The therapeutic potential of exercise to improve mood, cognition, and sleep in Parkinson's disease

Published in final edited form as: Mov Disord. 2016 January ; 31(1): 23–38. doi:10.1002/mds.26484.In addition to the classic motor symptoms, Parkinson's disease (PD) is associated with a variety of nonmotor symptoms that significantly reduce quality of life, even in the early stages of the disease. There is an urgent need to develop evidence‐based treatments for these symptoms, which include mood disturbances, cognitive dysfunction, and sleep disruption. We focus here on exercise interventions, which have been used to improve mood, cognition, and sleep in healthy older adults and clinical populations, but to date have primarily targeted motor symptoms in PD. We synthesize the existing literature on the benefits of aerobic exercise and strength training on mood, sleep, and cognition as demonstrated in healthy older adults and adults with PD, and suggest that these types of exercise offer a feasible and promising adjunct treatment for mood, cognition, and sleep difficulties in PD. Across stages of the disease, exercise interventions represent a treatment strategy with the unique ability to improve a range of nonmotor symptoms while also alleviating the classic motor symptoms of the disease. Future research in PD should include nonmotor outcomes in exercise trials with the goal of developing evidence‐based exercise interventions as a safe, broad‐spectrum treatment approach to improve mood, cognition, and sleep for individuals with PD.This work was supported by the National Institute of Mental Health (F31MH102961 to G.O.R.)

b --> s g g decay in the two and three Higgs doublet models with CP violating effects

We study the decay width and CP-asymmetry of the inclusive process b--> s g g (g denotes gluon) in the three and two Higgs doublet models with complex Yukawa couplings. We analyse the dependencies of the differential decay width and CP-asymmetry to the s- quark energy E_s and CP violating parameter \theta. We observe that there exist a considerable enhancement in the decay width and CP asymmetry is at the order of 10^{-2}. Further, it is possible to predict the sign of C_7^{eff} using the CP asymmetry.Comment: 15 pages, 7 Figures (required epsf style

Two-dimensional compressible flow in centrifugal compressors with straight blades

Six numerical examples are presented for steady, two-dimensional, compressible, nonviscous flow in centrifugal compressors with thin straight blades, the center lines of which generate the surface of a right circular cone when rotated about the axis of the compressor. A seventh example is presented for incompressible flow. The solutions were obtained in a region of the compressors, including the impeller tip, that was considered to be unaffected by the diffuser vanes or by the impeller-inlet configuration. Each solution applies to radial and mixed flow compressors with various cone angles but with the same angle between blades on the conic flow surface. The solution also apply to radial and mixed flow turbines with the rotation and the flow direction reversed. The effects of variations in the following parameters were investigated: (1) flow rate, (2) impeller-tip speed, (3) variation of passage height with radius, and (4) angle between blades on conic flow surface. The numerical results are presented in plots of the streamlines and constant Mach number lines. Correlation equations are developed whereby the flow conditions in any impeller with straight blades can be determined (in the region investigated by this analysis) for all operating conditions

Inflationary Baryogenesis

In this letter we explore the possibility of creating the baryon asymmetry of the universe during inflation and reheating due to the decay of a field associated with the inflaton. CP violation is attained by assuming that this field is complex with a phase that varies as the inflaton evolves. We consider chaotic and natural inflation scenarios. In the former case, the complex decaying field is the inflaton itself and, in the latter case, the phase of the complex field is the inflaton. We calculate the asymmetry produced using the Bogolyubov formalism that relates annihilation and creation operators at late time to the annihilation and creation operators at early time.Comment: 17 pages, Revte

Exact non-equilibrium solutions of the Einstein-Boltzmann equations. II

We find exact solutions of the Einstein-Boltzmann equations with relaxational collision term in FRW and Bianchi I spacetimes. The kinematic and thermodynamic properties of the solutions are investigated. We give an exact expression for the bulk viscous pressure of an FRW distribution that relaxes towards collision-dominated equilibrium. If the relaxation is toward collision-free equilibrium, the bulk viscosity vanishes - but there is still entropy production. The Bianchi I solutions have zero heat flux and bulk viscosity, but nonzero shear viscosity. The solutions are used to construct a realisation of the Weyl Curvature Hypothesis.Comment: 16 pages LaTex, CQG documentstyle (ioplppt

Dark Matter in SuperGUT Unification Models

After a brief update on the prospects for dark matter in the constrained version of the MSSM (CMSSM) and its differences with models based on minimal supergravity (mSUGRA), I will consider the effects of unifying the supersymmetry-breaking parameters at a scale above M_{GUT}. One of the consequences of superGUT unification, is the ability to take vanishing scalar masses at the unification scale with a neutralino LSP dark matter candidate. This allows one to resurrect no-scale supergravity as a viable phenomenological model.Comment: 12 pages, 16 figures, To be published in the Proceedings of the 6th DSU Conference, Leon, Mexico, ed. D. Delepin