Deep and abyssal ocean warming from 35 years of repeat hydrography

Global and regional ocean warming deeper than 2000 m is investigated using 35 years of sustained repeat hydrographic survey data starting in 1981. The global long-term temperature trend below 2000 m, representing the time period 1991–2010, is equivalent to a mean heat flux of 0.065 ± 0.040 W m?2 applied over the Earth's surface area. The strongest warming rates are found in the abyssal layer (4000–6000 m), which contributes to one third of the total heat uptake with the largest contribution from the Southern and Pacific Oceans. A similar regional pattern is found in the deep layer (2000–4000 m), which explains the remaining two thirds of the total heat uptake yet with larger uncertainties. The global average warming rate did not change within uncertainties pre-2000 versus post-2000, whereas ocean average warming rates decreased in the Pacific and Indian Oceans and increased in the Atlantic and Southern Oceans

Elevated maternal lipids in early pregnancy are not associated with risk of intrapartum caesarean in overweight and obese nulliparous women

Background: Maternal overweight and obesity are associated with slower labour progress and increased caesarean delivery for failure to progress. Obesity is also associated with hyperlipidaemia and cholesterol inhibits myometrial contractility in vitro. Our aim was, among overweight and obese nulliparous women, to investigate 1. the role of early pregnancy serum cholesterol and 2. clinical risk factors associated with first stage caesarean for failure to progress at term. Methods: Secondary data analysis from a prospective cohort of overweight/obese New Zealand and Australian nullipara recruited to the SCOPE study. Women who laboured at term and delivered vaginally (n=840) or required first stage caesarean for failure to progress (n=196) were included. Maternal characteristics and serum cholesterol at 14–16 weeks’ of gestation were compared according to delivery mode in univariable and multivariable analyses (adjusted for BMI, maternal age and height, obstetric care type, induction of labour and gestation at delivery ≥41 weeks). Results: Total cholesterol at 14–16 weeks was not higher among women requiring first stage caesarean for failure to progress compared to those with vaginal delivery (5.55 ± 0.92 versus 5.67 ± 0.85 mmol/L, p= 0.10 respectively). Antenatal risk factors for first stage caesarean for failure to progress in overweight and obese women were BMI (adjusted odds ratio [aOR (95% CI)] 1.15 (1.07-1.22) per 5 unit increase, maternal age 1.37 (1.17-1.61) per 5 year increase, height 1.09 (1.06-1.12) per 1cm reduction), induction of labour 1.94 (1.38-2.73) and prolonged pregnancy ≥41 weeks 1.64 (1.14-2.35). Conclusions: Elevated maternal cholesterol in early pregnancy is not a risk factor for first stage caesarean for failure to progress in overweight/obese women. Other clinically relevant risk factors identified are: increasing maternal BMI, increasing maternal age, induction of labour and prolonged pregnancy ≥41 weeks’ of gestation.Elaine M Fyfe, Karen S Rivers, John MD Thompson, Kamala PL Thiyagarajan, Katie M Groom, Gustaaf A Dekker, Lesley ME McCowan and On behalf of the SCOPE consortiu

Clinical, ultrasound and molecular biomarkers for early prediction of large for gestational age infants in nulliparous women: an international prospective cohort study

Objective: To develop a prediction model for term infants born large for gestational age (LGA) by customised birthweight centiles. Methods: International prospective cohort of nulliparous women with singleton pregnancy recruited to the Screening for Pregnancy Endpoints (SCOPE) study. LGA was defined as birthweight above the 90th customised centile, including adjustment for parity, ethnicity, maternal height and weight, fetal gender and gestational age. Clinical risk factors, ultrasound parameters and biomarkers at 14–16 or 19–21 weeks were combined into a prediction model for LGA infants at term using stepwise logistic regression in a training dataset. Prediction performance was assessed in a validation dataset using area under the Receiver Operating Characteristics curve (AUC) and detection rate at fixed false positive rates. Results: The prevalence of LGA at term was 8.8% (n = 491/5628). Clinical and ultrasound factors selected in the prediction model for LGA infants were maternal birthweight, gestational weight gain between 14–16 and 19–21 weeks, and fetal abdominal circumference, head circumference and uterine artery Doppler resistance index at 19–21 weeks (AUC 0.67; 95%CI 0.63–0.71). Sensitivity of this model was 24% and 49% for a fixed false positive rate of 10% and 25%, respectively. The addition of biomarkers resulted in selection of random glucose, LDL-cholesterol, vascular endothelial growth factor receptor-1 (VEGFR1) and neutrophil gelatinase-associated lipocalin (NGAL), but with minimal improvement in model performance (AUC 0.69; 95%CI 0.65–0.73). Sensitivity of the full model was 26% and 50% for a fixed false positive rate of 10% and 25%, respectively. Conclusion: Prediction of LGA infants at term has limited diagnostic performance before 22 weeks but may have a role in contingency screening in later pregnancy

Sexual abuse prevalence and association with adverse labour and birth outcomes

In the past decade there has been growing recognition that a sexual abuse history may manifest during health care examinations. More recently, awareness has been raised about a possible link between a history of sexual abuse and traumatic labour and birth. It is theoretically likely that the intimacy of labour and birth for women with a history of sexual abuse may trigger post-traumatic stress symptomatology. In this cross sectional study, a survey method was used to establish prevalence of sexual abuse and to measure obstetric outcomes, birth experience and birth trauma in a cohort of women who have recently given birth and to test whether there are associations between sexual abuse and birth outcomes. Eighty-five women whose 3½ to 5 year old children attend kindergarten participated. Lifetime sexual abuse was found to be a common experience for study participants. One out of every three women disclosed an experience of sexual abuse in her lifetime. A history of sexual abuse was not associated with adverse labour and birth outcomes; however women with a positive sexual abuse history were more likely to report postnatal depression. A quarter of the women had PTSD symptoms but overall, women had positive birth experiences and felt well supported. Many women are able to overcome traumatic abuse experiences and successfully cope with birth, an event that may potentially replicate the dynamics of sexual abuse. Further research is needed to identify women who may be at high risk for traumatic birth experiences. Undertaking screening for sexual abuse in the antenatal period in a safe environment may provide reassurance for women and enable identification of those women at high risk for abuse related traumatic birth experiences

A Perceiver-Centered Approach for Representing and Annotating Prosodic Functions in Performed Music

Musical prosody is characterized by the acoustic variations that make music expressive. However, few systematic and scalable studies exist on the function it serves or on effective tools to carry out such studies. To address this gap, we introduce a novel approach to capturing information about prosodic functions through a citizen science paradigm. In typical bottom-up approaches to studying musical prosody, acoustic properties in performed music and basic musical structures such as accents and phrases are mapped to prosodic functions, namely segmentation and prominence. In contrast, our top-down, human-centered method puts listener annotations of musical prosodic functions first, to analyze the connection between these functions, the underlying musical structures, and acoustic properties. The method is applied primarily to the exploring of segmentation and prominence in performed solo piano music. These prosodic functions are marked by means of four annotation types—boundaries, regions, note groups, and comments—in the CosmoNote web-based citizen science platform, which presents the music signal or MIDI data and related acoustic features in information layers that can be toggled on and off. Various annotation strategies are discussed and appraised: intuitive vs. analytical; real-time vs. retrospective; and, audio-based vs. visual. The end-to-end process of the data collection is described, from the providing of prosodic examples to the structuring and formatting of the annotation data for analysis, to techniques for preventing precision errors. The aim is to obtain reliable and coherent annotations that can be applied to theoretical and data-driven models of musical prosody. The outcomes include a growing library of prosodic examples with the goal of achieving an annotation convention for studying musical prosody in performed music

Detection rate and area under the receiver operating characteristic of the prediction models for LGA at term.

<p>Detection rate and area under the receiver operating characteristic of the prediction models for LGA at term.</p

Receiver operating characteristics curve for LGA prediction models in the validation dataset.

<p>Model 1—clinical factors at 14–16 weeks; Model 2—clinical factors and candidate biomarkers at 14–16 weeks; Model 3—clinical factors and ultrasound at 14–16 and 19–21 weeks; Model 4—clinical factors, ultrasound and candidate biomarkers at 14–16 and 19–21 weeks; Model 5—full model including additional list of biomarkers.</p