Limit theorems for monomer-dimer mean-field models with attractive potential

The number of monomers, in a monomer-dimer mean-field model with an attractive potential, fluctuates according to the central limit theorem when the parameters are outside the critical curve. At the critical point the model belongs to the same universality class of the mean-field ferromagnet. Along the critical curve the monomer and dimer phases coexist.Comment: 18 pages, 2 figure

Doubly-Fed Induction Generator (DFIG) in Connected or Weak Grids for Turbine-Based Wind Energy Conversion System

In the last thirty years the quantity of wind electricity generation has grown significantly due to its high-power density. Advances in wind energy technology have significantly decreased the cost of producing electricity from this renewable source. Nowadays, the generation of energy from wind sources plays a crucial role to increasing the green energy. In this context, wind energy conversion systems (WEC) must guarantee, in connected or weak grid operation, good stability in balanced or unbalanced conditions, high efficiency, high reliability and maximum power tracking in order to achieve the best performance when operating conditions vary

Multi-species mean-field spin-glasses. Rigorous results

We study a multi-species spin glass system where the density of each species is kept fixed at increasing volumes. The model reduces to the Sherrington-Kirkpatrick one for the single species case. The existence of the thermodynamic limit is proved for all densities values under a convexity condition on the interaction. The thermodynamic properties of the model are investigated and the annealed, the replica symmetric and the replica symmetry breaking bounds are proved using Guerra's scheme. The annealed approximation is proved to be exact under a high temperature condition. We show that the replica symmetric solution has negative entropy at low temperatures. We study the properties of a suitably defined replica symmetry breaking solution and we optimise it within a ziggurat ansatz. The generalized order parameter is described by a Parisi-like partial differential equation.Comment: 17 pages, to appear in Annales Henri Poincar\`

Comparison between balloon angioplasty and additional coronary stent implantation for the treatment of drug-eluting stent restenosis: 18-month clinical outcomes

OBJECTIVE: To evaluate the long-term outcomes after different modalities of treatment of drug-eluting stent (DES) in-stent restenosis (ISR) in a 'real world' setting. METHODS: Actually, few and conflicting data are available about the management of in-stent restenosis (ISR) after DES implantation. In our 'real world' registry 1082 consecutive patients who received a DES implantation were included. At 9-month angiographic follow-up, 93 patients presented a DES ISR that was treated with 'homo-DES' (HMD) (N = 27), 'hetero-DES' (HTD) (N = 19) and conventional balloon angioplasty (POBA) (N = 47). We evaluated the clinical outcomes in terms of major adverse cardiac event (MACE) (death, myocardial infarction and target vessel revascularization) at 18 months. RESULTS: There was no difference for clinical and angiographic characteristics between the three groups, except for the presence of silent ischaemia as clinical presentation (7.7 HMD vs. 2.2% POBA; P = 0.0001). No late stent thrombosis was found. At 18-month clinical follow-up patients treated with HMD, HTD and POBA presented a rate of MACE of 10.2, 0 and 8.7%, respectively (P = NS). Kaplan-Meier survival probability showed that HTD and POBA treatment tended to have more favourable outcomes at 18 months than the HMD treatment. CONCLUSION: In our registry, POBA seems to be as effective as other DES implantations in cases of DES ISR, especially in cases of focal type (Mehran classification IA, IC), in terms of long-term outcomes

DAVID The First 6U Cubesat Mission of the Italian Space Agency Programme Iperdrone as Demonstration of New On Orbit Services Performed by Space Drones

The Italian Space Agency is promoting a roadmap for the design, manufacturing and operation of a new space reentry drone. The Iperdrone program will qualify a new type of operative mission, through an incremental phased approach. The program includes, as first step, the demonstration of inspection services for the International Space Station, optimizing the EVA activities and increasing the in space experimentation opportunities. The paper will present the status of development of the first mission, which will demonstrate the system\u27s capabilities such as proximity operations, inspection and interaction with a target, including a close rendez-vous demonstration. The first mission, DAVID to be launched within 2023, is based on a 6U cubesat architecture

Human Herpesvirus 8 and Pulmonary Hypertension

Human herpesvirus 8 (HHV-8) antibodies were detected in 1 of 33 patients with pulmonary hypertension (including in 1 of 16 with idiopathic pulmonary arterial hypertension), 5 of 29 with cystic fibrosis, and 3 of 13 with interstitial lung disease. No relationship between HHV-8 infection and pulmonary hypertension was found

Human Herpesvirus 8 and Pulmonary Hypertension

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Human Herpesvirus 8 and Pulmonary Hypertension

El presente trabajo de investigación tuvo como objetivo evaluar el nivel de conocimiento sobre salud bucal y su relación con la prevalencia de gingivitis en embarazadas que acuden al servicio de gineco-obstericia del Hospital Camaná. Las técnicas usadas fueron el cuestionario y observación clínica; se aplicó un formulario de conocimiento en salud bucal a 100 gestantes que asistieron a dicho hospital en los meses de Junio y Julio. Para determinar la afectación de gingivitis se aplicó una ficha de observación, previa evaluación clínica, en donde se indicó el índice gingival de Löe y Silness de cada individuo. Los resultados indican que la mayor parte de gestantes presentaron un conocimiento regular en salud bucal con 63% y en cuanto a la prevalencia de gingivitis encontrada en el grupo evaluado de un 49% con inflamación leve, seguido por una inflamación severa con 25%. Se concluyó gracias a la prueba de chi cuadrado que la Gingivitis y el nivel de conocimiento sobre salud bucal presentaron relación estadística significativa (P<0.05) por lo que se rechaza la hipótesis nula y se aprueba la alterna. Finalmente se insta a implementar programas y charlas de salud bucal dirigidas a gestantes para lograr una cultura preventiva óptima. Palabras clave: Nivel conocimiento, salud bucal, gingivitis, gestantes

Adjunctive Perampanel in Older Patients With Epilepsy: A Multicenter Study of Clinical Practice

Background Clinical data regarding use of newer antiseizure medications (ASMs) in an older population are limited. In randomized-controlled, placebo-controlled trials, older patients are under-represented, and protocols deviate markedly from routine clinical practice, limiting the external validity of results. Studies performed in a naturalistic setting are a useful complement to characterize the drug profile. Perampanel is a third-generation ASM and the first and only non-competitive alfa-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptor antagonist.Objective The aim of this study was to assess the effectiveness and tolerability of adjunctive perampanel over a 1-year period in a population of older patients with epilepsy treated in a real-world setting.Methods Older (>= 65 years of age) patients prescribed add-on perampanel at 12 Italian epilepsy centers were retrospectively identified. Seizure occurrence, adverse events (AEs), and drug withdrawal were analyzed. Effectiveness outcomes included the rates of seizure response (>= 50% reduction in baseline monthly seizure frequency), seizure freedom, and treatment discontinuation. Safety and tolerability outcomes were the rate of treatment discontinuation due to AEs and the incidence of AEs.Results A total of 92 patients with a median age of 69 (range 65-88) years were included. The median daily dose of perampanel at 12 months was 6 mg (interquartile range 4-6 mg). At 12 months, 53 (57.6%) patients were seizure responders, and 22 (23.9%) patients were seizure free. Twenty (21.7%) patients discontinued perampanel; the reasons for treatment withdrawal were insufficient efficacy (n = 6/20; 30.0%), AEs (n = 12/20; 60.0%), and a combination of both (n = 2/20; 10%). The most common AEs included irritability (8.7%), somnolence (4.3%), and dizziness/vertigo (4.3%). The rate of behavioral and psychiatric AEs was higher in patients with history of psychiatric comorbidities (p = 0.044). There were no differences in the occurrence of behavioral and psychiatric AEs according to the concomitant use of levetiracetam (p = 0.776) and history of cognitive decline (p = 0.332).Conclusions Adjunctive perampanel was associated with improvement in seizure control and good tolerability in a real-life setting and can represent a viable therapeutic option in older patients with epilepsy