The Plains of Mars, European War Prints, 1500-1825

Over fifty original prints by renowned artists from the sixteenth through the early nineteenth century, including Albrecht Dürer, Lucas Cranach, Théodore Géricault, and Francisco de Goya, among many others, are featured inThe Plains of Mars: European War Prints, 1500-1825. On loan from the Sarah Campbell Blaffer Foundation at the Museum of Fine Arts, Houston, the works of art included in this exhibition examine the topics of war and peace, propaganda, heroism, brutal conflicts, and the harrowing aftermath of battle. Spanning from the Renaissance to the Romantic periods and encompassing a wide geographic scope including Italy, Germany, France, Spain, the Low Countries, England, and North America, the prints depict triumphant Renaissance soldiers, devastating scenes of violence, and satirical caricatures of political figures. Also on display is Goya’s compelling “Disasters of War” series, completed in response to the brutality of the Spanish War of Independence. Goya’s prints serve as a powerful testament to the horrors faced by both soldiers and civilians. Under the direction of Professor Felicia Else and Shannon Egan, Melissa Casale ‘19 and Bailey Harper ‘19 have researched and written didactic labels, catalogue essays, and created an interactive digital interface to complement the exhibition. Together, Melissa and Bailey will lead public tours of the exhibition. A Gallery Talk by Prof. Peter Carmichael will draw connections between the depictions of warfare on view in the Gallery with representations of the American Civil War. James Clifton, Director of the Sarah Campbell Blaffer Foundation at the Museum of Fine Arts, Houston, will be delivering a lecture in conjunction with the exhibition. Dr. Clifton, who also serves as curator of Renaissance and Baroque painting at MFAH, curated the exhibition in its first iteration and wrote the exhibition catalogue (published by Yale University Press). Dr. Clifton’s lecture not only will provide an overview of the exhibition, but also will focus on the concept of “mediated war.” A full-color catalogue with images and essays by Bailey Harper ’19 and Melissa Casale ’19, under the supervision of Profs. Felicia Else and Shannon Egan, is planned to accompany the exhibition.https://cupola.gettysburg.edu/artcatalogs/1028/thumbnail.jp

The Landless Voices Database: A Trajectory from Cultural Studies to Pedagogical Impact

This article initially addresses the conception of the web-enabled database Landless Voices (VIEIRA, 2003) as a contribution to Cultural Studies and, crucially, to the understanding of the relational workings of Brazil’s complex and regionally diverse culture of landlessness, and to the validation of the cultural self-expression of the sem-terra/Sem Terra. Secondly, it analyzes speculative data obtained from prospective primary teachers being trained at the Federal University of Paraná, Brazil, on the contribution of the database to the pedagogical context. The main findings are that the three predominant types of impact, using Meagher’s terminology (2013, p. 5) are conceptual (new knowledge), cultural (revising misconceptions) and instrumental (future development of pedagogic practices). It then moves to empirical research on social impact, understood as the contribution of academic research to non-academic users, more specifically to its presumably main beneficiaries – the Sem Terra learners themselves. The findings of these first exploratory workshops with learners in four rural schools in settlements in the states of Paraná and São Paulo, respectively in October and November 2013, are that the database broadens their educational resources and empowers a historically marginalized social segment. This article confirms, however, that impact is not a punctual activity (MEAGHER, 2013) and concludes on the need for continuous interaction with learners for the pedagogic impact of academic research to be generated[1].[1] This is part of Landless Voices Impact Enhancement Project, developed by Professor Else R. P. Vieira (Principal investigator) and co-researchers: Dr. Sônia Schwendler (Federal University of Paraná, UFPR) and Professor Bernardo Mançano Fernandes (São Paulo based UNESCO’s Chair in Territorial Development and Education for the Countryside; MA in Territorial Development in Latin American and Caribbean of the São Paulo State University – UNESP, and PhD Programme in Geography, Presidente Prudente Campus), both honorary researchers at Queen Mary’s Department of Iberian and Latin American Studies. This research on impact is financed by the School of Languages, Linguistics and Film (Queen Mary University of London) with the support of UFPR School of Education and of UNESP Centre for Agrarian Reform Studies, Research and Projects − NERA)

Bulge mass is king: The dominant role of the bulge in determining the fraction of passive galaxies in the Sloan Digital Sky Survey

We investigate the origin of galaxy bimodality by quantifying the relative role of intrinsic and environmental drivers to the cessation (or `quenching') of star formation in over half a million local Sloan Digital Sky Survey (SDSS) galaxies. Our sample contains a wide variety of galaxies at z=0.02-0.2, with stellar masses of 8 < log(M*/M_sun) < 12, spanning the entire morphological range from pure disks to spheroids, and over four orders of magnitude in local galaxy density and halo mass. We utilise published star formation rates and add to this recent GIM2D photometric and stellar mass bulge + disk decompositions from our group. We find that the passive fraction of galaxies increases steeply with stellar mass, halo mass, and bulge mass, with a less steep dependence on local galaxy density and bulge-to-total stellar mass ratio (B/T). At fixed internal properties, we find that central and satellite galaxies have different passive fraction relationships. For centrals, we conclude that there is less variation in the passive fraction at a fixed bulge mass, than for any other variable, including total stellar mass, halo mass, and B/T. This implies that the quenching mechanism must be most tightly coupled to the bulge. We argue that radio-mode AGN feedback offers the most plausible explanation of the observed trends.Comment: Accepted to MNRAS. 32 pages, 27 figures. [This version is virtually identical to v1

Screening the Medicines for Malaria Venture (MMV) Pandemic Response Box chemical library on Caenorhabditis elegans identifies re-profiled candidate anthelmintic drug leads

The 3 major classes of soil transmitted helminths (whipworm, hookworm and Ascaris) affect 1.5 billion people worldwide mostly in poor countries, where they have adverse effects on child development, nutrition, and the work capacity of adults. Although there are drugs effective on Ascaris, notably the benzimidazoles, those same drugs show poor efficacy particularly against whipworm (Trichuris trichiura) and to a certain extent hookworm. Parasitic nematodes also infect farm livestock and companion animals. Resistance to currently deployed human and veterinary anthelmintic drugs is a growing problem. Therefore, new chemical anthelmintic lead compounds are urgently needed. One of the fastest routes to a novel therapeutic lead is to screen libraries of drugs which are either already approved for human use or have already been part of clinical trials. We have pursued this approach to anthelmintic lead discovery using an invertebrate automated phenotyping platform (INVAPP) for screening chemicals and the well-established nematode genetic model organism Caenorhabditis elegans. The 400 compound Medicines for Malaria Venture (MMV) Pandemic Response Box library was screened with each compound tested initially at 1.0x10-4 M. We identified 6 compounds (MMV1593515 (vorapaxar), MMV102270 (diphyllin), MMV1581032 (ABX464), MMV1580796 (rubitecan), MMV1580505 and MMV1593531) active in both an L1-L4 growth/motility assay and in an L4 motility assay. For vorapaxar, an EC50 of 5.7x10-7 M was observed, a value comparable to those of some commercial anthelmintics. Although not a parasite, the ease with which high-throughput screens can be pursued on the free-living nematode C. elegans makes this a useful approach to identify chemical leads and complements the often lower-throughput experiments on parasitic nematode models

Symptomatic efficacy and safety of diacerein in the treatment of osteoarthritis:a meta-analysis of randomized placebo-controlled trials

SummaryObjectiveTo estimate the efficacy and safety of diacerein as a pain-reducing agent in the treatment of osteoarthritis (OA), using meta-analysis of published randomized placebo-controlled trials (RCTs).MethodsSystematic searches of the bibliographic databases Medline, Embase, Cinahl, Chemical Abstracts, Cochrane and Web of Science for RCTs concerning diacerein treatment of OA. Inclusion criteria: explicit statement about randomization to either diacerein or placebo, and co-primary outcomes being reduction in pain and improvement in function. Efficacy effect size (ES) was estimated using Hedges's standardized mean difference. Safety was measured via the risk ratio (RR) of patients having at least one episode of diarrhoea, or withdrawal due to adverse events. Trials were combined by using random-effects meta-analysis. Consistency was evaluated via the I-squared index.ResultsSix trials (seven sub-studies; 1533 patients) contributed to the meta-analysis, revealing a large degree of inconsistency among the trials (I2=56%) in regard to pain reduction: the combined ES was −0.24 [95% confidence intervals (CI): −0.39 to −0.08, P=0.003], favouring diacerein. The statistically significant improvement in function (P=0.01) was based on a small amount of heterogeneity (I2=11%), but presented a questionable clinical effect size (ES=−0.14). Risk of publication bias could not be excluded, and trials with duration of more than 6 months did not favour diacerein. There was an increased risk of diarrhoea with diacerein (RR=3.51 [2.55–4.83], P<0.0001), and some withdrawal from therapy following adverse events (RR=1.58 [1.05–2.36], P=0.03).ConclusionsDiacerein may be an alternative therapy for OA for patients who cannot take paracetamol or non-steroidal anti-inflammatory drugs (NSAIDs) because of adverse effects or lack of benefit. However, it is associated with increased risk of diarrhoea, and the symptomatic benefit after 6 months remains unknown

Anthelmintic drug discovery: target identification, screening methods and the role of open science

Helminths, including cestodes, nematodes and trematodes, are a huge global health burden, infecting hundreds of millions of people. In many cases, existing drugs such as benzimidazoles, diethylcarbamazine, ivermectin and praziquantel are insufficiently efficacious, contraindicated in some populations, or at risk of the development of resistance, thereby impeding progress towards World Health Organization goals to control or eliminate these neglected tropical diseases. However, there has been limited recent progress in developing new drugs for these diseases due to lack of commercial attractiveness, leading to the introduction of novel, more efficient models for drug innovation that attempt to reduce the cost of research and development. Open science aims to achieve this by encouraging collaboration and the sharing of data and resources between organisations. In this review we discuss how open science has been applied to anthelmintic drug discovery. Open resources, including genomic information from many parasites, are enabling the identification of targets for new antiparasitic agents. Phenotypic screening remains important, and there has been much progress in open-source systems for compound screening with parasites, including motility assays but also high content assays with more detailed investigation of helminth physiology. Distributed open science compound screening programs, such as the Medicines for Malaria Venture Pathogen Box, have been successful at facilitating screening in diverse assays against many different parasite pathogens and models. Of the compounds identified so far in these screens, tolfenpyrad, a repurposed insecticide, shows significant promise and there has been much progress in creating more potent and selective derivatives. This work exemplifies how open science approaches can catalyse drug discovery against neglected diseases