Graviton propagation within the context of the D-material universe

Motivated by the recent breakthrough of the detection of Gravitational Waves (GW) from coalescent black holes by the aLIGO interferometers, we study the propagation of GW in the {\sl D-material universe}, which we have recently shown to be compatible with large-scale structure and inflationary phenomenology. The medium of D-particles induces an effective mass for the graviton, as a consequence of the formation of recoil-velocity field condensates due to the underlying Born-Infeld dynamics. There is a competing effect, due to a super-luminal refractive index, as a result of the gravitational energy of D-particles acting as a dark matter component, with which propagating gravitons interact. We examine conditions for the condensate under which the latter effect is sub-leading. We argue that if quantum fluctuations of the recoil velocity are relatively strong, which can happen in the current era of the universe, then the condensate, and hence the induced mass of the graviton, can be several orders of magnitude larger than the magnitude of the cosmological constant today. Hence, we constrain the graviton mass using aLIGO and pulsar timing observations (which give the most stringent bounds at present). In such a sub-luminal graviton case, there is also a gravitational Cherenkov effect for ordinary high energy cosmic matter, which is further constrained by means of ultra-high-energy cosmic ray observations. Assuming cosmic rays of extragalactic origin, the bounds on the quantum condensate strength, based on the gravitational Cherenkov effect, are of the same order as those from aLIGO measurements, in contrast to the case where a galactic origin of the cosmic rays is assumed, in which case the corresponding bounds are much weaker.Comment: 21 pages, JCAP style, no figure

The D-material universe

In a previous publication by some of the authors (N.E.M., M.S. and M.F.Y.), we have argued that the "D-material universe", that is a model of a brane world propagating in a higher-dimensional bulk populated by collections of D-particle stringy defects, provides a model for the growth of large-scale structure in the universe via the vector field in its spectrum. The latter corresponds to D-particle recoil velocity excitations as a result of the interactions of the defects with stringy matter and radiation on the brane world. In this article, we first elaborate further on the results of the previous study on the galactic growth era and analyse the circumstances under which the D-particle recoil velocity fluid may "mimic" dark matter in galaxies. A lensing phenomenology is also presented for some samples of galaxies, which previously were known to provide tension for modified gravity (TeVeS) models. The current model is found in agreement with these lensing data. Then we discuss a cosmic evolution for the D-material universe by analysing the conditions under which the late eras of this universe associated with large-scale structure are connected to early epochs, where inflation takes place. It is shown that inflation is induced by dense populations of D-particles in the early universe, with the role of the inflaton field played by the condensate of the D-particle recoil-velocity fields under their interaction with relativistic stringy matter, only for sufficiently large brane tensions and low string mass scales compared to the Hubble scale. On the other hand, for large string scales, where the recoil-velocity condensate fields are weak, inflation cannot be driven by the D-particle defects alone. In such cases inflation may be driven by dilaton (or other moduli) fields in the underlying string theory.Comment: 42 pages latex, one pdf figure incorporated, uses special macro

Plasma 5-hydroxyindoleacetic acid as an endogenous index of renal plasma flow

Plasma 5-hydroxyindoleacetic acid as an endogenous index of renal plasma flow. 5-Hydroxyindoleacetic acid (5-HIAA), the major serotonin metabolite, was measured in human plasma and urine using liquid chromatography and electrochemical detection. The renal extraction of 5-HIAA was 78%, a value compatible with an almost complete extraction during a single passage of the blood through the kidney. In addition, plasma levels of 5-HIAA measured in patients with a wide range of renal function was inversely correlated (r = 0.85) with the clearance of para-aminohippuric acid (PAH). The results indicate that 5-HIAA determinations can be used as an alternative procedure to the PAH clearance method for the estimation of renal plasma flow in clinical practice

Chronic ethanol attenuates centrally-mediated hypotension elicited via alpha-2-adrenergic, but not I1-imidazoline, receptor activation in female rats

Aims—This study dealt with the effect of chronic ethanol administration on hemodynamic responses elicited by α2-adrenergic (α-methyldopa) or I1-imidazoline (rilmenidine) receptor activation in telemetered female rats. Main methods—The effects of α-methyldopa or rilmenidine on blood pressure (BP), heart rate (HR) and their variability were investigated in rats that received liquid diet without or with ethanol (5% w/v) for 12 weeks. To evaluate the effect of each drug on cardiovascular autonomic control (BP and HR variability) in the absence or presence of ethanol, three time-domain indices of hemodynamic variability were measured: (i) standard deviation of mean arterial pressure (SDMAP), (ii) standard deviation of beat-to-beat intervals, and (iii) root mean square of successive differences in R-R intervals. Key findings—In liquid diet-fed control rats, i.p. rilmenidine (600 μg/kg) or α-methyldopa (100 mg/kg) reduced BP along with decreases and increases, respectively, in HR. Both drugs had no effect on HR variability but reduced BP variability (SDMAP), suggesting a reduced vasomotor sympathetic tone. Ethanol feeding attenuated reductions in BP and SDMAP evoked by α-methyldopa but not by rilmenidine. Significance—We conclude that chronic ethanol preferentially compromises α2- but not I1- receptor-mediated hypotension in female rats probably via modulation of vasomotor sympathetic activity. These findings highlight the adequacy of rilmenidine use to lower BP in hypertensive alcoholic females

Sympathetic Activation and Baroreflex Function during Intradialytic Hypertensive Episodes

BACKGROUND: The mechanisms of intradialytic increases in blood pressure are not well defined. The present study was undertaken to assess the role of autonomic nervous system activation during intradialytic hypertensive episodes. METHODOLOGY/PRINCIPAL FINDINGS: Continuous interbeat intervals (IBI) and systolic blood pressure (SBP) were monitored during hemodialysis in 108 chronic patients. Intradialytic hypertensive episodes defined as a period of at least 10 mmHg increase in SBP between the beginning and the end of a dialysis session or hypertension resistant to ultrafiltration occurring during or immediately after the dialysis procedure, were detected in 62 out of 113 hemodialysis sessions. SBP variability, IBI variability and baroreceptor sensitivity (BRS) in the low (LF) and high (HF) frequency ranges were assessed using the complex demodulation technique (CDM). Intradialytic hypertensive episodes were associated with an increased (n = 45) or decreased (n = 17) heart rate. The maximal blood pressure was similar in both groups. In patients with increased heart rate the increase in blood pressure was associated with marked increases in SBP and IBI variability, with suppressed BRS indices and enhanced sympatho-vagal balance. In contrast, in those with decreased heart rate, there were no significant changes in the above parameters. End-of-dialysis blood pressure in all sessions associated with hypertensive episode was significantly higher than in those without such episodes. In logistic regression analysis, predialysis BRS in the low frequency range was found to be the main predictor of intradialytic hypertension. CONCLUSION/SIGNIFICANCE: Our data point to sympathetic overactivity with feed-forward blood pressure enhancement as an important mechanism of intradialytic hypertension in a significant proportion of patients. The triggers of increased sympathetic activity during hemodialysis remain to be determined. Intradialytic hypertensive episodes are associated with higher end-of-dialysis blood pressure, suggesting that intradialytic hypertension may play a role in generation of interdialytic hypertension

Cusps and pseudocusps in strings with Y-junctions

Contains fulltext : 135362.pdf (preprint version ) (Open Access

Gravitational wave bursts from cosmic string cusps and pseudocusps

We study the relative contribution of cusps and pseudocusps, on cosmic (super)strings, to the emitted bursts of gravitational waves. The gravitational wave emission in the vicinity of highly relativistic points on the string follows, for a high enough frequency, a logarithmic decrease. The slope has been analytically found to be $^{-4}/_3$ for points reaching exactly the speed of light in the limit $c=1$. We investigate the variations of this high frequency behaviour with respect to the velocity of the points considered, for strings formed through a numerical simulation, and we then compute numerically the gravitational waves emitted. We find that for string points moving with velocities as far as $10^{-3}$ from the theoretical (relativistic) limit $c=1$, gravitational wave emission follows a behaviour consistent with that of cusps, effectively increasing the number of cusps on a string. Indeed, depending on the velocity threshold chosen for such behaviour, we show the emitting part of the string worldsheet is enhanced by a factor ${\cal O}(10^3)$ with respect to the emission of cusps only.Comment: 26 pages, 18 figures; Added referenc