829 research outputs found
Female teat size is a reliable indicator of annual breeding success in European badgers: Genetic validation
Assessing which females have bred successfully is a central requirement in many ecological field studies,
providing an estimate of the effective female population size. Researchers have applied teat measurements
previously to assess whether females, in a variety of mammalian species, have bred; however, this
technique has not been validated genetically. Furthermore, several analytical techniques are available to
classify individuals, but their misclassification rates have not been compared. We used 22 microsatellite
loci to assign maternity, with 95% confidence, within a high-density population of European badgers Meles
meles, as plural and subterranean breeding means that maternity cannot be inferred from behavioural
observations. The teat lengths and diameters of 136 females, measured May–July 1994–2005, from social
groups in which all offspring were assigned a mother, were reliable indicators of recent breeding success.
A Generalised Linear Mixed Model (GLMM) classified both breeding and non-breeding females with
lower error rates than discriminant analyses and crude teat-size criteria. The GLMM model logit probability
=
−20 + 1.8 month + 1.6 mean teat length + 1.0 mean teat diameter can be applied quickly in the field
to assess the probability with which a female badger should be assigned maternity. This is a low-cost
measure which, after validation, could be used in other badger or mammalian populations to assess the
breeding success of females. This may be a particularly useful welfare tool for veterinary practitioners,
especially during badger culls
Proof of vanishing cohomology at the tachyon vacuum
We prove Sen's third conjecture that there are no on-shell perturbative
excitations of the tachyon vacuum in open bosonic string field theory. The
proof relies on the existence of a special state A, which, when acted on by the
BRST operator at the tachyon vacuum, gives the identity. While this state was
found numerically in Feynman-Siegel gauge, here we give a simple analytic
expression.Comment: 19 pages, 4 figures; v2: references adde
Genetic variation of Pyrenophora teres f. teres isolates in Western Australia and emergence of a Cyp51A fungicide resistance mutation
Plant Pathology published by John Wiley & Sons Ltd on behalf of British Society for Plant Pathology. Genome-wide, unlinked, simple sequence repeat markers were used to examine genetic variation and relationships within Pyrenophora teres f. teres, a common pathogen of barley, in Western Australia. Despite the region's geographic isolation, the isolates showed relatively high allelic variation compared to similar studies, averaging 7.11 alleles per locus. Principal component, Bayesian clustering and distance differentiation parameters provided evidence for both regional genotypic subdivision together with juxtaposing of isolates possessing different genetic backgrounds. Genotyping of fungicide resistant Cyp51A isolates indicated a single mutation event occurred followed by recombination and long-distance regional dispersal over hundreds of kilometres. Selection of recently emergent favourable alleles such as the Cyp51A mutation and a cultivar virulence may provide an explanation, at least in part, for juxtaposed genotypes. Factors affecting genotypic composition and the movement of new genotypes are discussed in the context of grower practices and pathogen epidemiology, together with the implications for resistance breeding
Superstring field theory equivalence: Ramond sector
We prove that the finite gauge transformation of the Ramond sector of the
modified cubic superstring field theory is ill-defined due to collisions of
picture changing operators.
Despite this problem we study to what extent could a bijective classical
correspondence between this theory and the (presumably consistent)
non-polynomial theory exist. We find that the classical equivalence between
these two theories can almost be extended to the Ramond sector: We construct
mappings between the string fields (NS and Ramond, including Chan-Paton factors
and the various GSO sectors) of the two theories that send solutions to
solutions in a way that respects the linearized gauge symmetries in both sides
and keeps the action of the solutions invariant. The perturbative spectrum
around equivalent solutions is also isomorphic.
The problem with the cubic theory implies that the correspondence of the
linearized gauge symmetries cannot be extended to a correspondence of the
finite gauge symmetries. Hence, our equivalence is only formal, since it
relates a consistent theory to an inconsistent one. Nonetheless, we believe
that the fact that the equivalence formally works suggests that a consistent
modification of the cubic theory exists. We construct a theory that can be
considered as a first step towards a consistent RNS cubic theory.Comment: v1: 24 pages. v2: 27 pages, significant modifications of the
presentation, new section, typos corrected, references adde
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Are Dietary Bioactives Ready for Recommended Intakes?12
Research has shown that numerous dietary bioactive components that are not considered essential may still be beneficial to health. The dietary reference intake (DRI) process has been applied to nonessential nutrients, such as fiber, yet the majority of bioactive components await a recommended intake. Despite a plethora of new research over the past several years on the health effects of bioactives, it is possible that the field may never reach a point where the current DRI framework is suitable for these food components. If bioactives are to move toward dietary guidance, they will likely require an alternative path to get there
Ambient particulate pollution and the world-wide prevalence of asthma, rhinoconjunctivitis and eczema in children: Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC)
Objectives: To investigate the effect of ambient particulate matter on variation in childhood prevalence of asthma, rhinoconjunctivitis and eczema.
Methods: Prevalences of asthma, rhinoconjunctivitis and eczema obtained in Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC) were matched with city-level estimates of residential PM10 obtained from a World Bank model. Associations were investigated using binomial regression adjusting for GNP per capita and for clustering within country. For countries with more than one centre, a two stage meta-analysis was carried out. The results were compared with a meta-analysis of published multi-centre studies.
Results: Annual concentrations of PM₁₀ at city level were obtained for 105 ISAAC centres in 51 countries. After controlling for GNP per capita, there was a weak negative association between PM₁₀ and various outcomes. For severe wheeze in 13-14-year-olds, the OR for a 10 μg/m³ increase in PM₁₀ was 0.92 (95 CI 0.84 to 1.00). In 24 countries with more than one centre, most summary estimates for within-country associations were weakly positive. For severe wheeze in 13-14-year-olds, the summary OR for a 10 μg/m³ increase in PM₁₀ was 1.01 (0.92 to 1.10). This result was close to a summary OR of 0.99 (0.91 to 1.06) obtained from published multi-centre studies.
Conclusions: Modelled estimates of particulate matter at city level are imprecise and incomplete estimates of personal exposure to ambient air pollutants. Nevertheless, our results together with those of previous multi-centre studies, suggest that urban background PM₁₀ has little or no association with the prevalence of childhood asthma, rhinoconjunctivitis or eczema either within or between countries
D-branes, KK-theory and duality on noncommutative spaces
We present a new categorical classification framework for D-brane charges on noncommutative manifolds using methods of bivariant K-theory. We describe several applications including an explicit formula for D-brane charge in cyclic homology, a refinement of open string T-duality, and a general criterion for cancellation of global worldsheet anomalies
On fluctuations of closed string tachyon solitons
We discuss fluctuations on solitons in the dilaton/graviton/tachyon system
using the low energy effective field theory approach. It is shown that closed
string solitons are free of tachyons in this approximation, regardless of the
exact shape of the tachyon potential.Comment: 13 pages, 1 figure, uses JHEP3.cl
Matrix theory origins of non-geometric fluxes
We explore the origins of non-geometric fluxes within the context of M theory
described as a matrix model. Building upon compactifications of Matrix theory
on non-commutative tori and twisted tori, we formulate the conditions which
describe compactifications with non-geometric fluxes. These turn out to be
related to certain deformations of tori with non-commutative and
non-associative structures on their phase space. Quantization of flux appears
as a natural consequence of the framework and leads to the resolution of
non-associativity at the level of the unitary operators. The quantum-mechanical
nature of the model bestows an important role on the phase space. In
particular, the geometric and non-geometric fluxes exchange their properties
when going from position space to momentum space thus providing a duality among
the two. Moreover, the operations which connect solutions with different fluxes
are described and their relation to T-duality is discussed. Finally, we provide
some insights on the effective gauge theories obtained from these matrix
compactifications.Comment: 1+31 pages, reference list update
Effect of dietary omega-3 fatty acids on castrate-resistant prostate cancer and tumor-associated macrophages.
BackgroundM2-like macrophages are associated with the pathogenesis of castrate-resistant prostate cancer (CRPC). We sought to determine if dietary omega-3 fatty acids (ω-3 FAs) delay the development and progression of CRPC and inhibit tumor-associated M2-like macrophages.MethodsMycCap cells were grown subcutaneously in immunocompetent FVB mice. Mice were castrated when tumors reached 300 mm2. To study effects of dietary ω-3 FAs on development of CRPC, ω-3 or ω-6 diets were started 2 days after castration and mice sacrificed after early regrowth of tumors. To study ω-3 FA effects on progression of CRPC, tumors were allowed to regrow after castration before starting the diets. M2 (CD206+) macrophages were isolated from allografts to examine ω-3 FA effects on macrophage function. Omega-3 fatty acid effects on androgen-deprived RAW264.7 M2 macrophages were studied by RT-qPCR and a migration/ invasion assay.ResultsThe ω-3 diet combined with castration lead to greater MycCap tumor regression (tumor volume reduction: 182.2 ± 33.6 mm3) than the ω-6 diet (tumor volume reduction: 148.3 ± 35.2; p = 0.003) and significantly delayed the time to CRPC (p = 0.006). Likewise, the ω-3 diet significantly delayed progression of established castrate-resistant MycCaP tumors (p = 0.003). The ω-3 diet (as compared to the ω-6 diet) significantly reduced tumor-associated M2-like macrophage expression of CSF-1R in the CRPC development model, and matrix metallopeptidase-9 (MMP-9) and vascular endothelial growth factor (VEGF) in the CRPC progression model. Migration of androgen-depleted RAW264.7 M2 macrophages towards MycCaP cells was reversed by addition of docosahexaenoic acid (ω-3).ConclusionsDietary omega-3 FAs (as compared to omega-6 FAs) decreased the development and progression of CRPC in an immunocompetent mouse model, and had inhibitory effects on M2-like macrophage function. Clinical trials are warranted evaluating if a fish oil-based diet can delay the time to castration resistance in men on androgen deprivation therapy, whereas further preclinical studies are warranted evaluating fish oil for more advanced CRPC
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