6 research outputs found
‘Everyone thought I was a very very bad person… no one want to know you like the nurses and doctors’:using focus groups to elicit the views of adults with learning disability who use challenging behaviour services
and Tables S1–S3. (PDF 3090 kb
An epigenetic clock for gestational age at birth based on blood methylation data
Background: Gestational age is often used as a proxy for developmental maturity by clinicians and researchers alike. DNA methylation has previously been shown to be associated with age and has been used to accurately estimate chronological age in children and adults. In the current study, we examine whether DNA methylation in cord blood can be used to estimate gestational age at birth. Results: We find that gestational age can be accurately estimated from DNA methylation of neonatal cord blood and blood spot samples. We calculate a DNA methylation gestational age using 148 CpG sites selected through elastic net regression in six training datasets. We evaluate predictive accuracy in nine testing datasets and find that the accuracy of the DNA methylation gestational age is consistent with that of gestational age estimates based on established methods, such as ultrasound. We also find that an increased DNA methylation gestational age relative to clinical gestational age is associated with birthweight independent of gestational age, sex, and ancestry. Conclusions: DNA methylation can be used to accurately estimate gestational age at or near birth and may provide additional information relevant to developmental stage. Further studies of this predictor are warranted to determine its utility in clinical settings and for research purposes. When clinical estimates are available this measure may increase accuracy in the testing of hypotheses related to developmental age and other early life circumstances.Peer reviewe
Legislative Documents
Also, variously referred to as: House bills; House documents; House legislative documents; legislative documents; General Court documents
Additional file 2: of An integrated -omics analysis of the epigenetic landscape of gene expression in human blood cells
eCpG-transcript pairs, plus additional information for MESA. (TXT 44022 kb
Additional file 4: of An integrated -omics analysis of the epigenetic landscape of gene expression in human blood cells
UCSC track for eCpGs from MESA. (BED 8181 kb
Additional file 3: of An integrated -omics analysis of the epigenetic landscape of gene expression in human blood cells
UCSC track for eCpGs from GTP. (BED 2584 kb