Antibacterial, Anti-HIV-1 Protease and Cytotoxic Activities of Aqueous Ethanolic Extracts from Combretum Adenogonium Steud. Ex A. Rich (Combretaceae).

\ud \ud Records have shown that Combretum adenogonium Steud. Ex A. Rich (Combretaceae) is used in traditional medicine systems of several tribes in Tanzania. This study focused on the investigation of antibacterial activity, anti-HIV-1 protease activity, toxicity properties and classes of phytochemicals in extracts from C. adenogonium Steud. Ex A. Rich (Combretaceae) to evaluate potential of these extracts for development as herbal remedies. Dried plant material were ground to fine powder and extracted using 80% aqueous ethanol to afford root, leaf and stem bark extracts. The extracts were assayed for anti-HIV-1 protease activities, antibacterial activities using microdilution methods and cytotoxicity using brine shrimps lethality assay. Screening for major phytochemical classes was carried out using standard chemical tests. All extracts exhibited antibacterial activity to at least one of the test bacteria with MIC-values ranging from 0.31-5.0 mg/ml. Two extracts, namely, root and stem bark exhibited anti-HIV-1 PR activity with IC50 values of 24.7 and 26.5 μg/ml, respectively. Stem bark and leaf extracts showed mild toxicity with LC50 values of 65.768 μg/ml and 76.965 μg/ml, respectively, whereas roots were relatively non-toxic (LC50 = 110.042 μg/ml). Phytochemical screening of the extracts indicated presence of flavonoids, terpenoids, alkaloids, tannins, glycosides and saponins. These results provide promising baseline information for the potential development of C. adenogonium extracts in treatment of bacterial and HIV/AIDS-related opportunistic infections

Conservation law enforcement : policing protected areas

This article examines how recent increases in commercial poaching of wildlife intensify the dictates that underpin conservation law and its enforcement; namely, the securing of space, punishing of transgressors, and protecting of nonhuman life. Drawing on ethnographic research with antipoaching personnel in Mozambique, I examine how rangers translate these legal and normative manifestations of conservation law enforcement on the ground and in their daily practices to police protected areas and the wildlife within them. This article makes two contributions. First, drawing on insights from the political geography and ecology of conservation with the political geography of policing, I demonstrate how territorial, sovereign, and biopolitical practices and logics coalesce to secure the spaces and the lives of the nonhuman from ostensible human threats. Second, it is rangers who are deployed as petty environmental sovereigns to achieve these objectives through often violent practices. Although many rangers might feel uncomfortable with the use of violence, their agency to commit or resist using violence is authorized, enabled, and constrained by the normative and legal structures of conservation law enforcement within which they operate. The social differentiation among rangers also means that some have more agency to navigate these structures than others. These insights help understand the actually existing operationalization of delegated and performative power over bodies, space, and the use of direct violence. I suggest that critiques of conservation violence, and the use of violence by those acting as petty sovereigns more broadly, should be primarily oriented at the broader structures within which they operate

The Ritvo Autism Asperger Diagnostic Scale-Revised (RAADS-R): A Scale to Assist the Diagnosis of Autism Spectrum Disorder in Adults: An International Validation Study

The Ritvo Autism Asperger Diagnostic Scale-Revised (RAADS-R) is a valid and reliable instrument to assist the diagnosis of adults with Autism Spectrum Disorders (ASD). The 80-question scale was administered to 779 subjects (201 ASD and 578 comparisons). All ASD subjects met inclusion criteria: DSM-IV-TR, ADI/ADOS diagnoses and standardized IQ testing. Mean scores for each of the questions and total mean ASD vs. the comparison groups’ scores were significantly different (p < .0001). Concurrent validity with Constantino Social Responsiveness Scale-Adult = 95.59%. Sensitivity = 97%, specificity = 100%, test–retest reliability r = .987. Cronbach alpha coefficients for the subscales and 4 derived factors were good. We conclude that the RAADS-R is a useful adjunct diagnostic tool for adults with ASD

Mobilising Knowledge through Global Partnerships to Support Research-informed Teaching: Five Models for Translational Research

Education Futures Collaboration Charity The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.Improving the quality of teaching is of global concern: UNESCO’s Sustainable Development Goal (SDG) 4c in the Education 2030: Framework for Action calls for high quality teaching for all. The OECD challenges the education system to improve Knowledge Management. JET’s (2015) special issue: Translational Research (TR) and Knowledge Mobilisation in Teacher Education introduced the concept of ‘translational’ or ‘theory to practice’ research - well-established in medicine but not in education. Five TR models were subsequently developed by the MESH charity’s international network with organisations in South Africa, Bangladesh, Australia, Pakistan, UK. These distinct models engage 1) university staff and teachers 2) subject associations, 3) research units, 4) an international NGO working in crisis settings, 5) PhD tutors and students. Each model shares common features forming the MESH Translational Research methodology introduced in this article. A TR repository is part of the MESH knowledge mobilisation strategy giving teachers access to research summaries which, overtime, accumulate knowledge. TR publications called MESHGuides (www.meshguides.org) complement existing forms of publication. This article proposes the MESH TR methodology as one affordable and scalable solution to OECD and UNESCO’s challenges of keeping teachers up-to-date and making new knowledge accessible to teachers regardless of location

Household, community, sub-national and country-level predictors of primary cooking fuel switching in nine countries from the PURE study

Introduction. Switchingfrom polluting (e.g. wood, crop waste, coal)to clean (e.g. gas, electricity) cooking fuels can reduce household air pollution exposures and climate-forcing emissions.While studies have evaluated specific interventions and assessed fuel-switching in repeated cross-sectional surveys, the role of different multilevel factors in household fuel switching, outside of interventions and across diverse community settings, is not well understood. Methods.We examined longitudinal survey data from 24 172 households in 177 rural communities across nine countries within the Prospective Urban and Rural Epidemiology study.We assessed household-level primary cooking fuel switching during a median of 10 years offollow up (∼2005–2015).We used hierarchical logistic regression models to examine the relative importance of household, community, sub-national and national-level factors contributing to primary fuel switching. Results. One-half of study households(12 369)reported changing their primary cookingfuels between baseline andfollow up surveys. Of these, 61% (7582) switchedfrom polluting (wood, dung, agricultural waste, charcoal, coal, kerosene)to clean (gas, electricity)fuels, 26% (3109)switched between different polluting fuels, 10% (1164)switched from clean to polluting fuels and 3% (522)switched between different clean fuels

Argeologiese studie van die Yster-tydperkkulture op die plaas Greeefswald

Die kulture van Greefswald: 'n Argeologiese studie van die ystertydperkkulture op die plaas Greefawald - FotosDigitised by the Department of Library Services in support of open access to information, University of Pretoria, 2021http://explore.up.ac.za/record=

Argeologiese studie van die Yster-tydperkkulture op die plaas Greeefswald

Die volgende verslag oor die fauna van die Greefswaldterreine is geskryf deur mev. E.A. Voigt van die Transvaal Museum. Dit vorm deel van 'n verhandeling wat sy by die Universiteit van Pretoria ingedien het vir die verkryging van 'n magistergraad in Argeologie. Die leiers vir die verhandeling was prof. J. F. Eloff en dr. C. K Brain. Die materiaal wat hierin beskryf word, is die wat tydens die opgrawings van 1971 tot 1973 gevind is, maar in TI paar gevalle is daar gebruik gemaak van vroeere vondste. Sekere gedeeltes van mev. Voigt se verhandeling het nie regstreeks betrekking op die hoofverslag wat by die RGN ingedien word nie. Daardie gedeeltes is gevolglik weggelaat en dit het sekere redaksionele wysigings vereis waarvan die volgende die belangrikste is.Digitised by the Department of Library Services in support of open access to information, University of Pretoria, 2021http://explore.up.ac.za/record=