Analysis of associations of polymorphic loci of the LOXL1 gene with the development of primary open-angle glaucoma in women of the Central Chernozem region of Russia

A replicative study of associations of the LOXL1 gene polymorphism with primary open-angle glaucoma (POAG) in the female population of the Central Chernozem region of Russia was performed. The work was done in the design "patients-control". The study sample consisted of 290 women with POAG and 220 women in the control grou

Statistics of Neutron Stars at the Stage of Supersonic Propeller

We analyze the statistical distribution of neutron stars at the stage of a supersonic propeller. An important point of our analysis is allowance for the evolution of the angle of inclination of the magnetic axis to the spin axis of the neutron star for the boundary of the transition to the supersonic propeller stage for two models: the model with hindered particle escape from the stellar surface and the model with free particle escape. As a result, we have shown that a consistent allowance for the evolution of the inclination angle in the region of extinct radio pulsars for the two models leads to an increase in the total number of neutron stars at the supersonic propeller stage. This increase stems from he fact that when allowing for the evolution of the inclination angle $\chi$ for neutron stars in the region of extinct radio pulsars and, hence, for the boundary of the transition to the propeller stage, this transition is possible at shorter spin periods (P~5-10 s) than assumed in the standard model.Comment: 15 pages, 6 figures; scale corrected for figures 3-

LOXL1 gene polymorphism candidates for exfoliation glaucoma are also associated with a risk for primary open-angle glaucoma in a Caucasian population from central Russia

This study was aimed to replicate the previously reported associations of the three LOXL1 gene polymorphisms with exfoliation glaucoma (XFG) and to analyze these genetic variants for their possible contribution to primary open-angle glaucoma (POAG) in Caucasians from central Russi

The haplotype of the CDKN2B-AS1 gene is associated with primary open-angle glaucoma and pseudoexfoliation glaucoma in the Caucasian population of Central Russia

To replicate the finding of the association of five CDKN2B-AS1 gene polymorphisms (rs7865618,rs1063192, rs944800, rs2157719, and rs4977756) with primary open-angle glaucoma (POAG) and to analyze them for possible association with pseudoexfoliation glaucoma (PXFG) in a Caucasian population of Central Russi

Dataset of allele, genotype and haplotype frequencies of five polymorphisms CDKN2B-AS1 gene in Russian patients with primary open-angle glaucoma

Data on the allele, genotype and haplotype frequencies of the five single nucleotide polymorphisms (SNPs) such as rs1063192, rs7865618, rs2157719, rs944800 and rs4977756 of the CDKN2B-AS gene in Russian patients with primary open-angle glaucoma (POAG) are provide

EQCM study of redox properties of PEDOT/MnO2 composite films in aqueous electrolytes

Electrochemical behavior of poly-3,4-ethylenedioxythiophene composites with manganese dioxide (PEDOT/MnO2) has been investigated by cyclic voltammetry and electrochemical quartz crystal microbalance at various component ratios and in different electrolyte solutions. The electrochemical formation of PEDOT film on the electrode surface and PEDOT/MnO2 composite film during the electrochemical deposition of manganese dioxide into the polymer matrix was gravimetrically monitored. The mass of manganese dioxide deposited into PEDOT at different time of electrodeposition and apparent molar mass values of species involved into mass transfer during redox cycling of PEDOT/MnO2 composites were evaluated. It was found that during the redox cycling of PEDOT/MnO2 composite films with various MnO2 content, the oppositely directed fluxes of counterions (anions and cations) occur, resulting in a change of the slope of linear parts of the Delta f-E plots with changing the mass fraction of MnO2 in the composite film. Rectangular shape of cyclic voltammograms of PEDOT/MnO2 composites with different loadings of manganese dioxide was observed, which is characteristic of the pseudocapacitive behavior of the composite material. Specific capacity values of PEDOT/MnO2 composites obtained from cyclic voltammograms were about 169 F g(-1). The specific capacity, related to the contribution of manganese dioxide component, was about 240 F g(-1)

Терапия неоваскулярной глаукомы

Neovascular glaucoma is a severe pathology of the eye, which is difficult to treat. It is characterized by rapid progression, high intraocular pressure (IOP) level, severe pain and an acute decrease in visual acuity. Its most common causes include diabetic retinopathy and ischemic central retinal vein occlusion. The endothelial vascular cells respond to a specific stimulus (tissular hypoxia) and secrete proangiogenic factors. The most significant is VEGF. The resulting imbalance between pro- and antiangiogenic factors produces neovascularization of the eye tissues. Panretinal photocoagulation and anti-VEGF therapy are used to reduce iris neovascularization and reduce the complications of surgical treatment. Currently, surgical methods such as trabeculectomy and tubular drainage implantation are used to treat neovascular glaucoma. An alternative to surgical interventions is presented by cyclodestructive procedures. Transscleral diode-laser micropulse cyclophotocoagulation is the latest technology, characterized by the absence of a pronounced damaging effect on tissues and a small number of complications.Неоваскулярная глаукома является тяжелой патологией органа зрения, которая трудно поддается медикаментозному и хирургическому лечению. Данная форма глаукомы характеризуется быстрым прогрессированием, высоким уровнем внутриглазного давления, выраженным болевым синдромом и снижением зрительных функций вплоть до полной их утраты. Наиболее частыми состояниями, при которых развивается неоваскулярная глаукома, являются диабетическая ретинопатия и тромбоз центральной вены сетчатки. Эндотелиальные клетки сосудов в ответ на специфический стимул в виде гипоксии вырабатывают проангиогенные факторы, наиболее значимым из которых является VEGF. Возникающий дисбаланс между про- и антиангиогенными факторами провоцирует развитие неоваскуляризации структур глаза. С целью уменьшения неоваскуляризации и снижения осложнений хирургического лечения применяются панретинальная лазеркоагуляция и введение анти-VEGF препаратов. В настоящее время для лечения неоваскулярной глаукомы применяются такие хирургические методы, как трабекулэктомия и имплантация трубчатых дренажей. Альтернативой хирургическим вмешательствам являются циклодеструктивные вмешательства. Новой технологией, характеризующейся отсутствием выраженного повреждающего действия на ткани и малым количеством осложнений, является транссклеральная циклофотокоагуляция в микроимпульсном режиме с использованием диодного лазера

Cyanomethylene-bis(phosphonate)-Based Lanthanide Complexes: Structural, Photophysical, and Magnetic Investigations

10 pagesInternational audienceThe syntheses, structural investigations, magnetic and photophysical properties of a series of 10 lanthanide mononuclear complexes, containing the heteroditopic ligand cyanomethylene-bis(5,5-dimethyl-2-oxo-1,3,2λ5-dioxa-phosphorinane) (L), are described. The crystallographic analyses indicate two structural types: in the first one, [LnIII(L)3(H2O)2]*H2O (Ln = La, Pr, Nd), the metal ions are eight-coordinated within a square antiprism geometry, while the second one, [LnIII(L)3(H2O)]*8H2O (Ln = Sm, Eu, Gd, Tb, Dy, Ho, Er), contains seven-coordinated LnIII ions within distorted monocapped trigonal prisms...

Severe inflammatory reaction induced by peritoneal trauma is the key driving mechanism of postoperative adhesion formation

<p>Abstract</p> <p>Background</p> <p>Many factors have been put forward as a driving mechanism of surgery-triggered adhesion formation (AF). In this study, we underline the key role of specific surgical trauma related with open surgery (OS) and laparoscopic (LS) conditions in postoperative AF and we aimed to study peritoneal tissue inflammatory reaction (TIR), remodelling specific complications of open surgery (OS) versus LS and subsequently evaluating AF induced by these conditions.</p> <p>Methods</p> <p>A prospective randomized study was done in 80 anaesthetised female Wistar rats divided equally into 2 groups. Specific traumatic OS conditions were induced by midline incision line (MIL) extension and tissue drying and specific LS conditions were remodelled by intraperitoneal CO₂insufflation at the 10 cm of water. TIR was evaluated at the 24^th, 72^nd, 120^thand 168^thhour by scoring scale. Statistical analysis was performed by the non-parametric t test and two-way ANOVA using Bonferroni post-tests.</p> <p>Results</p> <p>More pronounced residual TIR was registered after OS than after LS. There were no significant TIR interactions though highly significant differences were observed between the OS and LS groups (p < 0.0001) with regard to surgical and time factors. The TIR change differences between the OS and LS groups were pronounced with postoperative time p < 0.05 at the 24^thand 72^nd; p < 0.01 - 120^thand p < 0.001 - 168^thhrs. Adhesion free wounds were observed in 20.0 and 31.0% of cases after creation of OS and LS conditions respectively; with no significant differences between these values (p > 0.05). However larger adhesion size (41.67 ± 33.63) was observed after OS in comparison with LS (20.31 ± 16.38). The upper-lower 95% confidential limits ranged from 60.29 to 23.04 and from 29.04 to 11.59 respectively after OS and LS groups with significant differences (p = 0.03). Analogous changes were observed in adhesion severity values. Subsequently, severe TIR parameters were followed by larger sizes of severe postoperative adhesions in the OS group than those observed in the LS group.</p> <p>Conclusions</p> <p>MIL extension and tissue drying seem to be the key factors in the pathogenesis of adhesion formation, triggering severe inflammatory reactions of the peritoneal tissue surrounding the MIL resulting in local and systemic consequences. CO₂insufflation however, led to moderate inflammation and less adhesion formation.</p