Exploring young adults\u27 perspectives on communication with aunts

Women are typically studied as daughters, sisters, mothers, or grandmothers. However, many, if not most, women are also aunts. In this study, we offer a preliminary exploration of the meaning of aunts as familial figures. We collected 70 nieces\u27 and nephews\u27 written accounts of their aunts. Thematic analysis of these accounts revealed nine themes, which were divided into two categories. The first category represented the role of the aunt as a teacher, role model, confidante, savvy peer, and second mother. The second category represented the practices of aunting: gifts/treats, maintaining family connections, encouragement, and nonengagement. Our analysis illuminates important aspects of aunts in family schema and kin keeping

The Role of Plasma Membrane ATPase Pumps in the Regulation of Rhythmic Activity in Electrically Excitable Cells

Membrane bound ion pumps have long been studied in a housekeeping role, and it is well known that they play a major part in creating the ionic gradients which determine the electrical excitability in a cell. Recent work has begun to highlight other, more direct roles for ion pumps in rhythm generation and information processing. As many pumps obtain energy for active ion transport from adenosine triphosphate (ATP) hydrolysis, they can exchange ions in an electrically asymmetric manner, generating an outward current, which along with ion channel currents, drives the membrane potential of the cell. Membrane potential is a major determining characteristic for how information is transferred between neurons, and so in persistently active excitable cells, pumps can provide a considerable contribution to neuron dynamics. Specialized networks of neurons and non-neural cells which drive rhythmic behaviors such as breathing and locomotion, must robustly produce useful patterns for the animal under dynamic behavioral goals in a highly variable environment. Here we will focus on two well-studied classes of ATPase pumps (the plasma membrane calcium ATPase pump (PMCA) and the sodium-potassium ATPase pump (Na+/K+ pump)) and investigate the role of these pumps in two rhythm generating biological subsystems with a combination of modeling and experimental approaches. In a model of a leech heartbeat central pattern generator, we demonstrate how the neuromodulator myomodulin can regulate the temporal properties of rhythm generation through effects on the hyperpolarization-activated current and the Na+/K+ pump current, and discuss the benefits of modulators which target multiple currents. With this model, we also show how synaptic inhibition can support a functional pattern when pump current is downregulated. Then, in a model of interstitial cells of Cajal (ICC) in the muscular syncytium of the intestinal walls, we demonstrate that due to the importance of complex intracellular calcium oscillations in the generation of ICC rhythms, the PMCA pump can play a major role in regulating the temporal properties of rhythm generation. We discuss rhythm generation mechanisms in both systems and predict parameter domains of multistability which correspond to both functional and pathological states of rhythm generation

The poetic is political….and other notes on engaged scholarship

Instrumental and objectivist logics maintain a hegemonic place in Western scholarship, reasoning skills powerfully equipped to address certain dilemmas even as they may obscure other ways of knowing. In this chapter, we enlarge dominant notions of rationality by offering an aesthetic view of knowledge as vital for engaged communication scholarship. Our interest in aesthetic logics parallels concerns that have led scholars to develop feminist practices of inquiry (e.g., Harding, 1998; Hesse-Biber, 2007), interrogate the aesthetics of representations in West-centric knowledge structures from postcolonial and Subaltern Studies standpoints (e.g., Broadfoot & Munshi, 2007; Dutta, 2007, 2008), focus on autoethnographic and poetic accounts ( e.g., Carr, 2003; Ellingson, 2009), introduce reflexivity and the politics of personhood in the scholarly process ( e.g., Harding, 1991; Reinharz, 1992), and adopt narrative and dialogic understandings of knowledge constructions (e.g., Frank, 2005; Harter, 2005). Loosely coupled, these research trajectories advance alternative rationalities for witnessing and answering salient social issues. We argue for the theoretical and practical incorporation of aesthetic rationalities in engaged scholarship-logics of poss ibility that cultivate individuals \u27 capacities to imagine otherwise. Reimagining scholarly inquiry to reflect and embrace aesthetic logics requires us to rethink our methods of data collection, analysis, and representation and our own roles as researchers and writers . When we resist the art/science dichotomy, opportunities abound for sensemaking and representation that embody aesthetic ways of knowing. Furthermore, rejection of dichotomous thinking opens up possibilities for listening to ways of knowing that lie beyond the realm of Eurocentric knowledge structures (Dutta, in press). Even after the interpretive turn, instrumental and objectivist logics often underlie and sometimes constrain the processes and products of social scientific research (Denzin & Lincoln, 2005). Traditional structures and modes of research offer important but limited conceptualizations of knowing. We can open ourselves to other ways of asking questions that include overt attention to aesthetic sensibilities . We need not reject or abandon traditional modes of research. Instead, we can enlarge the realm of possibilities for what counts as accepted research practices and advance methods for studying the aesthetic nature of communal life (Ellingson, 2009). In this chapter, we develop an understanding of rationality that incorporates imagination, and we explore methodologies that draw on creative sensibilities. We then articul ate the salience of creativity for rendering credible previously subjugated voices, and we articulate its value for engaged communication theory and research

Effect of space environment on man's response to infection A review of literature and annotated bibliography

Review of literature on effects of space environment on human response to infectio

Red Sequence Cluster Finding in the Millennium Simulation

We investigate halo mass selection properties of red-sequence cluster finders using galaxy populations of the Millennium Simulation (MS). A clear red sequence exists for MS galaxies in massive halos at redshifts z < 1, and we use this knowledge to inform a cluster-finding algorithm applied to 500 Mpc/h projections of the simulated volume. At low redshift (z=0.4), we find that 90% of the clusters found have galaxy membership dominated by a single, real-space halo, and that 10% are blended systems for which no single halo contributes a majority of a cluster's membership. At z=1, the fraction of blends increases to 22%, as weaker redshift evolution in observed color extends the comoving length probed by a fixed range of color. Other factors contributing to the increased blending at high-z include broadening of the red sequence and confusion from a larger number of intermediate mass halos hosting bright red galaxies of magnitude similar to those in higher mass halos. Our method produces catalogs of cluster candidates whose halo mass selection function, p(M|\Ngal,z), is characterized by a bimodal log-normal model with a dominant component that reproduces well the real-space distribution, and a redshift-dependent tail that is broader and displaced by a factor ~2 lower in mass. We discuss implications for X-ray properties of optically selected clusters and offer ideas for improving both mock catalogs and cluster-finding in future surveys.Comment: final version to appear in MNRAS. Appendix added on purity and completeness, small shift in red sequence due to correcting an error in finding i

Most of the genetic covariation between major depressive and alcohol use disorders is explained by trait measures of negative emotionality and behavioral control

Background Mental health disorders commonly co-occur, even between conceptually distinct syndromes, such as internalizing and externalizing disorders. The current study investigated whether phenotypic, genetic, and environmental variance in negative emotionality and behavioral control account for the covariation between major depressive disorder (MDD) and alcohol use disorder (AUD). Method A total of 3623 members of a national twin registry were administered structured diagnostic telephone interviews that included assessments of lifetime histories of MDD and AUD, and were mailed self-report personality questionnaires that assessed stress reactivity (SR) and behavioral control (CON). A series of biometric models were fitted to partition the proportion of covariance between MDD and AUD into SR and CON. Results A statistically significant proportion of the correlation between MDD and AUD was due to variance specific to SR (men = 0.31, women = 0.27) and CON (men = 0.20, women = 0.19). Further, genetic factors explained a large proportion of this correlation (0.63), with unique environmental factors explaining the rest. SR explained a significant proportion of the genetic (0.33) and environmental (0.23) overlap between MDD and AUD. In contrast, variance specific to CON accounted for genetic overlap (0.32), but not environmental overlap (0.004). In total, SR and CON accounted for approximately 70% of the genetic and 20% of the environmental covariation between MDD and AUD. Conclusions This is the first study to demonstrate that negative emotionality and behavioral control confer risk for the co-occurrence of MDD and AUD via genetic factors. These findings are consistent with the aims of NIMH's RDoC proposal to elucidate how transdiagnostic risk factors drive psychopathology

Automated Laser Scatter Detection of Near-Surface Defects and Machining Damage in Ceramic Components

The need to achieve higher gas firing temperatures in new stationary gas turbines has led to the requirement for stronger, longer-lasting materials capable of functioning in environments more severe than traditional materials permit. The higher operating temperatures seen in these environments (\u3e1300 °C) would substantially increase energy efficiency and reduce emissions. Because conventional materials are not suitable, alternate materials are being considered for turbine components. Included among these are the Si3N4 ceramics. In an effort to improve and extend the working lifetime of the components, improvement in the detection of critical defects (such as cracks, voids, inclusions, or microstructural variations) in their surface and near-subsurface regions is being investigated. Although all of the defects can occur either during manufacturing or in operation, the specific type of defect most likely to occur in a given component depends on a various factors, including the material system, processing and machining parameters, component geometry, and application environment

A Small Family of Elements with Long Inverted Repeats is Located Near Sites of Developmentally Regulated DNA Rearrangement in \u3cem\u3eTetrahymena thermophila\u3c/em\u3e

Extensive DNA rearrangement occurs during the development of the somatic macronucleus from the germ line micronucleus in ciliated protozoans. The micronuclear junctions and the macronuclear product of a developmentally regulated DNA rearrangement in Tetrahymena thermophila, Tlr1, have been cloned. The intrachromosomal rearrangement joins sequences that are separated by more than 13 kb in the micronucleus with the elimination of moderately repeated micronucleus-specific DNA sequences. There is a long, 825-bp, inverted repeat near the micronuclear junctions. The inverted repeat contains two different 19-bp tandem repeats. The 19-bp repeats are associated with each other and with DNA rearrangements at seven locations in the micronuclear genome. Southern blot analysis is consistent with the occurrence of the 19-bp repeats within pairs of larger repeated sequences. Another family member was isolated. The 19-mers in that clone are also in close proximity to a rearrangement junction. We propose that the 19-mers define a small family of developmentally regulated DNA rearrangements having elements with long inverted repeats near the junction sites. We discuss the possibility that transposable elements evolve by capture of molecular machinery required for essential cellular functions