia; Casaccia, Sara; Scalise, Lorenzo; Frontoni, EmanueleAntognoli, Luca; Moccia, Sara; Migliorelli, Lucia; Casaccia, Sara; Scalise, Lorenzo; Frontoni, Emanuel

Il MUVISS, MUseo VIrtuale di Scienze Spaziali, dell’IAPS - Report anni 2018-2019

Il progetto della costituzione di un MUseo VIrtuale di Scienze Spaziali (MUVISS) dell’INAF - Istituto di Astrofisica e Planetologia Spaziali (IAPS) è nato nel 2018, con l’obiettivo di far vivere al pubblico l’esperienza della scienza e dell‘esplorazione spaziale grazie a tecnologie quali la realtà virtuale e aumentata, strumenti estremamente efficaci per la comunicazione, divulgazione e didattica dell’Astronomia e in particolare per l’esplorazione del Sistema Solare e dello spazio. Nel 2018/2019, il MUVISS è stato avviato con una prima dotazione hardware e software e la sperimentazione di alcuni progetti multimediali all’interno dei locali dell’IAPS, includendo anche progetti preesistenti come Pianeti in una stanza. I primi due anni di attività per il pubblico, raccontati in questo report, hanno incluso sia attività in sede che in manifestazioni esterne e hanno raggiunto un pubblico di circa 6000 persone. Come studio per la realizzazione del primo prototipo del MUVISS è stata anche pubblicata una tesi del Master in Scienza e Tecnologia Spaziali dell’Università di Roma Tor vergata, riportata come allegato a questo Report

A c.3037G > A mutation in FBN1 gene causing Marfan syndrome with an atypically severe phenotype.

Marfan syndrome is a pleiotropic connective tissue disease inherited as an autosomal dominant trait, mostly caused by mutations in the FBN1 gene, which is located on chromosome 15q21.1 and encoding fibrillin 1. We report a case of Marfan syndrome presenting with severe ocular and systemic manifestations, such as cardiac congenital anomalies. The patient underwent a multidisciplinary approach and his clinical diagnosis was associated with a c.3037G > A mutation in the FBN1 gene. Identification of this genetic alteration should instigate a prompt multidisciplinary assessment and monitoring, in order to prevent devastating consequences such as cardiac and ocular phenotype. Molecular modeling of the mutation highlighted the importance of the preservation of the calcium-dependent structure of an epidermal -growth-factor-like domain of fibrillin-1 and consequently the microfibrillar formation process. This report aims to highlight the importance of an early clinical and molecular diagnosis and once more, the importance of the multidisciplinary approach of this genetic entity

PCR real time assays for the early detection of BKV-DNA in immunocompromised patients

Testing for viral BKV-DNA in urine is a non-invasive early detection and monitoring tool in the diagnostic of BKVrelated pathologies: quantitative analysis by Real-Time PCR can provide useful information in addition to cytologic analysis, although our study suggests that high BKV viruria is not necessarily associated with kidney or bladder damage

IXPE instrument integration, testing and verification

The Imaging X-ray Polarimetry Explorer (IXPE) is a scientific observatory with the purpose of expand observation space adding polarization property to the X-ray source's currently measured characteristics. The mission selected in the context of NASA Small Explorer (SMEX) is a collaboration between NASA and ASI that will provide to observatory the instrumentation of focal plane. IXPE instrument is composed by three photoelectric polarimeters based on the Gas Pixel Detector (GPD) design, integrated by INFN inside the detector unit (DU) that comprises of the electrical interfaces required to control and communicate with the GPD. The three DUs are interfaced with spacecraft through a detector service unit (DSU) that collect scientific and ancillary data and provides a basically data handling and interfaces to manage the three DUs. AIV has been planned to combine calibration of DUs and Instrument integration and verification activities. Due the tight schedule and the scientific and functional requirements to be verified, in IAPS/INAF have been assembled two equipment's that work in parallel. The flight model of each DU after the environmental tests campaign was calibrated on-ground using the Instrument Calibration Equipment (ICE) and subsequently integrated in the instrument in the AIV-T process on a AIV and Calibration Equipment (ACE), both the facilities managed by Electrical Ground Support Equipment (EGSE) that emulate the spacecraft interfaces of power supply, functional and thermal control and scientific data collection. AIV activities test functionalities and nominal/off-nominal orbits activities of IXPE instrument each time a calibrated DU is connected to DSU flight model completing step by step the full instrument. Here we describe the details of instrumentation and procedures adopted to make possible the full integration and test activities compatibly with calibration of IXPE Instrument

The IXPE Instrument Calibration Equipment

The Imaging X-ray Polarimetry Explorer is a mission dedicated to the measurement of X-ray polarization from tens of astrophysical sources belonging to different classes. Expected to be launched at the end of 2021, the payload comprises three mirrors and three focal plane imaging polarimeters, the latter being designed and built in Italy. While calibration is always an essential phase in the development of high-energy space missions, for IXPE it has been particularly extensive both to calibrate the response to polarization, which is peculiar to IXPE, and to achieve a statistical uncertainty below the expected sensitivity. In this paper we present the calibration equipment that was designed and built at INAF-IAPS in Rome, Italy, for the calibration of the polarization-sensitive focal plane detectors on-board IXPE. Equipment includes calibration sources, both polarized and unpolarized, stages to align and move the beam, test detectors and their mechanical assembly. While all these equipments were designed to fit the specific needs of the IXPE Instrument calibration, their versatility could also be used in the future for other projects

Magnetic resonance enterography in Crohn's disease: How we do it and common imaging findings

Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract, with unpredictable clinical course by phases of relapses alternating with other of quiescence. The etiology is multifactorial and is still not completely known; globally the westernization of lifestyle is causing an increasing incidence of CD, with peak age of 20-30 years. The diagnostic workup begins with the evaluation of the clinical history, physical examination and laboratory tests. However, the clinical assessment is subjected interobserver variability and, occasionally, the symptoms of acute and chronic inflammation may be indistinguishable. In this regards, the role of magnetic resonance (MR) enterography is crucial to determine the extension, the disease activity and the presence of any complications without ionizing radiations, making this method very suitable for young population affected by CD. The purpose of this review article is to illustrate the MR enterography technique and the most relevant imaging findings of CD, allowing the detection of small bowel involvement and the assessment of disease activity

Cystic Lesions of the Pancreas: Is Apparent Diffusion Coefficient Value Useful at 3 T Magnetic Resonance Imaging?

Objective: The objective of this study is to determine the role of apparent diffusion coefficient (ADC) value at 3T magnetic resonance imaging (MRI) in the characterization of pancreatic cystic lesions. Methods: We retrospectively selected a total number of 223 patients with a conclusive diagnosis of pancreatic cystic lesion, previously undergoing MR examination on a 3 T system. The MRI protocol first included axial T1/T2-weighted sequences and magnetic resonance cholangiopancreatography. Diffusion-weighted MRI was performed using a spin-echo echo-planar sequence with multiple b values (0, 150, 500, 1000, and 1500 s/mm2) in all diffusion directions, obtaining an ADC map. Contrast-enhanced T1-weighted sequences were performed during the initial work-up of a pancreatic cystic lesion and when signs of malignancy were suspected during the MRI follow-up. The ADC value of each pancreatic lesion was measured using a monoexponential curve fitting with all the multiple b. Results: The final diagnosis of our study group included the following: serous cystadenomas (n = 42), mucinous cystadenomas (n = 14), intraductal papillary mucinous neoplasms (IPMNs) (n = 121), IPMNs with signs of malignancy at histopathologic examination (n = 24), pseudocysts (n = 9), other cystic lesions (n = 13). A statistically significant difference was observed between the ADC values of malignant IPMNs and those of each other group of pancreatic lesions (P < 0.001). The ADC value of benign IPMN was significantly higher than that of serous cystadenomas (P = 0.024). A statistically significant difference was observed between the ADCs of all mucinous cystic tumors (benign IPMNs together to mucinous cystadenomas) and the ADCs of serous cystadenomas (P = 0.014). Conclusions: Fitted ADC value obtained at 3T MRI may be helpful in the characterization of pancreatic cystic lesions with particular regards of differential diagnosis between mucinous and serous cystic tumors and between malignant and benign IPMNs