792 research outputs found

    Metric Perturbation Approach to Gravitational Waves in Isotropic Cosmologies

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    Gravitational waves in isotropic cosmologies were recently studied using the gauge-invariant approach of Ellis-Bruni. We now construct the linearised metric perturbations of the background Robertson-Walker space-time which reproduce the results obtained in that study. The analysis carried out here also facilitates an easy comparison with Bardeen.Comment: 29 pages, Latex file, accepted for publication in Physical Review

    A novel paradigm for attributing the diagnosis of CF disease

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    Implications of the HERA Events for the R-Parity Breaking SUSY Signals at Tevatron

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    The favoured R-parity violating SUSY scenarios for the anomalous HERA events correspond to top and charm squark production via the λ131â€Č\lambda'_{131} and λ121â€Č\lambda'_{121} couplings. In both cases the corresponding electronic branching fractions of the squarks are expected to be â‰Ș1\ll 1. Consequently the canonical leptoquark signature is incapable of probing these scenarios at the Tevatron collider over most of the MSSM parameter space. We suggest alternative signatures for probing them at Tevatron, which seem to be viable over the entire range of MSSM parameters.Comment: 20 pages Latex file with 4 ps files containing 4 figure

    Electroproduction and Hadroproduction of Light Gluinos

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    In a class of supergravity models, the gluino and photino are massless at tree level and receive small masses through radiative corrections. In such models, one expects a gluino-gluon bound state, the R0R_0, to have a mass of between 1.0 and 2.2 GeV and a lifetime between 10−1010^{-10} and 10−610^{-6} seconds. Applying peturbative QCD methods (whose validity we discuss), we calculate the production cross sections of R0R_0's in e−pe-p, π−p\pi-p, K−pK-p, p‟−p\overline{p}-p and p−pp-p collisions. Signatures are also discussed.Comment: 10 pages, latex, 6 figures uuencoded, figures also available via anonymous ftp to ftp://physics.wm.edu/pub/gluinofig.p

    Can black holes have Euclidean cores?

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    The search for regular black hole solutions in classical gravity leads us to consider a core of Euclidean signature in the interior of a black hole. Solutions of Lorentzian and Euclidean general relativity match in such a way that energy densities and pressures of an isotropic perfect fluid form are everywhere finite and continuous. Although the weak energy condition cannot be satisfied for these solutions in general relativity, it can be when higher derivative terms are added. A numerical study shows how the transition becomes smoother in theories with more derivatives. As an alternative to the Euclidean core, we also discuss a closely related time dependent orbifold construction with a smooth space-like boundary inside the horizon.Comment: 14 pages with figures, version to appear in PR

    Lorentz breaking Effective Field Theory and observational tests

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    Analogue models of gravity have provided an experimentally realizable test field for our ideas on quantum field theory in curved spacetimes but they have also inspired the investigation of possible departures from exact Lorentz invariance at microscopic scales. In this role they have joined, and sometime anticipated, several quantum gravity models characterized by Lorentz breaking phenomenology. A crucial difference between these speculations and other ones associated to quantum gravity scenarios, is the possibility to carry out observational and experimental tests which have nowadays led to a broad range of constraints on departures from Lorentz invariance. We shall review here the effective field theory approach to Lorentz breaking in the matter sector, present the constraints provided by the available observations and finally discuss the implications of the persisting uncertainty on the composition of the ultra high energy cosmic rays for the constraints on the higher order, analogue gravity inspired, Lorentz violations.Comment: 47 pages, 4 figures. Lecture Notes for the IX SIGRAV School on "Analogue Gravity", Como (Italy), May 2011. V.3. Typo corrected, references adde

    The design, construction and performance of the MICE scintillating fibre trackers

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    This is the Pre-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2011 ElsevierCharged-particle tracking in the international Muon Ionisation Cooling Experiment (MICE) will be performed using two solenoidal spectrometers, each instrumented with a tracking detector based on diameter scintillating fibres. The design and construction of the trackers is described along with the quality-assurance procedures, photon-detection system, readout electronics, reconstruction and simulation software and the data-acquisition system. Finally, the performance of the MICE tracker, determined using cosmic rays, is presented.This work was supported by the Science and Technology Facilities Council under grant numbers PP/E003214/1, PP/E000479/1, PP/E000509/1, PP/E000444/1, and through SLAs with STFC-supported laboratories. This work was also supportedby the Fermi National Accelerator Laboratory, which is operated by the Fermi Research Alliance, under contract No. DE-AC02-76CH03000 with the U.S. Department of Energy, and by the U.S. National Science Foundation under grants PHY-0301737,PHY-0521313, PHY-0758173 and PHY-0630052. The authors also acknowledge the support of the World Premier International Research Center Initiative (WPI Initiative), MEXT, Japan

    What Shall I Do Next? Intention Mining for Flexible Process Enactment

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    International audienceBesides the benefits of flexible processes, practical implementations of process aware information systems have also revealed difficulties encountered by process participants during enactment. Several support and guidance solutions based on process mining have been proposed, but they lack a suitable semantics for human reasoning and decisions making as they mainly rely on low level activities. Applying design science, we created FlexPAISSeer, an intention mining oriented approach, with its component artifacts: 1) IntentMiner which discovers the intentional model of the executable process in an unsupervised manner; 2) In-tentRecommender which generates recommendations as intentions and confidence factors, based on the mined intentional process model and probabilistic calculus. The artifacts were evaluated in a case study with a Netherlands software company, using a Childcare system that allows flexible data-driven process enactment

    Domain Wall Spacetimes: Instability of Cosmological Event and Cauchy Horizons

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    The stability of cosmological event and Cauchy horizons of spacetimes associated with plane symmetric domain walls are studied. It is found that both horizons are not stable against perturbations of null fluids and massless scalar fields; they are turned into curvature singularities. These singularities are light-like and strong in the sense that both the tidal forces and distortions acting on test particles become unbounded when theses singularities are approached.Comment: Latex, 3 figures not included in the text but available upon reques

    Rare variants in optic disc area gene CARD10 enriched in primary open-angle glaucoma

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    Background: Genome-wide association studies (GWAS) have identified association of common alleles with primary open-angle glaucoma (POAG) and its quantitative endophenotypes near numerous genes. This study aims to determine whether rare pathogenic variants in these disease-associated genes contribute to POAG. Methods: Participants fulfilled strict inclusion criteria of advanced POAG at a young age of diagnosis. Myocilin mutation carriers were excluded using direct sequencing. Whole exome sequencing was performed on 187 glaucoma cases and 103 local screened nonglaucoma controls then joint-called with exomes of 993 previously sequenced Australian controls. GWAS-associated genes were assessed for enrichment of rare predicted pathogenic variants in POAG. Significantly enriched genes were compared against Exome Aggregation Consortium (ExAC) public control. Results: Eighty-six GWAS disease or trait-associated glaucoma genes were captured and sequenced. CARD10 showed enrichment after Bonferroni correction for rare variants in glaucoma cases (OR = 13.2, P = 6.94 × 10−5) with mutations identified in 4.28% of our POAG cohort compared to 0.27% in controls. CARD10 was significantly associated with optic disc parameters in previous GWAS. The whole GWAS gene set showed no enrichment in POAG overall (OR = 1.12, P = 0.51). Conclusion: We report here an enrichment of rare predicted pathogenic coding variants within a GWAS-associated locus in POAG (CARD10). These findings indicate that both common and rare pathogenic coding variants in CARD10 may contribute to POAG pathogenesis.Tiger Zhou, Emmanuelle Souzeau, Shiwani Sharma, Owen M. Siggs, Ivan Goldberg, Paul R. Healey, Stuart Graham, Alex W. Hewitt, David A. Mackey, Robert J. Casson, John Landers, Richard Mills, Jonathan Ellis, Paul Leo, Matthew A. Brown, Stuart MacGregor, Kathryn P. Burdon and Jamie E. Crai
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