Patent thickets, licensing and innovative performance

We examine the relationship between fragmented intellectual property (IP) rights and the innovative performance of firms, taking into consideration the role played by in-licensing of IP. We find that firms facing more fragmented IP landscapes have a higher probability of in-licensing. We observe a negative relationship between IP fragmentation and innovative performance, but only for firms that engage in in-licensing. In contrast, greater IP fragmentation is associated with higher innovative performance for firms that do not in-license. Furthermore, the effects of fragmentation on innovation also appear to depend on the size of a firm's patent portfolio. These results suggest that the effects of fragmentation of upstream IP rights are not uniform, and instead vary according to the characteristics of the downstream firm. Copyright 2010 The Author 2010. Published by Oxford University Press on behalf of Associazione ICC. All rights reserved., Oxford University Press.

Performance-Enhancing Asymmetric Separator for Lithium–Sulfur Batteries

Asymmetric separators with polysulfide barrier properties consisting of porous polypropylene grafted with styrenesulfonate (PP<i>-<i>g</i>-</i>PLiSS) were characterized in lithium–sulfur cells to assess their practical applicability. Galvanostatic cycling at different C-rates with and without an electrolyte additive and cyclic voltammetry were used to probe the electrochemical performance of the cells with the PP<i>-<i>g</i>-</i>PLiSS separators and to compare it with the performance of the cells utilizing state-of-the-art separator, Celgard 2400. Overall, it was found that regardless of the applied cycling rate, the use of the grafted separators greatly enhances the Coulombic efficiency of the cell. An appropriate Li-exchange-site (−SO₃^–) concentration at and near the surface of the separator was found to be essential to effectively suppress the polysulfide shuttle without sacrificing the Li-ion mobility through the separator and to improve the practical specific charge of the cell

Radiochemical Determination of Long-Lived Radionuclides in Proton-Irradiated Heavy-Metal Targets: Part ITantalum

In this study, distillation, precipitation, and ion-exchange methods were chosen for the separation of the long-lived β-emitters ¹²⁹I, ³⁶Cl and the α-emitters ¹⁵⁴Dy, ¹⁴⁸Gd, ¹⁵⁰Gd, and ¹⁴⁶Sm from Ta targets irradiated with protons up to 2.6 GeV to determine their production cross sections. Measurements of ¹²⁹I/¹²⁷I and ³⁶Cl/³⁵Cl ratios were performed with accelerator mass spectrometry. After separation of the lanthanides, the molecular plating technique was applied to prepare thin samples to obtain highly resolved α-spectra. Autoradiography and focused ion beam/scanning electron microscopy techniques were used to characterize the lanthanide deposited layer. Experimental cross-section data are compared with theoretical predictions obtained with INCL++ and ABLA07 code, and a satisfactory agreement is observed

The CLIMTREE Project: Ecological and socioeconomic impacts of climate-induced tree diebacks in highland forests

International audienc

The Extent of Platinum-Induced Hydrogen Spillover on Cerium Dioxide

Hydrogen spillover from metal nanoparticles to oxides is an essential process in hydrogenation catalysis and other applications such as hydrogen storage. It is important to understand how far this process is reaching over the surface of the oxide. Here, we present a combination of advanced sample fabrication of a model system and in situ X-ray photoelectron spectroscopy to disentangle local and far-reaching effects of hydrogen spillover in a platinum–ceria catalyst. At low temperatures (25–100 °C and 1 mbar H2) surface O–H formed by hydrogen spillover on the whole ceria surface extending microns away from the platinum, leading to a reduction of Ce4+ to Ce3+. This process and structures were strongly temperature dependent. At temperatures above 150 °C (at 1 mbar H2), O–H partially disappeared from the surface due to its decreasing thermodynamic stability. This resulted in a ceria reoxidation. Higher hydrogen pressures are likely to shift these transition temperatures upward due to the increasing chemical potential. The findings reveal that on a catalyst containing a structure capable to promote spillover, hydrogen can affect the whole catalyst surface and be involved in catalysis and restructuring

Biochemical and Biophysical Analysis of a Chiral PqsD Inhibitor Revealing Tight-binding Behavior and Enantiomers with Contrary Thermodynamic Signatures

Antivirulence strategies addressing bacterial pathogenicity without exhibiting growth inhibition effects represent a novel approach to overcome today’s crisis in antibiotic development. In recent studies, we examined various inhibitors of PqsD, an enzyme involved in formation of <i>Pseudomonas aeruginosa</i> cell-to-cell signaling molecules, and observed desired cellular effects for 2-nitrophenyl derivatives. Herein, we investigated the binding characteristics of this interesting compound class using several biochemical and biophysical methods. The inhibitors showed time-dependent activity, tight-binding behavior, and interactions with the catalytic center. Furthermore, isothermal titration calorimetry (ITC) experiments with separated enantiomers revealed contrary thermodynamic signatures showing either enthalpy- or entropy-driven affinity. A combination of site-directed mutagenesis and thermodynamic profiling was used to identify key residues involved in inhibitor binding. This information allowed the proposal of experimentally confirmed docking poses. Although originally designed as transition state analogs, our results suggest an altered position for both enantiomers. Interestingly, the main difference between stereoisomers was found in the orientation of the hydroxyl group at the stereogenic center. The predicted binding modes are in accordance with experimental data and, thus, allow future structure-guided optimization

Structure Optimization of 2‑Benzamidobenzoic Acids as PqsD Inhibitors for Pseudomonas aeruginosa Infections and Elucidation of Binding Mode by SPR, STD NMR, and Molecular Docking

Pseudomonas aeruginosa employs a characteristic <i>pqs</i> quorum sensing (QS) system that functions via the signal molecules PQS and its precursor HHQ. They control the production of a number of virulence factors and biofilm formation. Recently, we have shown that sulfonamide substituted 2-benzamidobenzoic acids, which are known FabH inhibitors, are also able to inhibit PqsD, the enzyme catalyzing the last and key step in the biosynthesis of HHQ. Here, we describe the further optimization and characterization of this class of compounds as PqsD inhibitors. Structural modifications showed that both the carboxylic acid <i>ortho</i> to the amide and 3′-sulfonamide are essential for binding. Introduction of substituents in the anthranilic part of the molecule resulted in compounds with IC₅₀ values in the low micromolar range. Binding mode investigations by SPR with wild-type and mutated PqsD revealed that this compound class does not bind into the active center of PqsD but in the ACoA channel, preventing the substrate from accessing the active site. This binding mode was further confirmed by docking studies and STD NMR

Poly(Methyl Vinyl Ketone) as a Potential Carbon Fiber Precursor

Given their increasing importance in a variety of applications, the preparation of carbon fibers with well-defined chemical structures and innocuous byproducts has garnered a growing interest over the past decade. We report the preparation of medium molecular weight poly­(methyl vinyl ketone) (PMVK) as a potential carbon fiber precursor material which can easily undergo carbonization via the well-known, acid-catalyzed aldol condensation with water as a sole byproduct. Rheological studies further show that PMVK (MW ∼ 50 kg/mol) exhibits excellent physical and thermal properties for the spinning of single and multifilament fibers and easily produces carbon yields of 25% at temperatures as low as 250 °C. Analysis of the carbonized product also suggests a more defect-free structure than commercially available carbon fibers