Protecting Child Nutritional Status in the Aftermath of a Financial Crisis: Evidence from Indonesia

In response to concerns over the vulnerability of the young in the wake of Indonesia's 1997-1998 economic crises, the Government of Indonesia implemented a supplementary feeding program to support early childhood nutritional status. This paper exploits heterogeneity in duration of program exposure to evaluate the impact of the program on children aged 6 to 60 months. By examining differences in nutritional status of treated younger children and a placebo group of older children, the analysis finds that the program improved the nutritional status of treated children, and most significantly, led to 7 and 15 percent declines in rates of moderate and severe stunting, respectively, for children aged 12 to 24 months who were exposed to the program for at least 12 months over two years

Let’s Talk: A Study of the Impact of Gendered Racial Socialization on African American Adolescent Girls’ Mental Health

Internalized racial oppression in African American girls is understudied within research. As people of color are victimized by racism, they may internalize it, developing ideas, beliefs, actions and behaviors that support or collude with racism (Bivens, 1995). This internalized racism has its own systemic reality and its own negative consequences in the lives and communities of people of color. Understanding the way negative racial messages influence the mental health of African American adolescent girls allows for the development of intervention and prevention methods to reduce symptomology of depression, anxiety, and stress. In order for African American girls and young women to develop a healthy sense of self, families must prepare them to cope with the realities of experiencing intersecting oppression (i.e., racism and sexism; Edmondson Bell & Nkomo 1998; Lewis et al. 2013). This may occur through an African American-specific process of gendered racial socialization (Brown et al. 2016). While some research has examined the relationship between racial discrimination and race related stress outcomes (Buford, 2009) or internalized racial oppression on ethnic identity and self-efficacy (La Mar, 2018), there are no current studies that have looked at the impact of internalized gendered racial oppression (IGRO) on negative affect of African American adolescent girls or possible ways to moderate this impact. This study identifies a relationship between IGRO and depression, anxiety and stress symptoms while isolating messages of gendered racial pride and empowerment (GRPE) that reduce these symptoms in Black adolescent girls. To test the hypothesis, GRPE socialization moderates the relationship between IGRO socialization and indicators of psychological wellbeing (i.e., depressive, anxiety, and stress symptoms) this study analyzed the responses of 287 Black adolescent girls (MAge = 15.40) who completed questionnaires assessing the study variables of interest as part of a larger parent-teen dyadic study. A series of hierarchical multiple regression analyses were conducted. Models of the main effects of IGRO and GRPE on depression (R 2 = .04), anxiety (R 2 = .04), and stress (R 2 = .04) were significant (all ps \u3c .001), suggesting these variables accounted for significant variance in the mental health symptoms. For depression, increases in both IGRO (b=.83, p \u3c .001) and GRPE (b=.20, p \u3c .05) were associated with increases in reported depression symptoms. However, examination of the interaction (b=-.16, p \u3c .01) via simple slopes suggested that the Black girls reported higher levels of GRPE, the negative impact of IGRO on depressive symptoms was attenuated. Indeed, at the highest levels of GRPE, the effect of IGRO on depressive symptoms was reduced to non-significance. Similar patterns emerged for teen anxiety and stress, with increased IGRO associated with increasing symptom endorsement and increasing GRPE attenuating this effect. These findings suggest that it is particularly important for African-American youth to receive messages conveying pride and empowerment on being a black girl to aid in reducing the mental health symptoms associated with IGRO. By identifying key messages of gendered racial socialization, this study has the potential to educate parents and teachers on the impact of their messages on children’s mental health. Implications and future directions regarding gendered racial socialization of Black teenaged girls are discussed.https://scholarscompass.vcu.edu/gradposters/1053/thumbnail.jp

Dietary epidemiology of essential tremor: meat consumption and meat cooking pactices

Background/Aim: Harmane [1-methyl-9H-pyrido(3,4-b)indole] is a tremor-producing neurotoxin. Blood harmane concentrations are elevated in essential tremor (ET) patients for unclear reasons. Potential mechanisms include increased dietary harmane intake (especially through well-cooked meat) or genetic-metabolic factors. We tested the hypothesis that meat consumption and level of meat doneness are higher in ET cases than in controls. Methods: Detailed data were collected using the Lawrence Livermore National Laboratory Meat Questionnaire. Results: Total current meat consumption was greater in men with than without ET (135.3 ± 71.1 vs. 110.6 ± 80.4 g/day, p = 0.03) but not in women with versus without ET (80.6 ± 50.0 vs. 79.3 ± 51.0 g/day, p = 0.76). In an adjusted logistic regression analysis in males, higher total current meat consumption was associated with ET (OR = 1.006, p = 0.04, i.e., with 10 additional g/day of meat, odds of ET increased by 6%). Male cases had higher odds of being in the highest than lowest quartile of total current meat consumption (adjusted OR = 21.36, p = 0.001). Meat doneness level was similar in cases and controls. Conclusion: This study provides evidence of a dietary difference between male ET cases and male controls. The etiological ramifications of these results warrant additional investigation

The Combined Effect of Air Layers and Membrane Superhydrophobicity on Biofouling in Membrane Distillation

Previous studies of membrane distillation (MD) have shown that superhydrophobic membranes experience dramatically less inorganic and particulate fouling. However, little explanation for this improved performance has been given in the literature. Furthermore, studies comparing membrane superhydrophobicity and biofouling are lacking, though superhydrophobic surfaces are known to be more vulnerable to biofouling than other types. In non-membrane surfaces, visible air layers on superhydrophobic surfaces have been correlated with significant decreases in biofouling. Therefore, it was proposed here to use superhydrophobic MD membranes with periodic introduction of air to maintain an air layer on the membrane surface. Superhydrophobic membranes were created with initiated chemical vapor deposition (iCVD) of a fluorinated compound, perfluorodecyl acrylate (PFDA). The substrate membrane was PVDF. To test MD fouling, an MD membrane was placed on top of a fouling solution, with a heater and stirrer to caus e evaporation of water through the membrane. Results were analyzed with foulant mass measurements. Alginate gel fouling was examined, as this compound is a common proxy for biological fouling in ocean w ater. The introduction of air layers was found to dramatically decrease foulant adhesion to the membrane, by 95-97%. Membrane superhydrophobicity made a much smaller impact in reducing fouling. Keywords membrane distillation, superhydrophobic surfaces, alginate, air layers, anti-foulin

The effects of iCVD film thickness and conformality on the permeability and wetting of MD membranes

Membranes possessing high permeability to water vapor and high liquid entry pressure (LEP) are necessary for efficient membrane distillation (MD) desalination. A common technique to prepare specialized MD membranes consists of coating a hydrophilic or hydrophobic base membrane with a low surface-energy material. This increases its liquid entry pressure, making the membrane suitable for MD. However, in addition to increasing LEP, the surface-coating may also decrease permeability of the membrane by reducing its average pore size. In this study, we quantify the effects of initiated chemical vapor deposition (iCVD) polymer coatings on membrane permeability and LEP. We consider whether the iCVD films should have minimized thickness or maximized non-conformality, in order to maximize the permeability achieved for a given value of LEP. We determined theoretically that permeability of a single pore is maximized with a highly non-conformal iCVD coating. However, the overall permeability of a membrane consisting of many pores is maximized when iCVD film thickness is minimized. We applied the findings experimentally, preparing an iCVD-treated track-etched polycarbonate (PCTE) membrane and testing it in a permeate gap membrane distillation (PCMD) system. This study focuses on membranes with clearly defined, cylindrical pores. However, we believe that the principles we discuss will extend to membranes with more complex pore architectures. Overall, this work indicates that the focus of surface-coating development should be on minimizing film thickness, not on increasing their non-conformality.MIT & Masdar Institute Cooperative Program (02/MI/MI/CP/11/07633/GEN/G/00)Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies (W911NF-13-d-0001

Inferior Olivary nucleus degeneration does not lessen tremor in essential tremor

Background In traditional models of essential tremor, the inferior olivary nucleus was posited to play a central role as the pacemaker for the tremor. However, recent data call this disease model into question. Case presentation Our patient had progressive, long-standing, familial essential tremor. Upper limb tremor began at age 10 and worsened over time. It continued to worsen during the nine-year period he was enrolled in our brain donation program (age 85 – 94 years), during which time the tremor moved from the moderate to severe range on examination. On postmortem examination at age 94, there were degenerative changes in the cerebellar cortex, as have been described in the essential tremor literature. Additionally, there was marked degeneration of the inferior olivary nucleus, which was presumed to be of more recent onset. Such degeneration has not been previously described in essential tremor postmortems. Despite the presence of this degeneration, the patient’s tremor not only persisted but it continued to worsen during the final decade of his life. Conclusions Although the pathophysiology of essential tremor is not completely understood, evidence such as this suggests that the inferior olivary nucleus does not play a critical role in the generation of tremor in these patients

Evaluation of polygenic risk scores for breast and ovarian cancer risk prediction in BRCA1 and BRCA2 mutation carriers

Background: Genome-wide association studies (GWAS) have identified 94 common single-nucleotide polymorphisms (SNPs) associated with breast cancer (BC) risk and 18 associated with ovarian cancer (OC) risk. Several of these are also associated with risk of BC or OC for women who carry a pathogenic mutation in the high-risk BC and OC genes BRCA1 or BRCA2. The combined effects of these variants on BC or OC risk for BRCA1 and BRCA2 mutation carriers have not yet been assessed while their clinical management could benefit from improved personalized risk estimates. Methods: We constructed polygenic risk scores (PRS) using BC and OC susceptibility SNPs identified through population-based GWAS: for BC (overall, estrogen receptor [ER]-positive, and ER-negative) and for OC. Using data from 15 252 female BRCA1 and 8211 BRCA2 carriers, the association of each PRS with BC or OC risk was evaluated using a weighted cohort approach, with time to diagnosis as the outcome and estimation of the hazard ratios (HRs) per standard deviation increase in the PRS. Results: The PRS for ER-negative BC displayed the strongest association with BC risk in BRCA1 carriers (HR = 1.27, 95% confidence interval [CI] = 1.23 to 1.31, P = 8.2 x 10(53)). In BRCA2 carriers, the strongest association with BC risk was seen for the overall BC PRS (HR = 1.22, 95% CI = 1.17 to 1.28, P = 7.2 x 10(-20)). The OC PRS was strongly associated with OC risk for both BRCA1 and BRCA2 carriers. These translate to differences in absolute risks (more than 10% in each case) between the top and bottom deciles of the PRS distribution; for example, the OC risk was 6% by age 80 years for BRCA2 carriers at the 10th percentile of the OC PRS compared with 19% risk for those at the 90th percentile of PRS. Conclusions: BC and OC PRS are predictive of cancer risk in BRCA1 and BRCA2 carriers. Incorporation of the PRS into risk prediction models has promise to better inform decisions on cancer risk management

Mesodynamics in the SARS nucleocapsid measured by NMR field cycling

Protein motions on all timescales faster than molecular tumbling are encoded in the spectral density. The dissection of complex protein dynamics is typically performed using relaxation rates determined at high and ultra-high field. Here we expand this range of the spectral density to low fields through field cycling using the nucleocapsid protein of the SARS coronavirus as a model system. The field-cycling approach enables site-specific measurements of R1 at low fields with the sensitivity and resolution of a high-field magnet. These data, together with high-field relaxation and heteronuclear NOE, provide evidence for correlated rigid-body motions of the entire β-hairpin, and corresponding motions of adjacent loops with a time constant of 0.8 ns (mesodynamics). MD simulations substantiate these findings and provide direct verification of the time scale and collective nature of these motions

Recent Salmon Declines: A Result of Lost Feeding Opportunities Due to Bad Timing?

As the timing of spring productivity blooms in near-shore areas advances due to warming trends in global climate, the selection pressures on out-migrating salmon smolts are shifting. Species and stocks that leave natal streams earlier may be favoured over later-migrating fish. The low post-release survival of hatchery fish during recent years may be in part due to static release times that do not take the timing of plankton blooms into account. This study examined the effects of release time on the migratory behaviour and survival of wild and hatchery-reared coho salmon (Oncorhynchus kisutch) using acoustic and coded-wire telemetry. Plankton monitoring and near-shore seining were also conducted to determine which habitat and food sources were favoured. Acoustic tags (n = 140) and coded-wire tags (n = 266,692) were implanted into coho salmon smolts at the Seymour and Quinsam Rivers, in British Columbia, Canada. Differences between wild and hatchery fish, and early and late releases were examined during the entire lifecycle. Physiological sampling was also carried out on 30 fish from each release group. The smolt-to-adult survival of coho salmon released during periods of high marine productivity was 1.5- to 3-fold greater than those released both before and after, and the fish's degree of smoltification affected their downstream migration time and duration of stay in the estuary. Therefore, hatchery managers should consider having smolts fully developed and ready for release during the peak of the near-shore plankton blooms. Monitoring chlorophyll a levels and water temperature early in the spring could provide a forecast of the timing of these blooms, giving hatcheries time to adjust their release schedule