Lifestyle in children and adolescents with obesity: results of the survey of patients and their parents

Introduction. Growth of obesity prevalence in children and adolescents is a serious problem of modern medicine. To learn characteristics of patient’s behaviour, their dietary preference, feeding time and physical loads one can use specialized questionnaires.Aim. Evaluation of lifestyle, physical activity, dietary regimen and consumption of some meals according to results of questioning childrenand adolescents with obesity and their parents.Materials and methods. Hundreds of children and adolescents with obesity 10–17 years and their parents answered the questionnaire onage of obesity onset, its causes, physical activity and nutrition.Results and conclusion. Obesity develops more often at the age of 7–10 years. The most commonly insufficient physical activity and heredity. Specific characteristics of sedentary lifestyle and impared dietary regimen were identified. Comparison of patients’ and parents’ answers allowed to demonsrate the differense in attitude to the problem of obesity and to diminish the influence of not transparant answers on the results of investigation

New variants in the BRCA1 gene in Buryat Mongol breast cancer patients: Report from two families

BACKGROUND: The BRCA1 mutations that are endemic to the Slavic population of Russia have not been identified among indigenous peoples, including the Buryats, Tuvinians and Altaians with hereditary breast cancer. OBJECTIVE: This study was aimed to identify the mutations that are responsible for the occurrence of hereditary breast cancer in the indigenous population of the Republic of Buryatia. METHODS: Mutations in the BRCA1 gene were identified in blood samples by Sanger-based sequencing. RESULTS: We identified 11 polymorphisms (10 SNPs and 1 Indel) and 6 new unclassified sequence variants in the BRCA1 gene. In our study three new sequence variants (c.321T>A, c.366T>A, c.4357+2T>A) were found in position of previously described polymorphisms in dbSNPs: rs80357544 (c.321delT), rs190900046 (c.366T>G), and rs80358152 (c.4357+2T>C), respectively. Other three new sequence variants (c.3605A>G, c.1998A>C, and c.80+13A>C) have not been previously described in dbSNP, BIC and Human Gene Mutation Databases. CONCLUSIONS: We described six new sequence variants that have never been published in the literature or databases. Further studies are required to confirm the impact of new sequence variants on the risk of breast cancer in the Buryat Mongol population

New variants in the BRCA1 gene in Buryat Mongol breast cancer patients: Report from two families

BACKGROUND: The BRCA1 mutations that are endemic to the Slavic population of Russia have not been identified among indigenous peoples, including the Buryats, Tuvinians and Altaians with hereditary breast cancer. OBJECTIVE: This study was aimed to identify the mutations that are responsible for the occurrence of hereditary breast cancer in the indigenous population of the Republic of Buryatia. METHODS: Mutations in the BRCA1 gene were identified in blood samples by Sanger-based sequencing. RESULTS: We identified 11 polymorphisms (10 SNPs and 1 Indel) and 6 new unclassified sequence variants in the BRCA1 gene. In our study three new sequence variants (c.321T>A, c.366T>A, c.4357+2T>A) were found in position of previously described polymorphisms in dbSNPs: rs80357544 (c.321delT), rs190900046 (c.366T>G), and rs80358152 (c.4357+2T>C), respectively. Other three new sequence variants (c.3605A>G, c.1998A>C, and c.80+13A>C) have not been previously described in dbSNP, BIC and Human Gene Mutation Databases. CONCLUSIONS: We described six new sequence variants that have never been published in the literature or databases. Further studies are required to confirm the impact of new sequence variants on the risk of breast cancer in the Buryat Mongol population

Distorted <i>commo</i>-Cobaltacarboranes Based on the 5,6-Dicarba-<i>nido</i>-decaborane(12): The First Bimetal Cobalt–Copper Zwitterion-Containing Cluster with Four (B–H)₄···Cu Bonds Not Showing Fluxional Behavior in Solution

Treatment of a recently reported complex [Ph₄P]­[<i>closo,nido-</i>CoH­(2,4-C₂B₈H₁₀)­(7,8-C₂B₈H₁₁)] (<b>1</b>) either by H₂O₂ in acetone or NaH in THF leads to the loss of both the bridging and terminal hydrides yielding the diamagnetic salt of an anionic <i>commo</i>-cobaltacarborane [Ph₄P]­[Co­(2,4-<i>isonido</i>-C₂B₈H₁₀)₂] (<b>2</b>) with the {CoC₂B₈}-cluster units adopting a distorted skeletal geometry of the <i>isonido</i>-type. The anionic <i>commo</i> complex <b>2</b> reacts with in situ generated cationic [CuPPh₃]⁺ species to give stable copper–cobalt zwitterion [Ph₃PCu]­[Co­(2,4-<i>isonido</i>-C₂B₈H₁₀)₂] (<b>3</b>) with four two-electron, three-center (B–H)₄···Cu bonds, and exhibits no fluxional behavior in solution. Complex <b>3</b>, at the same time, in CH₂Cl₂ in the presence of 2-fold excess of PPh₃ readily converts to a new anionic species [(Ph₃P)₃Cu]­[Co­(2,4-<i>isonido</i>-C₂B₈H₁₀)₂] (<b>4</b>) which retains initial <i>isonido</i> geometry. All newly obtained diamagnetic <i>commo</i> complexes were characterized by a combination of analytical and multinuclear NMR spectroscopic data and by single-crystal X-ray diffraction studies of complexes <b>2</b> and <b>3</b>

Structure, Thermal Properties and Proton Conductivity of the Sulfonated Polyphenylquinoxalines

This paper briefly reviews the results of scientific research on the proton conductivity of sulfonated polyphenylquinoxalines. Synthesis, structure (IR spectroscopy, SEM, quantum-chemical modeling, molecular weight distribution), moisture capacity, thermal properties, and proton conductivity of sulfonated polyphenylquinoxalines (sulfur content 2.6, 4.2, 5.5, and 7%) were studied. The relative stable configurations of sulfonated polyphenylquinoxalines with different positions of benzene rings and sulfogroups with the help of quantum chemical modeling were modeled. Sulfonation of the starting polyphenylquinoxalines was confirmed by IR spectroscopy and elemental analysis. The SEM method was used to study the surface of sulfonated polyphenylquinoxalines, and sulfonation regions were found. It was shown that sulfonated polyphenylquinoxalines contain water and are stable up to 250 &deg;C; on further heating, the decomposition of the sulfogroups occurs. The conductivity of the obtained polymer electrolytes was studied by impedance spectroscopy, and long-term tests were carried out. It is shown that the proton conductivity at an ambient humidity of 98 rel. % reaches values 10&minus;6&ndash;10&minus;3 S/cm depending on the degree of sulfonation. It was shown that even after long-term storage in air (7 years), samples of sulfonated polyphenylquinoxalines with a high sulfur content of 7% at 98% air humidity have a conductivity of 8 &times; 10&minus;4 S/cm

Outcomes and complications among admissions with influenza.

<p>Outcomes and complications among admissions with influenza.</p

Risk of admission with influenza by site, strain, and patient-related characteristics.

<p>Risk of admission with influenza by site, strain, and patient-related characteristics.</p

Indicators of severity, complications, and major diagnoses at discharge.

<p>Indicators of severity, complications, and major diagnoses at discharge.</p

Proportion of admissions with underlying conditions by age group.

<p>Proportion of admissions with underlying conditions by age group.</p

Risk of admission with influenza related to underlying conditions.

<p>Risk of admission with influenza related to underlying conditions.</p