The structure of the accretion disk in NGC 4258 derived from observations of its water vapor masers

A wealth of new information about the structure of the maser disk in NGC 4258 has been obtained from a series of 18 VLBA observations spanning three years, as well as from 32 additional epochs of spectral monitoring data from 1994 to the present, acquired with the VLA, Effelsberg, and GBT. The warp of the disk has been defined precisely. The thickness of the maser disk has been measured to be 12 microarcseconds (FWHM), which is slightly smaller than previously quoted upper limits. Under the assumption that the masers trace the true vertical distribution of material in the disk, from the condition of hydrostatic equilibrium the sound speed is 1.5 km/s, corresponding to a thermal temperature of 600K. The accelerations of the high velocity maser components have been accurately measured for many features on both the blue and red side of the spectrum. The azimuthal offsets of these masers from the midline (the line through the disk in the plane of the sky) and derived projected offsets from the midline based on the warp model correspond well with the measured offsets. This result suggests that the masers are well described as discrete clumps of masing gas, which accurately trace the Keplerian motion of the disk. However, we have continued to search for evidence of apparent motions caused by ``phase effects.'' This work provides the foundation for refining the estimate of the distance to NGC 4258 through measurements of feature acceleration and proper motion. The refined estimate of this distance is expected to be announced in the near future.Comment: 8 pages, 5 figures, to appear in proceedings of IAU Symposium 242 "Astrophysical Masers and their Environments", held in Alice Springs, March 200

Making a Difference Program: Health and Wellness One Street at a Time

IMPACT. 1: Since its inception, the program has served a total of 787 adults, of which 709 were African American adults. Participants received free health screenings (blood pressure, blood sugar, and stress) and were provided with referrals as needed. -- 2. Collaborations were expanded by adding another academic partner (College of Pharmacy) and another community partner (New Salem Baptist Church). -- 3. Partnership established with East Columbus Elementary School and the Health Sciences Academy to encourage career exploration of the health science professions by children in grades 3 and 4.OSU PARTNERS: College of Nursing; College of Dentistry; College of Optometry; College of Pharmacy; African Studies Community; Extension CenterCOMMUNITY PARTNERS: Making a Difference, Inc.; A Cut above the Rest Barbershop; Eldon and Elsie Ward Family YMCA; New Salem Baptist ChurchPRIMARY CONTACT: Elizabeth Moran Fitzgerald ([email protected])To develop a model for community engagement that will inform student and faculty research/scholarship experiences in the study of health equity; to address the challenges to health and wellness in the underserved Linden Neighborhood by reducing health inequities and health disparities; and by empowering the community to engage in activities that promote health and wellness

BREEDING INDUCED ENDOMETRITIS IN THE MARE: THE LOCAL INNATE IMMUNE RESPONSE

Uterine inflammation after breeding is considered necessary for the clearance of excess semen and debris from the uterus. A subpopulation of mares fails to clear the inflammation in a timely fashion, and develops a persistent breeding induced endometritis (PBIE). Experiments were preformed to evaluate correlations of PBIE to endometrial quality and age. Mares of advanced age and poor endometrial quality had a higher incidence of PBIE. In addition, mares fluctuated in susceptibility to PBIE from one season to the next. The uterine inflammatory gene expression in susceptible and resistant mares within the first 24 hours after breeding was investigated. The peak endometrial cytokine gene expression occurred 6 hours after insemination, and susceptible mares were found to have a reduced response of the inflammatory modulating cytokines during this time. Intrauterine accumulation of the inflammatory byproduct nitric oxide (NO) was investigated in resistant and susceptible mares within the first 24 hours after breeding. Susceptible mares had an increase in NO accumulation over time, whereas NO accumulation in resistant mares remained relatively constant. The effects of immunomodulators on uterine inflammatory response and nitric oxide accumulation in susceptible mares was investigated. Immunomodulators decreased expression of the pro-inflammatory cytokine interleukin-1β and nitric oxide accumulation. In conclusion, endometrial quality and age are indicators of susceptibility to PBIE, and susceptibly can change from year to year. Six hours after breeding is a critical time for the development of PBIE, and susceptible and resistant mares have differential endometrial inflammatory gene expression, with susceptible mares appearing to have a defect in the inflammatory modulating immune response. Finally, treatment with immune modulators alters the IL1β gene expression and intrauterine nitric oxide accumulation, which may help to explain how they act to reduce inflammation during PBIE

Development and Evaluation of a Brief, Bystander Bullying Intervention for Low-Income, Ethnically-Blended Middle Schools

This dissertation includes three individual articles that examine a brief bystander bullying intervention (STAC) culturally adapted for low-income, ethnically-blended middle schools. Chapter One provides a brief introduction to the three articles that comprise this dissertation, the theoretical framework, and the rationale and purpose of this dissertation. Chapter Two includes a mixed-method study examining the development of the culturally adapted intervention. Qualitative data was used to inform the intervention adaptations. Quantitative data provides preliminary support for the cultural validity of the adapted intervention. Chapter Three includes a mixed-method study examining the appropriateness of the culturally adapted intervention. Qualitative data was collected to describe the experiences of the students who participated in the adapted intervention. Quantitative data indicates an increase in knowledge about bullying, confidence to intervene in bullying situations, and use of the STAC strategies to intervene in bullying situations. Chapter Four evaluates the effectiveness of the culturally adapted interventions on reducing bullying victimization. Quantitative data indicates a decrease in bullying victimization and bias-based bullying victimization from baseline to the 6-week follow-up. Chapter Five includes a summary of the three articles

DNA-binding properties of ARID family proteins

The ARID (A–T Rich Interaction Domain) is a helix–turn–helix motif-based DNA-binding domain, conserved in all eukaryotes and diagnostic of a family that includes 15 distinct human proteins with important roles in development, tissue-specific gene expression and proliferation control. The 15 human ARID family proteins can be divided into seven subfamilies based on the degree of sequence identity between individual members. Most ARID family members have not been characterized with respect to their DNA-binding behavior, but it is already apparent that not all ARIDs conform to the pattern of binding AT-rich sequences. To understand better the divergent characteristics of the ARID proteins, we undertook a survey of DNA-binding properties across the entire ARID family. The results indicate that the majority of ARID subfamilies (i.e. five out of seven) bind DNA without obvious sequence preference. DNA-binding affinity also varies somewhat between subfamilies. Site-specific mutagenesis does not support suggestions made from structure analysis that specific amino acids in Loop 2 or Helix 5 are the main determinants of sequence specificity. Most probably, this is determined by multiple interacting differences across the entire ARID structure

Nonshared Environmental Influences on Academic Achievement at Age 16 : A Qualitative Hypothesis-Generating Monozygotic-Twin Differences Study

Twin studies find ~20% of the variance in achievement in public examinations taken at age 16 in the United Kingdom can be explained by experiences not shared within families. Nonshared environmental (NSE) influences, including measurement error, explain why monozygotic (MZ) twins differ from each other. Such influences work independently of genetic effects and may represent strong candidates for intervention. This study aimed to generate hypotheses about what these NSE factors might be. Perceptions of within-pair differences were gathered from n  = 497 pairs of MZ twins and their parents, and telephone interviews were conducted with n  = 56 families reporting different General Certificate of Secondary Education grades. “Environmental” explanations related to teacher quality, teacher–pupil relationships, and ability grouping. Families also explained discordance in terms of effort, interest, ability, and personality

The characterization, management, and future considerations for ErbB-family TKI-associated diarrhea.

PurposeDiarrhea is recognized as a common adverse event associated with tyrosine kinase inhibitors (TKIs), with those targeting the ErbB family of receptors being associated with the highest rate of diarrhea.MethodsThis paper reviews data on the incidence, timing, and duration of diarrhea associated with US Food and Drug Administration-approved ErbB family-targeted TKIs from the published literature, and sets forth recommendations for management.ResultsIn the absence of anti-diarrheal prophylaxis the incidence of any-grade diarrhea varies and typically occurs early during the course of treatment. Although it is difficult to determine if the incidence and severity of diarrhea is related to inhibition of a particular kinase target because of the multi-targeted and overlapping activity of many agents, evidence suggests that second-generation TKIs with broader target profiles (i.e., afatinib, lapatinib, neratinib) result in a higher incidence of diarrhea compared with highly specific first- (erlotinib, gefitinib) or third- (osimertinib) generation agents. The mechanisms responsible for TKI-associated diarrhea are not fully understood and are likely multi-factorial, involving dysregulated ion transport, inflammation, and mucosal injury. Management strategies have been developed-and continue to be refined-to prevent and reduce the severity and duration of TKI-associated diarrhea. For agents associated with more significant symptoms, anti-diarrheal prophylaxis reduces the incidence and severity of diarrhea, and ongoing studies are evaluating specific strategies to further reduce incidence and duration of TKI-associated diarrhea.ConclusionsContinued investigations into risk factors and pharmacogenomic markers for diarrhea may further improve management of this common toxicity

The state of gender diversity in medical physics

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154924/1/mp14035.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154924/2/mp14035_am.pd