The Simulation of the Trend of the Time Series in the form of the Spline of Third-Order With a Random Number of Data at the Moments of Measurement

The possibility of simulation of trend of a time series as a spline of third-order with a random number of data at the moments of measurement is discussed. Estimations of coefficients of the spline are obtained in the explicit form. The statistical characteristics of the received estimations are studied in details

Analysis of the e-learning technologies used for teaching mathematics at Tomsk Polytechnic University

This article analyzes the implementation of e-learning technologies in the study of mathematics at Tomsk Polytechnic University. It describes research findings of the suitability of the e-learning technology for first year students of an engineering university. The research involved 248 students and 38 teachers of Tomsk Polytechnic University. The authors surveyed first-year students to check whether they are ready to learn in the electronic environment. In addition, the students and teachers were surveyed on the possibility of teaching a course in mathematics in the electronic environment and on the preferred mode of learning: web-based instruction, blended learning, or full e-learning. The research identified the main difficulties when working with e-learning courses as well as the optimal form of e-learning for the study of mathematics

On the self-testing (m,n)-code checker design

We propose an approach to a self-testing (m, n)code checker design, based on subdividing the set of all code words into special subsets called segments. The checker circuit is constructed by using one- and two-output configurable logic blocks (CLB). Previously, in each output of a CLB, a function representing exactly one segment was implemented. In the proposed approach, at each CLBs output, it is possible to implement functions that represent several segments and to provide the self-testing property. It allows reducing the number of CLBs and simplifying the circuit of the checker

E-learning as a Way to Improve the Quality of Educational for International Students

The article focuses on the problem of teaching mathematics to students of an engineering university learning in a non-native language. The results of a survey helped us identify the main difficulties facing international students when they begin their studies at Russian universities. We also describe a methodology of teaching mathematics using e-learning as web-based instruction. The use of e-learning in the educational process improves the quality of practical training and provides a better understanding of the course

Классики русской литературы: реализация проекта в Библиотеке им. А.П. Чехова

Review of the events in 2015 of the State Budgetary Institution of Culture “Library named after A. Chekhov” of the Centralized Library System of the Central Administrative District of Moscow, held in the framework of the Project “Round Tables and Research and Practical Conferences ‘Literary Process in the 20-21 centuries’” at the financial support of the Federal Agency for Press and Mass Communications and the Russian Book Union.Обзор мероприятий 2015 г. Библиотеки им. А. П. Чехова ГБУК г. Москвы «ЦБС ЦАО», прошедших в рамках проекта «Круглые столы и научно-практические конференции “Литературный процесс XX-XXI вв.”» при финансовой поддержке Федерального агентства по печати и массовым коммуникациям и Российского книжного союза

Nanosecond Pulsed Electric Signals Can Affect Electrostatic Environment of Protiens Below the Threshold of Conformational Effects: The Case Study of SOD1 With a Molecular Simulation Study

Electric fields can be a powerful tool to interact with enzymes or proteins, with an intriguing perspective to allow protein manipulation. Recently, researchers have focused the interest on intracellular enzyme modifications triggered by the application of nanosecond pulsed electric fields. These findings were also supported by theoretical predictions from molecular dynamics simulations focussing on significant variations in protein secondary structures. In this work, a theoretical study utilizing molecular dynamics simulations is proposed to explore effects of electric fields of high intensity and very short nanosecond duration applied to the superoxide dismutase (Cu/Zn-SOD or SOD-1), an important enzyme involved in the cellular antioxidant defence mechanism. The effects of 100-nanosecond pulsed electric fields, with intensities ranging from 108 to 7x108 V/m, on a single SOD1 enzyme are presented. We demonstrated that the lowest intensity of 108 V/m, although not inducing structural changes, can produce electrostatic modifications on the reaction centre of the enzyme, as apparent from the dipolar response and the electric field distribution of the protein active site. Electric pulses above 5x108 V/m produced a fast transition between the folded and a partially denatured state, as inferred by the secondary structures analysis. Finally, for the highest field intensity used (7x108 V/m), a not reversible transition toward an unfolded state was observed

Morphological Substantiation of Clinical Efficacy of Platelet Rich Plasma in the Treatment of Androgenetic Alopecia

The aim of the study was morphological substantiation of clinical efficacy of platelet rich plasma (PRP) in the treatment of patients with androgenetic alopecia (AGA). Materials and Methods: The study included 25 men aged from 20 to 43 years. AGA degree II-IV on the Hamilton-Norwood scale was diagnosed in 23 (92%) patients and degree I in 2 patients. All patients received intradermal injections of PRP. The course of treatment consisted of 4 procedures with an interval of 4 weeks between each procedure. The clinical efficacy of the therapy was evaluated by the dynamics of morphometric indicators of hair growth. The morphological analysis included an assessment of indicators in horizontal sections and was carried out at 4 levels: at the level of subcutaneous adipose tissue, sweat glands, sebaceous glands, and mouths of hair follicle (HF). Sections were stained with H&E. Histological examination was performed before and after treatment. Against the background of treatment with PRP, hair density increased by 12% (P=0.000), average hair diameter by 12% (P=0.002), and the share of vellus and telogen hair decreased by 17% (P=0.002) and 16% (P=0.028), respectively. At the same time, the amount of anagen hair in relation to telogen hair increased by 18% (P=0.016). Histologically, the increase in hair density was accompanied by a significant increase in the number of HF at the mouth level (∆+96%, P=0.004) and at the level of sweat glands (∆+54%, P=0.037), as well as a tendency for their number to increase at the level of the sebaceous glands. These increases were combined with a significant decrease in the proportion of telogen hair (∆-43%, P=0.023) and vellus hair (∆-29%, P=0.037). Conclusion: The positive clinical effect of PRP therapy is due to significant morphofunctional changes in hair follicles

The Cytotoxic Synergy of Nanosecond Electric Pulses and Low Temperature Leads to Apoptosis

Electroporation by nanosecond electric pulses (nsEP) is an emerging modality for tumor ablation. Here we show the efficient induction of apoptosis even by a non-toxic nsEP exposure when it is followed by a 30-min chilling on ice. This chilling itself had no impact on the survival of U-937 or HPAF-II cells, but caused more than 75% lethality in nsEP-treated cells (300 ns, 1.8-7 kV/cm, 50-700 pulses). The cell death was largely delayed by 5-23 hr and was accompanied by a 5-fold activation of caspase 3/7 (compared to nsEP without chilling) and more than 60% cleavage of poly-ADP ribose polymerase (compared to less than 5% in controls or after nsEP or chilling applied separately). When nsEP caused a transient permeabilization of 83% of cells to propidium iodide, cells placed at 37 ° C resealed in 10 min, whereas 60% of cells placed on ice remained propidium-permeable even in 30 min. The delayed membrane resealing caused cell swelling, which could be blocked by an isosmotic addition of a pore-impermeable solute (sucrose). However, the block of swelling did not prevent the delayed cell death by apoptosis. The potent enhancement of nsEP cytotoxicity by subsequent non-damaging chilling may find applications in tumor ablation therapies