12 research outputs found
Canagliflozin and renal outcomes in type 2 diabetes and nephropathy
- Author
- A Kaldun Nossuli
- Aamir Jamal
- Adalbert Schiller
- Adam Cheifetz
- Adarsh Daswani
- Adeera Levin
- Adline Ghazi
- Adrian Guinsburg
- Adriana Cif
- Adriana Gabriela Onaca
- Adriana Ilavska
- Adriana Villarino
- Agarwal R.
- Agnieszka Starzec
- Ahmed Arif
- Ahmed Awad
- Aiping Yin
- Akimichi Asano
- Alan Jackson
- Alan McMahon
- Alan Perlman
- Alberto Di Carlo
- Alberto Esquenazi
- Alejandra Oviedo
- Alejandro Valdes Depeda
- Aleksandra Kendereski
- Alex Valenzuela
- Alexander Dreval
- Alexander Gonzalez
- Alexander Shinkov
- Alexander Turchin
- Alexandre Klein
- Alfonso Soto Gonzalez
- Alfred Penfornis
- Alfredo Chew Wong
- Alfredo Wassermann
- Ali Torshizi
- Alicia Chilito
- Alina Agafyina
- Alison Dawson
- Alva Hansraj
- Amer Al-Karadsheh
- Amorin Remus Popa
- Amrendra Kumar
- Amy Sprague
- Ana Limos
- Ana Maria Cusumano
- Ana Maria Elosegui
- Anabella Amigo
- Anatoliy Kazmirchuk
- Andrea Phillips
- Andrea Stella
- Andreas Maddux
- Andrej Dzupina
- Andres Alvarisqueta
- Andrew Johnson
- Andrew O'Shaughnessy
- Andrew Steele
- Andrian Yakov
- Andrzej Januszewicz
- Andrzej Madej
- Angelina Angelova
- Anibal Gastaldi
- Anil Gupta
- Anita Bhajan Manocha
- Anjanette Tan
- Anna Kaminska
- Anna Maria Veronelli
- Anna Strzelecka
- Anna Zateyshchikova
- Anselmo Bordonava
- Antanas Navickas
- Anthony Gunstone
- Anthony Roberts
- Antonio Ceriello
- Antonio Galan Serrano
- Antonio Scafuto Scotton
- Antonio Terrelonge
- Antônio Roberto Chacra
- Anupama Gowda
- Arjun D Sinha
- Armando Perez
- Ashot Mkrtumyan
- Atanas Koundurdjiev
- Augusto Vallejos
- Aurelian-Emil Ranetti
- Ayim Akyea-Djamson
- Aysha Badat
- Bakris G.
- Baldev Singh
- Barbara Greco
- Barbara Kaczmarek
- Barbara Rewerska
- Barry M Brenner
- Belia Martin Del Camp Blanco
- Bernard Zinman
- Bertrand Cariou
- Bertrand Dussol
- Bhasker Mehta
- Bhimavarapu Sudhakar
- Björn Paschen
- Bompoint S.
- Borys Mankovskyy
- Botond Csiky
- Boyan Nonchev
- Brenner B. M.
- Brett Kissela
- Brian Nichol
- Bruce Neal
- Bruce Trippe
- Bruno Geloneze Neto
- Bull S.
- Byung-Wan Lee
- C B Keshavamurthy
- Cannon C. P.
- Capuano G.
- Carlo Giorda
- Carlos Alberto Cuneo
- Carlos Arauz-Pacheco
- Carlos Barrera
- Carlos Perez
- Carmel Hawley
- Carmen Crisan
- Carol Pollock
- Carolyn Droste
- Caroucel Chuateco
- Caryl David
- Cecilia Garcia Ballesteros
- Cecilia Jimeno
- Celso Amodeo
- Cesar Javier Zaidman
- Cesar Yoiti Hayashida
- Chamberlain Obialo
- Chang-Hsun Hsieh
- Charles Cook
- Charles Kaupke
- Charytan D. M.
- Chek Loong Loh
- Chen Leia
- Cheol-Young Park
- Chih-Ching Lin
- Christopher P Cannon
- Christy Yao
- Chu P. -L.
- Chwen-Tzuei Chang
- Chye Lee Gan
- Clara Barrios
- Claude Galphin
- Claudia Goycoa
- Claudia Moreira de Brito
- Clodoaido Caringal
- Cristian Serafinceanu
- Cristina Toarba
- Cristobal Morales Portillo
- Csaba Kovesdy
- Cynthia Bowman-Stroud
- Cynthia Christiano
- Cynthia Mustieles Rocha
- Cyrus Desouza
- Cássio Slompo Ramos
- Dagmar Bartaskova
- Dale Crawford Allison
- Dalia Kozloviene
- Dan Scharfstein
- Dana Cosma
- Daniel Coyne
- Daniel Hiser
- Daniel Kolansky
- Daniel Panarotto
- Daniel Pella
- Daniel Weiner
- Daniil Chizhov
- Dariusz Sowinski
- Darren K McGuire
- Davesh Sennik
- David C Wheeler
- David Cherney 3rd
- David Gorson
- David Johnson
- David M Charytan
- David Packham
- David Scott
- David Wheeler
- De Zeeuw D.
- Debbie Cohen-Stein
- Debbie Mascaro
- Deepak Koppolu
- Dennis Levinson
- Derek Lewis
- Detian Li
- Devasmita Dev
- Devesh Patel
- Dewan Deepak
- Dick de Zeeuw
- Diego Aizenberg
- Dinesh Jain
- Dinesh Khullar
- Diogo Belo
- Dmitry Zateyshshikov
- Domenico Santoro
- Domingos d'Avila
- Donald Brandon
- Donald Fraser
- Dong-Wan Chae
- Dora Inés Molina de Salazar
- Dorota Mlodawska-Choluj
- Doru Negru
- Edgar Arcos
- Edoardo Mannucci
- Eduardo Farias
- Edward Watson
- Edwards R.
- Egle Gaupsiene
- Egle Urbanaviciene
- Ekaterina Velichkova
- Elena Christofides
- Elena Grineva
- Elena Kolmakova
- Elena Shutemova
- Eleonora Harcsa
- Elizabeth Barranco
- Elizabeth Gelersztein
- Elizabeth Kern
- Elizete Keitel
- Eloisa Tellez Chavez
- Emanuela Orsi
- Emil Martinka
- Emyr Davies
- Enrique Gonzalez
- Eric Alamartine
- Eric Hernandez Triana
- Eric Thervet
- Erick Turcios Juarez
- Esteban Cercos
- Eugenia Galindo-Ramos
- Eva Peterfai
- Evaly Chen
- Evandro de Souza Portes
- Evgueniy Vazelov
- Fabian Otreras
- Fabiana Loss de Carvalho Contieri
- Fabio Malberti
- Fadi Saba
- Fadlo Fraige Filho
- Favio Edmundo Enriquez Sosa
- Fayzal Ahmed
- Ferdinando Carlo Sasso
- Fernanco Augusto Alves da Costa
- Fernanda Cristina Camelo Sanches
- Fernando Cereto Castro
- Fernando Flores Lozano
- Fernando Jimenez Florez
- Fernando Krynski
- Fernando M Edwin
- Fernando Thomé
- Fernando Trespalacios
- Florence Santos
- Florencia Kraft
- Fracisco Javier Gonzalez Martinez
- Fran Morren
- Franciso Jose Tinahones Madueno
- Frank Eder
- Franklin Joseph
- Franklin Paul Haase
- Frantisek Saudek
- François Dubé
- François Madore
- Freemu Varghese
- Gabriela Cecilia Coloma
- Gabriela Genova-Hristova
- Gabriele von Ingersleben
- Gaetano Serviddio
- Galina Nagibovich
- Gary Meininger
- Gema Fernandez Fresnedo
- Georg Plassmann
- George Bakris
- George Hon
- George Newman
- Gerald DaRoza
- Gerald Keightley
- Gerry Tan
- Giacomo Garibotto
- Giorgio Fuiano
- Giovanni Frascà
- Giovanni Gambaro
- Giuseppe Derosa
- Gizella Petro
- Glenn Chertow
- Gnyandev Patel
- Godwin Simon
- Goga Vukotic
- Gopal Krishna
- Grace Aquitania
- Grace Lin
- Graham Hillis
- Graziano Di Cianni
- Grazyna Orlowska-Kowalik
- Grazyna Popenda
- Greene T.
- Greg Fulcher
- Gregorio Obrador
- Gregorio Obrador Vera
- Grit Faulmann
- Guadalupe Morales Franco
- Guillermo Fragale
- Guixia Wang
- Gulam Latiff
- Gustavo Cristian Greloni
- Guy Chouinard
- Gyongyi Csecsei
- Gyorgy Paragh
- Halyna Tomashkevych
- Hans Prozesky
- Harpreet Bajaj
- Hasnain Khandwala
- Hector Rodriguez
- Heerspink H. J. L.
- Helena Oosthuizen
- Hendrik Nortje
- Henry Watson
- Hermann Haller
- Hernan Finkelstein
- Hernan Yupanqui
- Hiddo J L Heerspink
- Hiralal Maheshwari
- Hiroko Oishi
- Hiromi Aoki
- Hiromi Rodriguez Pattzi
- Hiroshi Kono
- Hitoshi Akiyama
- Holly Wang
- Hong Mao
- Hong Zhang
- Hongguang Zheng
- Hongli Lin
- Horacio Sessa
- Hugo Colombo
- Hugo Laviada Molina
- Hugo Roberto Kurtz Lisboa
- Humberto Pavon
- Hyuk-Sang Kwon
- Iain MacDougall
- Ian Fraser
- Idalia Acosta
- Ildiko Halmagyi
- In-Kyung Jeong
- Ines Bartolacci
- Ingrid Abrahamsen
- Ingrid Buganova
- Inna Kolesnyk
- Ioana Emilia Ferariu
- Irene Noronha
- Irina Glinkina
- Irina Osipova
- Iryna Dudar
- Isabel Erika Rucker Joerg
- Isabel Garcia
- Isam Marar
- Israel Hartman
- Iuliia Komisarenko
- Ivan Fushtey
- Ivan Ory
- Ivan Rychlik
- Ivan Rychlík
- Ivan Smirnov
- Ivan Topchii
- Ivan Villegas
- Iveta Smatanova
- Jaco Jurgens
- Jakkidi Reddy
- Jamal Hammoud
- James Conway
- James Januzzi
- James Welker
- Jan Culak
- Jana Babikova
- Jana Belobradkova
- Jana Dzuponova
- Janos Mucsi
- Jardine M. J.
- Jason Gaglia
- Javier Narvarte
- Javier Nieto Iglesias
- Jayameena Peringat
- Jayant Kumar
- Jean Carlo Tibes Hachmann
- Jean Welsh
- Jean-Pierre Fauvel
- Jeevren Reddy
- Jeffrey Kropp
- Jeffrey Stephens
- Jeimeen Agra
- Jelena Ignjatovic
- Jesus Cuadrado
- Jesus Egido de Los Rios
- Jian Liu
- Jiao Sun
- Jinkui Yang
- Jiri Lastuvka
- Jiri Pumprla
- Joaquin Pablo Gonzalez
- Johannes Breedt
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- Jose Esteban Jodar Gimeno
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- Jose Hector Sanchez Mijangos
- Jose L Górriz
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- Jose Osvaldo Fretes
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- Joseph Abdallah
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- Joseph Proietto
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- José Vicente Sanchez Polo
- João Lindolfo Cunha Borges
- João Soares Felício
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- Juan Villagordoa Mesa
- JungEun Lee
- Kamal Abouglila
- Karel Peterka
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- Karlton Pettis
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- Katalin Revesz
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- Kathy Nicholls
- Kati De Brouwer
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- Kazunori Koyama
- Kazuyuki Mizuyama
- Kee Sing Ng
- Kenneth Cohen
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- Kenneth W Mahaffey
- Khalid Abdul Kadir
- Khurram Wadud
- Kim Travis
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- Kun Ho Yoon
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- Larry Distiller
- Larysa Pererva
- Laszlo Deak
- Laszlo Konyves
- Laura Akright
- Laura Coffee
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- Lawrence Lehrner
- Lawrence Leiter
- Lech Lazuka
- Lee-Ming Chuang
- Lenka Dohnalova
- Leslie Spry
- Levin A.
- Li Yuan Lee
- Lidia Bermudez
- Ligia Petrica
- Lilia Beatriz Schiavi
- Liliana Monica Angelescu
- Liliia Zub
- Liliya Martynyuk
- Lin Sun
- Lincoln Chapin
- Linong Ji
- Lisa Rich
- Liudmila Kvitkova
- Lori Yost
- Luca Chiovato
- Luca De Nicola
- Luca Zanoli
- Lucas Rista
- Luciane Mônica Deboni
- Lucyna Hotlos
- Ludger Rose
- Luigi Gnudi
- Luis Alberto Ramirez Roca
- Luis Asmarats Mercadal
- Luis David Abraira Munoz
- Luis Enrique Herrera Jimenez
- Luis Fernando Flota Cervera
- Luis Henrique Canani
- Luis Hernando Garcia Ortiz
- Luis Isaias Juncos
- Luis Quesada-Suarez
- Luis Rodolfo Cartasegna
- Luis Valderrama Cometa
- Luis Venegas Carrillo
- Luiz Alberto Andreotti Turatti
- Luiza Despina Demian
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- Ma Dovie Lallaine Ygpuara
- Mahaffey K. W.
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- Masahiro Koizumi
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- Meg Jardine
- Meininger G.
- Melchor Alpizar Salazar
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- Phyllis August
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- Pietro Castellino
- Pilar Trueba
- Ping Tu
- Pollock C.
- Prasanth Surampudi
- Pusadee Suchinda
- Qinkai Chen
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- Raman Purighalla
- Ramesh Chandra Vyasam
- Ramesh Thimmaiah
- Ramon Berenguer
- Ramon Moreda
- Rangel Rangelov
- Rao K Satyanarayana
- Ravendran Govender
- Ravi Sarin
- Reddy Sreedhar
- Reginald Parker
- Rehan Symonds
- Reinhold Jerwan-Keim
- Remi Rabasa-Lhoret
- Renan Montenegro Junior
- Renata Bijata-Bronisz
- Rhea Severina Comia
- Rhonda Bentley-Lewis
- Riad Darwish
- Ricardo Alfonso Leon de la Fuente
- Ricardo Dario Dran
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- Robert Walker
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- Roberto Jorge da Silva Franco
- Roberto Pecoits Filho
- Roberto Pecoits-Filho
- Roberto Simões de Almeida
- Roberto Trevisan
- Rodica-Ioana Avram
- Rodolfo Andres Ahuad Guerrero
- Rohana Abdul Ghani
- Rohit Pankhaniya
- Rolando Zamarripa Escobedo
- Ronald Goldenberg
- Ronald Harris
- Ronald Watts
- Ronaldo Arturo Gonzalez Orellana
- Ronan Roussel
- Ronnie Aronson
- Rosa Isela Luna Ceballos
- Rosângela Milagres
- Ruben Dario Vargas Alonso
- Rury Holman
- Russell Scott
- Sacha De Serres
- Sahay Manisha
- Saiful Shahrizal Bin Shudim
- Sailaja Ventrapragada
- Salah Abusnana
- Salvatore De Cosmo
- Sam Henein
- Sam Philip
- Samuel Cohen
- Samuel Mujica Trenche
- Samy Hadjadj
- Sandor Keresztesi
- Sandor Vangel
- Sandra Berenice Saaveddra Sanchez
- Sanjeev Rastogi
- Sara Jaffer
- Sarah Olelewe
- Satoshi Ota
- Satu Pesickova
- Scott Kasner
- Secundino Cigarran Guldris
- Senan Sultan
- Serge Cournoyer
- Sergei Nedogoda
- Sergey Vorobyev
- Sergio Saul Irizar Santana
- Shahabul Arfeen
- Shahnaz Shahinfar
- Shang-Jyh Hwang
- Shelley Williams
- Shenaz Ramtoola
- Shenglian Gan
- Sherry Sussman
- Shizuo Kajiyama
- Shozo Miyauchi
- Silvia Ines Orio
- Silvia Nicolai
- Simon Davies
- Simon Roger
- Simon Young
- Sin Gon Kim
- Singhan Krishnan
- Sini George
- Slobodan Antic
- Sohan Dua
- Sonia Hermida
- Soo Kun Lim
- Sophie Borot
- Souhila Ounadjela
- Sreedhar Mandayam
- Srikanth Bellary
- Stanislav Zemek
- Stanislaw Mazur
- Stefan Dimitrov
- Stephan Maxeiner
- Stephen Grubb
- Stephen Smith
- Steven Fishbane
- Stuart Handelsman
- Suely Keiko Kohara
- Sun Kim
- Sun-Hee Park
- Sunil Sheth
- Susumu Kashine
- Svetlana Goykhman
- Svitlana D Bilyk
- Swee Win Lam
- Sylvia Rosas
- Sylvia Shaw
- Szilard Vasas
- Sérgio Alberto Cunha Vêncio
- Sérgio Yamada
- Tadashi Iitsuka
- Takamoto Kodera
- Takashi Wada
- Takayuki Watanabe
- Tamara Malek Marin
- Tamas Oroszlan
- Tara Chang
- Tareq Nassar
- Tarissa Beatrice Zanata Petry
- Tatiana Koroleva
- Tatiana Morugova
- Tatiana Raskina
- Tatyana Zykova
- Te-Lin Hsia
- Terue Sakakibara
- Tetiana Zlova
- Tetsuji Niiya
- Tetyana Pertseva
- Tiago Schuch
- Timothy Hall
- Tom Christensen
- Tom Greene
- Tomas Drasnar
- Tomas Smith Casabella
- Tonatiu Diaz Escalante
- Toshihiko Yanase
- Toshio Kawada
- Vadym Vizir
- Vanassa Ratnasingam
- Venessa Tsang
- Venkata Behara
- Vera Klokocnikova
- Vera Krane
- Veronica Anghel
- Veselka Genadieva
- Vesna Popovic-Radinovic
- Viacheslav Marasaev
- Victor Commendatore
- Victor Saavedra Gajardo
- Vijayaraman Arutchelvam
- Viktor Margaritov
- Viktor Zaviriukha
- Viktoria Andreeva
- Vimladhevi Govender
- Vincent Pichette
- Vincent Woo
- Vira Tseluyko
- Virginia Esther Visco
- Vivek Sood
- Vivekan Jha
- Vladimir Dobronravov
- Vladimir Khirmanov
- Vladimir Tesar
- Vlado Perkovic
- Volker Burst
- Volodymyr Botsyurko
- Walter Guillermo Douthat
- Walter Pharr
- Wasim Hanif
- Wataru Yumita
- Wayne H-H Sheu
- Wayne Turner
- Wei Yen Kong
- Weihong Song
- Weiping Lu
- Wendy Lane
- Wenge Li
- Wheeler D. C.
- Wladmir Saporito
- Xuemei Li
- Xueqing Yu
- Yamil Canaan
- Yan Ren
- Yannick Le Meur
- Yaozhong Kong
- Yasuro Kumeda
- Yasushi Wakida
- Yavin Y.
- Yeong Hoon Kim
- Yevgeniya Svyshchenko
- Young Min Cho
- Yulia Samoylova
- Yung-Chuan Lu
- Yuriy Mostovoy
- Yuriy Shwartz
- Yvette Ethel Yap
- Zaynab Abejuela
- Zdravko Kamenov
- Zeid Khitan
- Zhang H.
- Zinman B.
- Zishan Ali
- Zuzana Ochodnicka
- Ângela Regina Nazario Sabbag
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years
Long-term Safety and Immunogenicity of a Tetravalent Dengue Vaccine Candidate in Children and Adults: A Randomized, Placebo-Controlled, Phase 2 Study
- Author
- Astrid Borkowski
- Athanasia Papadimitriou
- Bhatt
- Biswal
- Biswal
- Brady
- Centers for Disease Control and Prevention
- Chukiat Sirivichayakul
- Derek Wallace
- Elizabeth A Barranco-Santana
- George
- Guzman
- Guzman
- Guzmán
- Huang
- Huang
- Inés Esquilín Rivera
- Jennifer Kilbury
- Marsha Raanan
- Osorio
- Osorio
- Rupp
- Saez-Llorens
- Schaefer
- Sirivichayakul
- Sáez-Llorens
- Thai
- World Health Organization.
- World Health Organization.
- World Health Organization.
- Yoksan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- Field of study
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Risk of COVID-19 after natural infection or vaccinationResearch in context
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- Abad Vanessa
- Abate Getahun
- Abbas Anum
- Ackerman Jamie
- Ackerman Ronald
- Ackermann Jeremy
- Adams Atoya
- Adams Mark S.
- Adams Michael R.
- Adelglass Jeffrey
- Afework Sarah
- Ahmad Nina
- Akamine Christine
- Ake Julie A.
- Al-Ibrahim Mohamed S.
- Albert Gary
- Alcaide Maria L.
- Alderson Nathan
- Aleman Lily
- Alemán José O.
- Allaw Mohammed
- Alva E. Javier Pretell
- Alvarado Hilario
- Amador Carmen
- Andersen James
- Anderson Corey G.
- Anderson Evan J.
- Anderson Victoria R.
- Andes David R.
- Andrasik Michele P.
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- Skipper Stephanie
- Slechta Stacy
- Sligh Teresa S.
- Smith Candace
- Smith Derek M.
- Smith Katherine
- Smith Mary
- Smith Michael J.
- Smith William B.
- Snell Kimberly
- Sobhanie M. Mahdee
- Sobieszczyk Magdalena E.
- Sogbetun Obiageli
- Solis Joel
- Sonnier Cora
- Sopher Carrie
- Sovic Brit
- Spector Stephen A.
- Sperber Steven
- Staben Jonathan
- Stahl Jessica
- Stanford Amber
- Stangl Lisa
- Stanton Ariana C.
- Stapleton Jack
- Stapleton Katherine
- Starlin Richard
- Starr Amy
- Starr Ryan P.
- Steil Kenneth
- Stephenson Carolene
- Stephenson Kathryn E.
- Sterling Stephanie
- Stewart Brittany
- Striker Robert
- Strout Cynthia Becher
- Struyf Frank
- Studdard Suzanna
- Stulken Laura
- Stull Mildred
- Sturgeon Rodney E.
- Suen May-Yin
- Sugimoto Danny
- Suyehira Janice
- Swaminathan Shobha
- Swan Suzanne
- Swann Edith
- Swanson Austin
- Sweet Christy
- Swieboda Elisa
- Syndergaard Scott N.
- Takizala Zudi-Mwak
- Takuva Simbarashe G.
- Talaat Kawsar R.
- Tan Chen S.
- Tapia Milagritos
- Tarakjian Denis
- Tashima Karen
- Tatelbaum David
- Taylor Barbara S.
- Taylor Brandie
- Tedder-Edwards Sharita
- Teherani Meghan
- Theodore Deborah A.
- Thessing Jeffrey
- Thomas Meagan
- Thomas-Seaton LaTeshia
- Thompson Amy
- Thompson Karl M.
- Thompson-Seim Teri
- Thomsen Isaac
- Tieu Hong V.
- Toma Ramy J.
- Tomaszewski Christian
- Tomatsu Lee
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- Tong Tina
- Tong Xiaomi
- Torres Juan P.
- Torres Julian A.
- Tovar Dalia
- Tran Carolyn
- Treanor John J.
- Tukuru Sade
- Turley Christine B.
- Turner Mark A.
- Tyson Stefanie
- Ulrich Robert J.
- Usdan Lisa S.
- Utz Gregory C.
- Vachris Timothy P.
- Valenti Bruno
- Valika Insiya
- Van Der Leden Mimi
- Van Dromme Ilse
- Van Ever Wesley
- Van Roey Griet
- Varughese Tilly
- Vega Jocelyn Zuleica Olmos
- Vega Norma
- Vegas Diana
- Vertucci Michele
- Viar Veronica
- Viens Nicholas A.
- Villegas Marysol
- Vingerhoets Johan
- Vogler Mary
- Vowell Mandy
- Vrbicky Keith W.
- Wahlin Tami
- Wakefield Paul H.
- Wald Anna
- Walker James
- Walker Shannon
- Walsh Edward E.
- Walsh Mary C.
- Walsh Stephen R.
- Walsh Stephen R.
- Walter Emmanuel B.
- Walters Ayanna
- Wang Tina
- Warden Ashley
- Waters Michael
- Watkins Breanz
- Webb Angella
- Webster Hala
- Weidler Jessica L.
- Weiss Thomas
- Wells Margaret
- Wendell Lewis III
- Wendrow Andrea
- Werne Melody
- West Whitney
- Whatley Jordan L.
- Whitaker Jennifer A.
- White Jewel J.
- White Julie
- White Toni
- Wijewardane Priyantha N.
- Wilkin Timothy
- Wilkinson Bethanie
- William S. Davis Jr
- Williams Barton G.
- Williams Hayes
- Williams Samantha
- Wilson Christine
- Wilson Clint
- Wilson Greg
- Wilson Natasha
- Winbigler Jennifer
- Winkle Peter J.
- Winokur Patricia L.
- Witbeck John
- Wohl David
- Woo Wayne
- Woodside Leana
- Wortman Glenn
- Wu Yi H.
- Wylie Paul E.
- Yang Fan
- Yang Kinara S.
- Yoon Anelgine C.
- York Jill
- Young Cheryl
- Yu Chenchen
- Yusin Joseph
- Zapata Luz
- Zash Rebecca
- Zegarra Eneyda Giuvanela Llerena
- Zemanek Arthur L.
- Zenlea Kate
- Zepeda Karla
- Zervos Marcus J.
- Zhai Nan
- Zhang Kevin
- Zhou James
- Zimmer Andrea
- Zingman Barry S.
- Zorrilla Carmen D.
- Áñez Germán
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/10/2023
- Field of study
Background: While vaccines have established utility against COVID-19, phase 3 efficacy studies have generally not comprehensively evaluated protection provided by previous infection or hybrid immunity (previous infection plus vaccination). Individual patient data from US government-supported harmonized vaccine trials provide an unprecedented sample population to address this issue. We characterized the protective efficacy of previous SARS-CoV-2 infection and hybrid immunity against COVID-19 early in the pandemic over three-to six-month follow-up and compared with vaccine-associated protection. Methods: In this post-hoc cross-protocol analysis of the Moderna, AstraZeneca, Janssen, and Novavax COVID-19 vaccine clinical trials, we allocated participants into four groups based on previous-infection status at enrolment and treatment: no previous infection/placebo; previous infection/placebo; no previous infection/vaccine; and previous infection/vaccine. The main outcome was RT-PCR-confirmed COVID-19 >7–15 days (per original protocols) after final study injection. We calculated crude and adjusted efficacy measures. Findings: Previous infection/placebo participants had a 92% decreased risk of future COVID-19 compared to no previous infection/placebo participants (overall hazard ratio [HR] ratio: 0.08; 95% CI: 0.05–0.13). Among single-dose Janssen participants, hybrid immunity conferred greater protection than vaccine alone (HR: 0.03; 95% CI: 0.01–0.10). Too few infections were observed to draw statistical inferences comparing hybrid immunity to vaccine alone for other trials. Vaccination, previous infection, and hybrid immunity all provided near-complete protection against severe disease. Interpretation: Previous infection, any hybrid immunity, and two-dose vaccination all provided substantial protection against symptomatic and severe COVID-19 through the early Delta period. Thus, as a surrogate for natural infection, vaccination remains the safest approach to protection. Funding: National Institutes of Health
Risk of COVID-19 after natural infection or vaccinationResearch in context
- Author
- A. Lina Rosengren
- Abram Burgher
- Adam B. Brosz
- Adam Rosen
- Adam Schwartz
- Adriana Sordo Duran
- Adrienna Marquez
- Adrienne E. Shapiro
- Aeiress Duhart
- Afsoon Roberts
- Albert Liu
- Alejandro Hoberman
- Alejandro Quintín Barrat Hernández
- Alex Greninger
- Alexander Clark
- Alfredo Gilberto Guerreros Benavides
- Alice McGarry
- Alicia Arrazcaeta
- Alisha Lutat
- Alison Bondell
- Alison Pellecchia
- Allie Oplinger
- Allison Green
- Allison O'Brien
- Alpa Patel
- Alyssa-Kay Peay
- Amanda Horn
- Amanda Lilienthal
- Amanda Occhino
- Amanda Philyaw
- Amaran Moodley
- Amber Grant
- Amber Stanford
- Amesika Nyaku
- Amie Shannon
- Amina Z. Haggag
- Amit Paliwal
- Amy Caldwell
- Amy Chamberlain
- Amy Dye
- Amy Falk
- Amy Kelley
- Amy Medina
- Amy Potts
- Amy Salzl
- Amy Sherman
- Amy Starr
- Amy Thompson
- Andrea Berry
- Andrea Clement
- Andrea Wendrow
- Andrea Zimmer
- Andres Bran
- Andres Camacho-Gonzalez
- Andrew Lauria
- Andrew McConnell
- Andrew McWilliams
- Anelgine C. Yoon
- Angela Lee
- Angela R. Branche
- Angelica Kottkamp
- Angella Webb
- Ann M. Milliken
- Ann R. Falsey
- Anna S. Lok
- Anna Wald
- Anne Marit de Groot
- Anne-Marie Rick
- Annette R. Bennett
- Annie Ciambruschini
- Annie Luetkemeyer
- Anthony Kim
- Anum Abbas
- Anyela Lara
- April Pixler
- Ariana C. Stanton
- Arthur L. Zemanek
- Asha Inniss
- Ashley Kennedy
- Ashley Perez
- Ashley Warden
- Asif Noor
- Atoya Adams
- Aurelio Cruz-Valdez
- Austin Chan
- Austin Swanson
- Ayanna Walters
- Ayoade Avworo
- Bailey Jordan
- Barbara Corral
- Barbara Rizzardi
- Barbara Rizzardi
- Barbara S. Taylor
- Barry S. Zingman
- Barton G. Williams
- Beatriz Grinsztejn
- Becky Martinez
- Ben Ladner
- Benjamin Eckhardt
- Benjamin J. Luft
- Bernard Grunstra
- Beth Safirstein
- Bethanie Wilkinson
- Beverly E. Sha
- Beverly Ewing
- Bindu Balani
- Blanca Gomez
- Bo Shopsin
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- Brandy Ball
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- Brittany Stewart
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- Bruce G. Rankin
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- C. Mary Healy
- Caitlin J. Guiney
- Caitlin Moran
- Candace Smith
- Candice Montros
- Carina A. Rodriguez
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- Carl P. Griffin
- Carlos A. Fierro
- Carlos del Rio
- Carlos Lopez
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- Carrie Sopher
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- Catherine Mary Healy
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- Chelsea Miles
- Chelsie Nutsch
- Chelsie Nutsch
- Chen S. Tan
- Chenchen Yu
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- Christian Tomaszewski
- Christina A. Rostad
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- Robert W. Frenck Jr.
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- Sharon Nachman
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- Stephan Hong
- Stephanie Andree
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- Stephanie Sterling
- Stephen A. Spector
- Stephen Daniels
- Stephen Morris
- Stephen R. Walsh
- Stephen R. Walsh
- Steve Clemons
- Steven E. Carsons
- Steven Palmer
- Steven Shinn
- Steven Shoptaw
- Steven Sperber
- Stuart H. Cohen
- Surisday Mederos
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- Susan Kline
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- Susan Parker
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- Taylor Nelson
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- Teresa Becker
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- Tiffany Schwasinger-Schmidt
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- Timothy W. Schacker
- Timothy Wilkin
- Tina Tong
- Tina Wang
- Toby Briskin
- Todd Simmons
- Tom Fiel
- Toni Robinson
- Toni White
- Tracy Okonya
- Tracy R. Klein
- Trina L. Reynolds
- Troy Holdeman
- Tyler D. Bold
- Uriel R. Felsen
- Valentine M. Ebuh
- Valeria D. Cantos
- Valerie K. Arnold
- Vanessa Abad
- Vanessa Raabe
- Veronica G. Fragoso
- Veronica Garcia-Fragoso
- Veronica Procasky
- Veronica Viar
- Vicki E. Miller
- Vickie Leathers
- Victoria Andriulis
- Victoria Engler
- Victoria Mosteller
- Victoria R. Anderson
- Vida Veronica Ruiz Herrera
- Vincent Huynh
- Vincent Mirkil
- Vivek Rajasekhar
- Viviana Gonzalez
- Vladimir Berthaud
- Walter Patton
- Wanda Ramon
- Waseem Chughtai
- Wayne L. Harper
- Wayne Woo
- Wendell Lewis
- Wendell Lewis III
- Wendy A. Keitel
- Wesley Campbell
- Wesley Van Ever
- Westly Keating
- Whitney West
- Will Hernandez
- William B. Davis
- William B. Smith
- William H. Jones
- William Jennings
- William Kirby
- William P. Silver
- William R. Hartman
- William S. Davis Jr.
- William Schnitz
- William Seger
- Winniberg Stephany Alvarez León
- Winston Cavert
- Xiaomi Tong
- Yaa D. Oppong
- Yi H. Wu
- Ying Huang
- Yogesh K. Paliwal
- Youyi Fong
- Yunda Huang
- Yunda Huang
- Yvonne Davis
- Zachary Bittner
- Zainab Rizvi
- Zindy Yazmín Zárate Hinojosa
- Zudi-Mwak Takizala
- Publication venue
- Elsevier
- Publication date
- 01/10/2023
- Field of study
Summary: Background: While vaccines have established utility against COVID-19, phase 3 efficacy studies have generally not comprehensively evaluated protection provided by previous infection or hybrid immunity (previous infection plus vaccination). Individual patient data from US government-supported harmonized vaccine trials provide an unprecedented sample population to address this issue. We characterized the protective efficacy of previous SARS-CoV-2 infection and hybrid immunity against COVID-19 early in the pandemic over three-to six-month follow-up and compared with vaccine-associated protection. Methods: In this post-hoc cross-protocol analysis of the Moderna, AstraZeneca, Janssen, and Novavax COVID-19 vaccine clinical trials, we allocated participants into four groups based on previous-infection status at enrolment and treatment: no previous infection/placebo; previous infection/placebo; no previous infection/vaccine; and previous infection/vaccine. The main outcome was RT-PCR-confirmed COVID-19 >7–15 days (per original protocols) after final study injection. We calculated crude and adjusted efficacy measures. Findings: Previous infection/placebo participants had a 92% decreased risk of future COVID-19 compared to no previous infection/placebo participants (overall hazard ratio [HR] ratio: 0.08; 95% CI: 0.05–0.13). Among single-dose Janssen participants, hybrid immunity conferred greater protection than vaccine alone (HR: 0.03; 95% CI: 0.01–0.10). Too few infections were observed to draw statistical inferences comparing hybrid immunity to vaccine alone for other trials. Vaccination, previous infection, and hybrid immunity all provided near-complete protection against severe disease. Interpretation: Previous infection, any hybrid immunity, and two-dose vaccination all provided substantial protection against symptomatic and severe COVID-19 through the early Delta period. Thus, as a surrogate for natural infection, vaccination remains the safest approach to protection. Funding: National Institutes of Health
Effect of SGLT2 Inhibitors on Stroke and Atrial Fibrillation in Diabetic Kidney Disease: Results From the CREDENCE Trial and Meta-Analysis
- Author
- (Jay) Kropp Jeffrey
- Abdul Kadir Khalid
- Abdullah Raied
- Abraham Oomman India:
- Abramowitz Matthew
- Acosta Idalia
- Africa: Fayzal Ahmed South
- Agra Jeimeen
- Aiello Joseph
- Ainsworth Paul
- Aizenberg Diego
- Akright Laura
- Akyea-Djamson Ayim
- Al-Karadsheh Amer
- Alappan Rajendran
- Alberto Andreotti Turatti Luiz
- Alberto Berli Mario
- Alberto Cuneo Carlos
- Alberto Cunha V\ueancio S\ue9rgio
- Alberto Ramirez Roca Luis
- Alexandra Terront Lozano Monica
- Alfonso Leon de la Fuente Ricardo
- Ali Norsiah
- Ali Zishan
- Alicic Radica
- Alina Agafyina Russia:
- Alpizar Salazar Melchor
- Alva Hansraj
- Alvarisqueta Andres
- Amodeo Celso
- Andres Ahuad Guerrero Rodolfo
- Angel Reyes Rosano Miguel
- Angelova Angelina
- Anghel Veronica
- Angustias Quesada Sim\uf3n Mar\ueda
- Ant\uf4nio Pereira M\ue1rcio
- Antonia Munar Vila Maria
- Antonio Novoa Pablo
- Antonio S\ue1nchez Arenales Jose
- Aoki Hiromi
- Aquitania Grace
- Arauz-Pacheco Carlos
- Archibaldo Glenny Jorge
- Arcos Edgar
- Arfeen Shahabul
- Arif Ahmed
- Aronson Ronnie
- Arutchelvam Vijayaraman
- Arvind Moogali
- Asano Akimichi
- Asmarats Mercadal Luis
- Atray Naveen
- Augusto Alves da Costa Fernando
- Avendano Jorge
- Avram Rodica-Ioana
- Awad Ahmed
- Baas Cruz Juan
- Badat Aysha
- Bajaj Harpreet
- Bakris George
- Barbarash Olga
- Barnard Maria
- Barnhill Peggy
- Barranco Elizabeth
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- Barrios Clara
- Bartolacci Ines
- Barton Petr
- Barysheva Olga
- Beacom Matthew
- Beatrice Zanata Petry Tarissa
- Beatriz Schiavi Lilia
- Behara Venkata
- Bellary Srikanth
- Belo Diogo
- Belobradkova Jana
- Bentley-Lewis Rhonda
- Benusova Olga
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- Carlo Tibes Hachmann Jean
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- Cecilia Coloma Gabriela
- Cercos Esteban
- Cereto Castro Fernando
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- Chen Qinkai
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- Chew Wong Alfredo
- Chilito Alicia
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- Chizhov Daniil
- Chouinard Guy
- Christensen Tom
- Christiano Cynthia
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- Chuang Lee-Ming
- Chuateco Caroucel
- Chwen-Tzuei Chang Taiwan:
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- Hermida Sonia
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- Hitoshi Akiyama Japan:
- Ho Yoon Kun
- Hon George
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- Horacio Garcia Nestor
- Hotlos Lucyna
- Hristozov Kiril
- Hsia Te-Lin
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- Jerwan-Keim Reinhold
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- Jimeno Cecilia
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- Santoro Domenico
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- Saporito Wladmir
- Sarin Ravi
- Satyanarayana Rao K.
- Saudek Frantisek
- Saul Irizar Santana Sergio
- Saulnier Pierre-Jean
- Saxena Manish
- Sazonova Olga
- Scafuto Scotton Antonio
- Schreiman Robert
- Schuch Tiago
- Scott David
- Scott Russell
- Seeber Mary
- Sekkarie Mohamed
- Sennik Davesh
- Sensenbrenner John
- Serafinceanu Cristian
- Serrano Sanson Pablo
- Serviddio Gaetano
- Sessa Horacio
- Severina Comia Rhea
- Shahrizal Bin Shudim Saiful
- Shakeel Muhammad
- Shamkhalova Minara
- Shanik Michael
- Shaw Sylvia
- Shinkov Alexander
- Shutemova Elena
- Shwartz Yuriy
- Sim\uf5es de Almeida Roberto
- Simo Canonge Rafael
- Simon Godwin
- Sing Ng Kee
- Singh Baldev
- Slobodan Antic Serbia:
- Slompo Ramos C\ue1ssio
- Smatanova Iveta
- Smirnov Ivan
- Smith Casabella Tomas
- Smith Stephen
- Soares Fel\uedcio Jo\ue3o
- Solomon Richard
- Song Weihong
- Soto Gonzalez Alfonso
- Sowinski Dariusz
- Sprague Amy
- Spry Leslie
- States: Joseph Abdallah United
- Steele Andrew
- Stella Andrea
- Stephens Jeffrey
- Strzelecka Anna
- Suchinda Pusadee
- Sudhakar Bhimavarapu
- Sultan Senan
- Sun Jiao
- Sun Lin
- Surampudi Prasanth
- Sussman Sherry
- Svyshchenko Yevgeniya
- Symonds Rehan
- Takacs Robert
- Takai Masahiko
- Tan Anjanette
- Tan Gerry
- Tangri Navdeep
- Tarsicio Moreno Loza Oscar
- Tellez Chavez Eloisa
- Temelkova Margarita
- Teresa Zanella Maria
- Terns Riera Manel
- Terrelonge Antonio
- Tesar Vladimir
- Thervet Eric
- Thom\ue9 Fernando
- Thompson Michael
- Toarba Cristina
- Tolentino Marsha
- Tomashkevych Halyna
- Tomonaga Osamu
- Topchii Ivan
- Torshizi Ali
- Trespalacios Fernando
- Trevisan Roberto
- Trippe Bruce
- Trueba Pilar
- Tryshchuk Nadiya
- Tsang Venessa
- Tseluyko Vira
- Tsujimoto Mitsuru
- Tu Ping
- Turcios Juarez Erick
- Turner Wayne
- Twahirwa Marcel
- Updegrove John
- Urbanaviciene Egle
- Uriasyev Oleg
- Valderrama Cometa Luis
- Valdes Cepeda Alejandro
- Valdez Maria
- Valenzuela Alex
- Valis Martin
- Vallejos Augusto
- Van Buren Peter
- Vangel Sandor
- Vannorsdall Mark
- Varghese Freemu
- Vasas Szilard
- Vejar Margarita
- Velasquez-Mieyer Pedro
- Velichkova Ekaterina
- Velo Plaza Mercedes
- Venegas Carrillo Luis
- Vengadasalam Paranthaman
- Ventrapragada Sailaja
- Vicente Sanchez Polo Jos\ue9
- Viktoria Andreeva Bulgaria:
- Villagordoa Mesa Juan
- Villarino Adriana
- Villegas Ivan
- Virginia Lanchiotti Paulina
- Vizir Vadym
- Vlasenko Maryna
- Volker Burst Germany:
- Vorobyev Sergey
- Vukotic Goga
- Wada Takashi
- Wadud Khurram
- Wahba Mona
- Wakasugi Masakiyo
- Wakeling John
- Wakida Yasushi
- Walker Robert
- Wang Guixia
- Warren Mark
- Wassermann Alfredo
- Watanabe Takayuki
- Watson Edward
- Watson Henry
- Watts Ronald
- Weiner Daniel
- Weiner Pavel
- Welker James
- Welsh Jean
- Wheeler David
- Williams Michael
- Williams Shelley
- Win Lam Swee
- Winocour Peter
- Woo Vincent
- y Orozco Juan Alfredo Tamayo
- Yakov Andrian
- Yamada Masayo
- Yamada S\ue9rgio
- Yanagida Kazuhiro
- Yanase Toshihiko
- Yang Jinkui
- Yao Christy
- Yen Kong Wei
- Yin Aiping
- Yoiti Hayashida Cesar
- Young Simon
- Yu Xueqing
- Yuan Lee Li
- Yumita Wataru
- Yupanqui Hernan
- Zalunardo Nadia
- Zamarripa Escobedo Rolando
- Zaniewski-Singh Michelle
- Zanoli Luca
- Zaoui Philippe
- Zateyshchikova Anna
- Zateyshshikov Dmitry
- Zaynab Abejuela Philippines:
- Zealand: John Baker New
- Zemek Stanislav
- Zhao Minghui
- Zheng Hongguang
- Zlova Tetiana
- Zsom Marianna
- Zub Liliia
- Zykova Tatyana
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2021
- Field of study
BACKGROUND AND PURPOSE: Chronic kidney disease with reduced estimated glomerular filtration rate or elevated albuminuria increases risk for ischemic and hemorrhagic stroke. This study assessed the effects of sodium glucose cotransporter 2 inhibitors (SGLT2i) on stroke and atrial fibrillation/flutter (AF/AFL) from CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation) and a meta-analysis of large cardiovascular outcome trials (CVOTs) of SGLT2i in type 2 diabetes mellitus.METHODS: CREDENCE randomized 4401 participants with type 2 diabetes mellitus and chronic kidney disease to canagliflozin or placebo. Post hoc, we estimated effects on fatal or nonfatal stroke, stroke subtypes, and intermediate markers of stroke risk including AF/AFL. Stroke and AF/AFL data from 3 other completed large CVOTs and CREDENCE were pooled using random-effects meta-analysis.RESULTS: In CREDENCE, 142 participants experienced a stroke during follow-up (10.9/1000 patient-years with canagliflozin, 14.2/1000 patient-years with placebo; hazard ratio [HR], 0.77 [95% CI, 0.55-1.08]). Effects by stroke subtypes were: ischemic (HR, 0.88 [95% CI, 0.61-1.28]; n=111), hemorrhagic (HR, 0.50 [95% CI, 0.19-1.32]; n=18), and undetermined (HR, 0.54 [95% CI, 0.20-1.46]; n=17). There was no clear effect on AF/AFL (HR, 0.76 [95% CI, 0.53-1.10]; n=115). The overall effects in the 4 CVOTs combined were: total stroke (HRpooled, 0.96 [95% CI, 0.82-1.12]), ischemic stroke (HRpooled, 1.01 [95% CI, 0.89-1.14]), hemorrhagic stroke (HRpooled, 0.50 [95% CI, 0.30-0.83]), undetermined stroke (HRpooled, 0.86 [95% CI, 0.49-1.51]), and AF/AFL (HRpooled, 0.81 [95% CI, 0.71-0.93]). There was evidence that SGLT2i effects on total stroke varied by baseline estimated glomerular filtration rate (P=0.01), with protection in the lowest estimated glomerular filtration rate (<45 mL/min/1.73 m2]) subgroup (HRpooled, 0.50 [95% CI, 0.31-0.79]).CONCLUSIONS: Although we found no clear effect of SGLT2i on total stroke in CREDENCE or across trials combined, there was some evidence of benefit in preventing hemorrhagic stroke and AF/AFL, as well as total stroke for those with lowest estimated glomerular filtration rate. Future research should focus on confirming these data and exploring potential mechanisms. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02065791
Kidney and Cardiovascular Effects of Canagliflozin According to Age and Sex: A Post Hoc Analysis of the CREDENCE Randomized Clinical Trial
- Author
- Abdallah Joseph
- Abdul Ghani Rohana
- Abdullah Raied
- Abejuela Zaynab
- Abouglila Kamal
- Abraham Oomman
- Abraira Munoz Luis David
- Abramowitz Matthew
- Abusnana Salah
- Acosta Idalia
- Agafyina Alina
- Agarwal Rajiv
- Agarwal Rajiv
- Aggarwal Naresh
- Agra Jeimeen
- Ahmad Nik Nur Fatnoon Nik
- Ahmed Fayzal
- Aiello Joseph
- Ainsworth Paul
- Aizenberg Diego
- Aizenberg Diego
- Akiyama Hitoshi
- Akright Laura
- Akyea-Djamson Ayim
- Al-Karadsheh Amer
- Alamartine Eric
- Alappan Rajendran
- Albisu Juan Pablo
- Alexandra Terront Lozano Monica
- Ali Norsiah
- Ali Zishan
- Alicic Radica
- Allison Dale Crawford
- Alvarisqueta Andres
- Amodeo Celso
- Andreeva Viktoria
- Angelescu Liliana Monica
- Angelova Angelina
- Anghel Veronica
- Antic Slobodan
- Aoki Hiromi
- Aquitania Grace
- Arauz-Pacheco Carlos
- Arcos Edgar
- Arfeen Shahabul
- Arif Ahmed
- Arnott Clare
- Aronson Ronnie
- Arutchelvam Vijayaraman
- Arvind Moogali
- Asano Akimichi
- Atray Naveen
- Avendano Jorge
- Avram Rodica-Ioana
- Awad Ahmed
- Babikova Jana
- Badat Aysha
- Bajaj Harpreet
- Baker John
- Bakris George
- Bakris George
- Bakris George
- Ballesteros Cecilia Garcia
- Barbarash Olga
- Barna Olga
- Barnard Maria
- Barnhill Peggy
- Baron Paul Frenk
- Barranco Elizabeth
- Barrera Carlos
- Barrios Clara
- Bartaskova Dagmar
- Bartolacci Ines
- Barton Petr
- Barysheva Olga
- Beacom Matthew
- Behara Venkata
- Bellary Srikanth
- Belo Diogo
- Belobradkova Jana
- Bentley-Lewis Rhonda
- Benusova Olga
- Berenguer Ramon
- Berli Mario Alberto
- Bermudez Lidia
- Bernardo Marializa
- Bhushan Raju Sree
- Bijata-Bronisz Renata
- Bilyk Svitlana D.
- Biscoveanu Mihaela
- Bonadonna Riccardo
- Bordonava Anselmo
- Borges João Lindolfo Cunha
- Borot Sophie
- Botsyurko Volodymyr
- Bowman-Stroud Cynthia
- Brandon Donald
- Breedt Johannes
- Bregman Rachel
- Brenner Barry M.
- Brusco Osvaldo
- Buganova Ingrid
- Burst Volker
- Busch Robert
- Busegeanu Mihaela-Magdalena
- Calcaneo Juan Peralta
- Calella Pedro
- Canaan Yamil
- Canani Luis Henrique
- Cannon Christopher P.
- Cannon Christopher P.
- Canonge Rafael Simo
- Cantero Maria Cecilia
- Cardoza Kathryn
- Caringal Clodoaido
- Cariou Bertrand
- Carrillo Luis Venegas
- Cartasegna Luis Rodolfo
- Casabella Tomas Smith
- Castellanos Ricardo Orozco
- Castellino Pietro
- Castro Fernando Cereto
- Cepeda Alejandro Valdes
- Cercos Esteban
- Ceriello Antonio
- Chacra Antônio Roberto
- Chae Dong-Wan
- Chae Dong-Wan
- Chandra Vyasam Ramesh
- Chang Chwen-Tzuei
- Chang Tara
- Charytan David M.
- Charytan David M.
- Charytan David M.
- Chavez Eloisa Tellez
- Che Yusof Mohd Daud
- Chen Nan
- Chen Qinkai
- Cherney David
- Cherney David
- Chertow Glenn
- Cheung Ngai Wah
- Chilito Alicia
- Chiovato Luca
- Chizhov Daniil
- Cho Young Min
- Chouinard Guy
- Christensen Tom
- Christiano Cynthia
- Christofides Elena
- Chuang Lee-Ming
- Chuateco Caroucel
- Cif Adriana
- Cohen Kenneth
- Cohen Robert
- Cohen-Stein Debbie
- Colaso Patricia del Carmen Gonzalez
- Coloma Gabriela Cecilia
- Colombo Hugo
- Cometa Luis Valderrama
- Comia Rhea Severina
- Commendatore Victor
- Contieri Fabiana Loss de Carvalho
- Conway James
- Cook Charles
- Correa Rotter Jose Ricardo
- Cosma Dana
- Costa Fernando Augusto Alves da
- Cournoyer Serge
- Coyne Daniel
- Crisan Carmen
- Cruz Juan Baas
- Csecsei Gyongyi
- Csiky Botond
- Cuadrado Jesus
- Culak Jan
- Cuneo Carlos Alberto
- Cusumano Ana Maria
- Daboul Nizar
- Danos Peter
- DaRoza Gerald
- Darwish Riad
- Daswani Adarsh
- David null
- Davies Emyr
- Davies Mark
- Davies Simon
- Dawson Alison
- de Almeida Roberto Simões
- de Brito Claudia Moreira
- De Cosmo Salvatore
- De Nicola Luca
- De Nicola Luca
- de Salazar Dora Inés Molina
- De Serres Sacha
- de Souza Pedro
- de Zeeuw Dick
- de Zeeuw Dick
- Deak Laszlo
- Deboni Luciane Mônica
- Deck Kenneth
- Deepak Dewan
- del Campo Blanco Belia Martin
- Demian Luiza Despina
- Derosa Giuseppe
- Desouza Cyrus
- Dev Devasmita
- Dhillon Monika
- Di Carlo Alberto
- Di Cianni Graziano
- Di Tanna Gian Luca
- Diaz Ruiz Jorge Ernesto Andres
- Dimitrov Stefan
- Distiller Larry
- Distiller Lawrence
- Djordjevic Miodrag
- Dobronravov Vladimir
- Dohnalova Lenka
- Douthat Walter Guillermo
- Dran Ricardo Dario
- Drasnar Tomas
- Dreval Alexander
- Dreval Alexander
- Droste Carolyn
- Dua Sohan
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- Dudar Iryna
- Dudas Mihaly
- Dussol Bertrand
- Dzupina Andrej
- Dzuponova Jana
- d’Avila Domingos
- Eder Frank
- Edwin Fernando M.
- Egido de los Rios Jesus
- El Kossi Mohsen
- El-Shahawy Mohamed
- Elosegui Ana Maria
- English Patrick
- Enriquez Sosa Favio Edmundo
- Ervin John
- Escalante Tonatiu Diaz
- Escobedo Rolando Zamarripa
- Esquenazi Alberto
- Evans John
- Faghih Markus
- Farias Eduardo
- Fariña Marcelo Medina
- Faulmann Grit
- Fauvel Jean-Pierre
- Felício João Soares
- Ferariu Ioana Emilia
- Ferkl Richard
- Fernandez Maria Florencia
- Filho Roberto Pecoits
- Finkelstein Hernan
- Fishbane Steven
- Flores Fernando Jimenez
- Flota Cervera Luis Fernando
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- Franco Guadalupe Morales
- Franco Roberto Jorge da Silva
- Frascà Giovanni
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- Frias Juan
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- Galindo-Ramos Eugenia
- Galphin Claude
- Gambaro Giovanni
- Gan Chye Lee
- Gan Shenglian
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- Garcia Pere Alvarez
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- Gastaldi Anibal
- Gaupsiene Egle
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- Genadieva Veselka
- Genova-Hristova Gabriela
- Ghazi Adline
- Giorda Carlo
- Glenny Jorge Archibaldo
- Glinkina Irina
- Gnudi Luigi
- Godlevska Olga
- Goldenberg Ronald
- Golovchenko Oleksandr
- Gomes Marcus
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- Gomez Olivert
- Gonzalez Martinez Francisco Javier
- Gonzalez Orellana Ronaldo Arturo
- Gonzalez Alexander
- Gonzalez Alfonso Soto
- Gonzalez Enrique
- Gonzalez Joaquin Pablo
- Gonzalo Godoy Jorquera Juan
- Gopalakrishnan Natarajan
- Gorson David
- Gourdy Pierre
- Govender Ravendran
- Govender Vimladhevi
- Gowda Anupama
- Goycoa Claudia
- Górriz Jose L.
- Gracious Noble
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- Greene Tom
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- Guldris Secundino Cigarran
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- Gupta Milan
- Guzman Juan Rosas
- Gyrina Olga
- Haase Franklin Paul
- Hachmann Jean Carlo Tibes
- Hadjadj Samy
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- Haller Hermann
- Halmagyi Ildiko
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- Hancu Nicolae
- Handelsman Stuart
- Hanif Wasim
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- Harcsa Eleonora
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- Hawley Carmel
- Hayashida Cesar Yoiti
- Heerspink Hiddo J. L.
- Heerspink Hiddo J. L.
- Heerspink Hiddo J. L.
- Henein Sam
- Hermida Sonia
- Herrera Jimenez Luis Enrique
- Hershon Kenneth
- Higuera Juan Diego
- Hiser Daniel
- Hissa Miguel Nasser
- Hon George
- Hotlos Lucyna
- Hristozov Kiril
- Hsia Te-Lin
- Hsieh Chang-Hsun
- Hwang Shang-Jyh
- Hwang Shang-Jyh
- Iglesias Javier Nieto
- Iitsuka Tadashi
- Ilavska Adriana
- Irizar Santana Sergio Saul
- Ismail Mastura
- Jackson Alan
- Jacob Radu
- Jaime Maria
- Jain Dinesh
- Jamal Aamir
- Januszewicz Andrzej
- Jardine Meg
- Jardine Meg
- Jardine Meg J.
- Jeong In-Kyung
- Jerwan-Keim Reinhold
- Jha Vivekanand
- Ji Linong
- Jimeno Cecilia
- Jodar Gimeno Jose Esteban
- Johnson Andrew
- Johnson David
- Joseph Franklin
- Joshi Mukesh
- Juarez Erick Turcios
- Juncos Luis Isaias
- Junior Renan Montenegro
- Jurgens Jaco
- Kaczmarek Barbara
- Kadir Khalid Abdul
- Kajiyama Shizuo
- Kamenov Zdravko
- Kaminska Anna
- Kang Amy
- Kashine Susumu
- Kaupke Charles
- Kawada Toshio
- Kazmirchuk Anatoliy
- Keightley Gerald
- Keitel Elizete
- Keltai Katalin
- Kendereski Aleksandra
- Keresztesi Sandor
- Kern Elizabeth
- Keshavamurthy C. B.
- Khandwala Hasnain
- Khanna Rakhi
- Khirmanov Vladimir
- Khitan Zeid
- Khullar Dinesh
- Kim Sin Gon
- Kim Sun
- Kim Yeong Hoon
- Kiss Krisztian
- Klein Alexandre
- Klokocnikova Vera
- Klyver Maria Isabel
- Kodera Takamoto
- Kohara Suely Keiko
- Kolesnyk Inna
- Kolesnyk Mykola
- Kolesnyk Mykola
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- Komisarenko Iuliia
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- Koroleva Tatiana
- Korzh Oleksii
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- Krane Vera
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- Krishnan Singhan
- Kropp Jeffrey (Jay)
- Krynski Fernando
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- Kumar Neil
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- Mahaffey Kenneth W.
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- Munar Vila Maria Antonia
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- Saudek Frantisek
- Saulnier Pierre-Jean
- Saxena Manish
- Sazonova Olga
- Sánchez Arenales Jose Antonio
- Schiavi Lilia Beatriz
- Schiller Adalbert
- Schreiman Robert
- Schuch Tiago
- Scott David
- Scott Russell
- Scotton Antonio Scafuto
- Seeber Mary
- Sekkarie Mohamed
- Sennik Davesh
- Sensenbrenner John
- Serafinceanu Cristian
- Serrano Antonio Galan
- Serviddio Gaetano
- Sessa Horacio
- Shakeel Muhammad
- Shamkhalova Minara
- Shanik Michael
- Shaw Sylvia
- Sheu Wayne H-H
- Shinkov Alexander
- Shudim Saiful Shahrizal Bin
- Shutemova Elena
- Shwartz Yuriy
- Simon Godwin
- Singh Baldev
- Smatanova Iveta
- Smirnov Ivan
- Smith Stephen
- Smyth Brendan
- Solomon Richard
- Song Weihong
- Soto Mario Burgos
- Sowinski Dariusz
- Sprague Amy
- Spry Leslie
- Sreedhar Reddy
- Sreelatha Melemadathil
- Steele Andrew
- Stella Andrea
- Stephens Jeffrey
- Strzelecka Anna
- Suchinda Pusadee
- Sudhakar Bhimavarapu
- Sultan Senan
- Sun Jiao
- Sun Lin
- Surampudi Prasanth
- Sussman Sherry
- Svyshchenko Yevgeniya
- Symonds Rehan
- Takacs Robert
- Takai Masahiko
- Tamayo y Orozco Juan Alfredo
- Tan Anjanette
- Tan Gerry
- Tangri Navdeep
- Temelkova Margarita
- Terrelonge Antonio
- Tesar Vladimir
- Thervet Eric
- Thomé Fernando
- Thompson Michael
- Tinahones Madueno Francisco Jose
- Toarba Cristina
- Tolentino Marsha
- Tomashkevych Halyna
- Tomonaga Osamu
- Topchii Ivan
- Torres Manuel Muñoz
- Torshizi Ali
- Trenche Samuel Mujica
- Trespalacios Fernando
- Trevisan Roberto
- Triana Eric Hernandez
- Trippe Bruce
- Trueba Pilar
- Tryshchuk Nadiya
- Tsang Venessa
- Tseluyko Vira
- Tsujimoto Mitsuru
- Tu Ping
- Turatti Luiz Alberto Andreotti
- Turner Wayne
- Twahirwa Marcel
- Ulla Maria Rosa
- Updegrove John
- Urbanaviciene Egle
- Uriasyev Oleg
- Valdez Maria
- Valenzuela Alex
- Valis Martin
- Vallejos Augusto
- Van Buren Peter
- Vangel Sandor
- Vannorsdall Mark
- Vargas Alonso Ruben Dario
- Varghese Freemu
- Vasas Szilard
- Vazelov Evgueniy
- Vejar Margarita
- Velasquez-Mieyer Pedro
- Velichkova Ekaterina
- Vengadasalam Paranthaman
- Ventrapragada Sailaja
- Vera Gregorio Obrador
- Vera Merce Perez
- Veronelli Anna Maria
- Vêncio Sérgio Alberto Cunha
- Villarino Adriana
- Villegas Ivan
- Visco Virginia Esther
- Vizir Vadym
- Vlasenko Maryna
- Vorobyev Sergey
- Vukotic Goga
- Wada Takashi
- Wada Takashi
- Wadud Khurram
- Wahba Mona
- Wakasugi Masakiyo
- Wakeling John
- Wakida Yasushi
- Walker Robert
- Wang Guixia
- Warren Mark
- Wassermann Alfredo
- Watanabe Takayuki
- Watson Edward
- Watson Henry
- Watts Ronald
- Weiner Daniel
- Weiner Pavel
- Welker James
- Welsh Jean
- Wheeler C.
- Wheeler David
- Wheeler David C.
- Wheeler David C.
- Williams Michael
- Williams Shelley
- Winocour Peter
- Wong Alfredo Chew
- Woo Vincent
- Yakov Andrian
- Yamada Masayo
- Yamada Sérgio
- Yanagida Kazuhiro
- Yanase Toshihiko
- Yang Jinkui
- Yao Christy
- Yap Yvette Ethel
- Yi Tae Won
- Yin Aiping
- Yoon Kun Ho
- Young Simon
- Yu Xueqing
- Yumita Wataru
- Yupanqui Hernan
- Zaidman Cesar Javier
- Zalunardo Nadia
- Zanella Maria Teresa
- Zaniewski-Singh Michelle
- Zanoli Luca
- Zaoui Philippe
- Zateyshchikova Anna
- Zateyshshikov Dmitry
- Zemek Stanislav
- Zhang Hong
- Zhang Hong
- Zhang Hong
- Zhao Minghui
- Zheng Hongguang
- Zinman Bernard
- Zinman Bernard
- Zlova Tetiana
- Zsom Marianna
- Zub Liliia
- Zykova Tatyana
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Rationale & Objective: It is unclear whether the effect of canagliflozin on adverse kidney and cardiovascular events in those with diabetic kid-ney disease varies by age and sex. We assessed the effects of canagliflozin among age group categories and between sexes in the Canagli-flozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) study.Study Design: Secondary analysis of a random-ized controlled trial. Setting & Participants: Participants in the CREDENCE trial. Intervention: Participants were randomly assigned to receive canagliflozin 100 mg/d or placebo.Outcomes: Primary composite outcome of kid-ney failure, doubling of serum creatinine con-centration, or death due to kidney or cardiovascular disease. Prespecified secondary and safety outcomes were also analyzed. Out-comes were evaluated by age at baseline (<60, 60-69, and >_70 years) and sex in the intention-to-treat population using Cox regression models.Results: The mean age of the cohort was 63.0 & PLUSMN; 9.2 years, and 34% were female. Older age and female sex were independently associ-ated with a lower risk of the composite of adverse kidney outcomes. There was no evidence that the effect of canagliflozin on the primary outcome (acomposite of kidney failure, a doubling of serum creatinine concentration, or death from kidney or cardiovascular causes) differed between age groups (HRs, 0.67 [95% CI, 0.52-0.87], 0.63 [0.4 8-0.82], and 0.89 [0.61-1.29] for ages <60, 60-69, and >_70 years, respectively; P = 0.3 for interaction) or sexes (HRs, 0.71 [95% CI, 0.5 4-0.95] and 0.69 [0.56-0.8 4] in women and men, respectively; P = 0.8 for interaction). No differences in safety outcomes by age group or sex were observed.Limitations: This was a post hoc analysis with multiple comparisons.Conclusions: Canagliflozin consistently reduced the relative risk of kidney events in people with diabetic kidney disease in both sexes and across age subgroups. As a result of greater background risk, the absolute reduction in adverse kidney outcomes was greater in younger participants.Funding: This post hoc analysis of the CREDENCE trial was not funded. The CREDENCE study was sponsored by Janssen Research and Development and was conducted collaboratively by the sponsor, an academic-led steering committee, and an academic research organization, George Clinical.Trial Registration: The original CREDENCE trial was registered at ClinicalTrials.gov with study number NCT02065791
Deep Underground Neutrino Experiment (DUNE), Far Detector Technical Design Report, Volume I Introduction to DUNE
- Author
- Abi Babak
- Acciarri Roberto
- Acero Mario
- Adamov Giorge
- Adams David
- Adinolfi Marco
- Ahmad Zubayer
- Ahmed Jhanzeb
- Alion Tyler
- Alonso Monsalve Saul
- Alt Christoph
- Anderson John
- Andreopoulos Costas
- Andrews Michael P
- Andriamirado Manoa
- Andrianala Fenompanirina
- Andringa Sofia
- Ankowski Artur
- Anthony Jack
- Antoniu Iliescu
- Antonova Maria
- Antusch Stefan
- Aranda Fernandez Alfredo
- Ariga Akitaka
- Arnold Lukas
- Arroyave Manuel
- Asaadi Jonathan
- Aurisano Adam
- Aushev Vladimir
- Autiero Dario
- Azfar Farrukh
- Back Ashley
- Back Henning
- Back John
- Backhouse Chris
- Baesso Paolo
- Bagby Linda
- Bajou Raphael
- Balasubramanian Supraja
- Baldi Pierre
- Bambah Bindu
- Barao Fernando
- Barenboim Gabriela
- Barker Gary J
- Barkhouse Wayne
- Barnes Christopher
- Barr Giles
- Barranco Monarca Juan
- Barros Nuno
- Barrow Joshua
- Bashyal Amit
- Basque Vincent
- Bay Fatih
- Beacom John
- Bechetoille Edouard
- Behera Biswaranjan
- Bellantoni Leo
- Bellettini Giorgio
- Bellini Vincenzo
- Beltramello Olga
- Benekos Nektarios
- Bento Neves Francisco
- Berger Joshua
- Berkman Sophie
- Bernardini Paolo
- Berner Roman
- Berns Hans-Gerd
- Bertolucci Sergio
- Betancourt Minerba
- Bhattacharjee Maharnab
- Bhuyan Bipul
- Biagi Simone
- Bian Jianming
- Biassoni Matteo
- Biery Kurt
- Bilki Burak
- Bishai Mary
- Bitadze Alexander
- Blake Andrew
- Blanco Siffert Beatriz
- Blaszczyk Flor de Maria
- Blazey Gerald C
- Blucher Edward
- Boissevain Jan
- Bolognesi Sara
- Bolton Timothy
- Bonesini Maurizio
- Bongrand Mathieu
- Bonini Filiberto
- Booth Alexander
- Booth Chris
- Bordoni Stefania
- Borkum Aran
- Boschi Tommaso
- Bostan Nilay
- Bour Petr
- Boyd Steve B
- Boyden Daniel
- Bracinik Juraj
- Braga Davide
- Brailsford Dominic
- Brandt Andrew
- Bremer Johan
- Brew Chris
- Brianne Eldwan
- Brice Stephen
- Brizzolari Claudia
- Bromberg Carl
- Brooijmans Gustaaf
- Brooke Jim
- Bross Alan
- Brunetti Giulia
- Buchanan Norman
- Budd Howard
- Caiulo Davide
- Calafiura Paolo
- Calcutt Jacob
- Calin Marius
- Calvez Steven
- Calvo Enrique
- Camilleri Leslie
- Caminata Alessio
- Campanelli Mario
- Caratelli David
- Carini Gabriella
- Carlus Bruno
- Carniti Paolo
- Caro Terrazas Ivan
- Carranza Hector
- Castillo Andrés
- Castromonte Cesar
- Cattadori Carla
- Cavalier Fabien
- Cavanna Flavio
- Centro Sandro
- Cerati Giuseppe
- Cervelli Alberto
- Cervera Villanueva Anselmo
- Chalifour Michel
- Chardonnet Etienne
- Chatterjee Animesh
- Chattopadhyay Subhasish
- Chaves Jorge
- Chen Hucheng
- Chen Mu-Chun
- Chen Yifan
- Cherdack Daniel
- Chi Cheng-Yi
- Childress Sam
- Chiriacescu Ana
- Cho Kihyeon
- Choubey Sandhya
- Christensen Anne
- Christian David
- Christodoulou Georgios
- Church Eric
- Clarke Peter
- Coan Thomas
- Cocco Alfredo
- Coelho Joao
- Conley Erin
- Conrad Janet M
- Convery Mark
- Corwin Luke
- Cotte Philippe
- Cremaldi Lucien
- Cremonesi Linda
- Crespo-Anadón Jose I
- Cristaldo Esteban
- Cross Ryan
- Cuesta Clara
- Cui Yanou
- Cussans David
- da Motta Helio
- Dabrowski Mieczyslaw
- David Quentin
- Davies Gavin
- Davini Stefano
- Dawson Jaime
- de Almeida Rogerio
- de Bonis Isabelle
- de Gouvea Andre
- de Holanda Pedro
- de Icaza Astiz Iker
- de Jong Paul
- de Lurgio Patrick
- de Roeck Albert
- de Romeri Valentina
- De Kaushik
- Debbins Paul
- Decowski M Patrick
- Deisting Alexander
- Delbart Alain
- Delepine David
- Delgado Maritza
- Dell'Acqua Andrea
- Demuth David
- Dennis Steve
- Densham Chris
- Dharmapalan Ranjan
- Di Domizio Sergio
- Di Giulio Letizia
- Di Noto Lea
- Diaz Felix
- Diaz Jorge S
- Ding Pengfei
- Distefano Carla
- Diurba Richard
- Diwan Milind
- Djurcic Zelimir
- Dokania Neha
- Dolinski Michelle J
- Domine Laura
- Douglas Daniel
- Drielsma Francois
- Duchesneau Dominique
- Duffy Kirsty
- Dunne Patrick
- Durkin Tim
- Duyang Hongyue
- Dvornikov Olexiy
- Dwyer Daniel A
- Dyshkant Alexandre S
- Eads Michael
- Edmunds Daniel
- Eisch Jonathan
- Emery Sandrine
- Ereditato Antonio
- Escobar Carlos O
- Escudero Sanchez Lorena
- Evans Justin
- Ewart Kevin
- Ezeribe Anthony
- Fahey Kevin
- Falcone Andrea
- Farnese Christian
- Farzan Yasaman
- Felix Julian
- Fernandez Menendez Pablo
- Fernandez-Martinez Enrique
- Ferraro Federico
- Fields Laura
- Filthaut Frank
- Fitzpatrick Rory
- Flanagan Will
- Fleming Bonnie
- Flight Robert
- Fowler Jack
- Fox Walt
- Franc Jiri
- Francis Kurt
- Franco Domenico
- Freeman John
- Freestone Julian
- Fried Jack
- Friedland Alex
- Fuess Stu
- Furic Ivan
- Furmanski Andrew
- Gallagher Hugh
- Gallego-Ros Ana
- Gallice Niccolo
- Galymov Vyacheslav
- Gamberini Enrico
- Gamble Trevor
- Gandhi Raj
- Gandrajula Reddy
- Gao Shanshan
- Garcia-Gamez Diego
- García-Peris Miguel
- Gardiner Steven
- Gastler Dan
- Ge Guanqun
- Gelli Bruno
- Gendotti Adamo
- Gent Stephen
- Ghorbani-Moghaddam Zahra
- Gibin Daniele
- Gil-Botella Ines
- Girerd Claude
- Giri Anjan Kumar
- Gogota Olga
- Gold Michael
- Gollapinni Sowjanya
- Gollwitzer Keith
- Gomes Ricardo
- Gomez Bermeo Laura Vanessa
- Gomez Fajardo Luz
- Gonnella Francesco
- Gonzalez-Cuevas Juan Alberto
- Goodman Maury
- Goodwin Owen
- Goswami Srubabati
- Gotti Claudio
- Goudzovski Evgueni
- Grace Carl
- Graham Mathew
- Gran Rik
- Granados Everardo
- Grant Alan
- Grant Christopher
- Grant Nick
- Gratieri Diego
- Green Patrick
- Green Steven
- Greenler Leland
- Greer Joel
- Gregor Recalde Derlis
- Griffith Clark
- Groh Micah
- Grudzinski James
- Grzelak Katarzyna
- Gu Wenqiang
- Guarino Victor
- Guenette Roxanne
- Guglielmi Alberto
- Guo Bing
- Guthikonda K K
- Gutierrez Rafael
- Guzowski Pawel
- Guzzo Marcelo
- Gwon Sunwoo
- Habig Alec
- Hadavand Haleh
- Haenni Roger
- Hahn Alan
- Haigh Jennifer
- Haiston James
- Hamernik Thomas
- Hamilton Philip
- Han Jiyeon
- Harder Kristian
- Harris Debbie
- Hartnell Jeffrey
- Hasegawa Takyua
- Hatcher Robert
- Hazen Eric
- Heavey Anne
- Heeger Karsten
- Hennessy Karol
- Henry Sarah
- Hernandez Morquecho Miguel Angel
- Herner Kenneth
- Hertel Lars
- Hewes Jeremy
- Higuera Pichardo Aaron
- Hill Tony
- Hillier Stephen
- Himmel Alexander
- Hoff James
- Hohl Christian
- Holin Anna
- Hoppe Eric
- Horton-Smith Glenn
- Hostert Matheus
- Hourlier Adrien
- Howard Bruce
- Howell Ryan
- Huang Junting
- Huang Junying
- Hugon Justin
- Iles Gregory
- Illingworth Robert
- Ioannisian Ara
- Itay Ran
- Izmaylov Alexander
- James Eric
- Jan de Vries Joris
- Jediny Filip
- Jesús-Valls César
- Ji Xiangpan
- Jiménez Sergio
- Jipa Alexandru
- Johnson Connor
- Johnson Randy
- Jones Benjamin
- Jones Sebastian
- Jung Chang Kee
- Junk Thomas
- Jwa Yeon-Jae
- Kabirnezhad Monireh
- Kaboth Asher
- Kadenko I
- Kamiya Felipe
- Karagiorgi Georgia
- Karolak Mark
- Karyotakis Yannis
- Kasai Seiji
- Kasetti Siva
- Kashur Lane
- Kazaryan Narine
- Kearns Edward
- Keener Paul
- Kelly Kevin
- Kemp Ernesto
- Ketchum Wes
- Kettell Steve H
- Khabibullin Marat
- Khotjantsev Alexei
- Khvedelidze Arsen
- King Bonnie
- Kirby Brian
- Kirby Mike
- Klein Joshua
- Koehler Kevin
- Koerner Lisa
- Kohn Sam
- Koller Patrick
- Kordosky Mike
- Kosc Thomas
- Kose Umut
- Kostelecky V Alan
- Kothekar Kunal
- Krennrich Frank
- Kreslo Igor
- Kudenko Yury
- Kudryavtsev Vitaly A
- Kulagin Sergey
- Kumar Jason
- Kumar Rajeev
- Kuruppu Chatura
- Kus Vaclav
- Kutter Thomas
- Lande Kenneth
- Lane Charles
- Lang Karol
- Langford Thomas
- Lasorak Pierre
- Last David
- Lastoria Chiara
- Laundrie Andy
- Lazanu Ionel
- Lazur Ryan
- Le Trung
- Learned John
- Lebrun Patrice
- Lehmann Miotto Giovanna
- Lehnert Ralf
- Leigui de Oliveira M A
- Leyton Michael
- Li Lingge
- Li Shaorui
- Li Shirley W
- Li Teng
- Li Yichen
- Liao Heng-Ye
- Lin Cheng-Ju Stephen
- Lin Shih-Kai
- Lister Adam
- Littlejohn Bryce
- Lockwitz Sarah
- Loew Timothy
- Lokajicek Milos
- Lomidze Irakli
- Long Ken
- Loo Kai
- Lorca David
- Lord Tom
- Losecco John M
- Louis William
- Luk Kam-Biu
- Luo Xiao
- Lurkin Nicolas
- Lux Thorsten
- Luzio Vitor Prestes
- Macfarlane David
- Machado Ana Amelia
- Machado Pedro
- Macias Christopher Thomas
- Macier Jolie R
- Maddalena Antonello
- Madigan Peter
- Magill Steve
- Mahn Kendall
- Maio Amélia
- Maloney James
- Mandrioli Gianni
- Maneira José
- Manenti Laura
- Manly Steve
- Mann Anthony
- Manolopoulos Konstantinos
- Manrique Plata Maria
- Marchionni Alberto
- Marciano William
- Marfatia Danny
- Mariani Camillo
- Maricic Jelena
- Marinho Franciole
- Marino Alysia
- Marshak Marvin
- Marshall Chris
- Marshall John
- Marteau Jacques
- Martin-Albo Justo
- Martinez Caicedo David
- Martinez Norman
- Martynenko Sergey
- Mason Katie
- Mastbaum Andrew
- Masud Mehedi
- Matsuno Shigenobu
- Matthews James
- Mauger Christopher
- Mauri Nicoletta
- Mavrokoridis Konstantinos
- Mazza Roberto
- Mazzacane Anna
- Mazzucato Edoardo
- Mccluskey Elaine
- Mcconkey Nicola
- Mcfarland Kevin
- Mcgrew Clark
- Mcnab Andrew
- Mefodiev Alexander
- Mehta Poonam
- Melas Pantelis
- Mellinato Michele
- Mena Olga
- Menary Scott
- Mendes Santos Lucas
- Mendez Hector
- Menegolli A
- Meng Guang
- Messier Mark
- Metcalf William
- Mewes Matthew
- Meyer Holger
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- Miller William
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- Milne Cody
- Mineev Oleg
- Miranda Omar
- Miryala Sandeep
- Mishra C Shekhar
- Mishra Sanjib R
- Mislivec Aaron
- Mladenov Dimitar
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- Moggi Niccolo
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- Montanari David
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- Prince Sebastien
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- Qian Xin
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- Radeka Veljko
- Rademacker Jonas
- Radics Balint
- Rafique Aleena
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- Rai Mousam
- Rajaoalisoa Miriama
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- Rakotondravohitra Laza
- Ramachers Yorck A
- Rameika Regina
- Ramirez Delgado Manuel Alejandro
- Ramson Bryan
- Rappoldi A
- Raselli Gl
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- Real Jean-Sebastien
- Rebel Brian
- Redondo David
- Reggiani-Guzzo Marina
- Rehak Tyler
- Reichenbacher Juergen
- Reitzner S
- Renshaw Andrew
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- Rodriguez Alonso Manual Jesus
- Rodriguez Rondon Jairo
- Roeth Alison J
- Rogers Hannah
- Rosauro-Alcaraz Salvador
- Rossella M
- Rout Jogesh
- Roy Samiran
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- Seong Ilsoo
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- Shaevitz Michael H
- Shafaq Sheeba
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- Sipos Roland
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- Trevor Jason
- Trzaska Wladyslaw
- Tsai Yun-Tse
- Tsamalaidze Zviadi
- Tsang Ka Vang
- Tsverava Nikolozi
- Tufanli Serhan
- Tull Craig
- Tyley E.
- Tzanov Martin
- Uchida Melissa
- Urheim Jon
- Usher Tracy
- Vagins Mark R
- Vahle Patricia
- Valdiviesso Gustavo
- Vallari Zoya
- Valle Jose
- Vallecorsa Sofia
- van Berg Rick
- van de Water Richard
- Vanegas Forero David
- Varanini Filippo
- Vargas Danaisis
- Varner Gary
- Vasel Justin
- Vasseur Georges
- Vaziri Kamran
- Ventura Sandro
- Verdugo Antonio
- Vergani Stefano
- Vermeulen Milo
- Verzocchi Marco
- Vieira de Souza Henrique
- Vignoli Chiara
- Vilela Cristovao
- Viren Brett
- Vrba Tomas
- Wachala Tomasz
- Waldron Abigail
- Wallbank Michael
- Wang Hanguo
- Wang Jingbo
- Wang Yi
- Wang Yue
- Warburton Karl
- Warner David
- Wascko Morgan
- Waters David
- Watson Alan
- Weatherly Pierce
- Weber Alfons
- Weber Michele
- Wei Hanyu
- Weinstein Amanda
- Wenman Dan
- Wetstein Matthew
- White Andy
- Whitehead Leigh
- Whittington Denver
- Wilking Michael
- Wilkinson Callum
- Williams Zachary
- Wilson Fergus
- Wilson Robert
- Wolcott Jeremy
- Wongjirad Taritree
- Wood Kevin
- Wood Lynn
- Worcester Elizabeth
- Worcester Matthew
- Wret Clarence
- Wu Wanwei
- Yang Guang
- Yang Shaokai
- Yang Tingjun
- Yershov Nikolai
- Yonehara Katsuya
- Young Tim
- Yu Bo
- Yu Jae
- Zalesak Jaroslav
- Zambelli Laura
- Zamorano Bruno
- Zani Andrea
- Zazueta Luis
- Zeller Geralyn
- Zennamo Joseph
- Zeug Kyle
- Zhang Chao
- Zhao Manhong
- Zhivun Elena
- Zhu Guanying
- Zimmerman Eric
- Zito Marco
- Zucchelli Stefano
- Zuklin Josef
- Zutshi Vishnu
- Zwaska Robert
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2020
- Field of study
International audienceThe preponderance of matter over antimatter in the early universe, the dynamics of the supernovae that produced the heavy elements necessary for life, and whether protons eventually decay—these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our universe, its current state, and its eventual fate. The Deep Underground Neutrino Experiment (DUNE) is an international world-class experiment dedicated to addressing these questions as it searches for leptonic charge-parity symmetry violation, stands ready to capture supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector technical design report (TDR) describes the DUNE physics program and the technical designs of the single- and dual-phase DUNE liquid argon TPC far detector modules. This TDR is intended to justify the technical choices for the far detector that flow down from the high-level physics goals through requirements at all levels of the Project. Volume I contains an executive summary that introduces the DUNE science program, the far detector and the strategy for its modular designs, and the organization and management of the Project. The remainder of Volume I provides more detail on the science program that drives the choice of detector technologies and on the technologies themselves. It also introduces the designs for the DUNE near detector and the DUNE computing model, for which DUNE is planning design reports. Volume II of this TDR describes DUNE's physics program in detail. Volume III describes the technical coordination required for the far detector design, construction, installation, and integration, and its organizational structure. Volume IV describes the single-phase far detector technology. A planned Volume V will describe the dual-phase technology
Deep Underground Neutrino Experiment (DUNE), Far Detector Technical Design Report, Volume II: DUNE Physics
- Author
- Abi Babak
- Acciarri Roberto
- Acero Mario
- Adamov Giorge
- Adams David
- Adinolfi Marco
- Ahmad Zubayer
- Ahmed Jhanzeb
- Alion Tyler
- Alonso Monsalve Saul
- Alt Christoph
- Anderson John
- Andreopoulos Costas
- Andrews Michael P
- Andriamirado Manoa
- Andrianala Fenompanirina
- Andringa Sofia
- Ankowski Artur
- Anthony Jack
- Antoniu Iliescu
- Antonova Maria
- Antusch Stefan
- Aranda Fernandez Alfredo
- Ariga Akitaka
- Arnold Lukas
- Arroyave Manuel
- Asaadi Jonathan
- Aurisano Adam
- Aushev Vladimir
- Autiero Dario
- Azfar Farrukh
- Back Ashley
- Back Henning
- Back John
- Backhouse Chris
- Baesso Paolo
- Bagby Linda
- Bajou Raphael
- Balasubramanian Supraja
- Baldi Pierre
- Bambah Bindu
- Barao Fernando
- Barenboim Gabriela
- Barker Gary J
- Barkhouse Wayne
- Barnes Christopher
- Barr Giles
- Barranco Monarca Juan
- Barros Nuno
- Barrow Joshua
- Bashyal Amit
- Basque Vincent
- Bay Fatih
- Bazo Alba J.L.
- Beacom John
- Bechetoille Edouard
- Behera Biswaranjan
- Bellantoni Leo
- Bellettini Giorgio
- Bellini Vincenzo
- Beltramello Olga
- Belver D.
- Benekos Nektarios
- Bento Neves Francisco
- Berger Joshua
- Berkman Sophie
- Bernardini Paolo
- Berner Roman
- Berns Hans-Gerd
- Bertolucci Sergio
- Betancourt Minerba
- Bezawada Y.
- Bhattacharjee maharnab
- Bhuyan Bipul
- Biagi Simone
- Bian Jianming
- Biassoni Matteo
- Biery Kurt
- Bilki Burak
- Bishai Mary
- Bitadze Alexander
- Blake Andrew
- Blanco Siffert Beatriz
- Blaszczyk Flor de Maria
- Blazey Gerald C
- Blucher Edward
- Boissevain Jan
- Bolognesi Sara
- Bolton Timothy
- Bonesini Maurizio
- Bongrand Mathieu
- Bonini Filiberto
- Booth Alexander
- Booth Chris
- Bordoni Stefania
- Borkum Aran
- Boschi Tommaso
- Bostan Nilay
- Bour Petr
- Boyd Steve B
- Boyden Daniel
- Bracinik Juraj
- Braga Davide
- Brailsford Dominic
- Brandt Andrew
- Bremer Johan
- Brew Chris
- Brianne Eldwan
- Brice Stephen
- Brizzolari Claudia
- Bromberg Carl
- Brooijmans Gustaaf
- Brooke Jim
- Bross Alan
- Brunetti Giulia
- Buchanan Norman
- Budd Howard
- Caiulo Davide
- Calafiura Paolo
- Calcutt Jacob
- Calin Marius
- Calvez Steven
- Calvo Enrique
- Camilleri Leslie
- Caminata Alessio
- Campanelli Mario
- Caratelli David
- Carini Gabriella
- Carlus Bruno
- Carniti Paolo
- Caro Terrazas Ivan
- Carranza Hector
- Castillo Andrés
- Castromonte Cesar
- Cattadori Carla
- Cavalier Fabien
- Cavanna Flavio
- Centro Sandro
- Cerati Giuseppe
- Cervelli Alberto
- Cervera Villanueva Anselmo
- Chalifour Michel
- Chang C.
- Chardonnet Etienne
- Chatterjee Animesh
- Chattopadhyay Subhasish
- Chaves Jorge
- Chen Hucheng
- Chen Mu-Chun
- Chen Yifan
- Cherdack Daniel
- Chi Cheng-Yi
- Childress Sam
- Chiriacescu Ana
- Cho Kihyeon
- Choubey Sandhya
- Christensen Anne
- Christian David
- Christodoulou Georgios
- Church Eric
- Clarke Peter
- Coan Thomas
- Cocco Alfredo
- Coelho Joao
- Conley Erin
- Conrad Janet M
- Convery Mark
- Corwin Luke
- Cotte Philippe
- Cremaldi Lucien
- Cremonesi Linda
- Crespo-Anadón Jose I
- Cristaldo Esteban
- Cross Ryan
- Cuesta Clara
- Cui Yanou
- Cussans David
- Da Motta Helio
- Dabrowski Mieczyslaw
- David Quentin
- Davies Gavin
- Davini Stefano
- Dawson Jaime
- de Almeida Rogerio
- De Bonis Isabelle
- de Gouvea Andre
- de Holanda Pedro
- de Icaza Astiz Iker
- De Jong Paul
- De Lurgio Patrick
- De Roeck Albert
- De Romeri Valentina
- De Kaushik
- Debbins Paul
- Decowski M Patrick
- Deisting Alexander
- Delbart Alain
- Delepine David
- Delgado Maritza
- Dell'Acqua Andrea
- DeMuth David
- Dennis Steve
- Densham Chris
- Dharmapalan Ranjan
- Di Domizio Sergio
- Di Giulio Letizia
- Di Noto Lea
- Diaz Felix
- Diaz Jorge S
- Ding Pengfei
- Distefano Carla
- Diurba Richard
- Diwan Milind
- Djurcic Zelimir
- Dokania Neha
- Dolinski Michelle J
- Domine Laura
- Douglas Daniel
- Drielsma Francois
- Duchesneau Dominique
- Duffy Kirsty
- Dunne Patrick
- Durkin Tim
- Duyang Hongyue
- Dvornikov Olexiy
- Dwyer Daniel A
- Dyshkant Alexandre S
- Eads Michael
- Edmunds Daniel
- Eisch Jonathan
- Emery Sandrine
- Ereditato Antonio
- Escobar Carlos O
- Escudero Sanchez Lorena
- Evans Justin
- Ewart E.
- Ewart Kevin
- Ezeribe Anthony
- Fahey Kevin
- Falcone Andrea
- Farnese Christian
- Farzan Yasaman
- Felix Julian
- Fernandez Menendez Pablo
- Fernandez-Martinez Enrique
- Ferraro Federico
- Fields Laura
- Filkins A.
- Filthaut Frank
- Fitzpatrick Rory
- Flanagan Will
- Fleming Bonnie
- Flight Robert
- Fowler Jack
- Fox Walt
- Franc Jiri
- Francis Kurt
- Franco Domenico
- Freeman John
- Freestone Julian
- Fried Jack
- Friedland Alex
- Fuess Stu
- Furic Ivan
- Furmanski Andrew
- Gago A.
- Gallagher Hugh
- Gallego-Ros Ana
- Gallice Niccolo
- Galymov Vyacheslav
- Gamberini Enrico
- Gamble Trevor
- Gandhi Raj
- Gandrajula Reddy
- Gao Shanshan
- Garcia-Gamez Diego
- García-Peris Miguel
- Gardiner Steven
- Gastler Dan
- Ge Guanqun
- Gelli Bruno
- Gendotti Adamo
- Gent Stephen
- Ghorbani-Moghaddam Zahra
- Gibin Daniele
- Gil-Botella Ines
- Girerd Claude
- Giri Anjan Kumar
- Gnani D.
- Gogota Olga
- Gold Michael
- Gollapinni Sowjanya
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- Gomes Ricardo
- Gomez Bermeo Laura Vanessa
- Gomez Fajardo Luz
- Gonnella Francesco
- Gonzalez-Cuevas Juan Alberto
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- Greenler Leland
- Greenwood M.
- Greer Joel
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- Groh Micah
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- Grzelak Katarzyna
- Gu Wenqiang
- Guarino Victor
- Guenette Roxanne
- Guglielmi Alberto
- Guo Bing
- Guthikonda K K
- Gutierrez Rafael
- Guzowski Pawel
- Guzzo Marcelo
- Gwon Sunwoo
- Habig Alec
- Hackenburg A.
- Hadavand Haleh
- Haenni Roger
- Hahn Alan
- Haigh Jennifer
- Haiston James
- Hamernik Thomas
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- Hartnell Jeffrey
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- Hazen Eric
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- Heeger Karsten
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- Herner Kenneth
- Hertel Lars
- Hewes Jeremy
- Hewes V.
- Higuera Pichardo Aaron
- Hill Tony
- Hillier Stephen
- Himmel Alexander
- Hoff James
- Hohl Christian
- Holin Anna
- Hoppe Eric
- Horton-Smith Glenn
- Hostert Matheus
- Hourlier Adrien
- Howard Bruce
- Howell Ryan
- Huang Junting
- Huang Junying
- Hugon Justin
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- Karcher A.
- Karolak Mark
- Karyotakis Yannis
- Kasai Seiji
- Kasetti Siva
- Kashur Lane
- Kazaryan Narine
- Kearns Edward
- Keener Paul
- Kelly Kevin
- Kemp Ernesto
- Ketchum Wes
- Kettell Steve H
- Khabibullin Marat
- Khotjantsev Alexei
- Khvedelidze Arsen
- Kim D.
- King Bonnie
- Kirby Brian
- Kirby Mike
- Klein Joshua
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- Kohn Sam
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- Kose Umut
- Kostelecky V Alan
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- Krennrich Frank
- Kreslo Igor
- Kudenko Yury
- Kudryavtsev Vitaly A
- Kulagin Sergey
- Kumar Jason
- KUMAR Rajeev
- Kuruppu Chatura
- Kus Vaclav
- Kutter Thomas
- Lambert A.
- Lande Kenneth
- Lane Charles
- Lang Karol
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- LaZur Ryan
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- Learned John
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- Lehmann Miotto Giovanna
- Lehnert Ralf
- Leigui de Oliveira M A
- Leitner M.
- Leyton Michael
- Li Lingge
- Li Shaorui
- Li Shirley W
- Li Teng
- Li Yichen
- Liao Heng-Ye
- Lin Cheng-Ju Stephen
- Lin Shih-Kai
- Lister Adam
- Littlejohn Bryce
- Liu J.
- Lockwitz Sarah
- Loew Timothy
- Lokajicek Milos
- Lomidze Irakli
- Long Ken
- Loo Kai
- Lorca David
- Lord Tom
- LoSecco John M
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- Luk Kam-Biu
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- MacFarlane David
- Machado Ana Amelia
- Machado Pedro
- Macias Christopher Thomas
- Macier Jolie R
- Maddalena Antonello
- Madigan Peter
- Magill Steve
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- Martinez Norman
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- Miller William H.
- Mills Joshua
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- Mishra C Shekhar
- Mishra Sanjib R
- Mislivec Aaron
- Mladenov Dimitar
- Mocioiu Irina
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- Qian Xin
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- Raboanary R.
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- Ramirez Delgado Manuel Alejandro
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- Rodriguez Alonso Manual Jesus
- Rodriguez Rondon Jairo
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- Tsamalaidze Zviadi
- Tsang Ka Vang
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- Tufanli Serhan
- Tull Craig
- Tyley E.
- Tzanov Martin
- Uchida Melissa
- Urheim Jon
- Usher Tracy
- Vagins Mark R
- Vahle Patricia
- Valdiviesso Gustavo
- Valencia E.
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- Valle Jose
- Vallecorsa Sofia
- Van Berg Rick
- Van de Water Richard
- Vanegas Forero David
- Varanini Filippo
- Vargas Danaisis
- Varner Gary
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- Xiao Y.
- Yang Guang
- Yang Shaokai
- Yang Tingjun
- Yershov Nikolai
- Yonehara Katsuya
- Young Tim
- Yu Bo
- Yu Jae
- Zalesak Jaroslav
- Zambelli Laura
- Zamorano Bruno
- Zani Andrea
- Zazueta Luis
- Zeller G.P.
- Zeller Geralyn (Sam)
- Zennamo Joseph
- Zeug Kyle
- Zhang Chao
- Zhao Manhong
- Zhivun Elena
- Zhu Guanying
- Zimmerman Eric
- Zito Marco
- Zucchelli Stefano
- Zuklin Josef
- Zutshi Vishnu
- Zwaska Robert
- Publication venue
- HAL CCSD
- Publication date
- 07/02/2020
- Field of study
The preponderance of matter over antimatter in the early universe, the dynamics of the supernovae that produced the heavy elements necessary for life, and whether protons eventually decay -- these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our universe, its current state, and its eventual fate. DUNE is an international world-class experiment dedicated to addressing these questions as it searches for leptonic charge-parity symmetry violation, stands ready to capture supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector technical design report (TDR) describes the DUNE physics program and the technical designs of the single- and dual-phase DUNE liquid argon TPC far detector modules. Volume II of this TDR, DUNE Physics, describes the array of identified scientific opportunities and key goals. Crucially, we also report our best current understanding of the capability of DUNE to realize these goals, along with the detailed arguments and investigations on which this understanding is based. This TDR volume documents the scientific basis underlying the conception and design of the LBNF/DUNE experimental configurations. As a result, the description of DUNE's experimental capabilities constitutes the bulk of the document. Key linkages between requirements for successful execution of the physics program and primary specifications of the experimental configurations are drawn and summarized. This document also serves a wider purpose as a statement on the scientific potential of DUNE as a central component within a global program of frontier theoretical and experimental particle physics research. Thus, the presentation also aims to serve as a resource for the particle physics community at large
Deep Underground Neutrino Experiment (DUNE) Near Detector Conceptual Design Report
- Author
- Abed Abud Adam
- Abi Babak
- Acciarri Roberto
- Acero Mario
- Adamov Giorge
- Adams David
- Adinolfi Marco
- Aduszkiewicz Antoni
- Ahmad Zubayer
- Ahmed Jhanzeb
- Alion Tyler
- Alonso Monsalve Saul
- Alrashed Munerah
- Alt Christoph
- Alton Andrew
- Amedo Pablo
- Anderson John
- Andreopoulos Costas
- Andrews Michael P
- Andrianala Fenompanirina
- Andringa Sofia
- Anfimov Nikolay
- Ankowski Artur
- Antonova Maria
- Antusch Stefan
- Aranda-Fernandez Alfredo
- Ariga Akitaka
- Arnold Lukas
- Arroyave Manuel
- Asaadi Jonathan
- Aurisano Adam
- Aushev Vladimir
- Autiero Dario
- Ayala-Torres Marco Alberto
- Azfar Farrukh
- Back A.
- Back Henning
- Back John
- Backhouse Chris
- Baesso Paolo
- Bagaturia Iuri
- Bagby Linda
- Balasubramanian Supraja
- Baldi Pierre
- Baller Bruce
- Bambah Bindu
- Barao Fernando
- Barenboim Gabriela
- Barker Gary J
- Barkhouse Wayne
- Barnes Christopher
- Barr Giles
- Barranco Monarca Juan
- Barros Nuno
- Barrow Joshua
- Basharina-Freshville Anastasia
- Bashyal Amit
- Basque Vincent
- Batista das Chagas Ewerton
- Battat J.B. R.
- Battisti Federico
- Bay Fatih
- Bazo Alba José Luis
- Beacom John
- Bechetoille Edouard
- Behera Biswaranjan
- Belchior E.
- Bellantoni Leo
- Bellettini Giorgio
- Bellini Vincenzo
- Beltramello Olga
- Belver Daniel
- Benekos Nektarios
- Bento Neves Francisco
- Berkman Sophie
- Bernardini Paolo
- Berner Roman
- Berns Hans-Gerd
- Bertolucci Sergio
- Betancourt Minerba
- Betancur Rodríguez Amalia
- Bhattacharjee Maharnab
- Bhuller Shyam
- Bhuyan Bipul
- Biagi Simone
- Bian Jianming
- Biassoni Matteo
- Biery Kurt
- Bilki Burak
- Bishai Mary
- Bitadze Alexander
- Blake Andrew
- Blaszczyk Flor de Maria
- Blazey Gerald C
- Blucher Edward
- Boissevain Jan
- Bolognesi Sara
- Bolton Timothy
- Bomben Luca
- Bonesini Maurizio
- Bongrand Mathieu
- Bonini Filiberto
- Booth Alexander
- Booth Chris
- Bordoni Stefania
- Borkum Aran
- Boschi Tommaso
- Bostan Nilay
- Bour Petr
- Bourgeois Christian
- Boyd Steve B
- Boyden Daniel
- Bracinik Juraj
- Braga Davide
- Brailsford Dominic
- Brandt Andrew
- Bremer Johan
- Brew Christopher
- Brianne Eldwan
- Brice Stephen
- Brizzolari Claudia
- Bromberg Carl
- Brooijmans Gustaaf
- Brooke Jim
- Bross Alan
- Brunetti Giulia
- Brunetti Maria
- Buchanan Norman
- Budd Howard
- Cagnoli I.
- Caiulo Davide
- Calafiura Paolo
- Calcutt Jacob
- Calin Marius
- Calvez Steven
- Calvo Enrique
- Caminata Alessio
- Campanelli Mario
- Cankocak Kerem
- Caratelli David
- Carini Gabriella
- Carlus Bruno
- Carniti Paolo
- Caro Terrazas Ivan
- Carranza Hector
- Carroll Thomas
- Castaño Forero Javier
- Castillo Andrés
- Castromonte Cesar
- Catano-Mur Erika
- Cattadori Carla
- Cavalier Fabien
- Cavanna Flavio
- Centro Sandro
- Cerati Giuseppe
- Cervelli Alberto
- Cervera Villanueva Anselmo
- Chalifour Michel
- Chappell Andrew
- Chardonnet Etienne
- Charitonidis Nikolas
- Chatterjee Animesh
- Chattopadhyay Subhasish
- Chen Hucheng
- Chen Mu-Chun
- Chen Yifan
- Chen Zheyang
- Cherdack Daniel
- Chi Cheng-Yi
- Childress Sam
- Chiriacescu Ana
- Chisnall Georgia
- Cho Kihyeon
- Choate Sarah
- Chokheli David
- Choubey Sandhya
- Christensen Anne
- Christian David
- Christodoulou Georgios
- Chukanov Artem
- Church Eric
- Cicero V.
- Clarke Peter
- Coan Thomas
- Cocco Alfredo
- Coelho J.A. B.
- Conley Erin
- Conley Robert
- Conrad Janet M
- Convery Mark
- Copello Simone
- Corwin Luke
- Cremaldi Lucien
- Cremonesi Linda
- Crespo-Anadón José
- Cristaldo Esteban
- Cross Ryan
- Cudd Andrew
- Cuesta Clara
- Cui Yanou
- Cussans David
- da Motta Helio
- da Silva Peres Leonardo
- Dabrowski Mieczyslaw
- Dalager Olivia
- David Claire
- David Quentin
- Davies Gavin
- Davini Stefano
- Dawson Jaime
- de Almeida Rogerio
- De Bonis Isabelle
- de Gouvea Andre
- de Holanda Pedro
- de Icaza Astiz Iker
- De Jong Paul
- De Lurgio Patrick
- de Mello Neto J.R. T.
- de Oliveira M.A. Leigui
- De Roeck Albert
- De Romeri Valentina
- de Souza Greg
- De Kaushik
- Debbins Paul
- Decowski M Patrick
- Deisting Alexander
- Delbart Alain
- Delepine David
- Delgado Maritza
- Dell'Acqua Andrea
- DeMuth David
- Dennis Steve
- Densham Chris
- Deptuch Grzegorz
- Dharmapalan Ranjan
- Di Domizio Sergio
- Di Giulio Letizia
- Di Noto Lea
- Diaz Felix
- Diaz Jorge S
- Ding Pengfei
- Distefano Carla
- Diurba Richard
- Diwan Milind
- Djurcic Zelimir
- Dokania Neha
- Dolan Stephen
- Dolinski Michelle J
- Domine Laura
- Douglas Daniel
- Douillet Denis
- Drake Gary
- Drielsma Francois
- Duchesneau Dominique
- Duffy Kirsty
- Dunne Patrick
- Durkin Tim
- Duyang Hongyue
- Dvornikov Olexiy
- Dwyer Daniel A
- Dyshkant Alexandre S
- Eads Michael
- Earle Antony
- Edmunds Daniel
- Eisch Jonathan
- Emberger Lorenz
- Emery Sandrine
- Ereditato Antonio
- Escobar Carlos O
- Eurin Guillaume
- Evans Justin
- Ewart Erin
- Ezeribe Anthony
- Fahey Kevin
- Fajardo L.S. Gomez
- Falcone Andrea
- Farnese Christian
- Farzan Yasaman
- Felix Julian
- Fernandes Carneiro da Silva Mateus
- Fernandez Menendez Pablo
- Fernandez-Martinez Enrique
- Ferraro Federico
- Fields Laura
- Filthaut Frank
- Fiorentini Arturo
- Fitzpatrick Rory
- Flanagan Will
- Fleming Bonnie
- Flight Robert
- Forero David
- Fowler Jack
- Fox Walt
- Franc Jiri
- Francis Kurt
- Franco Domenico
- Freeman John
- Freestone Julian
- Fried Jack
- Friedland Alex
- Fuess Stu
- Furic Ivan
- Furmanski Andrew
- Gabrielli A.
- Gago AM
- Gallagher Hugh
- Gallas Alexandre
- Gallego-Ros Ana
- Gallice Niccolo
- Galymov Vyacheslav
- Gamberini Enrico
- Gamble Trevor
- Gandhi Raj
- Gandrajula Reddy
- Gao Fan
- Gao Shanshan
- Garcia-Gamez Diego
- García-Peris Miguel
- Gardiner Steven
- Gastler Dan
- Ge Guanqun
- Gelli Bruno
- Gendotti Adamo
- Gent Stephen
- Ghorbani-Moghaddam Zahra
- Gibin Daniele
- Gil-Botella Ines
- Gilligan Sean
- Girerd Claude
- Giri Anjan Kumar
- Gnani Dario
- Gogota Olga
- Gold Michael
- Gollapinni Sowjanya
- Gollwitzer Keith
- Gomes Ricardo
- Gomez Bermeo Laura Vanessa
- Gonnella Francesco
- Gonzalez-Cuevas Juan Alberto
- Gonzalez-Diaz Deigo
- Gonzalez-Lopez Manuel
- Goodman Maury
- Goodwin Owen
- Goswami Srubabati
- Gotti Claudio
- Goudzovski Evgueni
- Grace Carl
- Graham Mathew
- Gran Rik
- Granados Everardo
- Granger Pierre
- Grant Alan
- Grant Christopher
- Gratieri Diego
- Green Patrick
- Greenler Leland
- Greer Joel
- Griffith Clark
- Groh Micah
- Grudzinski James
- Grzelak Katarzyna
- Gu Wenqiang
- Guarino Victor
- Guenette Roxanne
- Guerard Eric
- Guerzoni M.
- Guglielmi Alberto
- Guo Bing
- Guthikonda K.K.
- Gutierrez Rafael
- Guzowski Pawel
- Guzzo Marcelo
- Gwon Sunwoo
- Habig Alec
- Hadavand Haleh
- Haenni Roger
- Hahn Alan
- Haiston James
- Hamacher-Baumann Philip
- Hamernik Thomas
- Hamilton Philip
- Han Jiyeon
- Harris Deborah
- Hartnell Jeffrey
- Harton John
- Hasegawa Takyua
- Hasnip Ciaran
- Hatcher Robert
- Hatfield Kaleb
- Hatzikoutelis Athanasios
- Hayes Christopher
- Hazen Eric
- Heavey Anne
- Heeger Karsten
- Heise Jaret
- Hennessy Karol
- Henry Sarah
- Hernandez Morquecho Miguel Angel
- Herner Kenneth
- Hertel Lars
- Hewes Jeremy
- Hewes V.
- Hewes V.
- Higuera Pichardo Aaron
- Hill Tony
- Hillier Stephen
- Himmel Alexander
- Hoff James
- Hohl Christian
- Holin Anna
- Hoppe Eric
- Horton-Smith Glenn
- Hostert Matheus
- Hourlier Adrien
- Howard Bruce
- Howell Ryan
- Huang Junting
- Huang Junying
- Hugon Justin
- Iles Gregory
- Ilic Nikolina
- Iliescu Antoniu
- Illingworth Robert
- Ingratta G.
- Ioannisian Ara
- Isenhower Larry
- Itay Ran
- Izmaylov Alexander
- Jackson Saskia
- Jain Vivek
- James Eric
- Jargowsky Benjamin
- Jediny Filip
- Jena Deepika
- Jeong Yu Seon
- Jesús-Valls César
- Ji Xiangpan
- Jiang Libo
- Jiménez Sergio
- Jipa Alexandru
- Johnson Randy
- Johnston N.
- Jones Benjamin
- Jones Sebastian
- Judah Matthew
- Jung Chang Kee
- Junk Thomas
- Jwa Yeon-jae
- Kabirnezhad Monireh
- Kaboth Asher
- Kadenko I.
- Kakorin Igor
- Kamiya Felipe
- Kaneshige Nathaniel
- Karagiorgi Georgia
- Karaman Gurkan
- Karcher Armin
- Karolak Mark
- Karyotakis Yannis
- Kasai Seiji
- Kasetti Siva
- Kashur Lane
- Kazaryan Narine
- Kearns Edward
- Keener Paul
- Kelly Kevin
- Kemp Ernesto
- Kemularia O.
- Ketchum Wes
- Kettell Steve
- Khabibullin Marat
- Khotjantsev Alexei
- Khvedelidze Arsen
- Kim Doojin
- King Bonnie
- Kirby Brian
- Kirby Mike
- Klein Joshua
- Koehler Kevin
- Koerner Lisa
- Kohn Sam
- Koller Patrick
- Kolupaeva Liudmila
- Kordosky Mike
- Kosc Thomas
- Kose Umut
- Kostelecky V Alan
- Kothekar Kunal
- Krennrich Frank
- Kreslo Igor
- Kudenko Yury
- Kudryavtsev Vitaly A
- Kulagin Sergey
- Kumar Jason
- Kumar Praveen
- Kumar R.
- Kunze Pablo
- Kurita Nadine
- Kuruppu Chatura
- Kus Vaclav
- Kutter Thomas
- Lambert Andrew
- Land Benjamin
- Lande Kenneth
- Lane Charles
- Lang Karol
- Langford Thomas
- Larkin Jacob
- Lasorak Pierre
- Last David
- Lastoria Chiara
- Laundrie Andy
- Laurenti G.
- Lawrence Andrew
- Lazanu Ionel
- LaZur Ryan
- Le Trung
- Leardini Sara
- Learned John
- LeBrun Patrice
- LeCompte Thomas
- Lehmann Miotto Giovanna
- Lehnert Ralf
- Leitner Matthaeus
- Li Lingge
- Li Shirley W
- Li Teng
- Li Yichen
- Liao Heng-Ye
- Lin Cheng-Ju Stephen
- Lin Qing
- Lin Shih-Kai
- Lister Adam
- Littlejohn Bryce
- Liu Junze
- Lockwitz Sarah
- Loew Timothy
- Lokajicek Milos
- Lomidze Irakli
- Long Ken
- Loo Kai
- Lorca David
- Lord Tom
- LoSecco John M
- Louis William
- Lu Xianguo
- Luk Kam-Biu
- Luo Xiao
- Lurkin Nicolas
- Lux Thorsten
- Luzio Vitor
- MacFarlane David
- Machado Ana Amelia
- Machado Pedro
- Macias Christopher Thomas
- Macier Jolie R
- Maddalena Antonello
- Madera Alfonso
- Madigan Peter
- Magill Steve
- Mahn Kendall
- Maio Amélia
- Major Adryanna
- Maloney James
- Mandrioli Gianni
- Mandujano Roberto
- Maneira José
- Manenti Laura
- Manly Steve
- Mann Anthony
- Manolopoulos Konstantinos
- Manrique Plata Maria
- Manyam Venkata
- Manzanillas Luis
- Marchan Miquel
- Marchionni Alberto
- Marciano William
- Marfatia Danny
- Mariani Camillo
- Maricic Jelena
- Marie Rodolphe
- Marinho Franciole
- Marino Alysia
- Marsden David
- Marshak Marvin
- Marshall Chris
- Marshall John
- Marteau Jacques
- Martin-Albo Justo
- Martinez Caicedo David
- Martinez Norman
- Martynenko Sergey
- Mason Katie
- Mastbaum Andrew
- Masud Mehedi
- Matsuno Shigenobu
- Matthews James
- Mauger Christopher
- Mauri Nicoletta
- Mavrokoridis Konstantinos
- Mawby Isobel
- Mazza Roberto
- Mazzacane Anna
- Mazzucato Edoardo
- McAskill Tracy
- McCluskey Elaine
- McConkey Nicola
- McFarland Kevin
- McGrew Clark
- McNab Andrew
- Mefodiev Alexander
- Mehta Poonam
- Melas Pantelis
- Mena Olga
- Menary Scott
- Mendez Hector
- Menegolli A.
- Meng Guang
- Messier Mark
- Metcalf William
- Mettler Thomas
- Mewes Matthew
- Meyer Holger
- Miao Ting
- Michna Gregory
- Miedema Thijs
- Migenda Jost
- Mikola Veera
- Milincic Radovan
- Miller William
- Mills Joshua
- Milne Cody
- Mineev Oleg
- Miranda Omar
- Miryala Sandeep
- Mishra C Shekhar
- Mishra Sanjib R
- Mislivec Aaron
- Mladenov Dimitar
- Mocioiu Irina
- Moffat Kristian
- Moggi Niccolo
- Mohanta Rukmani
- Mohayai Tanaz
- Mokhov Nikolai
- Molina Bueno Laura
- Molina Jorge
- Montagna E.
- Montanari Alessandro
- Montanari Claudio
- Montanari David
- Montano Zetina Luis
- Moon Jarrett
- Mooney Michael
- Moor Alexandra
- Moreno Deywis
- Morris Casandra
- Mossey Chris
- Motuk Erdem
- Moura Célio
- Mousseau Joel
- Mu Wei
- Mualem Leon
- Mueller Justin
- Muether Mathew
- Mufson Stuart
- Muheim Franz
- Muir Alan
- Mulhearn Mike
- Munford Donnie
- Muramatsu Hajime
- Murphy Sebastien
- Musser Jim
- Méndez Diana
- Nachtman Jane
- Nagu Srishti
- Nalbandyan Mikayel
- Nandakumar Raja
- Naples Donna
- Narita Shinya
- Navas-Nicolás Diana
- Navrer-Agasson Anyssa
- Nayak Nitish
- Nebot-Guinot Miquel
- Negishi Kentaro
- Nelson Jeff
- Nesbit Jake
- Nessi Marzio
- Newbold David
- Newcomer Mitch
- Newhart Duane
- Newton Hannah
- Niccolo M.
- Nichol Ryan
- Nicolas-Arnaldos Francisco
- Nicoletta M.
- Niner Evan
- Nishimura Kurtis
- Norman Andrew
- Norrick Anne
- Northrop Rich
- Novella Pau
- Nowak Jaroslaw
- Oberling Michael
- Ochoa-Ricoux Juan Pedro
- Olivares Del Campo Andres
- Olivier Andrew
- Olshevskiy Alexander
- Onel Yasar
- Onishchuk Yuriy
- Ott Jordan
- Pagani Luca
- Pakvasa Sandip
- Palacio Guillermo
- Palamara Ornella
- Palestini Sandro
- Paley Jonathan
- Pallavicini Marco
- Palomares Carmen
- Palomino-Gallo Jose
- Pantic Emilija
- Paolone Vittorio
- Papadimitriou Vaia
- Papaleo Riccardo
- Papanestis Antonis
- Paramesvaran Sudarshan
- Parke Stephen
- Parsa Zohreh
- Parvu Mihaela
- Pascoli Silvia
- Pasqualini Laura
- Pasternak Jaroslaw
- Pater Joleen
- Patrick Cheryl
- Patrizii Laura
- Patterson Ryan
- Patton Simon John
- Patzak Thomas
- Paudel Ajib
- Paulos Bob
- Paulucci Laura
- Pavlovic Zarko
- Pawloski Greg
- Payne David
- Pec Viktor
- Peeters S.J. M.
- Pennacchio Elisabetta
- Penzo Aldo
- Peres Orlando
- Perry James
- Pershey Daniel
- Pessina Gianluigi
- Petrillo Gianluca
- Petta Catia
- Petti Roberto
- Piastra Francesco
- Pickering Luke
- Pietropaolo Francesco
- Plunkett Robert
- Poling Ronald
- Pons Xavier
- Poonthottathil Navaneeth
- Poppi F.
- Pordes Stephen
- Porter Joshua
- Potekhin Maxim
- Potenza Renato
- Potukuchi B.V. K.S.
- Pozimski Juergen
- Pozzato Michele
- Prakash Suprabh
- Prakash Tarun
- Prince Sebastien
- Pugnere Denis
- Qian Xin
- Queiroga Bazetto Maria Cecilia
- Raaf Jennifer L
- Radeka Veljko
- Rademacker Jonas
- Radics Balint
- Rafique Aleena
- Raguzin Eric
- Rai Mousam
- Rajaoalisoa Miriama
- Rakhno Igor
- Rakotonandrasana Andrianjafy Michaël
- Rakotondravohitra Laza
- Ramachers Yorck A
- Rameika Regina
- Ramirez Delgado Manuel Alejandro
- Ramson Bryan
- Rappoldi A.
- Raselli GL
- Ratoff Peter
- Raut Sanil
- Razakamiandra Rado Fanantenana
- Real Jean-Sebastien
- Rebel Brian
- Reggiani-Guzzo Marina
- Rehak Tyler
- Reichenbacher Juergen
- Reitzner S.D.
- Rejeb Sfar Haifa
- Renshaw Andrew
- Rescia Sergio
- Resnati Filippo
- Reynolds Aidan
- Riccio Ciro
- Riccobene Giorgio
- Rice L.C. J.
- Ricol Jean-Stephane
- Rigamonti Alberto
- Rigaut Yann-Axel
- Rivera David
- Rochester Leon
- Roda Marco
- Rodrigues Philip
- Rodriguez Alonso Manuel
- Rodriguez Bonilla Engelver
- Rodriguez Rondon Jairo
- Rosauro-Alcaraz Salvador
- Rosenberg Matt
- Rosier Philippe
- Roskovec Bedrich
- Rossella Massimo
- Rout Jogesh
- Roy Palash
- Roy Samiran
- Rubbia Andre
- Rubbia Carlo
- Rubio Francisco
- Russell Brooke
- Ruterbories Daniel
- Saakyan Ruben
- Sacerdoti Sabrina
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- Sahay Rahul
- Sahu Narendra
- Sala Paola
- Samios Nicholas
- Samoylov Oleg
- Sanchez Mayly
- Sanders David
- Sankey David
- Santana Samuel
- Santos-Maldonado Marvin
- Saoulidou Niki
- Sapienza Piera
- Sarasty Carlos
- Sarcevic Ina
- Savage Geoffrey
- Savinov Vladimir
- Scaramelli Alberto
- Scarff Andrew
- Scarpelli Andrea
- Schaffer Tom
- Schellman Heidi
- Schlabach Philip
- Schmitz David
- Scholberg Kate
- Schukraft Anne
- Segreto Ettore
- Sensenig Jon
- Seong Ilsoo
- Sergi Antonino
- Sgalaberna Davide
- Shaevitz Michael H
- Shafaq Sheeba
- Shamma Michael
- Sharankova Ralitsa
- Sharma Hans
- Sharma Rahul
- Sharma Rajeev
- Shaw Terri
- Shepherd-Themistocleous Claire
- Shin Seodong
- Shooltz Dean
- Shrock Robert
- Simard Laurent
- Simon F.
- Simos Nikolaos
- Sinclair James
- Sinev Gleb
- Singh Jaydip
- Singh Jyotsna
- Singh Venktesh
- Sipos Roland
- Sippach F.W.
- Sirri Gabriele
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- Siyeon Kim
- Skarpaas VIII Knut
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- Smolik Jan
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- Snopok Pavel
- Soares Nunes Mônica
- Sobel Henry
- Soderberg Mitch
- Solano Salinas Carlos
- Soleti S.
- Solomey Nicholas
- Solovov Vladimir
- Sondheim Walter
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- Soto-Oton Jose
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- Soustruznik Karel
- Spagliardi Fabio
- Spanu Maura
- Spitz Joshua
- Spooner N.J. C.
- Spurgeon Kyle
- Staley Richard
- Stancari Michelle
- Stanco Luca
- Stanley Rose
- Stein Raul
- Steiner Herbert M
- Stewart James
- Stillwell Ben
- Stock Jason
- Stocker Francesca
- Stokes Tyler
- Strait Matthew
- Strauss Thomas
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- Tariq Salman
- Tatar E.
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- Teklu Abraham Meles
- Tenti Matteo
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- Testera Gemma
- Thea Alessandro
- Thompson Joshua
- Thorn Craig
- Timm Steven C
- Todd Jacob
- Tonazzo Alessandra
- Torbunov Dmitri
- Torti Marta
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- Tortorici Francesco
- Tosi N.
- Totani Dante
- Toups Matthew
- Touramanis Christos
- Travaglini R.
- Trevor Jason
- Trilov Stoyan
- Trzaska Wladyslaw
- Tsai Yun-Tse
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- Tull Craig
- Tyley E.
- Tzanov Martin
- Uchida Melissa
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- Usher Tracy
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- Vahle Patricia
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- Valencia Edgar
- Valerio P.
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- Valle J.W. F.
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- Van de Water Richard
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- Vilela Cristovao
- Viren Brett
- Vrba Tomas
- Wachala Tomasz
- Waldron Abigail
- Wallbank Michael
- Wang Hanguo
- Wang Jingbo
- Wang L.
- Wang M.H. L.S.
- Wang Yi
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- Warburton Karl
- Warner David
- Wascko Morgan
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- Watson Alan
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- Worcester Elizabeth
- Worcester Matthew
- Wret Clarence
- Wu Wanwei
- Wu Wenjie
- Xiao Yiwen
- Yandel Erin
- Yang Guang
- Yang Kang
- Yang Shaokai
- Yang Tingjun
- Yankelevich Alejandro
- Yershov Nikolai
- Yonehara Katsuya
- Young Tim
- Yu Bo
- Yu Haiwang
- Yu Jae
- Yuan Wenlong
- Zaki Rowan
- Zalesak Jaroslav
- Zambelli Laura
- Zamorano Bruno
- Zani Andrea
- Zazueta Luis
- Zeit Grace
- Zeller G.P.
- Zeller Geralyn
- Zennamo Joseph
- Zeug Kyle
- Zhang Chao
- Zhao Manhong
- Zhivun Elena
- Zhu Guanying
- Zilberman Perri
- Zimmerman Eric
- Zito Marco
- Zucchelli Stefano
- Zuklin Josef
- Zutshi Vishnu
- Zwaska Robert
- Publication venue
- 'MDPI AG'
- Publication date
- 01/01/2021
- Field of study
International audienceThe Deep Underground Neutrino Experiment (DUNE) is an international, world-class experiment aimed at exploring fundamental questions about the universe that are at the forefront of astrophysics and particle physics research. DUNE will study questions pertaining to the preponderance of matter over antimatter in the early universe, the dynamics of supernovae, the subtleties of neutrino interaction physics, and a number of beyond the Standard Model topics accessible in a powerful neutrino beam. A critical component of the DUNE physics program involves the study of changes in a powerful beam of neutrinos, i.e., neutrino oscillations, as the neutrinos propagate a long distance. The experiment consists of a near detector, sited close to the source of the beam, and a far detector, sited along the beam at a large distance. This document, the DUNE Near Detector Conceptual Design Report (CDR), describes the design of the DUNE near detector and the science program that drives the design and technology choices. The goals and requirements underlying the design, along with projected performance are given. It serves as a starting point for a more detailed design that will be described in future documents
Separation of track- and shower-like energy deposits in ProtoDUNE-SP using a convolutional neural network
- Author
- Abed Abud Adam
- Abi Babak
- Acciarri Roberto
- Acero Mario
- Adames Marcio
- Adamov George
- Adamowski Mark
- Adams David
- Adinolfi Marco
- Aduszkiewicz Antoni
- Aguilar Jessica
- Ahmad Zubayer
- Ahmed Jhanzeb
- Aimard Benjamin
- Ali-Mohammadzadeh Behnam
- Alion Tyler
- Allison Kyle
- Alonso Monsalve Saul
- Alrashed Munera
- Alt Christoph
- Alton Andrew
- Alvarez Rodrigo
- Amedo Pablo
- Anderson John
- Andreopoulos Costas
- Andreotti Mirco
- Andrews Michael P.
- Andrianala Fenompanirina
- Andringa Sofia
- Anfimov Nikolay
- Ankowski Artur
- Antoniassi Marcelo
- Antonova Maria
- Antoshkin Alexander
- Antusch Stefan
- Aranda-Fernandez Alfredo
- Arellano Luciano
- Arnold Lukas
- Arroyave Manuel
- Asaadi Jonathan
- Asquith Lily
- Aurisano Adam
- Aushev Vladimir
- Autiero Dario
- Ayala Lara Victor
- Ayala-Torres Marco Alberto
- Azfar Farrukh
- Babicz Marta
- Back Ashley
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- Backhouse Chris
- Bagaturia Iuri
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- Balashov Nikita
- Balasubramanian Supraja
- Baldi Pierre
- Baller Bruce
- Bambah Bindu
- Barao Fernando
- Barenboim Gabriela
- Barker Gary J.
- Barkhouse Wayne
- Barnes Christopher
- Barr Giles
- Barranco Monarca Juan
- Barros Adilson
- Barros Nuno
- Barrow Joshua
- Basharina-Freshville Anastasia
- Bashyal Amit
- Basque Vincent
- Batchelor Charlie
- Batista das Chagas Ewerton
- Battat James
- Battisti Federico
- Bay Fatih
- Bazetto Maria Cecilia
- Bazo Alba José Luis
- Beacom John
- Bechetoille Edouard
- Behera Biswaranjan
- Beigbeder Christophe
- Bellantoni Leo
- Bellettini Giorgio
- Bellini Vincenzo
- Beltramello Olga
- Benekos Nektarios
- Benitez Montiel Carlos
- Bento Neves Francisco
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- Berkman Sophie
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- Blaszczyk Flor de Maria
- Blazey Gerald C.
- Blucher Edward
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- Bolton Timothy
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- Cervelli Alberto
- Cervera Villanueva Anselmo
- Chalifour Michel
- Chappell Andrew
- Chardonnet Etienne
- Charitonidis Nikolas
- Chatterjee Animesh
- Chattopadhyay Subhasish
- Chavarry Neyra Michael Steve
- Chen Hucheng
- Chen Mu-Chun
- Chen Yifan
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- Cheon Yoolim
- Cherdack Daniel
- Chi Cheng-Yi
- Childress Sam
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- Colton Nicole
- Conley Erin
- Conley Robert
- Conrad Janet M.
- Convery Mark
- Copello Simone
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- da Motta Helio
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- de Bonis Isabelle
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- de Holanda Pedro
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- de Lurgio Patrick
- de Mello Neto Joao
- de Roeck Albert
- de Romeri Valentina
- de Souza Greg
- De Kaushik
- De Shruti
- Debbins Paul
- Decowski M. Patrick
- Deisting Alexander
- Delbart Alain
- Delepine David
- Delgado Maritza
- Dell'Acqua Andrea
- Delmonte Nicola
- Demuth David
- Dennis Steve
- Densham Chris
- Deptuch Grzegorz
- Devi Ritu
- Dharmapalan Ranjan
- Di Domizio Sergio
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- Di Noto Lea
- Dias Marco
- Diaz Felix
- Diaz Jorge S.
- Ding Pengfei
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- Diurba Richard
- Diwan Milind
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- Doering Dionisio
- Dolan Stephen
- Dolek Furkan
- Dolinski Michelle J.
- Domine Laura
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- Drielsma Francois
- Duarte Laura Cristina
- Duchesneau Dominique
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- Dvornikov Olexiy
- Dwyer Daniel A.
- Dyshkant Alexandre S.
- Eads Michael
- Earle Antony
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- Filthaut Frank
- Fiorini Massimiliano
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- Fogarty Sam
- Foreman Will
- Fowler Jack
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- Gallagher Hugh
- Gallas Alexandre
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- Gardiner Steven
- Gastler Dan
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- Ge Guanqun
- Geffroy Nicolas
- Gelli Bruno
- Gendotti Adamo
- Gent Stephen
- Ghorbani-Moghaddam Zahra
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- Gomez Fajardo L.S.
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- Hostert Matheus
- Hourlier Adrien
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- Huang Junying
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- Isenhower Larry
- Itay Ran
- Jackson Christopher
- Jain Vivek
- James Eric
- Jang Wooyoung
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- Jediny Filip
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- Ji Xiangpan
- Jiang Libo
- Jiménez Sergio
- Jipa Alexandru
- Johnson Randy
- Johnson Walker
- Johnston Nicholas
- Jones Benjamin
- Jones Sebastian
- Judah Matthew
- Jung Chang Kee
- Junk Thomas
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- Kaboth Asher
- Kadenko I.
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- Kalitkina Anastasia
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- Kaneshige Nathaniel
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- Karagiorgi Georgia
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- Karcher Armin
- Karolak Mark
- Karyotakis Yannis
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- Kashur Lane
- Kazaryan Narine
- Kearns Edward
- Keener Paul
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- Kobilarcik Thomas
- Koehler Kevin
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- Kohn Sam
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- Kostelecky V. Alan
- Kothekar Kunal
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- Kreslo Igor
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- Kulagin Sergey
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- Lang Karol
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- Laurenti Giuliano
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- Solomey Nicholas
- Solovov Vladimir
- Sondheim Walter
- Sorel Michel
- Sotnikov Albert
- Soto Ugaldi Fidel Antonio
- Soto-Oton Jose
- Sousa Alexandre
- Soustruznik Karel
- Spagliardi Fabio
- Spanu Maura
- Spitz Joshua
- Spooner N.J. C.
- Spurgeon Kyle
- Stancari Michelle
- Stanco Luca
- Stanford Chris
- Stefan Dorota
- Stein Raul
- Steiner Herbert M.
- Steklain Lisbôa André
- Stewart James
- Stillwell Ben
- Stock Jason
- Stocker Francesca
- Stokes Tyler
- Strait Matthew
- Strauss Thomas
- Strigari Louis
- Stuart Alexander
- Suarez Juan
- Sulej Robert
- Sullivan Hunter
- Summers Don
- Surdo Antonio
- Susic Vasja
- Suter Louise
- Sutera Concetta Maria
- Suárez Sunción Juan Martín
- Svoboda Robert
- Szczerbinska Barbara
- Szelc Andrzej
- Söldner-Rembold Stefan
- Tanaka Hirohisa
- Tang Shaochun
- Tapia Oregui Beatriz
- Tapia Alex
- Tapper Alexander
- Tariq Salman
- Tarpara Eaglekumar
- Tata Neeraj
- Tatar E.
- Tayloe Rex
- Teklu Abraham Meles
- Tennessen Peter
- Tenti Matteo
- Terao Kazuhiro
- Ternes Christoph
- Terranova Francesco
- Testera Gemma
- Thakore Tarak
- Thea Alessandro
- Thompson Joshua
- Thorn Craig
- Timm Steven C.
- Tishchenko Vladimir
- Tomassetti Luca
- Tonazzo Alessandra
- Torbunov Dmitri
- Torti Marta
- Tortola Mariam
- Tortorici Francesco
- Tosi Nicolo
- Totani Dante
- Toups Matthew
- Touramanis Christos
- Travaglini Riccardo
- Trevor Jason
- Trilov Stoyan
- Trzaska Wladyslaw
- Tsai Yu-Dai
- Tsai Yun-Tse
- Tsamalaidze Zviadi
- Tsang Ka Vang
- Tsverava Nikolozi
- Tufanli Serhan
- Tull Craig
- Tyley E.
- Tzanov Martin
- Uboldi Lorenzo
- Uchida Melissa
- Urheim Jon
- Usher Tracy
- Uzunyan Sergey
- Vagins Mark
- Vahle Patricia
- Valder Sammy
- Valdiviesso Gustavo
- Valencia Edgar
- Valentim Rodolfo
- Vallari Zoya
- Vallazza Erik
- Valle Jose
- Vallecorsa Sofia
- van Berg Rick
- van de Water Richard
- Vanegas Forero David
- Vannerom David
- Varanini Filippo
- Vargas Danaisis
- Varner Gary
- Vasel Justin
- Vasina Svetlana
- Vasseur Georges
- Vaughan Noah
- Vaziri Kamran
- Ventura Sandro
- Verdugo Antonio
- Vergani Stefano
- Vermeulen Milo
- Verzocchi Marco
- Vicenzi Matteo
- Vieira de Souza Henrique
- Vignoli Chiara
- Vilela Cristovao
- Viren Brett
- Vrba Tomas
- Wachala Tomasz
- Waldron Abigail
- Wallbank Michael
- Wallis Connor
- Wang Hanguo
- Wang Jingbo
- Wang Li
- Wang Michael
- Wang Xiaoran
- Wang Yi
- Wang Yue
- Warburton Karl
- Warner David
- Wascko Morgan
- Waters David
- Watson Alan
- Wawrowska Klaudia
- Weatherly Pierce
- Weber Alfons
- Weber Michele
- Wei Hanyu
- Weinstein Amanda
- Wenman Dan
- Wetstein Matthew
- White Andy
- Whitehead Leigh
- Whittington Denver
- Wilking Michael
- Wilkinson Alexander
- Wilkinson Callum
- Williams Zachary
- Wilson Fergus
- Wilson Robert
- Wisniewski William
- Wolcott Jeremy
- Wongjirad Taritree
- Wood Anthony
- Wood Kevin
- Worcester Elizabeth
- Worcester Matthew
- Wresilo Karolina
- Wret Clarence
- Wu Wanwei
- Wu Wenjie
- Xiao Yiwen
- Xie Fang
- Yaeggy Barbara
- Yandel Erin
- Yang Guang
- Yang Kang
- Yang Tingjun
- Yankelevich Alejandro
- Yershov Nikolai
- Yonehara Katsuya
- Yoon Young Soo
- Young Tim
- Yu Bo
- Yu Haiwang
- Yu Hongzhao
- Yu Jae
- Yu Yiding
- Yuan Wenlong
- Zaki Rowan
- Zalesak Jaroslav
- Zambelli Laura
- Zamorano Bruno
- Zani Andrea
- Zazueta Luis
- Zeller Geralyn
- Zennamo Joseph
- Zeug Kyle
- Zhang Chao
- Zhang Shuaixiang
- Zhang Yuze
- Zhao Manhong
- Zhivun Elena
- Zhu Guanying
- Zimmerman Eric
- Zucchelli Stefano
- Zuklin Josef
- Zutshi Vishnu
- Zwaska Robert
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
International audienceLiquid argon time projection chamber detector technology provides high spatial and calorimetric resolutions on the charged particles traversing liquid argon. As a result, the technology has been used in a number of recent neutrino experiments, and is the technology of choice for the Deep Underground Neutrino Experiment (DUNE). In order to perform high precision measurements of neutrinos in the detector, final state particles need to be effectively identified, and their energy accurately reconstructed. This article proposes an algorithm based on a convolutional neural network to perform the classification of energy deposits and reconstructed particles as track-like or arising from electromagnetic cascades. Results from testing the algorithm on experimental data from ProtoDUNE-SP, a prototype of the DUNE far detector, are presented. The network identifies track- and shower-like particles, as well as Michel electrons, with high efficiency. The performance of the algorithm is consistent between experimental data and simulation