AROMA: Automatic Generation of Radio Maps for Localization Systems

WLAN localization has become an active research field recently. Due to the wide WLAN deployment, WLAN localization provides ubiquitous coverage and adds to the value of the wireless network by providing the location of its users without using any additional hardware. However, WLAN localization systems usually require constructing a radio map, which is a major barrier of WLAN localization systems' deployment. The radio map stores information about the signal strength from different signal strength streams at selected locations in the site of interest. Typical construction of a radio map involves measurements and calibrations making it a tedious and time-consuming operation. In this paper, we present the AROMA system that automatically constructs accurate active and passive radio maps for both device-based and device-free WLAN localization systems. AROMA has three main goals: high accuracy, low computational requirements, and minimum user overhead. To achieve high accuracy, AROMA uses 3D ray tracing enhanced with the uniform theory of diffraction (UTD) to model the electric field behavior and the human shadowing effect. AROMA also automates a number of routine tasks, such as importing building models and automatic sampling of the area of interest, to reduce the user's overhead. Finally, AROMA uses a number of optimization techniques to reduce the computational requirements. We present our system architecture and describe the details of its different components that allow AROMA to achieve its goals. We evaluate AROMA in two different testbeds. Our experiments show that the predicted signal strength differs from the measurements by a maximum average absolute error of 3.18 dBm achieving a maximum localization error of 2.44m for both the device-based and device-free cases.Comment: 14 pages, 17 figure

Effects of Ginkgo biloba and other nutraceuticals on cognition and mood

With the growing interest in the use of nutraceuticals for their putative cognitive enhancing effects, there is the need for the thorough examination of their profile of effects using well-defined populations. This thesis explores the effects on attention, memory, executive functions and mood of (1) Ginkgo biloba; (2) Gincosan (a preparation containing Ginkgo biloba and Panax ginseng) and (3) soya isoflavones. The first two studies were conducted in young adults (males and females), and the remaining studies explored the potential benefits in postmenopausal women - a population in which impaired cognition is a frequent complaint. In student volunteers, an acute dose of ginkgo improved performance in tests of attention and episodic memory, however, these effects did not persist after a chronic treatment period of six weeks. Similarly, in postmenopausal women one week's treatment with ginkgo improved attention, short-term episodic memory and mental flexibility, whereas the only lasting improvement after six weeks' treatment was in mental flexibility, which was limited to the older group of women. This suggests that tolerance may develop to the effects of ginkgo after chronic periods of treatment. There were no beneficial effects of Gincosan after six or twelve weeks of treatment in postmenopausal women. A final aim of the thesis was to determine whether six weeks was a time-point at which beneficial effects of another herbal supplement could be detected, and thus the effects of six weeks treatment with soya supplements was investigated in postmenopausal women. Improvements were found in short-term memory and the executive functions of mental flexibility and planning. In summary, this thesis has demonstrated that ginkgo has cognitive benefits in both young adults and postmenopausal women, but only after acute/short-term treatment, whereas soya was associated with the greatest range of benefits after chronic treatment in postmenopausal women

Knowledge, attitude and practice of Tanta University medical students towards hepatitis B and C

Background: Egypt lies among the world’s highest prevalence rates of HCV and intermediate levels of HBV infection. The objectives of the study were detection of the knowledge, attitude and practice of Medical Students of Tanta University towards hepatitis B and C.Methods: This was a cross-sectional study, conducted in The Faculty of Medicine, Tanta University, Egypt; from 15th October 2013 to 15th of January 2014.Results: The study included 185 Students; their ages ranged between 17 to 28 years with a mean 20±1.731years. Sixty percent of students were males and 65% were urban residents. 50.8% of the participants were in the basic level of the academic study. More than half (57.85%) of the participants had sufficient knowledge, 77.3% of them had a positive attitude towards hepatitis C and B and more than two-thirds (68.1%) showed good practice. A significant association occurred between a positive attitude and good practice. Sufficient knowledge was significantly recorded among older students, females, urban residents and the clinical stage students. The most frequent sources of student information were family or friends, internet followed by TV or radio, healthcare workers, and newspapers.Conclusions: The students had reasonable knowledge, positive attitude and good practices towards B and C viral hepatitis. Areas of insufficient knowledge needed to be reinforced included some modes of transmission, complications, and treatment for B and C viral hepatitis

C-Reactive Protein to Albumin Ratio and Albumin to Fibrinogen Ratio in Rheumatoid Arthritis Patients

Objective: the albumin to fibrinogen ratio (AFR) and the C-reactive protein (CRP) to albumin ratio (CAR) have been proposed as markers of systemic inflammation. The goal of this study was to differentiate rheumatoid arthritis (RA) patients from healthy people and to study the association between AFR/CAR and DAS28 in RA.Patients and methods. A case control study including 30 RA patients and 30 healthy controls was performed. Fibrinogen, albumin, CRP and erythrocyte sedimentation rate (ESR) were measured. We calculated CAR and AFR in each group and compared them. Correlations of AFR, and CAR with disease activity were examined. Receiver operation characteristic (ROC) curves of AFR and CAR were also used to detect cutoffs for disease activity assessment.Results and discussion. CAR was higher while AFR was lower in RA patients than in control group. ROC curve analyses showed that CAR can be used to detect disease activity of RA at cut off 2.66 with sensitivity 81.3% and specificity 64.3% with an area under the curve (AUC) 0.78. So, CAR was a fair parameter to discriminate disease activity among RA patients. AFR has AUC 0.62, sensitivity 87.5% and specificity 42.9% at cutoff value 5.96. So, in our group AFR was a poor indicator to discriminate disease activity among RA patients.Conclusion. AFR and CAR have been recently proposed as inflammatory markers for assessment of disease activity in RA. AFR and CAR are simple, and inexpensive biomarkers, they also can be rapidly evaluated. CAR was found to be a fair parameter to depict disease activity in RA patients. AFR poorly depicted RA activity.Objective: the albumin to fibrinogen ratio (AFR) and the C-reactive protein (CRP) to albumin ratio (CAR) have been proposed as markers of systemic inflammation. The goal of this study was to differentiate rheumatoid arthritis (RA) patients from healthy people and to study the association between AFR/CAR and DAS28 in RA.Patients and methods. A case control study including 30 RA patients and 30 healthy controls was performed. Fibrinogen, albumin, CRP and erythrocyte sedimentation rate (ESR) were measured. We calculated CAR and AFR in each group and compared them. Correlations of AFR, and CAR with disease activity were examined. Receiver operation characteristic (ROC) curves of AFR and CAR were also used to detect cutoffs for disease activity assessment.Results and discussion. CAR was higher while AFR was lower in RA patients than in control group. ROC curve analyses showed that CAR can be used to detect disease activity of RA at cut off 2.66 with sensitivity 81.3% and specificity 64.3% with an area under the curve (AUC) 0.78. So, CAR was a fair parameter to discriminate disease activity among RA patients. AFR has AUC 0.62, sensitivity 87.5% and specificity 42.9% at cutoff value 5.96. So, in our group AFR was a poor indicator to discriminate disease activity among RA patients.Conclusion. AFR and CAR have been recently proposed as inflammatory markers for assessment of disease activity in RA. AFR and CAR are simple, and inexpensive biomarkers, they also can be rapidly evaluated. CAR was found to be a fair parameter to depict disease activity in RA patients. AFR poorly depicted RA activity

Towards Efficient Energy Usage at Ain Shams University Campus

In the light of global energy transition to renewable resources and energy efficiency usage, Ain Shams University (ASU) developed an ambitious plan to transform its campus into Green Campus. From an energy perspective, energy consumption data were continuously collected and audited to calculate the university campus carbon footprint. An energy usage strategy was established to tackle various pillars such as electrifying the campuses’ transportation system, improving energy efficiency usage, generating Renewable Energy (RE) for self-consumption, etc. Extensive research has been initiated on electric vehicles, wind and solar Photovoltaic (PV) energy generation with students’ activities/competitions. Thus, electric cars and buses were manufactured at the Faculty of Engineering (FoE) for elderly people and staff movement in ASU campus. Solar PV lighting poles with batteries were installed in the main campus. A small-scale Wind Turbine (WT) is manufactured and installed at the FoE and a pilot solar PV system is installed as well. Currently, an energy efficiency project is under implementation in various buildings/faculties and a parking lot that targets energy efficiency and solar PV energy generation. An energy efficiency measure is under implementation through replacing lamps with LED lamps, installing motion sensors, setting up a control center for monitoring and operation that is supported by Artificial Intelligence decision making algorithms. Rooftop solar PV energy systems are under design with smart meters. The project is targeting energy saving and bill reduction by at least 30% and as a result a reduction of carbon footprint will be achieved following the COP27 recommendations

Proteomic profile in congenital microcephaly

Autosomal recessive primary microcephaly (MCPH) consists of a group of disorders characterized by microcephaly and intellectual disability. This study is essential to complement previous findings of MCPH as it helps clarify the role of different genes and proteins involved in the underlying pathophysiology of MCPH. To date, 27 different mutations have been identified. This study defines a number of changes in gene expression occurring in MCPH. This helps deepen our understanding of the effect of MCPH mutations on gene expression. This study also shows the functions of proteins that increase, are unaffected or become dysfunctional due to MCPH. We identified a marked reduction of about 30 proteins with vital roles in several processes including cell cytoskeleton dynamics, cell cycle progression, ciliary functions, and apoptosis. We used Cdk5rap2 (Hartwig's anemia mice (an/an)), which is a model that closely represents MCPH3. Gel electrophoresis was utilized in order to separate brain proteins. Fixation and protein identification was then done in order to detect changes in the level of the tested protein

Comparative efficacy and safety of PD-1/PD-L1 inhibitors in triple negative breast cancer: a systematic review and network meta-analysis of randomized controlled trials.

Triple-Negative Breast Cancer (TNBC) is a lethal subtype of breast cancer with limited treatment options. The purpose of this Network Meta-Analysis (NMA) is to compare the efficacy and safety of inhibitors of programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) in treating TNBC. Our search strategy was used in six databases: PubMed, Cochrane Library, Cumulative Index to Nursing and Allied Health Literature database, Embase, Scopus, and Web of Science up to November 2nd, 2022, as well as a thorough search in the most used trial registries. We included phase II and III randomized controlled trials that looked at the efficacy of PD-1/PD-L1 inhibitors in the treatment of TNBC and reported either Overall Survival (OS), Progression-Free Survival (PFS), or pathological Complete Response (pCR). The risk of bias was assessed utilizing Cochrane's risk of bias 2 tool, and the statistical analysis was performed using a frequentist contrast-based method for NMA by employing standard pairwise meta-analysis applying random effects model. 12 trials (5324 patients) were included in our NMA including seven phase III trials. Pembrolizumab in a neoadjuvant setting achieved a pooled OS of 0.82 (95% Confidence Interval (CI) 0.65 to 1.03), a PFS of 0.82 (95% CI 0.71 to 0.94) and a pCR 2.79 (95% CI 1.07 to 7.24) compared to Atezolizumab's OS of 0.92 (95% CI 0.74 to 1.15), PFS of 0.82 (95% CI 0.69 to 0.97), and pCR of 1.94 (95% CI 0.86 to 4.37). Atezolizumab had less grade ≥ 3 adverse events (OR 1.48, 95% CI 0.90 to 2.42) than Pembrolizumab (OR 1.90, 95% CI 1.08 to 3.33) in the neoadjuvant setting. PD-1/PD-L1 inhibitors exhibited varying efficacy in terms of OS, PFS, and pCR. They were associated with an increase in immune-related adverse effects. When used early in the course of TNBC, PD-1/PD-L1 inhibitors exert their maximum benefit. Durvalumab as a maintenance treatment instead of chemotherapy has shown promising outcomes. Future studies should focus on PD-L1 expression status and TNBC subtypes, since these factors may contribute to the design of individualized TNBC therapy regimens. Systematic review registration PROSPERO Identifier: CRD42022380712.Open Access funding provided by the Qatar National Library. This research did not receive any specific grants from funding agencies in the public, commercial, or not-for-profit sectors

Clinical Implications of COVID-19 Presence in CSF: Systematic Review of Case Reports

This systematic review focused on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients that had detected SARS-CoV-2 virus in cerebrospinal fluid (CSF). A systematic literature search was carried out in PubMed, Embase, Scopus, Web of Science, Medrxiv, and Biorxiv databases from inception to 19 December 2021. Case reports or case series involving patients with proved SARS-CoV-2 presence in CSF by polymerize chain reaction were included. Our search strategy produced 23 articles documenting a total of 23 patients with positive SARS-CoV-2 in the CSF. Fever (55%) was the most common symptom, followed by headaches (41%), cough (32%), and vomiting/nausea (32%). The majority of the cases included was encephalitis (57%), 8 of which were confirmed by magnetic resonance imaging. The second most prevalent presentation was meningitis. The cerebral spinal fluid analysis found disparities in protein levels and normal glucose levels in most cases. This study demonstrates that SARS-CoV-2 can enter the nervous system via various routes and cause CNS infection symptoms. SARS-CoV-2 has been shown to infect the CNS even when no respiratory symptoms are present and nasopharyngeal swabs are negative. As a result, SARS-CoV-2 should be considered as a possible cause of CNS infection and tested for in the CSF.Open Access funding provided by the QU Health, Qatar University