Trypanosoma rangeli: a new perspective for studying the modulation of immune reactions of Rhodnius prolixus

Insects are exposed to a wide range of microorganisms (bacteria, fungi, parasites and viruses) and have interconnected powerful immune reactions. Although insects lack an acquired immune system they have well-developed innate immune defences that allow a general and rapid response to infectious agents

Structural health monitoring algorithm comparisons using standard data sets

The real-world structures are subjected to operational and environmental condition changes that impose difficulties in detecting and identifying structural damage. The aim of this report is to detect damage with the presence of such operational and environmental condition changes through the application of the Los Alamos National Laboratory’s statistical pattern recognition paradigm for structural health monitoring (SHM). The test structure is a laboratory three-story building, and the damage is simulated through nonlinear effects introduced by a bumper mechanism that simulates a repetitive impact-type nonlinearity. The report reviews and illustrates various statistical principles that have had wide application in many engineering fields. The intent is to provide the reader with an introduction to feature extraction and statistical modelling for feature classification in the context of SHM. In this process, the strengths and limitations of some actual statistical techniques used to detect damage in the structures are discussed. In the hierarchical structure of damage detection, this report is only concerned with the first step of the damage detection strategy, which is the evaluation of the existence of damage in the structure. The data from this study and a detailed description of the test structure are available for download at: http://institute.lanl.gov/ei/software-and-data/

Síndrome de Torsades de Pointes: análise de casos: Torsades de Pointes Syndrome: case analysis

A Síndrome de Torsades de Pointes (TdP) é uma taquiarritmia ventricular polimórfica de pacientes com um intervalo QT longo congênito ou induzido por fármacos, cujo eletrocardiograma possui aspecto de “torção das pontas” e os sinais e sintomas característicos são síncope, palpitação ou mesmo evolução para fibrilação ventricular e morte súbita. O sexo mais frequentemente acometido é o feminino, o diagnóstico se baseia no eletrocardiograma e o tratamento preconizado é o sulfato de magnésio (MgSO4) intravenoso, a correção dos distúrbios eletrolíticos, principalmente a hipocalemia e o tratamento da causa base, na TdP farmacoinduzida. O objetivo do estudo é analisar os casos de Síndrome de Torsades de Pointes em pacientes com alterações do intervalo QT no eletrocardiograma. Trata-se de uma revisão bibliográfica integrativa, do tipo quantitativa, que utilizou as plataformas do PubMed, SciELO e Cochrane Library como bases de dados para seleção dos artigos, todos na língua inglesa. Foram utilizadas literaturas publicadas com recorte temporal de 2017 a 2022. De acordo com as literaturas analisadas, conclui-se que a TdP é uma taquiarritmia ventricular polimórfica com um mau prognóstico se não tratada precocemente com o MgSO4 intravenoso e, por ter diversas etiologias, é primordial que o diagnóstico preciso seja estabelecido de forma rápida, devido ao alto índice de mortalidade. Pacientes portadores da síndrome do QT longo congênita, bradicardia sinusal e bloqueio atrioventricular de 1º grau possuem predisposição para o desenvolvimento de TdP. Observa-se escassez na literatura a respeito das formas adequadas de prevenção da TdP, já que muitos pacientes que participam das triagens, muitas das vezes inefetivas, adquirem a síndrome após o uso de drogas que a predispõem, com prolongamento do intervalo QT, ou não sabem que possuem uma SQTL pré-existente, obrigatória para o desenvolvimento da TdP

Application of modal filters for damage detection in the presence of non-linearities

info:eu-repo/semantics/publishe

Smartphone Application for Structural Health Monitoring of Bridges

The broad availability and low cost of smartphones have justified their use for structural health monitoring (SHM) of bridges. This paper presents a smartphone application called App4SHM, as a customized SHM process for damage detection. App4SHM interrogates the phone’s internal accelerometer to measure accelerations, estimates the natural frequencies, and compares them with a reference data set through a machine learning algorithm properly trained to detect damage in almost real time. The application is tested on data sets from a laboratory beam structure and two twin post-tensioned concrete bridges. The results show that App4SHM retrieves the natural frequencies with reliable precision and performs accurate damage detection, promising to be a low-cost solution for long-term SHM. It can also be used in the context of scheduled bridge inspections or to assess bridges’ condition after catastrophic events

Parasite-mediated interactions within the insect vector: Trypanosoma rangeli strategies

Submitted by Sandra Infurna ([email protected]) on 2017-05-25T18:25:55Z No. of bitstreams: 1 eloi_garcia_etal_IOC_2012.pdf: 784202 bytes, checksum: 04110815684ba7a549fd1ac176077093 (MD5)Approved for entry into archive by Sandra Infurna ([email protected]) on 2017-05-25T18:32:36Z (GMT) No. of bitstreams: 1 eloi_garcia_etal_IOC_2012.pdf: 784202 bytes, checksum: 04110815684ba7a549fd1ac176077093 (MD5)Made available in DSpace on 2017-05-25T18:32:36Z (GMT). No. of bitstreams: 1 eloi_garcia_etal_IOC_2012.pdf: 784202 bytes, checksum: 04110815684ba7a549fd1ac176077093 (MD5) Previous issue date: 2012Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Entomologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ. Brasil / Universidade Federal Rural do Rio de Janeiro. Instituto de Ciências Exatas. Departamento de Química. Seropédica, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Entomologia Molecular. Rio de Janeiro, RJ, Brasil.Trypanosoma rangeli is a protozoan that is non-pathogenic for humans and other mammals but causes pathology in the genus Rhodnius. T. rangeli and R. prolixus is an excellent model for studying the parasite-vector interaction, but its cycle in invertebrates remains unclear. The vector becomes infected on ingesting blood containing parasites, which subsequently develop in the gut, hemolymph and salivary glands producing short and large epimastigotes and metacyclic trypomastigotes, which are the infective forms. The importance of the T. rangeli cycle is the flagellate penetration into the gut cells and invasion of the salivary glands. The establishment of the parasite depends on the alteration of some vector defense mechanisms. Herein, we present our understanding of T. rangeli infection on the vector physiology, including gut and salivary gland invasions, hemolymph reactions and behavior alteration