Urticaria Causes and Cure with Apt Diet and Anxiety Stabilization: A Case Study Experiment

Urticaria is the inflammation of the skin due to a reaction to allergens, which presents itself as swollen pale red bumps or plaques. Urticaria is a very common type of allergic reaction, which can be triggered by food, dust, medicine, irritants, etc. Though the causes may seem infinite, the trigger is specific to an individual. The scientific research method of observation was followed to collect qualitative and quantitative data. The experiment or test element was a single patient with Urticaria. The patient was monitored and data were collected for a year and a half. The case experiment considered two categories, namely: 1. reaction to meat and dairy products were identified and appropriate measures were designed to eliminate all oral intake of said factors and replace it with neutral restorative foods, i.e. a vegan diet. 2. Understanding the mental impact of the patient with regular bodily functions, stress and anxiety stimulants such as peer pressure, were identified and other alternative life-style adaptations were designed and introduced to eliminate or minimize urticaria causes. The method of dietary doses and anxiety stabilization were administered regularly to find a cure for one and a half years. Findings show a major factor that alleviated the effects of diet and anxiety and increased dependence on God by spending more time on learning from the Holy Bible. Gradual implementation of the remedies gradually decreased the outbreaks. The patient stopped medication (Antihistamine) and is on a better lifestyle. One could further study on moderate life-style and its significance to avoid extreme living both on positive and negative aspects of life. Discussions on other factors like situation, demographics, food, lifestyle, and others could be different from time to time and from one individual to another. &nbsp

ANTIOXIDANT ACTIVITY OF FOURTEEN EULOPHIA SPECIES TRADITIONALLY KNOWN AS AMARKAND

Objective: Amarkand is a group of medicinal plants, of which tubers are regularly consumed by the tribal people in India as food and medicine. It has a strong background of regional ethnopharmacological and food uses. Thus it can be effectively utilized as a source of natural antioxidants. The present study, of fourteen Eulophia species which are predominantly considered as Amarkandâ€, were focused for their antioxidant potential and polyphenolic content which facilitates the contribution of the traditional knowledge of plants from India.Methods: Radical scavenging activity, ferric reducing antioxidant power and anti-lipid peroxidation assay were used to evaluate the antioxidant potential. In addition, total phenols, flavonoid and proanthocynidins were estimated.Results: Results showed that all the studied amarkand species have promising antioxidant potential. Eulophia epidendrea (J. Koenig ex. Retz.) C. E. C. Fisch. (EE) and Eulophia mannii (Rchb. f.) Hook. f. (EM) had highest free radical scavenging potential among all. Eulophia epidendrea have highest ferric reducing potential which may be due to high flavonoid and proanthocyanidin content present.Conclusion: The data clearly demonstrated that EE and EM may serve as a good natural antioxidant source against oxidative stress and related diseases

A new cryptic species of Tylototriton (Amphibia, Caudata, Salamandridae) from mysterious mountain lakes in Manipur, north-eastern India

An integrative taxonomic analysis combining molecular and morphological lines of evidence revealed a new cryptic species in the Tylototriton verrucosus species group from Manipur, north-eastern India. The new species was previously confused with T. himalayanus and T. verrucosus. Tylototriton zaimeng sp. nov. can be distinguished from its congeners by medium body size, head massive and wide with rounded snout and very wide and protruding supratemporal bony ridges and a well-developed sagittal ridge, short limbs not overlapping when adpressed along body, wide and not segmented vertebral ridge distinct, 13–14 pairs of rib nodules, brown colouration with dull orange to yellowish-brown markings on head, vertebral ridge, rib nodules, palms, soles, vent and ventral tail ridge and by vomerine teeth organised in two distinctly curved bell-shaped series. Phylogenetic analysis of the ND2 and 16S rRNA mtDNA genes confirmed the placement of the new species to the Clade I of the subgenus Tylototriton and suggested it is a sister species of T. panwaensis and T. houi (p-distance 3.0% in ND2 gene). The range of the new species is restricted to the Khongtheng Mountain Range and is isolated from the range of T. panwaensis and T. houi in northern Myanmar and southern China, respectively. We suggest the new species to be considered as Vulnerable (VU) in the IUCN Red List

Effects of the mu-opioid receptor antagonist GSK1521498 on hedonic and consummatory eating behaviour: a proof of mechanism study in binge-eating obese subjects.

The opioid system is implicated in the hedonic and motivational processing of food, and in binge eating, a behaviour strongly linked to obesity. The aim of this study was to evaluate the effects of 4 weeks of treatment with the mu-opioid receptor antagonist GSK1521498 on eating behaviour in binge-eating obese subjects. Adults with body mass index ⩾30 kg m−2 and binge eating scale scores ⩾19 received 1-week single-blind placebo run-in, and were then randomized to 28 days with either 2 mg day−1 GSK1521498, 5 mg day−1 GSK1521498 or placebo (N=21 per arm) in a double-blind parallel group design. The outcome measures were body weight, fat mass, hedonic and consummatory eating behaviour during inpatient food challenges, safety and pharmacokinetics. The primary analysis was the comparison of change scores in the higher-dose treatment group versus placebo using analysis of covariance at each relevant time point. GSK1521498 (2 mg and 5 mg) was not different from placebo in its effects on weight, fat mass and binge eating scores. However, compared with placebo, GSK1521498 5 mg day−1 caused a significant reduction in hedonic responses to sweetened dairy products and reduced calorific intake, particularly of high-fat foods during ad libitum buffet meals, with some of these effects correlating with systemic exposure of GSK1521498. There were no significant effects of GSK1521498 2 mg day−1 on eating behaviour, indicating dose dependency of pharmacodynamics. GSK1521498 was generally well tolerated and no previously unidentified safety signals were detected. The potential for these findings to translate into clinically significant effects in the context of binge eating and weight regain prevention requires further investigation

Extravasation of leukocytes in comparison to tumor cells

The multi-step process of the emigration of cells from the blood stream through the vascular endothelium into the tissue has been termed extravasation. The extravasation of leukocytes is fairly well characterized down to the molecular level, and has been reviewed in several aspects. Comparatively little is known about the extravasation of tumor cells, which is part of the hematogenic metastasis formation. Although the steps of the process are basically the same in leukocytes and tumor cells, i.e. rolling, adhesion, transmigration (diapedesis), the molecules that are involved are different. A further important difference is that leukocyte interaction with the endothelium changes the endothelial integrity only temporarily, whereas tumor cell interaction leads to an irreversible damage of the endothelial architecture. Moreover, tumor cells utilize leukocytes for their extravasation as linkers to the endothelium. Thus, metastasis formation is indirectly susceptible to localization signals that are literally specific for the immune system. We herein compare the extravasation of leukocytes and tumor cells with regard to the involved receptors and the localization signals that direct the cells to certain organs and sites of the body

Two-piece hollow bulb obturator

There are various types of obturator fabrication achievable by prosthodontist. Maxillectomy, which is a term used by head and neck surgeons and prosthodontists to describe the partial or total removal of the maxilla in patients suffering from benign or malignant neoplasms is a defect for which to provide an effective obturator is a difficult task for the maxillofacial prosthodontist. Multidisciplinary treatment planning is essential to achieve adequate retention and function for the prosthesis. Speech is often unintelligible as a result of the marked defects in articulation and nasal resonance. This paper describes how to achieve the goal for esthetics and phonetics and also describes the fabrication of a hollow obturator by two piece method, which is simple and maybe used as definitive obturator for maximum comfort of the patient