Uncertainty assessment for measurement and simulation in selective laser melting: a case study of an aerospace part

In this work, the additive manufacturing process selective laser melting is analysed with the aim of realising a complex piece for aerospace applications. In particular, the effect of the manufacturing process and of the following thermal treatments on the dimensions of the workpiece is evaluated. The study is based on a hybrid approach including a simulation of the whole manufacturing process by advanced software packages and the dimensional measurements of the realised pieces taken by a coordinate measuring machine (CMM). The integrated use of simulation and measurements is carried out with the aim of validating the simulation results and of identifying the operational limits of both approaches; this analysis is based on metrological evaluation of the results of both the simulation and the tests, taking into account the uncertainty of the data. In addition, the main causes of uncertainty for the simulation activity and the experimental data have been identified, and the effects of some of them have also been experimentally evaluated. Based on the experimental validation, the simulation seems to predict the absolute displacement of the supports of the piece in a satisfactory way, while it is unable, in the actual configuration, to assess the conformity of the surface to its very tight shape tolerances. Conformity assessment of the surface should be carried out by CMM measurement. Integrated use of simulation and experimental results is expected to strongly improve the accuracy of simulation results for the effective and accurate design and control of the additive manufacturing process, including dimensional control and thermal treatments to mitigate induced thermal stresses.</p

The effect of pharmacological treatment on ADMA in patients with heart failure.

Asymmetric dimethylarginine (ADMA) plays a crucial role in the arginine-nitric oxide (NO) pathway. NO plays an important role in controlling vascular tone and regulates the contractile properties of cardiac myocytes. The purpose of this study was to investigate the effect of pharmacological treatment on asymmetrical dimethylarginine (ADMA) plasma levels in patients with acute congestive heart failure (HF). Patients with symptomatic acute congestive HF (NYHA Class III-IV) and impaired left ventricular (LV) function (ejection fraction less than 40 percent) were included in the study. ADMA and SDMA concentrations were assessed before and after pharmacological treatment in 18 critically ill patients on the intensive care unit by high performance liquid chromatography. All patients received a complete pharmacological treatment (diuretics, digoxin, ACE-inhibitors or angiotensin receptor blockers, and nitroglicerin) for the treatment of acute congestive HF. ADMA plasma levels of critically ill patients were significantly higher after pharmacological treatment respect baseline values (pre-treatment). In critically ill patients with acute congestive HF acute renal impairment function and the modulation of NOS determine plasma ADMA/SDMA levels after therapy