95 research outputs found
Addressing Health Disparities in LEP Communities through Language Access
A presentation exploring how health reform will impact access to interpreters for individuals with Limited English Proficiency and individuals who are deaf with a focus on barriers to care and payment reform
A Case of Lambert-Eaton Myasthenic Syndrome Associated with Atypical Bronchopulmonary Carcinoid Tumor
The Lambert-Eaton myasthenic syndrome (LEMS) is typically recognized as a paraneoplastic syndrome associated with a small cell lung carcinoma (SCLC), whereas LEMS with other neuroendocrine lung tumors, including carcinoids or large cell lung carcinoma, are highly unusual. Here, we report a rare case of LEMS with atypical bronchopulmonary carcinoid tumor: A 65-yr-old man presented with progressive leg weakness and a diagnosis of LEMS was made by serial repetitive nerve stimulation test. Chest CT revealed a lung nodule with enlargement of paratracheal lymph nodes, and surgically resected lesion showed pathological features of atypical carcinoid tumor. We concluded that LEMS could be associated with rare pulmonary neuroendocrine tumor other than SCLC, which necessitates pathologic confirmation followed by aggressive treatment for optimal management in these rare cases
Pain as a First Manifestation of Paraneoplastic Neuropathies: A Systematic Review and Meta-Analysis.
INTRODUCTION: Paraneoplastic neurological syndromes (PNS) consist of a heterogeneous group of neurological disorders triggered by cancer. The aim of this systematic review is to estimate the reported prevalence of pain in patients with paraneoplastic peripheral neuropathy (PPN).
METHODS: A systematic computer-based literature search was conducted on PubMed database.
RESULTS: Our search strategy resulted in the identification of 126 articles. After the eligibility assessment, 45 papers met the inclusion criteria. Full clinical and neurophysiological data were further extracted and involved 92 patients with PPN (54.5% males, mean age 60.0 ± 12.2 years). The commonest first manifestation of PPN is sensory loss (67.4%), followed by pain (41.3%), weakness (22.8%), and sensory ataxia (20.7%). In 13.0% of the cases, pain was the sole first manifestation of the PPN. During the course of the PPN, 57.6% of the patients may experience pain secondary to the neuropathy.
CONCLUSIONS: Pain is very prevalent within PPN. Pain specialists should be aware of this. Detailed history-taking, full clinical examination, and requesting nerve conduction studies might lead to an earlier diagnosis of an underlying malignancy
John of Salisbury's Entheticus De Dogmate Philosophorum: The Light it Throws on the Educational Background of the Twelfth Century
John of Salisbury's Entheticus De Dogmate Philosophorum is a poem of 1852 lines, written in elegiac couplets. It is in part didactic and in part a satire on the educational and moral standards of the time. Because in many respects it foreshadows the same author's Pollicaticus and Metalogicon it has been neglected in favour of these two works. Dr. R.L. Poole has written: "The latter part of the Policraticus covers substantially the same ground, although with far greater elaboration and completeness, as the elegiac poem, the Entheticus.... The latter is however by no means superseded by the prose work, and we can readily forgive the jejune rhythm of its imitation of Ovi for the pointed epigrammatic accuracy with which it depicts the learning and manners of the day" (Illustrations of the History of Medieval Thought and Learning, p.191.) On the whole, the Entheticus can be allowed to speak for itself. The edition of the poem by C. Petersen (Hamburg, 1843) is based on only one of the two manuscripts, and Petersen's interpretation of the poem is vitiated by his belief that John of Salisbury attended the schools at Oxford. Dr. J. A. Giles's edition of the poem in Joannis Seresberiensis Opers Omnia (vol.v) is without introduction, notes or sommentary; it is reprinted by Migne in Patrologia Latina, vol.199. This thesis aims to put the Entheticus in perspective against the background of John of Salisbury's life and the intellectual environment of the twelfth century, to examine some of the problems and points raised by the poem, and to provide a critical edition of the text together with an English prose translation
John of Salisbury's Entheticus de dogmate philosophorum: The light it throws on the educational background of the twelfth century
John of Salisbury's Entheticus de dogmate philosophorum is a poem of 1852 lines, written in elegiac couplets. It is in part didactic and in part a satire on the educational and moral standards of the time. Because in many respects it foreshadows the same author's Policraticus and Metalogicon it has been neglected in favour of these two works. Dr. R.L. Poole has written: ''The latter part of the Policraticus covers substantially the same ground, although with far greater elaboration and completeness, as the elegiac poem, the Entheticus .... The latter is however by no means superseded by the prose work, and we can readily forgive the jejune rhythm of its imitation of Ovid for the pointed epigrammatic accuracy with which it depicts the learning and manners of the day." (Illustrations of the History of Mediaeval Thought and Learning, p.191.) On the whole, the Entheticus can be allowed to speak for itself. The edition of the poem by C. Petersen (Hamburg, 1843) is based on only one of the two manuscripts, and Petersen's interpretation of the poem is vitiated by his belief that John of Salisbury attended the schools at Oxford. Dr. J.A. Giles's edition of the poem in Joannis Sare sberiensi s Opera Omnia (vol. v) is without introduction, notes or commentary; it is reprinted by Migne in Patrologia Latina, vol. 199. This thesis aims to put the Enthetlcus in perspective against the background of John of Salisbury's life and the intellectual environment of the twelfth century, to examine some of the problems and points raised by the poem, and to provide a critical edition of the text together with an English prose translation.<p
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