Extended Lower Limb Venous Ultrasound for the Diagnosis of Proximal and Distal Vein Thrombosis in Asymptomatic Patients after Total Hip Replacement

AbstractObjective. To assess the performance of extended lower limb venous ultrasound (US) for the diagnosis of asymptomatic deep vein thrombosis (DVT) and to estimate a 3-month DVT incidence on repeated US after total hip replacement.Design. Diagnostic performance study and prospective cohort study.Materials and methods. US was compared to phlebography in 70 consecutive patients and interobserver agreement was assessed in the last 48 patients at day 8. US was repeated in these 48 patients at day 13 and day 90.Results. Phlebography demonstrated a DVT in 18/70 (26%) patients, with five proximal and 13 distal and US in 23/70 (33%) patients, with eight proximal and 15 distal. Sensitivity and specificity of US with 95% CI were 94% (73–100) and 89% (76–96), respectively. Sensitivity in isolated distal vein thrombosis was 92% (67–99). The Kappa coefficient for agreement between observers was 0.84 (0.66–1.00). Follow-up showed a DVT in 15/48 (31%) patients on day 8, in 20/48 patients (42%) on day 13. DVT recurred in two patients during follow-up.Conclusions. The incidence of asymptomatic DVT is still significant despite prophylaxis but most DVTs remain distal and occur in the first 2 weeks. Extended US could replace phlebography for systematic screening in clinical trials using surrogate endpoints in view of its high accuracy and reliability

Narrow-band photodetection based on M-plane GaN films

Rapid identification of a range of hazardous airborne biological and chemical agents requires simultaneous detection at several specific wavelengths, and consequently a set of photodetectors with very narrow-band spectral responsivity. We demonstrate two ultraviolet photodetection configurations based on strained M-plane GaN films on LiAlO2(100) substrates grown by molecular-beam epitaxy with a detection bandwidth below 8 nm. The optical band gap of the film depends on the orientation of the linear polarization of the incident light relative to the c-axis of GaN, which lies in the film plane. The first configuration consists of a polarizationsensitive planar Schottky photodetector and a filter. An orthogonal alignment of the c-axis of the photodetector and the filter produces a detection system with a peak responsivity at 360 nm and a bandwidth of 6 nm. The second one consists of two planar Schottky photodetectors with their c-axes oriented perpendicular to each other. The difference signal between the two photodetectors produces a peak responsivity at 358 nm and a bandwidth of 7.3 nm

Detection of Pathogenic Leptospires in Water and Soil in Areas Endemic to Leptospirosis in Nicaragua

In Nicaragua, there are ideal environmental conditions for leptospirosis. The objective of this investigation was to detect pathogenic and saprophytic leptospires in water and soil samples from leptospirosis-endemic areas in Nicaragua. Seventy-eight water and 42 soil samples were collected from houses and rivers close to confirmed human cases.Leptospiraspp was isolated in Ellinghausen-McCullough-Johnson-Harris (EMJH) culture medium with 5-fluororacil and positive samples were analyzed through PCR for theLipL32gene, specific for pathogenic leptospires (P1 clade). There were 73 positive cultures from 120 samples, however only six of these (5% of all collected samples) were confirmed to be pathogenic, based on the presence of theLipL32gene (P1 clade). Of these six pathogenic isolates, four were from Leon and two from Chinandega. Four pathogenic isolates were obtained from water and two from soil. This study proved the contamination of water and soil with pathogenic leptospires, which represents a potential risk for public health

Predicting the deleterious effects of mutation load in fragmented populations.

Human-induced habitat fragmentation constitutes a major threat to biodiversity. Both genetic and demographic factors combine to drive small and isolated populations into extinction vortices. Nevertheless, the deleterious effects of inbreeding and drift load may depend on population structure, migration patterns, and mating systems and are difficult to predict in the absence of crossing experiments. We performed stochastic individual-based simulations aimed at predicting the effects of deleterious mutations on population fitness (offspring viability and median time to extinction) under a variety of settings (landscape configurations, migration models, and mating systems) on the basis of easy-to-collect demographic and genetic information. Pooling all simulations, a large part (70%) of variance in offspring viability was explained by a combination of genetic structure (F(ST)) and within-deme heterozygosity (H(S)). A similar part of variance in median time to extinction was explained by a combination of local population size (N) and heterozygosity (H(S)). In both cases the predictive power increased above 80% when information on mating systems was available. These results provide robust predictive models to evaluate the viability prospects of fragmented populations

Estimating sigma-meson couplings from D \to 3\pi decays

Using recent experimental evidence from E791 on the sigma meson in D \to 3\pi decays, we study the relevant couplings in D \to \sigma \pi and \sigma \to \pi\ pi within the accepted theoretical framework for non leptonic D decays. We also review the linear sigma model, finding that it gives a description which is consistent with the experimental data.Comment: 6 pages, no figures. Final version accepted for publication as a Brief Report in Physical Review

On the equivalence between Implicit Regularization and Constrained Differential Renormalization

Constrained Differential Renormalization (CDR) and the constrained version of Implicit Regularization (IR) are two regularization independent techniques that do not rely on dimensional continuation of the space-time. These two methods which have rather distinct basis have been successfully applied to several calculations which show that they can be trusted as practical, symmetry invariant frameworks (gauge and supersymmetry included) in perturbative computations even beyond one-loop order. In this paper, we show the equivalence between these two methods at one-loop order. We show that the configuration space rules of CDR can be mapped into the momentum space procedures of Implicit Regularization, the major principle behind this equivalence being the extension of the properties of regular distributions to the regularized ones.Comment: 16 page

Neutron charge form factor at large q2q^2

The neutron charge form factor $G_{En}(q)$ is determined from an analysis of the deuteron quadrupole form factor $F_{C2}$ data. Recent calculations, based on a variety of different model interactions and currents, indicate that the contributions associated with the uncertain two-body operators of shorter range are relatively small for $F_{C2}$, even at large momentum transfer $q$. Hence, $G_{En}(q)$ can be extracted from $F_{C2}$ at large $q^2$ without undue systematic uncertainties from theory.Comment: 8 pages, 3 figure

Recent Results from PHOBOS at RHIC

The PHOBOS experiment at RHIC has recorded measurements for Au-Au collisions spanning nucleon-nucleon center-of-mass energies from 19.6 GeV to 200 GeV. Global observables such as elliptic flow and charged particle multiplicity provide important constraints on model predictions that characterize the state of matter produced in these collisions. The nearly 4 pi acceptance of the PHOBOS experiment provides excellent coverage for complete flow and multiplicity measurements. Results including beam energy and centrality dependencies are presented and compared to elementary systems.Comment: 4 pages, 4 figures, proceedings from PANIC02 in Osaka, Japa

Global Observations from PHOBOS

Particle production in Au+Au collisions has been measured in the PHOBOS experiment at RHIC for a range of collision energies. Three empirical observations have emerged from this dataset which require theoretical examination. First, there is clear evidence of limiting fragmentation. Namely, particle production in central Au+Au collisions, when expressed as $dN/d\eta'$ ($\eta' \equiv \eta-y_{beam}$), becomes energy independent at high energy for a broad region of $\eta'$ around $\eta'=0$. This energy-independent region grows with energy, allowing only a limited region (if any) of longitudinal boost-invariance. Second, there is a striking similarity between particle production in e+e- and Au+Au collisions (scaled by the number of participating nucleon pairs). Both the total number of produced particles and the longitudinal distribution of produced particles are approximately the same in e+e- and in scaled Au+Au. This observation was not predicted and has not been explained. Finally, particle production has been found to scale approximately with the number of participating nucleon pairs for $N_{part}>65$. This scaling occurs both for the total multiplicity and for high \pT particles (3 <\pT< 4.5 GeV/c).Comment: QM2002 plenary talk, 10 pages, 11 figure

Approximating open quantum system dynamics in a controlled and efficient way: A microscopic approach to decoherence

We demonstrate that the dynamics of an open quantum system can be calculated efficiently and with predefined error, provided a basis exists in which the system-environment interactions are local and hence obey the Lieb-Robinson bound. We show that this assumption can generally be made. Defining a dynamical renormalization group transformation, we obtain an effective Hamiltonian for the full system plus environment that comprises only those environmental degrees of freedom that are within the effective light cone of the system. The reduced system dynamics can therefore be simulated with a computational effort that scales at most polynomially in the interaction time and the size of the effective light cone. Our results hold for generic environments consisting of either discrete or continuous degrees of freedom