The therapeutic potential of exercise to improve mood, cognition, and sleep in Parkinson's disease

Published in final edited form as: Mov Disord. 2016 January ; 31(1): 23–38. doi:10.1002/mds.26484.In addition to the classic motor symptoms, Parkinson's disease (PD) is associated with a variety of nonmotor symptoms that significantly reduce quality of life, even in the early stages of the disease. There is an urgent need to develop evidence‐based treatments for these symptoms, which include mood disturbances, cognitive dysfunction, and sleep disruption. We focus here on exercise interventions, which have been used to improve mood, cognition, and sleep in healthy older adults and clinical populations, but to date have primarily targeted motor symptoms in PD. We synthesize the existing literature on the benefits of aerobic exercise and strength training on mood, sleep, and cognition as demonstrated in healthy older adults and adults with PD, and suggest that these types of exercise offer a feasible and promising adjunct treatment for mood, cognition, and sleep difficulties in PD. Across stages of the disease, exercise interventions represent a treatment strategy with the unique ability to improve a range of nonmotor symptoms while also alleviating the classic motor symptoms of the disease. Future research in PD should include nonmotor outcomes in exercise trials with the goal of developing evidence‐based exercise interventions as a safe, broad‐spectrum treatment approach to improve mood, cognition, and sleep for individuals with PD.This work was supported by the National Institute of Mental Health (F31MH102961 to G.O.R.)

b --> s g g decay in the two and three Higgs doublet models with CP violating effects

We study the decay width and CP-asymmetry of the inclusive process b--> s g g (g denotes gluon) in the three and two Higgs doublet models with complex Yukawa couplings. We analyse the dependencies of the differential decay width and CP-asymmetry to the s- quark energy E_s and CP violating parameter \theta. We observe that there exist a considerable enhancement in the decay width and CP asymmetry is at the order of 10^{-2}. Further, it is possible to predict the sign of C_7^{eff} using the CP asymmetry.Comment: 15 pages, 7 Figures (required epsf style

Exact non-equilibrium solutions of the Einstein-Boltzmann equations. II

We find exact solutions of the Einstein-Boltzmann equations with relaxational collision term in FRW and Bianchi I spacetimes. The kinematic and thermodynamic properties of the solutions are investigated. We give an exact expression for the bulk viscous pressure of an FRW distribution that relaxes towards collision-dominated equilibrium. If the relaxation is toward collision-free equilibrium, the bulk viscosity vanishes - but there is still entropy production. The Bianchi I solutions have zero heat flux and bulk viscosity, but nonzero shear viscosity. The solutions are used to construct a realisation of the Weyl Curvature Hypothesis.Comment: 16 pages LaTex, CQG documentstyle (ioplppt

Contrasting abundance and residency patterns of two sympatric populations of transient killer whales (Orcinus orca) in the northern Gulf of Alaska

Two sympatric populations of “transient” (mammal-eating) killer whales were photo-identified over 27 years (1984–2010) in Prince William Sound and Kenai Fjords, coastal waters of the northern Gulf of Alaska (GOA). A total of 88 individuals were identified during 203 encounters with “AT1” transients (22 individuals) and 91 encounters with “GOA” transients (66 individuals). The median number of individuals identified annually was similar for both populations (AT1=7; GOA=8), but mark-recapture estimates showed the AT1 whales to have much higher fidelity to the study area, whereas the GOA whales had a higher exchange of individuals. Apparent survival estimates were generally high for both populations, but there was a significant reduction in the survival of AT1 transients after the Exxon Valdez oil spill in 1989, with an abrupt decline in estimated abundance from a high of 22 in 1989 to a low of seven whales at the end of 2010. There was no detectable decline in GOA population abundance or survival over the same period, but abundance ranged from just 6 to 18 whales annually. Resighting data from adjacent coastal waters and movement tracks from satellite tags further indicated that the GOA whales are part of a larger population with a more extensive range, whereas AT1 whales are resident to the study area

Methods for calculating nonconcave entropies

Five different methods which can be used to analytically calculate entropies that are nonconcave as functions of the energy in the thermodynamic limit are discussed and compared. The five methods are based on the following ideas and techniques: i) microcanonical contraction, ii) metastable branches of the free energy, iii) generalized canonical ensembles with specific illustrations involving the so-called Gaussian and Betrag ensembles, iv) restricted canonical ensemble, and v) inverse Laplace transform. A simple long-range spin model having a nonconcave entropy is used to illustrate each method.Comment: v1: 22 pages, IOP style, 7 color figures, contribution for the JSTAT special issue on Long-range interacting systems. v2: Open problem and references added, minor typos corrected, close to published versio

Hubble Space Telescope imaging of the CFRS and LDSS redshift surveys - IV. Influence of mergers in the evolution of faint field galaxies from z~1

HST images of a sample of 285 galaxies with measured z from the CFRS and Autofib-LDSS redshift surveys are analysed to derive the evolution of the merger fraction out to z~1. We have performed visual and machine-based merger identifications, as well as counts of bright pairs of galaxies with magnitude differences less than 1.5 mag. We find that the pair fraction increases with z, with up to ~20% of the galaxies being in physical pairs at z~0.75-1. We derive a merger fraction varying with z as (1+z)^{3.2 +/- 0.6}, after correction for line-of-sight contamination, in excellent agreement with the merger fraction derived from the visual classification of mergers for which m = 3.4 +/- 0.6. After correcting for seeing effects on the ground-based selection of survey galaxies, we conclude that the pair fraction evolves as (1+z)^{2.7 +/- 0.6}. This implies that an average L* galaxy will have undergone 0.8 to 1.8 merger events from z=1 to 0, with 0.5 to 1.2 merger events occuring in a 2 Gyr time span at z~0.9. This result is consistent with predictions from semi-analytical models of galaxy formation. From the simple co-addition of the observed luminosities of the galaxies in pairs, physical mergers are computed to lead to a brightening of 0.5 mag for each pair on average, and a boost in star formation rate of a factor of 2, as derived from the average [O II] equivalent widths. Mergers of galaxies are therefore contributing significantly to the evolution of both the luminosity function and luminosity density of the Universe out to z~1.Comment: 14 pages, 6 PS figures included. Accepted for publication in MNRA

N=1 Supergravity Chaotic Inflation in the Braneworld Scenario

We study a N=1 Supergravity chaotic inflationary model, in the context of the braneworld scenario. It is shown that successful inflation and reheating consistent with phenomenological constraints can be achieved via the new terms in the Friedmann equation arising from brane physics. Interestingly, the model satisfies observational bounds with sub-Planckian field values, implying that chaotic inflation on the brane is free from the well known difficulties associated with the presence of higher order non-renormalizable terms in the superpotential. A bound on the mass scale of the fifth dimension, M_5 \gsim 1.3 \times 10^{-6} M_P, is obtained from the requirement that the reheating temperature be higher than the temperature of the electroweak phase transition.Comment: 5 pages, 1 Table, Revtex

Cosmology with a TeV mass GUT Higgs

The most natural way to break the GUT gauge symmetry is with a Higgs field whose vacuum expectation value is of order 10^{16}\,\mbox{GeV} but whose mass is of order $10^2$ to 10^3\,\mbox{GeV}. This can lead to a cosmological history radically different from what is usually assumed to have occurred between the standard inflationary and nucleosynthesis epochs, which may solve the gravitino and Polonyi/moduli problems in a natural way.Comment: 4 pages, revte

Low-energy theorems of QCD and bulk viscosity at finite temperature and baryon density in a magnetic field

The nonperturbative QCD vacuum at finite temperature and a finite baryon density in an external magnetic field is studied. Equations relating nonperturbative condensates to the thermodynamic pressure for $T\neq 0$, $\mu_q \neq 0$ and $H\neq 0$ are obtained, and low-energy theorems are derived. A bulk viscosity $\zeta(T, \mu, H)$ is expressed in terms of basic thermodynamical quantities describing the quark-gluon matter at $T\neq 0$, $\mu_q \neq 0$, and $H\neq 0$. Various limiting cases are also considered.Comment: 12 pages; v2: title changed, new section about bulk viscosity and new references added; v3: new discussion adde