33 research outputs found
DSR as an explanation of cosmological structure
Deformed special relativity (DSR) is one of the possible realizations of a
varying speed of light (VSL). It deforms the usual quadratic dispersion
relations so that the speed of light becomes energy dependent, with preferred
frames avoided by postulating a non-linear representation of the Lorentz group.
The theory may be used to induce a varying speed of sound capable of generating
(near) scale-invariant density fluctuations, as discussed in a recent Letter.
We identify the non-linear representation of the Lorentz group that leads to
scale-invariance, finding a universal result. We also examine the higher order
field theory that could be set up to represent it
A Terminal Velocity on the Landscape: Particle Production near Extra Species Loci in Higher Dimensions
We investigate particle production near extra species loci (ESL) in a higher
dimensional field space and derive a speed limit in moduli space at weak
coupling. This terminal velocity is set by the characteristic ESL-separation
and the coupling of the extra degrees of freedom to the moduli, but it is
independent of the moduli's potential if the dimensionality of the field space
is considerably larger than the dimensionality of the loci, D >> d. Once the
terminal velocity is approached, particles are produced at a plethora of nearby
ESLs, preventing a further increase in speed via their backreaction. It is
possible to drive inflation at the terminal velocity, providing a
generalization of trapped inflation with attractive features: we find that more
than sixty e-folds of inflation for sub-Planckian excursions in field space are
possible if ESLs are ubiquitous, without fine tuning of initial conditions and
less tuned potentials. We construct a simple, observationally viable model with
a slightly red scalar power-spectrum and suppressed gravitational waves; we
comment on the presence of additional observational signatures originating from
IR-cascading and individual massive particles. We also show that
moduli-trapping at an ESL is suppressed for D >> d, hindering dynamical
selection of high-symmetry vacua on the landscape based on this mechanism.Comment: 46 pages, 6 figures. V3: typos corrected compared to JHEP version,
conclusions unchange
Prediction of malignant transformation in oral epithelial dysplasia using infrared absorbance spectra
Oral epithelial dysplasia (OED) is a histopathologically-defined, potentially premalignant condition of the oral cavity. The rate of transformation to frank carcinoma is relatively low (12% within 2 years) and prediction based on histopathological grade is unreliable, leading to both over- and under-treatment. Alternative approaches include infrared (IR) spectroscopy, which is able to classify cancerous and non-cancerous tissue in a number of cancers, including oral. The aim of this study was to explore the capability of FTIR (Fourier-transform IR) microscopy and machine learning as a means of predicting malignant transformation of OED. Supervised, retrospective analysis of longitudinally-collected OED biopsy samples from 17 patients with high risk OED lesions: 10 lesions transformed and 7 did not over a follow-up period of more than 3 years. FTIR spectra were collected from routine, unstained histopathological sections and machine learning used to predict malignant transformation, irrespective of OED classification. PCA-LDA (principal component analysis followed by linear discriminant analysis) provided evidence that the subsequent transforming status of these 17 lesions could be predicted from FTIR data with a sensitivity of 79 ± 5% and a specificity of 76 ± 5%. Six key wavenumbers were identified as most important in this classification. Although this pilot study used a small cohort, the strict inclusion criteria and classification based on known outcome, rather than OED grade, make this a novel study in the field of FTIR in oral cancer and support the clinical potential of this technology in the surveillance of OED
Prediction of malignant transformation in oral epithelial dysplasia using machine learning.
A machine learning algorithm (MLA) has been applied to a Fourier transform infrared spectroscopy (FTIR) dataset previously analysed with a principal component analysis (PCA) linear discriminant analysis (LDA) model. This comparison has confirmed the robustness of FTIR as a prognostic tool for oral epithelial dysplasia (OED). The MLA is able to predict malignancy with a sensitivity of 84 ± 3% and a specificity of 79 ± 3%. It provides key wavenumbers that will be important for the development of devices that can be used for improved prognosis of OED
Tissue discrimination in head and neck cancer using image fusion of IR and optical microscopy.
A regression-based fusion algorithm has been used to merge hyperspectral Fourier transform infrared (FTIR) data with an H&E image of oral squamous cell carcinoma metastases in cervical lymphoid nodal tissue. This provides insight into the success of the ratio of FTIR absorbances at 1252 cm-1 and 1285 cm-1 in discriminating between these tissue types. The success is due to absorbances at these two wavenumbers being dominated by contributions from DNA and collagen, respectively. A pixel-by-pixel fit of the fused spectra to the FTIR spectra of collagen, DNA and cytokeratin reveals the contributions of these molecules to the tissue at high spatial resolution
Inflation in Realistic D-Brane Models
We find successful models of D-brane/anti-brane inflation within a string
context. We work within the GKP-KKLT class of type IIB string vacua for which
many moduli are stabilized through fluxes, as recently modified to include
`realistic' orbifold sectors containing standard-model type particles. We allow
all moduli to roll when searching for inflationary solutions and find that
inflation is not generic inasmuch as special choices must be made for the
parameters describing the vacuum. But given these choices inflation can occur
for a reasonably wide range of initial conditions for the brane and antibrane.
We find that D-terms associated with the orbifold blowing-up modes play an
important role in the inflationary dynamics. Since the models contain a
standard-model-like sector after inflation, they open up the possibility of
addressing reheating issues. We calculate predictions for the CMB temperature
fluctuations and find that these can be consistent with observations, but are
generically not deep within the scale-invariant regime and so can allow
appreciable values for as well as predicting a potentially
observable gravity-wave signal. It is also possible to generate some admixture
of isocurvature fluctuations.Comment: 39 pages, 21 figures; added references; identified parameters
combining successful inflation with strong warping, as needed for consistency
of the approximation
Diagnostic and therapeutic medical devices for safer blood management in cardiac surgery : systematic reviews, observational studies and randomised controlled trials
Funding: This project was funded by the National Institute for Health Research (NIHR) Programme Grants for Applied Research programme and will be published in full in Programme Grants for Applied Research; Vol. 5, No. 17. See the NIHR Journals Library website for further project information.Peer reviewedPublisher PD