NAFLD and cognitive decline in older adults: a longitudinal cohort study

Nonalcoholic Fatty Liver Disease (NAFLD) is increasing in older adults, but no evidence exists on the longitudinal association between NAFLD and cognitive decline at old ages. The aim of this 7-year longitudinal study was to examine whether presence of NAFLD at baseline and/or its change (i.e. progression or regression) over the follow up predict the rate of cognitive decline over the same timeframe in older adults, independent of potential confounders. Participants included 457 community dwelling men and women aged 65 to 87 (mean ±SD: 70.9±4.1) years old, living near Bologna (Northern Italy). Global cognitive status was evaluated using Mini-mental State Examination (MMSE). Hepatic steatosis was assessed by abdominal ultrasound and categorized as absent, mild, moderate or severe. Participants were also classified into three subgroups according to their progression, stability or regression in hepatic steatosis over the follow up. Generalized estimating equation (GEE) models with 30 minus MMSE total score as the dependent variable with a Poisson distribution were used to test the longitudinal associations. Covariates included demographics, education, activities of daily living, alcohol, smoke, body mass index (BMI), waist circumference, hypertension, dyslipidemia, diabetes, insulin resistance and inflammation. As results, I found no significant association between baseline presence/severity of hepatic steatosis and either cross-sectional cognitive status or longitudinal rate of cognitive decline (P> .05). In addition, participants who underwent regression in the degree of hepatic steatosis over the follow-up presented accelerate cognitive decline over the same timeframe compared to the rest of the population, independent of covariates and even after adjusting for longitudinal change in BMI and waist circumference (P= .03). A nested sensitivity analysis confirmed this trend even when including only participants starting from moderate-severe hepatic steatosis at baseline. In conclusion, the present study suggests that in older adults NAFLD regression rather than progression is associated with accelerated cognitive decline

Analysis of total organic carbon in soil-biochar systems

Amending agricultural soils with biochar can contribute to negative carbon strategies when the resistance to oxidation of soil carbon is improved (avoided CO2 emission) and plant growth is promoted (increased CO2 fixation). The environmental stability and sequestering capacity of biochar is dependent on the chemical form of carbon and its physical location in the carbonaceous matrix. The addition of biochar in soil increases noticeably the stable carbon pool, while the effect on labile carbon, including polyaromatic structures, is less marked.1 The fertilizing action can be lost if biochar is removed from the cultivated area due to physical processes (vertical transport, lateral export, slacking). Assessing the fate of carbon in the soil requires the use of suitable analytical methods that should be validated for the presence of biochar. Please click on the file below for full content of the abstract

Essential (Mg, Fe, Zn and Cu) and non-essential (Cd and Pb) elements in predatory insects (Vespa crabro and Vespa velutina): a molecular perspective

The recent introduction of the Asian hornet, Vespa velutina, into Europe has raised concern regarding the threat to honeybees and the competition with the European hornet, Vespa crabro. The aim of this study was to investigated essential (Mg, Fe, Zn, Cu) and non-essential (Cd and Pb) elements in these two species. Element concentrations were determined in the whole body and separately in the head, thorax and abdomen using atomic absorption spectrometry (AAS). The changes in essential element concentration and speciation during metamorphosis were also studied using gel filtration chromatography followed by AAS and proteomic analysis. In both species, the essential elements were more concentrated in the abdomen due to the presence of fat bodies. Magnesium, Fe and Zn concentrations were significantly higher in V. crabro than in V. velutina and could have been related to a higher aerobic energy demand of the former species required to sustain foraging flight at higher speeds and to cover longer distances. Low concentrations of Cd and Pb were indicative of low environmental exposure. The concentration and speciation of essential elements, particularly Fe, varied among the developmental stages, indicating a modification of ligand preferences during metamorphosis. Overall, the results in the present study provide a better understanding of the hornet metal metabolism and a foundation for additional studies

Biochar from gasification in cultivated soils and riparian buffer zones: Chemical characterization

During rain events, pollutants in agricultural soils can be transported from fields to surface and/or groundwater resulting in contamination of streams and rivers. Researchers and farmers must work together to find solutions to ensure the preservation of crop production without jeopardizing water quality or the health of the ecosystem. Establishment of riparian zones may reduce the effects of diffuse discharges of pollutants into waterways. The addition of biochar to soils, particularly in a riparian zones, can reduce the mobility of contaminants and improve removal efficiency due its sorptive capacity. Please click on the file below for full content of the abstract

Growing Strong and Healthy with Mister Bone: An Educational Program to Have Strong Bones Later in Life.

Optimal peak bone mass and bone health later in life are favored by a sufficient calcium intake in infancy, childhood and adolescence. The purpose of this study was to test a new educational program created to monitor and to improve calcium and vitamin D intake in children. Nutritional habits in children were evaluated through a food frequency questionnaire (FFQ) to assess the intake of calcium, vitamin D, dairy products, and total caloric energy at baseline and after seven months of exposure to a unique educational program applied between November 2013 and May 2014 in 176 schoolchildren (48% male, 52% female) attending the fourth and fifth grades of two selected primary schools in Florence, Italy. A significant increase of calcium (from 870 ± 190 to 1100 ± 200 mg/day, p < 0.05), and vitamin D (from 3.6 ± 1.53 to 4.1 ± 2 µg/day) intake in children was documented after the educational program. The amount of specific foods important for bone health consumed, such as milk and vegetables, increased significantly, both in male and female children (p < 0.05). The proposed educational program appears to be effective in modifying calcium intake in children, with a significant increase in the consumption of dairy products and vegetables, but without a significant change in the total caloric intake

Aging and the burden of multimorbidity: Associations with inflammatory and anabolic hormonal biomarkers

open9siThe InCHIANTI study baseline (1998–2000) was supported as a “targeted project” (ICS110.1/RF97.71) by the Italian Ministry of Health and in part by the U.S. National Institute on Aging (contracts: 263 MD 9164 and 263 MD 821336); the InCHIANTI Follow-up 1 (2001–2003) was funded by the U.S. National Institute on Aging (contracts: N.1-AG-1-1 and N.1-AG-1-2111); the InCHIANTI Follow-ups 2 and 3 studies (2004–2010) were financed by the U.S. National Institute on Aging (contract: N01-AG-5-0002); supported in part by the Intramural Research Program of the National Institute on Aging, National Institutes of Health, Baltimore, MarylandBackground. Multimorbidity increases with aging, but risk factors beyond age are unknown. Objective. To investigate the association of inflammatory and anabolic hormonal biomarkers with presence and prospective development of multimorbidity. Methods. Nine-year longitudinal study of 1018 participants aged 60 years or older (InCHIANTI Study). Multimorbidity was evaluated at baseline and follow-up visits as number of diagnosed diseases from a predefined list of 15 candidate chronic conditions, defined according to standard clinical criteria. Linear mixed models were used to test cross-sectional and longitudinal associations between candidate biomarkers and multimorbidity. Results. At baseline, multimorbidity was significantly higher in older participants (p <. 001) and higher IL-6, IL-1ra, TNF-α receptor II (TNFAR2), and lower dehydroepiandrosterone sulfate were associated with higher number of diseases, independent of age, sex, body mass index, and education. The rate of longitudinal increase in number of chronic diseases was significantly steeper in participants who were older at baseline (p <. 001). In addition, higher baseline IL-6 and steeper increase of IL-6 levels were significantly and independently associated with a steeper increase in multimorbidity over time (p <. 001 and p =. 003, respectively). Sensitivity analyses, performed using 15 different models obtained by removing each of 15 conditions included in the original list of candidate diseases, confirmed that results were not driven by any specific condition. Conclusions. Accumulation of chronic diseases accelerates at older ages and in persons with higher baseline levels and steeper increase over time of IL-6. High IL-6 and increase in IL-6 may serve as early warning sign to better target interventions aimed at reducing the burden of multimorbidity.openFabbri, Elisa; An, Yang; Zoli, Marco; Simonsick, Eleanor M.; Guralnik, Jack M.; Bandinelli, Stefania; Boyd, Cynthia M.; Ferrucci, LuigiFabbri, Elisa; An, Yang; Zoli, Marco; Simonsick, Eleanor M.; Guralnik, Jack M.; Bandinelli, Stefania; Boyd, Cynthia M.; Ferrucci, Luig