2,209 research outputs found
Testing of Milliwatt Power Source Components
A milliwatt power source (MPS) has been developed to satisfy the requirements of several potential solar system exploration missions. The MPS is a small power source consisting of three major components: a space qualified heat source (RHU), a thermopile (thermoelectric converter or TEC) and a container to direct the RHU heat to the TEC. Thermopiles from Hi-Z Technology, Inc. of San Diego and the Institute of Thermoelectricity of Chernivtsi Ukraine suitable for the MPS were tested and shown to perform as expected, producing 40 mW of power with a temperature difference of about 170°C. Such thermopiles were successfully life tested for up to a year. A MPS container designed and built by Swales Aerospace was tested with both a TEC simulator and actual TEC. The Swales unit, tested under dynamic vacuum, provided less temperature difference than anticipated, such that the TEC produced 20 mW of power with heat input equivalent to a RHU
Mycobacterium tuberculosis subverts negative regulatory pathways in human macrophages to drive immunopathology.
Tuberculosis remains a global pandemic and drives lung matrix destruction to transmit. Whilst pathways driving inflammatory responses in macrophages have been relatively well described, negative regulatory pathways are less well defined. We hypothesised that Mycobacterium tuberculosis (Mtb) specifically targets negative regulatory pathways to augment immunopathology. Inhibition of signalling through the PI3K/AKT/mTORC1 pathway increased matrix metalloproteinase-1 (MMP-1) gene expression and secretion, a collagenase central to TB pathogenesis, and multiple pro-inflammatory cytokines. In patients with confirmed pulmonary TB, PI3Kδ expression was absent within granulomas. Furthermore, Mtb infection suppressed PI3Kδ gene expression in macrophages. Interestingly, inhibition of the MNK pathway, downstream of pro-inflammatory p38 and ERK MAPKs, also increased MMP-1 secretion, whilst suppressing secretion of TH1 cytokines. Cross-talk between the PI3K and MNK pathways was demonstrated at the level of eIF4E phosphorylation. Mtb globally suppressed the MMP-inhibitory pathways in macrophages, reducing levels of mRNAs encoding PI3Kδ, mTORC-1 and MNK-1 via upregulation of miRNAs. Therefore, Mtb disrupts negative regulatory pathways at multiple levels in macrophages to drive a tissue-destructive phenotype that facilitates transmission
Automated Determination of Stellar Parameters from Simulated Dispersed Images for DIVA
We have assessed how well stellar parameters (T_eff, logg and [Fe/H]) can be
retrieved from low-resolution dispersed images to be obtained by the DIVA
satellite. Although DIVA is primarily an all-sky astrometric mission, it will
also obtain spectrophotometric information for about 13 million stars
(operational limiting magnitude V ~ 13.5 mag). Constructional studies foresee a
grating system yielding a dispersion of ~200nm/mm on the focal plane (first
spectral order). For astrometric reasons there will be no cross dispersion
which results in the overlapping of the first to third diffraction orders. The
one-dimensional, position related intensity function is called a DISPI
(DISPersed Intensity). We simulated DISPIS from synthetic spectra (...) for a
limited range of metallicites i.e. our results are for [Fe/H] in the range -0.3
to 1 dex. We show that there is no need to deconvolve these low resolution
signals in order to obtain basic stellar parameters. Using neural network
methods and by including simulated data of DIVA's UV telescope, we can
determine T_eff to an average accuracy of about 2% for DISPIS from stars with
2000 K < T_eff < 20000 K and visual magnitudes of V=13 mag (end of mission
data). logg can be determined for all temperatures with an accuracy better than
0.25 dex for magnitudes brighter than V=12 mag. For low temperature stars with
2000 K < T_eff < 5000 K and for metallicities in the range -0.3 to +1 dex a
determination of [Fe/H] is possible (to better than 0.2 dex) for these
magnitudes. Additionally we examined the effects of extinction E(B-V) on DISPIS
and found that it can be determined to better than 0.07 mag for magnitudes
brighter than V=14 mag if the UV information is included.Comment: 12 pages, 8 figures, Accepted for publication in A&
Superconductivity in Organic Compounds with Pseudo-Triangular Lattice
We study spin fluctuation (SF) mediated superconductivity (SC) in a
half-filled square lattice Hubbard model with the transfer matrices -t between
nearest neighbor sites and -t' between a half of next nearest neighbor sites
neighboring along only one of the directions, considering application of
this model to organic kappa-(BEDT-TTF)2X compounds. Varying the t'/t value from
0 to 1, one can interpolate between a square and an equilateral triangular
lattice, the latter giving frustration to antiferromagnetically (AF) coupled
spin systems. Within the fluctuation exchange (FLEX) approximation, we
calculate chi(q,omega), Tc and the SC order parameter for various model
parameter values and find that both AF and SC are suppressed as one approaches
the frustration geometry or |(t'/t)-1| \to 0. The SC phase, however, extends
beyond the AF phase boundary fairly close to t'/t=1 for realistic U/t values.
The order parameter is of x2-y2-type for t'/t1.Comment: 4 pages, 5 eps figures, to appear in J. Phys. Soc. Jp
Using of polypropylene fibers for cleaning of industrial waste water from the fat-soluble organic pollutants
The paper shows the perspective of using methods of ion implantation and microwave irradiation for modifying polypropylene fiber by iron (II), lanthanum (II) and iron metal ions. It was shown that this method is very useful in order to obtain a material with a high photocatalytic activity for extracting liposoluble dyes from non-aqueous media under UV and visible light
Toward Increased Utilization of Historical Hurricane Chronologies
The record of past tropical cyclones provides an important means to evaluate the hurricane hazard. Historical chronologies are a source of information about tropical cyclones prior to the modern era. Chenoweth (2006) describes an archive of 383 tropical cyclones occurring during the eighteenth and nineteenth centuries, largely before the official hurricane record. The present study demonstrates a novel way this archive can be used to articulate historical tropical cyclone activity across space. First, an event in the archive is assigned a series of latitude/longitude coordinates approximating the descriptive locations of the cyclone’s affect. Second, tropical cyclones from the modern record that approach these locations (modern analogs) are mapped. Third, a probable pathway and a realistic track of the archived event is created by averaging the modern analog tracks. As an example, the procedure is used to generate a map showing the tracks of the Atlantic tropical cyclones of 1766. Sensitivity of the methodology to changes in event location and event timing are considered. The study shows that historical hurricane chronologies when combined with a history of cyclone tracks can provide useful information about the older events that is not directly related to where the original information was gathered. When this information is available for all cyclones it should help climatologists better understand long-term variations in tropical cyclone activity
High-resolution x-ray telescopes
High-energy astrophysics is a relatively young scientific field, made
possible by space-borne telescopes. During the half-century history of x-ray
astronomy, the sensitivity of focusing x-ray telescopes-through finer angular
resolution and increased effective area-has improved by a factor of a 100
million. This technological advance has enabled numerous exciting discoveries
and increasingly detailed study of the high-energy universe-including accreting
(stellar-mass and super-massive) black holes, accreting and isolated neutron
stars, pulsar-wind nebulae, shocked plasma in supernova remnants, and hot
thermal plasma in clusters of galaxies. As the largest structures in the
universe, galaxy clusters constitute a unique laboratory for measuring the
gravitational effects of dark matter and of dark energy. Here, we review the
history of high-resolution x-ray telescopes and highlight some of the
scientific results enabled by these telescopes. Next, we describe the planned
next-generation x-ray-astronomy facility-the International X-ray Observatory
(IXO). We conclude with an overview of a concept for the next next-generation
facility-Generation X. The scientific objectives of such a mission will require
very large areas (about 10000 m2) of highly-nested lightweight
grazing-incidence mirrors with exceptional (about 0.1-arcsecond) angular
resolution. Achieving this angular resolution with lightweight mirrors will
likely require on-orbit adjustment of alignment and figure.Comment: 19 pages, 11 figures, SPIE Conference 7803 "Adaptive X-ray Optics",
part of SPIE Optics+Photonics 2010, San Diego CA, 2010 August 2-
Changes in the long term intensity variations in Cyg X-2 and LMC X-3
We report the detection of changes in the long-term intensity variations in
two X-ray binaries, Cyg X-2 and LMC X-3. In this work, we have used the
long-term light curves obtained with the All-Sky Monitors (ASMs) of the Rossi
X-Ray Timing Explorer (RXTE), Ginga, Ariel 5, and Vela 5B and the scanning
modulation collimator of HEAO 1. It is found that in the light curves of both
the sources, obtained with these instruments at various times over the last 30
years, more than one periodic or quasi-periodic component is always present.
The multiple prominent peaks in the periodograms have frequencies unrelated to
each other. In Cyg X-2, RXTE-ASM data show strong peaks at 40.4 and 68.8 days,
and Ginga-ASM data show strong peaks at 53.7 and 61.3 days. Multiple peaks are
also observed in LMC X-3. The various strong peaks in the periodograms of LMC
X-3 appear at 104, 169, and 216 days (observed with RXTE-ASM) and 105, 214, and
328 days (observed with Ginga-ASM). The present results, when compared with the
earlier observations of periodicities in these two systems, demonstrate the
absence of any stable long period. The 78 day periodicity detected earlier in
Cyg X-2 was probably due to the short time base in the RXTE data that were
used, and the periodicity of 198 days in LMC X-3 was due to a relatively short
duration of observation with HEAO 1.Comment: 11 pages, 7 postscript figures include
Holographic Dark Information Energy
Landauer's principle and the Holographic principle are used to derive the
holographic information energy contribution to the Universe. Information energy
density has increased with star formation until sufficient to start
accelerating the expansion of the universe. The resulting reduction in the rate
of star formation due to the accelerated expansion may provide a feedback that
limits the information energy density to a constant level. The characteristics
of the universe's holographic information energy then closely match those
required to explain dark energy and also answer the cosmic coincidence problem.
Furthermore the era of acceleration will be clearly limited in time.Comment: 12 pages, 2 figure
- …