Use of apomorphine in Parkinsonian patients with neuropsychiatric complications to oral treatment

Neuropsychiatric side effects often complicate anti-Parkinsonian therapy and pose a significant problem in the optimal management of idiopathic Parkinson's disease. Several publications report a relative lack of neuropsychiatric side effects in Parkinsonian patients treated with subcutaneous apomorphine. To investigate this further, we have used subcutaneous apomorphine to treat 12 non-demented IPD patients with previous oral drug-related neuropsychiatric problems. Treatment with apomorphine allowed alteration of anti-Parkinsonian medication and led to the abolition or reduction of neuropsychiatric complications in all patients. The mechanism remains unclear but may be due, in part, to a reduction in oral medication or a psychotropic action of apomorphine, possibly due to the piperidine moiety in its structure, or both

Moduli Inflation from Dynamical Supersymmetry Breaking

Moduli fields, which parameterize perturbative flat directions of the potential in supersymmetric theories, are natural candidates to act as inflatons. An inflationary potential on moduli space can result if the scale of dynamical SUSY breaking in some sector of the theory is determined by a moduli dependent coupling. The magnitude of density fluctuations generated during inflation then depends on the scale of SUSY breaking in this sector. This can naturally be hierarchically smaller than the Planck scale in a dynamical model, giving small fluctuations without any fine tuning of parameters. It is also natural for SUSY to be restored at the minimum of the moduli potential, and to leave the universe with zero cosmological constant after inflation. Acceptable reheating can also be achieved in this scenario.Comment: 14 pages, latex, improved discussion of reheating for composite inflaton

Molecular Mechanisms of Notochord Vacuole Formation and Their Role in Zebrafish Development

<p>The notochord plays critical structural and signaling roles during vertebrate development. At the center of the vertebrate notochord is a large fluid-filled organelle, the notochord vacuole. While these highly conserved intracellular structures have been described for decades, little is known about the molecular mechanisms involved in their biogenesis and maintenance. Here we show that zebrafish notochord vacuoles are specialized lysosome-related organelles whose formation and maintenance requires late endosomal trafficking regulated by the vacuole-specific Rab32a, and H+-ATPase-dependent acidification. We establish that notochord vacuoles are required for body axis elongation during embryonic development and identify a novel role for notochord vacuoles in spine morphogenesis. Thus, the vertebrate notochord plays important structural roles beyond early development.</p>Dissertatio

SAVI and SAVI Revisited

SAVI and SAVI Revisite