IMP Science Gateway: from the Portal to the Hub of Virtual Experimental Labs in Materials Science

"Science gateway" (SG) ideology means a user-friendly intuitive interface between scientists (or scientific communities) and different software components + various distributed computing infrastructures (DCIs) (like grids, clouds, clusters), where researchers can focus on their scientific goals and less on peculiarities of software/DCI. "IMP Science Gateway Portal" (http://scigate.imp.kiev.ua) for complex workflow management and integration of distributed computing resources (like clusters, service grids, desktop grids, clouds) is presented. It is created on the basis of WS-PGRADE and gUSE technologies, where WS-PGRADE is designed for science workflow operation and gUSE - for smooth integration of available resources for parallel and distributed computing in various heterogeneous distributed computing infrastructures (DCI). The typical scientific workflows with possible scenarios of its preparation and usage are presented. Several typical use cases for these science applications (scientific workflows) are considered for molecular dynamics (MD) simulations of complex behavior of various nanostructures (nanoindentation of graphene layers, defect system relaxation in metal nanocrystals, thermal stability of boron nitride nanotubes, etc.). The user experience is analyzed in the context of its practical applications for MD simulations in materials science, physics and nanotechnologies with available heterogeneous DCIs. In conclusion, the "science gateway" approach - workflow manager (like WS-PGRADE) + DCI resources manager (like gUSE)- gives opportunity to use the SG portal (like "IMP Science Gateway Portal") in a very promising way, namely, as a hub of various virtual experimental labs (different software components + various requirements to resources) in the context of its practical MD applications in materials science, physics, chemistry, biology, and nanotechnologies.Comment: 6 pages, 5 figures, 3 tables; 6th International Workshop on Science Gateways, IWSG-2014 (Dublin, Ireland, 3-5 June, 2014). arXiv admin note: substantial text overlap with arXiv:1404.545

Training in cooperation with the use of information technology

Training of modern graduate takes place in the conditions of requirements of the Federal state educational standards aimed at development of students’ competences. In order to train a competent graduate, higher education institutions are looking for ways that will make this process more effective and dynamic. The purpose of the article is to analyze the experience of higher education institutions in the implementation of training in cooperation with the use of information technology. The wide development of information technologies and their penetration into various spheres of society has determined their implementation in the educational process. The use of information technology is based on the use of personal computers. Now this tool is an integral part of the modern educational process. Placing emphasis on the fact that learning in cooperation is not a fundamentally new technology the authors say that it acquires relevance by incorporating innovative technologies. The article considers the ideas of training in cooperation with the use of information technologies, raises the importance and significance of this issue in modern educational conditions. Training in cooperation expands the students' information field. On the basis of the study of scientific literature, the features of training in cooperation, its essence and value purpose for the formation of competence of students of pedagogical University are highlighted. The study suggests an increase in students ' motivation to study materials after the introduction of information technologies that allow them to be more mobile and creative. The process of mutual learning in the process of cooperation becomes more effective. The higher the motivation of the student to study the discipline is, the higher the level of his knowledge is. The results of the study can be used in the further implementation of information technologies for the development of the learning process in cooperation

Мікроскопічна оцінка будови регенерату губчастої кістки статевозрілих щурів за умов загального зневоднення організму.

Дана робота є фрагментом НДР «Закономірності вікових і конституціональних морфологічних перетворень внутрішніх органів і кісткової системи за умов впливу ендо- та екзогенних чинників і шляхи їх корекції», № державної реєстрації 0113U001347 від 01.01.2013 року

Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas

Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue sarcomas representing 6 major types. Along with novel insights into the biology of individual sarcoma types, we report three overarching findings: (1) unlike most epithelial malignancies, these sarcomas (excepting synovial sarcoma) are characterized predominantly by copy-number changes, with low mutational loads and only a few genes (, , ) highly recurrently mutated across sarcoma types; (2) within sarcoma types, genomic and regulomic diversity of driver pathways defines molecular subtypes associated with patient outcome; and (3) the immune microenvironment, inferred from DNA methylation and mRNA profiles, associates with outcome and may inform clinical trials of immune checkpoint inhibitors. Overall, this large-scale analysis reveals previously unappreciated sarcoma-type-specific changes in copy number, methylation, RNA, and protein, providing insights into refining sarcoma therapy and relationships to other cancer types

REACTION OF ORTHOTROPIC CYLINDRIC SHELLS TO ACTIONS OF SHOCK AXIAL LOADS

The investigation object is the circular thin-walled elastic orthotropic cylindric shell. The reaction of the cylindric shells to the axial loads of the shock type has been studied, the methods for evaluation of the shell serviceability have been proposed, the expressions for critical parameters of the applied loads have been obtained, the positive influence of the high-frequency vibrations on stability of the sudden-loaded shells has been shown, the evaluations of the upper boundary in the relative run of the net field have been obtainedAvailable from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio

Stability estimating in optimal sequential hypotheses testing

summary:We study the stability of the classical optimal sequential probability ratio test based on independent identically distributed observations $X_1,X_2,\dots$ when testing two simple hypotheses about their common density $f$: $f=f_0$ versus $f=f_1$. As a functional to be minimized, it is used a weighted sum of the average (under $f_0$) sample number and the two types error probabilities. We prove that the problem is reduced to stopping time optimization for a ratio process generated by $X_1,X_2,\dots$ with the density $f_0$. For $\tau_*$ being the corresponding optimal stopping time we consider a situation when this rule is applied for testing between $f_0$ and an alternative $\tilde f_1$, where $\tilde f_1$ is some approximation to $f_1$. An inequality is obtained which gives an upper bound for the expected cost excess, when $\tau_*$ is used instead of the rule $\tilde\tau_*$ optimal for the pair $(f_0,\tilde f_1)$. The inequality found also estimates the difference between the minimal expected costs for optimal tests corresponding to the pairs $(f_0,f_1)$ and $(f_0,\tilde f_1)$